@{MTMT:34794891,
	title = {Expression of nutrient sensing genes mediate the effect of dietary unpredictability in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34794891},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	booktitle = {II. Magyar Agrártudományi Doktoranduszok Szimpóziuma 2024},
	unique-id = {34794891},
	year = {2024},
	pages = {27},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34786100,
	title = {Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34786100},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Knop, Renáta and Lugata, James Kachungwa and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1038/s41598-024-58487-9},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34786100},
	issn = {2045-2322},
	abstract = {Limited resources affect an organism’s physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails ( Coturnix japonica ). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34785047,
	title = {Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quails},
	url = {https://m2.mtmt.hu/api/publication/34785047},
	author = {Gebrehaweria Kidane, Reda and Ndunguru, Sawadi Fransisco and Csernus, Brigitta and Tóthné Gulyás, Gabriella and Knop, Renáta and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1242/jeb.247064},
	journal-iso = {J EXP BIOL},
	journal = {JOURNAL OF EXPERIMENTAL BIOLOGY},
	unique-id = {34785047},
	issn = {0022-0949},
	abstract = {Resources are needed for growth, reproduction and survival, and organisms must trade-off limited resources among competing processes. Nutritional availability in organisms is sensed and monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed that one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form of adaptive plasticity when individuals encounter constraints in their energy budget. Despite the fundamental importance of this process in evolutionary biology, how nutritional limitation is regulated through the expression of genes governing this pathway and its consequential effects on fitness remains understudied, particularly in birds. We used dietary restriction to simulate resource depletion and examined its effects on body mass, reproduction and gene expression in Japanese quails (Coturnix japonica). Quails were subjected to feeding 20%, 30%, 40% restriction levels or ad libitum for two weeks. All restricted groups exhibited reduced body mass, whereas reductions in the number and mass of eggs were observed only under more severe restrictions. Additionally, dietary restriction led to decreased expression of mTOR and insulin-like growth factor 1 (IGF1), whereas the ribosomal protein S6 kinase 1 (RPS6K1) and autophagy-related genes (ATG9A and ATG5) were upregulated. The pattern in which mTOR respond to restriction was similar to what has been seen in body mass. Regardless of the treatment, proportionally higher reproductive investment was associated with individual variation in mTOR expression. These findings reveal the connection between dietary intake and the expression of mTOR and related genes in this pathway.},
	year = {2024},
	eissn = {1477-9145},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34756167,
	title = {Embryonic methionine triggers post-natal developmental programming in Japanese quail},
	url = {https://m2.mtmt.hu/api/publication/34756167},
	author = {Ndunguru, Sawadi Fransisco and Gebrehaweria Kidane, Reda and Csernus, Brigitta and Knop, Renáta and Tóthné Gulyás, Gabriella and Szabó, Csaba and Czeglédi, Levente and Lendvai, Ádám Zoltán},
	doi = {10.1007/s00360-024-01542-8},
	journal-iso = {J COMP PHYSIOL B},
	journal = {JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY},
	unique-id = {34756167},
	issn = {0174-1578},
	abstract = {Embryonic development is one of the most sensitive and critical stages when maternal effects may influence the offspring’s phenotype. In birds and other oviparous species, embryonic development is confined to the eggs, therefore females must deposit resources into the eggs to prepare the offspring for the prevailing post-natal conditions. However, the mechanisms of such phenotypic adjustments remain poorly understood. We simulated a maternal nutritional transfer by injecting 1 mg of l -methionine solution into Japanese quail eggs before the onset of incubation. The increase in early methionine concentration in eggs activated the insulin/insulin-like signalling and mechanistic target of rapamycin (IIS/mTOR) signalling pathways and affected post-natal developmental trajectories. Chicks from methionine-supplemented eggs had higher expression of liver IGF1 and mTOR genes at hatching but were similar in size, and the phenotypic effects of increased growth became apparent only a week later and remained up to three weeks. Circulating levels of insulin-like growth factor-1 (IGF-1) and expression of ribosomal protein serine 6 kinase 1 ( RPS6K1), the mTOR downstream effector, were elevated only three weeks after hatching. These results show that specific nutritional cues may have phenotypic programming effects by sequentially activating specific nutrient-sensing pathways and achieving transgenerational phenotypic plasticity.},
	year = {2024},
	eissn = {1432-136X},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@{MTMT:34632723,
	title = {The prenatal window: Influence of leucine on growth and development of Japanese quail},
	url = {https://m2.mtmt.hu/api/publication/34632723},
	author = {Ndunguru, Sawadi Fransisco and Gebrehaweria Kidane, Reda and Csernus, Brigitta and Szabó, Csaba and Lendvai, Ádám Zoltán and Czeglédi, Levente},
	booktitle = {II. Magyar Agrártudományi Doktoranduszok Szimpóziuma 2024},
	unique-id = {34632723},
	year = {2024},
	pages = {25},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34519831,
	title = {Evolution in European and Israeli school curricula – a comparative analysis},
	url = {https://m2.mtmt.hu/api/publication/34519831},
	author = {Mavrikaki, Evangelia and Realdon, Giulia and Aivelo, Tuomas and Bajrami, Ani and Dilek Bakanay, Çiçek and Beniermann, Anna and Blagojević, Jelena and Butkeviciene, Egle and Cavadas, Bento and Cossu, Costantina and Cvetković, Dragana and Drobniak, Szymon M. and Özgür Durmuş, Zelal and Marta Dvořáková, Radka and Eens, Marcel and Eret, Esra and Eroglu, Seckin and Anna Gazda, Małgorzata and Georgiou, Martha and Gostling, Neil J. and Gregorčič, Tanja and Janštová, Vanda and Jenkins, Tania and Kervinen, Anttoni and Korfiatis, Konstantinos and Kuschmierz, Paul and Lendvai, Ádám Zoltán and de Lima, Joelyn and Miri, Fundime and Nogueira, Teresa and Panayides, Andreas and Paolucci, Sylvia and Papadopoulou, Penelope and Pessoa, Patrícia and Pinxten, Rianne and Rios Rocha, Joana and Fernández Sánchez, Andrea and Siani, Merav and Sokoli, Elvisa and Sousa, Bruno and Stasinakis, Panagiotis K. and Torkar, Gregor and Valackiene, Asta and Varga, Máté and Vázquez Ben, Lucía and Yarden, Anat and Sá-Pinto, Xana},
	doi = {10.1080/09500693.2023.2293090},
	journal-iso = {INT J SCI EDUC},
	journal = {INTERNATIONAL JOURNAL OF SCIENCE EDUCATION},
	unique-id = {34519831},
	issn = {0950-0693},
	year = {2024},
	eissn = {1464-5289},
	orcid-numbers = {Mavrikaki, Evangelia/0000-0001-9029-6340; Realdon, Giulia/0000-0001-8269-4269; Aivelo, Tuomas/0000-0003-4285-7179; Bajrami, Ani/0000-0001-5349-2510; Dilek Bakanay, Çiçek/0000-0001-9491-2569; Beniermann, Anna/0000-0001-5123-5588; Blagojević, Jelena/0000-0001-7102-5510; Butkeviciene, Egle/0000-0002-5631-360X; Cavadas, Bento/0000-0001-6021-6581; Cossu, Costantina/0000-0002-0113-1657; Cvetković, Dragana/0000-0002-1311-7481; Drobniak, Szymon M./0000-0001-8101-6247; Özgür Durmuş, Zelal/0000-0003-3091-4279; Marta Dvořáková, Radka/0000-0002-0118-8290; Eens, Marcel/0000-0001-7538-3542; Eroglu, Seckin/0000-0002-9494-7080; Anna Gazda, Małgorzata/0000-0001-8369-1350; Georgiou, Martha/0000-0003-2762-5150; Gostling, Neil J./0000-0002-5960-7769; Gregorčič, Tanja/0009-0007-6679-245X; Jenkins, Tania/0000-0002-6816-3848; Kervinen, Anttoni/0000-0003-1689-6457; Korfiatis, Konstantinos/0000-0003-0297-6499; Kuschmierz, Paul/0000-0001-8530-4342; Lendvai, Ádám Zoltán/0000-0002-8953-920X; de Lima, Joelyn/0000-0001-9235-9704; Miri, Fundime/0000-0003-3817-4615; Nogueira, Teresa/0000-0002-0059-5177; Panayides, Andreas/0000-0003-2607-7957; Papadopoulou, Penelope/0000-0001-9644-8798; Pessoa, Patrícia/0000-0001-8114-795X; Pinxten, Rianne/0000-0001-5686-3284; Rios Rocha, Joana/0000-0003-3106-8553; Fernández Sánchez, Andrea/0000-0002-8625-8955; Siani, Merav/0000-0003-4321-3068; Sousa, Bruno/0000-0003-1497-030X; Stasinakis, Panagiotis K./0000-0002-3396-6464; Torkar, Gregor/0000-0003-4125-8529; Valackiene, Asta/0000-0002-0079-9508; Varga, Máté/0000-0003-4289-1705; Vázquez Ben, Lucía/0000-0003-1685-5671; Yarden, Anat/0000-0002-3948-9400; Sá-Pinto, Xana/0000-0002-6049-110X}
}

@article{MTMT:34428380,
	title = {Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study},
	url = {https://m2.mtmt.hu/api/publication/34428380},
	author = {Vágási, István Csongor and Vincze, Orsolya and Adámková, Marie and Kauzálová, Tereza and Lendvai, Ádám Zoltán and Pătraș, Laura and Pénzes, Janka and Pap, Péter L. and Albrecht, Tomáš and Tomášek, Oldřich},
	doi = {10.1242/jeb.246848},
	journal-iso = {J EXP BIOL},
	journal = {JOURNAL OF EXPERIMENTAL BIOLOGY},
	volume = {227},
	unique-id = {34428380},
	issn = {0022-0949},
	abstract = {Chronically high blood glucose levels (hyperglycaemia) can compromise healthy ageing and lifespan at the individual level. Elevated oxidative stress can play a central role in hyperglycaemia-induced pathologies. Nevertheless, the lifespan of birds shows no species-level association with blood glucose. This suggests that the potential pathologies of high blood glucose levels can be avoided by adaptations in oxidative physiology at the macroevolutionary scale. However, this hypothesis remains unexplored. Here, we examined this hypothesis using comparative analyses controlled for phylogeny, allometry and fecundity based on data from 51 songbird species (681 individuals with blood glucose and 1021 individuals with oxidative state data). We measured blood glucose at baseline and after stress stimulus and computed glucose stress reactivity as the magnitude of change between the two time points. We also measured three parameters of non-enzymatic antioxidants (uric acid, total antioxidants and glutathione) and a marker of oxidative lipid damage (malondialdehyde). We found no clear evidence for blood glucose concentration being correlated with either antioxidant or lipid damage levels at the macroevolutionary scale, as opposed to the hypothesis postulating that high blood glucose levels entail oxidative costs. The only exception was the moderate evidence for species with a stronger stress-induced increase in blood glucose concentration evolving moderately lower investment into antioxidant defence (uric acid and glutathione). Neither baseline nor stress-induced glucose levels were associated with oxidative physiology. Our findings support the hypothesis that birds evolved adaptations preventing the (glyc)oxidative costs of high blood glucose observed at the within-species level. Such adaptations may explain the decoupled evolution of glycaemia and lifespan in birds and possibly the paradoxical combination of long lifespan and high blood glucose levels relative to mammals.},
	year = {2024},
	eissn = {1477-9145},
	orcid-numbers = {Adámková, Marie/0000-0003-2156-9194; Kauzálová, Tereza/0000-0003-1247-2497; Lendvai, Ádám Zoltán/0000-0002-8953-920X; Pătraș, Laura/0000-0002-6981-3881; Pap, Péter L./0000-0002-3659-7684; Albrecht, Tomáš/0000-0002-9213-0034; Tomášek, Oldřich/0000-0002-2657-5916}
}

@{MTMT:34794572,
	title = {A takarmányfelvétel hatást gyakorol az mTOR útvonalban részt vevő gének expressziójára a japán fürjnél},
	url = {https://m2.mtmt.hu/api/publication/34794572},
	author = {Gebrehaweria Kidane, Reda and Lendvai, Ádám Zoltán},
	booktitle = {39. ÓVÁRI TUDOMÁNYOS NAP KONFERENCIA},
	unique-id = {34794572},
	year = {2023},
	pages = {121},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34153920,
	title = {Short- and long-term effects of nutritional state on IGF-1 levels in nestlings of a wild passerine},
	url = {https://m2.mtmt.hu/api/publication/34153920},
	author = {Lodjak, Jaanis and Boonekamp, Jelle and Lendvai, Ádám Zoltán and Verhulst, Simon},
	doi = {10.1007/s00442-023-05445-3},
	journal-iso = {OECOLOGIA},
	journal = {OECOLOGIA},
	volume = {203},
	unique-id = {34153920},
	issn = {0029-8549},
	abstract = {Growth trajectories of young animals are intimately connected to their fitness prospects, but we have little knowledge of growth regulation mechanisms, particularly in the wild. Insulin-like growth factor 1 (IGF-1) is a central hormone in regulating resource allocation, with higher IGF-1 levels resulting in more growth. IGF-1 levels generally increase in conjunction with nutritional state, but whether IGF-1 levels are adjusted in response to current nutrient availability or to the nutrient availability integrated over a longer term is not well known. We tested for such effects by supplementary feeding the jackdaw ( Corvus monedula ) nestlings in experimentally reduced or enlarged broods with either water (control) or a food solution; these manipulations have long- and short-term effects on the nutritional state, respectively. Baseline plasma IGF-1 levels were higher in reduced broods. Food supplementation induced an increase in plasma IGF-1 levels measured one hour later, and this effect was significantly more substantial in nestlings in reduced broods. Changes in plasma IGF-1 levels increased with increased retention of the supplementary food, which was higher in reduced broods, explaining the stronger IGF-1 response. Thus, IGF-1 levels respond to short-term variations in the nutritional state, but this effect is amplified by longer-term variations in the nutritional state. We discuss our findings using a graphical model that integrates the results of the two treatments.},
	year = {2023},
	eissn = {1432-1939},
	pages = {27-35},
	orcid-numbers = {Lodjak, Jaanis/0000-0001-8089-948X; Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:34117393,
	title = {Bearded Reedling (Panurus biarmicus) : the biology of a remarkable bird – a review of the recent literature},
	url = {https://m2.mtmt.hu/api/publication/34117393},
	author = {Lendvai, Ádám Zoltán},
	doi = {10.2478/orhu-2023-0001},
	journal-iso = {ORNIS HUNG},
	journal = {ORNIS HUNGARICA},
	volume = {31},
	unique-id = {34117393},
	issn = {1215-1610},
	abstract = {The Bearded Reedling Panurus biarmicus is a frequent, yet relatively little-known passerine bird found in wetlands across Eurasia. The species is difficult to study because of its elusive nature and the challenging access to its habitat: old, particularly dense reed patches standing in water. However, a detailed body of knowledge of the species’ natural history, morphology, and behaviour has been gathered over the years, providing insight into the adaptations this unusual bird uses to survive and even thrive under favourable conditions. In 2023, BirdLife Hungary named the Bearded Reedling as the ‘bird of the year’. In light of this notable designation, this article provides an overview of research advances on some of the unique characteristics of the Bearded Reedling, focusing on the factors that affect their population dynamics and potential conservation management strategies to protect the species.},
	year = {2023},
	eissn = {2061-9588},
	pages = {1-1},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}