TY - CHAP AU - Dóczi, Tamás Péter ED - Vámos, Zoltán TI - Agyödéma T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 67 EP - 74 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823698 ID - 34823698 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Perlaki, Gábor AU - Darnai, Gergely AU - Arató, Ákos AU - Alhour, Husamalddin Ali Mohammad AU - Szente, Anna Tímea AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Horváth, Réka AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Orsi, Gergely AU - Janszky, József Vladimír TI - Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People JF - JOURNAL OF MAGNETIC RESONANCE IMAGING J2 - JMRI - J MAGN RESON IM PY - 2024 SN - 1053-1807 DO - 10.1002/jmri.28970 UR - https://m2.mtmt.hu/api/publication/34113102 ID - 34113102 AB - Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3. LA - English DB - MTMT ER - TY - JOUR AU - Harmouche, Ahmed Mouhamad AU - Kövér, Ferenc AU - Szukits, Sándor AU - Dóczi, Tamás Péter AU - Bogner, Péter AU - Tóth, Arnold TI - WebMRI: Brain extraction and linear registration in the web browser Brain extraction and linear registration JF - IMAGING J2 - IMAGING VL - 15 PY - 2023 IS - 1 SP - 31 EP - 36 PG - 6 SN - 2732-0960 DO - 10.1556/1647.2023.00111 UR - https://m2.mtmt.hu/api/publication/34067799 ID - 34067799 LA - English DB - MTMT ER - TY - GEN AU - Rohonczi, Mirtill AU - Perlaki, Gábor AU - Hernádi, Gabriella AU - Kovács, Norbert AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Harmat, Márk AU - Pintér, Dávid AU - Aschermann, Zsuzsanna TI - A fecskefarok jel aszimmetria és a klinikai lateralitás kapcsolata Parkinson-kórban PY - 2023 UR - https://m2.mtmt.hu/api/publication/34012040 ID - 34012040 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Nagy, Szilvia Anett AU - Ivic, Ivan AU - Tóth, Péter József AU - Komoly, Sámuel AU - Kiss, Tamás AU - Pénzes, Máté AU - Málnási Csizmadia, András AU - Dóczi, Tamás Péter AU - Perlaki, Gábor AU - Orsi, Gergely TI - Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-023-32679-1 UR - https://m2.mtmt.hu/api/publication/33742456 ID - 33742456 N1 - * Megosztott szerzőség AB - Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10-6), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion. LA - English DB - MTMT ER - TY - GEN AU - Tóth, Márton AU - Szőcs, Szilárd AU - Henn-Mike, Nóra AU - Agócs-Laboda, Ágnes AU - Kovács, Tamás AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Varga, Csaba TI - Altered h-current in cortical interneurons of drug-resistant epileptic patients PY - 2022 UR - https://m2.mtmt.hu/api/publication/33335271 ID - 33335271 N1 - előadás AB - Approximately 30% of the epileptic patients are drug-resistant. Most of this drugresistant group has a well-defined, focal onset region. For these focal onset, drug-resistant epilepsy patients the surgical resection might be the best therapeutic option for achieving seizure freedom. In many cases the pathological high-frequency oscillations (pHFO) are continuously present in the epileptogenic zone (EZ), however, the pHFOs do not always propagate to neighboring areas. The mechanism which blocks this continuously ongoing pHFOs from generating generalized epilepsy is not entirely known. In the present study, we compared the basic electrophysiological properties of GABAergic interneurons of surgically removed EZ and control (non-epileptic, subcortical tumor patient) cortical interneurons. Most GABAergic interneurons in the control cortical preparations showed prominent sag-potentials caused by hcurrent. In contrast, sag-potentials were less prominent or completely missing in epileptic interneurons. H-current in fast-spiker interneurons have been shown previously to be involved in the maintenance of repeated, high-frequency bursting of interneurons. We hypothesize that the epileptic interneurons are unable to maintain high-frequency bursting activity for longer period, which contributes to the propagation and generalization of pHFOs in epilepsy.Our research was funded by TKP20214. The research was performed in collaboration with the Nano-Bio-Imaging core facility at the Szentágothai Research Centre of the University of Pécs. LA - English DB - MTMT ER - TY - CHAP AU - Molnár, B. AU - Micsinyei, L. AU - Perlaki, Gábor AU - Orsi, Gergely AU - Hejjel, László AU - Dóczi, Tamás Péter AU - Janszky, József Vladimír AU - Laky, N. AU - Tényi, Á. ED - Rojas, I. ED - Valenzuela, O. ED - Rojas, F. ED - Herrera, L.J. ED - Ortuno, F. TI - Data Quality Enhancement for Machine Learning on Wearable ECGs VL - 13346 LNBI PB - Springer Science+Business Media SN - 9783031077036 T3 - Lecture Notes in Computer Science, ISSN 0302-9743 ; 13346 LNBI. PY - 2022 SP - 269 EP - 279 PG - 11 DO - 10.1007/978-3-031-07704-3_22 UR - https://m2.mtmt.hu/api/publication/32925495 ID - 32925495 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - Darnai, Gergely AU - Perlaki, Gábor AU - Orsi, Gergely AU - Arató, Ákos AU - Szente, Anna Tímea AU - Horváth, Réka AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Janszky, József Vladimír TI - Language processing in Internet use disorder : Task-based fMRI study JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 6 PG - 14 SN - 1932-6203 DO - 10.1371/journal.pone.0269979 UR - https://m2.mtmt.hu/api/publication/32907490 ID - 32907490 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program [20017-1.2.1-NKP-2017-00002]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUSTRAT]; National Research, Development and Innovation Fund of Hungary [TKP2021-EGA-16] Funding text: This study was supported by the Hungarian Brain Research Program 20017-1.2.1-NKP-2017-00002 government-based fund. Our research was partly financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pe ' cs, Hungary (20765/3/2018/FEKUSTRAT) and by the National Research, Development and Innovation Fund of Hungary (TKP2021-EGA-16). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. AB - Internet use disorder (IUD) is generally conceptualized as a fast-growing behavioral addiction. Several structural and functional brain alterations have been revealed in this condition, but previous behavioral studies indicated that language systems may also be impaired. We used a silent word generation task to induce brain activation in Broca's area and other parts of the language system. Blood-oxygen-level-dependent activation analysis and psychophysiological interaction analysis were applied to assess functional brain changes. IUD was measured by the Problematic Internet Use Questionnaire and two additional questions concerning usage time and subjective rating of addiction. According to our key findings, areas strongly related to the default mode network were altered in IUD during the task. Moreover, Broca's area showed altered functional connectivity with other language network and occipital areas in IUD. These findings may address the neural background of decreased verbal fluency performance previously reported in the literature, and we emphasize that beside the brain's reward and inhibitory control systems, the language system is the next candidate to be involved in the pathogenesis of IUD. LA - English DB - MTMT ER - TY - JOUR AU - Trischlerné Gyimesi, Csilla AU - Barsi, Péter AU - Bóné, Beáta AU - Dóczi, Tamás Péter AU - Horváth, Réka AU - Horváth, Zsolt AU - Komoly, Sámuel AU - Lőrincz, Katalin Nóra AU - Tóth, Márton AU - Janszky, József Vladimír TI - Epilepsziasebészet a pécsi epilepsziacentrumban JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 17 EP - 17 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893951 ID - 32893951 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Büki, András AU - Lujber, László AU - Dóczi, Tamás Péter AU - Nepp, Nelli AU - Piski, Zalán AU - Tóth, Péter József TI - Transnasalis endoszkópos műtétek az elülső koponyaalap kórfolyamataiban JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 12 EP - 12 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893921 ID - 32893921 LA - Hungarian DB - MTMT ER -