@{MTMT:34823698, title = {Agyödéma}, url = {https://m2.mtmt.hu/api/publication/34823698}, author = {Dóczi, Tamás Péter}, booktitle = {Súlyos baleseti agysérültek ellátása}, unique-id = {34823698}, year = {2024}, pages = {67-74} } @article{MTMT:34113102, title = {Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People}, url = {https://m2.mtmt.hu/api/publication/34113102}, author = {Perlaki, Gábor and Darnai, Gergely and Arató, Ákos and Alhour, Husamalddin Ali Mohammad and Szente, Anna Tímea and Áfra, Eszter and Nagy, Szilvia Anett and Horváth, Réka and Kovács, Norbert and Dóczi, Tamás Péter and Orsi, Gergely and Janszky, József Vladimír}, doi = {10.1002/jmri.28970}, journal-iso = {JMRI - J MAGN RESON IM}, journal = {JOURNAL OF MAGNETIC RESONANCE IMAGING}, unique-id = {34113102}, issn = {1053-1807}, abstract = {Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3.}, keywords = {Brain; morphometry; cortical thickness; SARS-CoV-2}, year = {2024}, eissn = {1522-2586}, orcid-numbers = {Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652; Nagy, Szilvia Anett/0000-0001-6483-9209; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:34067799, title = {WebMRI: Brain extraction and linear registration in the web browser Brain extraction and linear registration}, url = {https://m2.mtmt.hu/api/publication/34067799}, author = {Harmouche, Ahmed Mouhamad and Kövér, Ferenc and Szukits, Sándor and Dóczi, Tamás Péter and Bogner, Péter and Tóth, Arnold}, doi = {10.1556/1647.2023.00111}, journal-iso = {IMAGING}, journal = {IMAGING}, volume = {15}, unique-id = {34067799}, year = {2023}, eissn = {2732-0960}, pages = {31-36} } @misc{MTMT:34012040, title = {A fecskefarok jel aszimmetria és a klinikai lateralitás kapcsolata Parkinson-kórban}, url = {https://m2.mtmt.hu/api/publication/34012040}, author = {Rohonczi, Mirtill and Perlaki, Gábor and Hernádi, Gabriella and Kovács, Norbert and Janszky, József Vladimír and Dóczi, Tamás Péter and Harmat, Márk and Pintér, Dávid and Aschermann, Zsuzsanna}, unique-id = {34012040}, year = {2023}, orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:33742456, title = {Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats}, url = {https://m2.mtmt.hu/api/publication/33742456}, author = {Nagy, Szilvia Anett and Ivic, Ivan and Tóth, Péter József and Komoly, Sámuel and Kiss, Tamás and Pénzes, Máté and Málnási Csizmadia, András and Dóczi, Tamás Péter and Perlaki, Gábor and Orsi, Gergely}, doi = {10.1038/s41598-023-32679-1}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {33742456}, issn = {2045-2322}, abstract = {Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10-6), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Málnási Csizmadia, András/0000-0002-2430-8398} } @misc{MTMT:33335271, title = {Altered h-current in cortical interneurons of drug-resistant epileptic patients}, url = {https://m2.mtmt.hu/api/publication/33335271}, author = {Tóth, Márton and Szőcs, Szilárd and Henn-Mike, Nóra and Agócs-Laboda, Ágnes and Kovács, Tamás and Dóczi, Tamás Péter and Horváth, Zsolt and Janszky, József Vladimír and Varga, Csaba}, unique-id = {33335271}, abstract = {Approximately 30% of the epileptic patients are drug-resistant. Most of this drugresistant group has a well-defined, focal onset region. For these focal onset, drug-resistant epilepsy patients the surgical resection might be the best therapeutic option for achieving seizure freedom. In many cases the pathological high-frequency oscillations (pHFO) are continuously present in the epileptogenic zone (EZ), however, the pHFOs do not always propagate to neighboring areas. The mechanism which blocks this continuously ongoing pHFOs from generating generalized epilepsy is not entirely known. In the present study, we compared the basic electrophysiological properties of GABAergic interneurons of surgically removed EZ and control (non-epileptic, subcortical tumor patient) cortical interneurons. Most GABAergic interneurons in the control cortical preparations showed prominent sag-potentials caused by hcurrent. In contrast, sag-potentials were less prominent or completely missing in epileptic interneurons. H-current in fast-spiker interneurons have been shown previously to be involved in the maintenance of repeated, high-frequency bursting of interneurons. We hypothesize that the epileptic interneurons are unable to maintain high-frequency bursting activity for longer period, which contributes to the propagation and generalization of pHFOs in epilepsy.Our research was funded by TKP20214. The research was performed in collaboration with the Nano-Bio-Imaging core facility at the Szentágothai Research Centre of the University of Pécs.}, year = {2022}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @inproceedings{MTMT:32925495, title = {Data Quality Enhancement for Machine Learning on Wearable ECGs}, url = {https://m2.mtmt.hu/api/publication/32925495}, author = {Molnár, B. and Micsinyei, L. and Perlaki, Gábor and Orsi, Gergely and Hejjel, László and Dóczi, Tamás Péter and Janszky, József Vladimír and Laky, N. and Tényi, Á.}, doi = {10.1007/978-3-031-07704-3_22}, volume = {13346 LNBI}, unique-id = {32925495}, year = {2022}, pages = {269-279}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32907490, title = {Language processing in Internet use disorder : Task-based fMRI study}, url = {https://m2.mtmt.hu/api/publication/32907490}, author = {Darnai, Gergely and Perlaki, Gábor and Orsi, Gergely and Arató, Ákos and Szente, Anna Tímea and Horváth, Réka and Áfra, Eszter and Nagy, Szilvia Anett and Kovács, Norbert and Dóczi, Tamás Péter and Janszky, József Vladimír}, doi = {10.1371/journal.pone.0269979}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {32907490}, issn = {1932-6203}, abstract = {Internet use disorder (IUD) is generally conceptualized as a fast-growing behavioral addiction. Several structural and functional brain alterations have been revealed in this condition, but previous behavioral studies indicated that language systems may also be impaired. We used a silent word generation task to induce brain activation in Broca's area and other parts of the language system. Blood-oxygen-level-dependent activation analysis and psychophysiological interaction analysis were applied to assess functional brain changes. IUD was measured by the Problematic Internet Use Questionnaire and two additional questions concerning usage time and subjective rating of addiction. According to our key findings, areas strongly related to the default mode network were altered in IUD during the task. Moreover, Broca's area showed altered functional connectivity with other language network and occipital areas in IUD. These findings may address the neural background of decreased verbal fluency performance previously reported in the literature, and we emphasize that beside the brain's reward and inhibitory control systems, the language system is the next candidate to be involved in the pathogenesis of IUD.}, year = {2022}, eissn = {1932-6203}, orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32893951, title = {Epilepsziasebészet a pécsi epilepsziacentrumban}, url = {https://m2.mtmt.hu/api/publication/32893951}, author = {Trischlerné Gyimesi, Csilla and Barsi, Péter and Bóné, Beáta and Dóczi, Tamás Péter and Horváth, Réka and Horváth, Zsolt and Komoly, Sámuel and Lőrincz, Katalin Nóra and Tóth, Márton and Janszky, József Vladimír}, journal-iso = {IDEGGYÓGY SZEMLE PROC}, journal = {IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS}, volume = {7}, unique-id = {32893951}, issn = {2498-6240}, year = {2022}, pages = {17-17}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32893921, title = {Transnasalis endoszkópos műtétek az elülső koponyaalap kórfolyamataiban}, url = {https://m2.mtmt.hu/api/publication/32893921}, author = {Büki, András and Lujber, László and Dóczi, Tamás Péter and Nepp, Nelli and Piski, Zalán and Tóth, Péter József}, journal-iso = {IDEGGYÓGY SZEMLE PROC}, journal = {IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS}, volume = {7}, unique-id = {32893921}, issn = {2498-6240}, year = {2022}, pages = {12-12}, orcid-numbers = {Piski, Zalán/0000-0003-2592-9652} }