@article{MTMT:32753550,
	title = {Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD},
	url = {https://m2.mtmt.hu/api/publication/32753550},
	author = {Borbély, Emőke and Varga, Viktória and Szögi, Titanilla and Schuster, Ildikó and Bozsó, Zsolt and Penke, Botond and Fülöp, Lívia},
	doi = {10.3390/ijms23052514},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {32753550},
	issn = {1661-6596},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Schuster, Ildikó/0000-0001-9997-5729; Bozsó, Zsolt/0000-0002-5713-3096; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:33111245,
	title = {Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon},
	url = {https://m2.mtmt.hu/api/publication/33111245},
	author = {Szögi, Titanilla and Borbély, Emőke and Schuster, Ildikó and Bozsó, Zsolt and Sántha, Miklós and Tóth, Erzsébet Melinda and Penke, Botond and Fülöp, Lívia},
	doi = {10.3390/ijms231810364},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33111245},
	issn = {1661-6596},
	abstract = {Neurogenesis plays a crucial role in cognitive processes. During aging and in Alzheimer’s disease (AD), altered neurogenesis and neuroinflammation are evident both in C57BL/6J, APPSwe/PS1dE9 (Tg) mice and humans. AD pathology may slow down upon drug treatment, for example, in a previous study of our group P33, a putative neuroprotective agent was found to exert advantageous effects on the elevated levels of APP, Aβ, and neuroinflammation. In the present study, we aimed to examine longitudinal alterations in neurogenesis, neuroinflammation and AD pathology in a transgenic (Tg) mouse model, and assessed the putative beneficial effects of long-term P33 treatment on AD-specific neurological alterations. Hippocampal cell proliferation and differentiation were significantly reduced between 8 and 12 months of age. Regarding neuroinflammation, significantly elevated astrogliosis and microglial activation were observed in 6- to 7-month-old Tg animals. The amounts of the molecules involved in the amyloidogenic pathway were altered from 4 months of age in Tg animals. P33-treatment led to significantly increased neurogenesis in 9-month-old animals. Our data support the hypothesis that altered neurogenesis may be a consequence of AD pathology. Based on our findings in the transgenic animal model, early pharmacological treatment before the manifestation of AD symptoms might ameliorate neurological decline.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Schuster, Ildikó/0000-0001-9997-5729; Bozsó, Zsolt/0000-0002-5713-3096; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:30744451,
	title = {Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target},
	url = {https://m2.mtmt.hu/api/publication/30744451},
	author = {Szögi, Titanilla and Schuster, Ildikó and Borbély, Emőke and Gyebrovszki, Andrea and Bozsó, Zsolt and Gera, Janos and Rajkó, Róbert and Sántha, Miklós and Penke, Botond and Fülöp, Lívia},
	doi = {10.3390/ijms20123050},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {20},
	unique-id = {30744451},
	issn = {1661-6596},
	abstract = {Regulated intramembrane proteolysis (RIP) of the amyloid precursor protein (APP) leads to the formation of fragments, among which the intracellular domain of APP (AICD) was also identified to be a causative of early pathological events. AICD-counteracting proteins, such as Fe65, may serve as alternative therapeutic targets of Alzheimer's disease (AD). The detection of elevated levels of Fe65 in the brains of both human patients and APP transgenic mice may further strengthen the hypothesis that influencing the interaction between Fe65 and APP may have a beneficial effect on the course of AD. Based on a PXP motif, proven to bind to the WW domain of Fe65, a new pentapeptide was designed and tested. The impedimental effect of P33 on the production of beta amyloid (A beta) (soluble fraction and aggregated plaques) and on the typical features of the AD pathology (decreased dendritic spine density, synaptic markers, elevated inflammatory reactions) was also demonstrated. Significant enhancements of both learning ability and memory function were observed in a Morris water maze paradigm. The results led us to formulate the theory that P33 acts by altering the conformation of Fe65 via binding to its WW domain, consequently hindering any interactions between Fe65 and key members involved in APP processing.},
	year = {2019},
	eissn = {1422-0067},
	orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Schuster, Ildikó/0000-0001-9997-5729; Bozsó, Zsolt/0000-0002-5713-3096; Rajkó, Róbert/0000-0002-6234-658X; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:30310687,
	title = {Structural optimization of foldamer-dendrimer conjugates as multivalent agents against the toxic effects of amyloid beta oligomers},
	url = {https://m2.mtmt.hu/api/publication/30310687},
	author = {Bartus, Éva and Olajos, Gábor and Schuster, Ildikó and Bozsó, Zsolt and Deli, Mária Anna and Veszelka, Szilvia and Walter, Fruzsina and Datki, Zsolt László and Szakonyi, Zsolt and Martinek, Tamás and Fülöp, Lívia},
	doi = {10.3390/molecules23102523},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {23},
	unique-id = {30310687},
	issn = {1420-3049},
	abstract = {Alzheimer's disease is one of the most common chronic neurodegenerative disorders. Despite several in vivo and clinical studies, the cause of the disease is poorly understood. Currently, amyloid β (Aβ) peptide and its tendency to assemble into soluble oligomers are known as a main pathogenic event leading to the interruption of synapses and brain degeneration. Targeting neurotoxic Aβ oligomers can help recognize the disease at an early stage or it can be a potential therapeutic approach. Unnatural β-peptidic foldamers are successfully used against many different protein targets due to their favorable structural and pharmacokinetic properties compared to small molecule or protein-like drug candidates. We have previously reported a tetravalent foldamer-dendrimer conjugate which can selectively bind Aβ oligomers. Taking advantage of multivalency and foldamers, we synthesized different multivalent foldamer-based conjugates to optimize the geometry of the ligand. Isothermal titration calorimetry (ITC) was used to measure binding affinity to Aβ, thereafter 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) based tissue viability assay and impedance-based viability assay on SH-SY5Y cells were applied to monitor Aβ toxicity and protective effects of the compounds. Important factors for high binding affinity were determined and a good correlation was found between influencing the valence and the capability of the conjugates for Aβ binding.},
	keywords = {MOLECULAR RECOGNITION; protein aggregation; foldamer; Multivalency; amyloid β},
	year = {2018},
	eissn = {1420-3049},
	orcid-numbers = {Bartus, Éva/0000-0001-9976-6978; Olajos, Gábor/0000-0002-2479-4891; Schuster, Ildikó/0000-0001-9997-5729; Bozsó, Zsolt/0000-0002-5713-3096; Deli, Mária Anna/0000-0001-6084-6524; Walter, Fruzsina/0000-0001-8145-2823; Datki, Zsolt László/0000-0002-2537-4741; Szakonyi, Zsolt/0000-0003-2432-8409; Martinek, Tamás/0000-0003-3168-8066; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:3193785,
	title = {Multivalent foldamer-based affinity assay for selective recognition of Aβ oligomers},
	url = {https://m2.mtmt.hu/api/publication/3193785},
	author = {Olajos, Gábor and Bartus, Éva and Schuster, Ildikó and Lautner, Gergely and Gyurcsányi, Ervin Róbert and Szögi, Titanilla and Fülöp, Lívia and Martinek, Tamás},
	doi = {10.1016/j.aca.2017.01.013},
	journal-iso = {ANAL CHIM ACTA},
	journal = {ANALYTICA CHIMICA ACTA},
	volume = {960},
	unique-id = {3193785},
	issn = {0003-2670},
	abstract = {Abstract Mimicking the molecular recognition functionality of antibodies is a great challenge. Foldamers are attractive candidates because of their relatively small size and designable interaction surface. This paper describes a sandwich type enzyme-linked immunoassay with a tetravalent β-peptide foldamer helix array as capture element and enzyme labeled tracer antibodies. The assay was found to be selective to β-amyloid oligomeric species with surface features transiently present in ongoing aggregation. In optimized conditions, with special emphasis on the foldamer immobilization, a detection limit of 5 pM was achieved with a linear range of 10–500 pM. These results suggest that protein mimetic foldamers can be useful tools in biosensors and affinity assays.},
	keywords = {FOLDAMERS; MOLECULAR RECOGNITION; Antibody mimetics; Bioaffinity assay; β-Amyloid oligomers},
	year = {2017},
	eissn = {1873-4324},
	pages = {131-137},
	orcid-numbers = {Olajos, Gábor/0000-0002-2479-4891; Bartus, Éva/0000-0001-9976-6978; Schuster, Ildikó/0000-0001-9997-5729; Gyurcsányi, Ervin Róbert/0000-0002-9929-7865; Szögi, Titanilla/0000-0002-9854-7340; Fülöp, Lívia/0000-0002-8010-0129; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:3317847,
	title = {The Effects of the Neuroprotective Pentapeptide p33 on the Neurogenesis in APP/PS1 Mice},
	url = {https://m2.mtmt.hu/api/publication/3317847},
	author = {Szögi, Titanilla and E., Borbély and D., Tüdős and Schuster, Ildikó and Penke, Botond and Fülöp, Lívia},
	journal-iso = {NEURODEGENER DIS},
	journal = {NEURODEGENERATIVE DISEASES},
	volume = {17},
	unique-id = {3317847},
	issn = {1660-2854},
	year = {2017},
	eissn = {1660-2862},
	pages = {793-793},
	orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Schuster, Ildikó/0000-0001-9997-5729; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:1366571,
	title = {Convenient Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Acid Derivatives via Isocyanide-Based, Three-Component Reactions},
	url = {https://m2.mtmt.hu/api/publication/1366571},
	author = {Schuster, Ildikó and Lázár, László and Fülöp, Ferenc},
	doi = {10.1080/00397910903277920},
	journal-iso = {SYNTHETIC COMMUN},
	journal = {SYNTHETIC COMMUNICATIONS},
	volume = {40},
	unique-id = {1366571},
	issn = {0039-7911},
	abstract = {The three-component reactions of 3,4-dihydroisoquinolines, isocyanides, and benzyl chloroformate furnished 2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Hydrogenolysis or selective hydrolysis of the benzyloxycarbonyl group provided 1,2,3,4-tetrahydroisoquinoline-1-carboxamides, further hydrolysis of which resulted in the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids.},
	keywords = {WATER; Isoquinolines; ISOQUINOLINE; TETRAHYDROISOQUINOLINE; MULTICOMPONENT REACTIONS; ISOCYANIDES; ugi reactions; SALTS; STRONG CH-ACIDS; -Amino acids},
	year = {2010},
	eissn = {1532-2432},
	pages = {2488-2498},
	orcid-numbers = {Schuster, Ildikó/0000-0001-9997-5729; Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287}
}

@mastersthesis{MTMT:26386197,
	title = {Syntheses and transformations of difunctional tetrahydroisoquinolines},
	url = {https://m2.mtmt.hu/api/publication/26386197},
	author = {Schuster, Ildikó},
	publisher = {SZTE},
	unique-id = {26386197},
	year = {2010}
}

@article{MTMT:2494108,
	title = {1,2,3,4-Tetrahidroizokinolin-1-karbonsav származékok előállítása izocianid alapú háromkomponensű reakcióval},
	url = {https://m2.mtmt.hu/api/publication/2494108},
	author = {Schuster, Ildikó and Sztojkov-Ivanov, Anita and Lázár, László and Fülöp, Ferenc},
	journal-iso = {MAGY KÉM FOLY KÉM KÖZL},
	journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)},
	volume = {116},
	unique-id = {2494108},
	issn = {1418-9933},
	year = {2010},
	eissn = {1418-8600},
	pages = {126-130},
	orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287}
}

@article{MTMT:1140193,
	title = {Synthesis and conformational analysis of phenyl-substituted 1,3,2-oxazaphosphino[4,3-a]- and 1,2,3-oxathiazino[4,3-a]isoquinolines},
	url = {https://m2.mtmt.hu/api/publication/1140193},
	author = {Schuster, Ildikó and Koch, A and Heydenreich, M and Kleinpeter, E and Lázár, László and Fülöp, Ferenc},
	doi = {10.1016/j.molstruc.2007.11.054},
	journal-iso = {J MOL STRUCT},
	journal = {JOURNAL OF MOLECULAR STRUCTURE},
	volume = {888},
	unique-id = {1140193},
	issn = {0022-2860},
	abstract = {Through the ring closures of tetrahydroisoquinoline 1,3-amino alcohols
		bearing a phenyl group in the side-chain, diastereomers of novel 1- or
		2-phenyl-substituted 1,3,2-oxazaphosphino[4,3-a]isoquinoline 4-oxides,
		and 1,2,3-oxathiazino[4,3-a]isoquinoline 4-oxides and 4,4-dioxides were
		prepared. NMR analysis and DFT calculations on the prepared
		tetrahydroisoquinoline-condensed 1,2,3-heterocycles revealed that their
		conformational equilibria of cis(1)-trans-cis(2) type are influenced by
		the relative configuration of P-4 in the 1,3,2-oxazaphosphinanes, and
		by the position of the phenyl group in the 1,2,3-oxathiazines. (C) 2007
		Elsevier B.V. All rights reserved.},
	year = {2008},
	eissn = {1872-8014},
	pages = {124-137},
	orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287}
}

@article{MTMT:1124327,
	title = {Synthesis and conformational analysis of tetrahydroisoquinoline-fused 1,3,2-oxazaphospholidines and 1,2,3-oxathiazolidines},
	url = {https://m2.mtmt.hu/api/publication/1124327},
	author = {Schuster, Ildikó and Koch, A and Heydenreich, M and Kleinpeter, E and Forró, Enikő and Lázár, László and Sillanpaa, R and Fülöp, Ferenc},
	doi = {10.1002/ejoc.200701026},
	journal-iso = {EUR J ORG CHEM},
	journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
	volume = {2008},
	unique-id = {1124327},
	issn = {1434-193X},
	abstract = {The cyclizations of tetrahydroisoquinoline 1,2-amino alcohols with
		phenylphosphonic dichloride, bis(2-chloroethyl)phosphoramidic
		dichloride, thionyl chloride and sulfuryl chloride were utilized to
		synthesize
		1,5,6,10b-tetrahydro-1,3,2-oxazaphospholo[4,3-a]isoquinolines (2, 3),
		1,5,10,10a-tetrahydro-1,3,2-oxazaphospholo[3,4-b]isoquinolines (8, 9),
		1,5,6,10b-tetrahydro-1,2,3-oxathiazolo[4,3-a]isoquinolines (4-6) and a
		1,5,10,10a-tetrahydro-1,2,3-oxathiazolo[3,4-b]isoquinoline (11), which
		are the first representatives of these ring systems. NMR spectroscopic
		analysis revealed the existence of conformational equilibria that are
		fast on the NMR timescale. Theoretical DFT calculations pointed to the
		participation of generally two preferred conformers in the
		conformational equilibria; the positions of the equilibria were
		indicated by the experimental NMR spectroscopic parameters, and they
		are in good agreement with the theoretically calculated energy
		differences of the participating conformers. For two compounds, which
		could be not isolated (10, 12), both the preferred conformers and the
		stereochemistry could be concluded from the DFT calculation results.
		((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).},
	year = {2008},
	eissn = {1099-0690},
	pages = {1464-1472},
	orcid-numbers = {Forró, Enikő/0000-0001-6796-3889; Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287}
}

@article{MTMT:1399684,
	title = {Mass spectra of tetrahydroisoquinoline-fused 1,3,2-O,N,P- and 1,2,3-O,S,N-heterocycles: influence of ring size and fusion, of present heteroatoms, substituent effects and of the stereochemistry on fragmentation},
	url = {https://m2.mtmt.hu/api/publication/1399684},
	author = {Starke, I and Schuster, Ildikó and Fülöp, Ferenc and Kleinpeter, E},
	doi = {10.1002/rcm.3543},
	journal-iso = {RAPID COMMUN MASS SPECTR},
	journal = {RAPID COMMUNICATIONS IN MASS SPECTROMETRY},
	volume = {22},
	unique-id = {1399684},
	issn = {0951-4198},
	abstract = {The electron ionization (EI) mass spectra of a variety of stereoisomeric tricyclic 1,3,2-oxazaphosphino-[4,3-a]isoquinolines (1-4), 1,2,3-oxathiazino[4,3-a]isoquinoline-4-oxides (5-7) and the -4,4-dioxides (8-10) of oxazaphospholo- and oxathiazolo[4,3-a]- (11, 12, 15 and 16) and -[3,4-b]isoquinolines (13, 14 and 17) were recorded. Ring size and fusion, the different heteroatoms (P and S) and substituents on the ring systems strongly influence the mass spectra. In addition, mass spectra of the stereoisomers of compounds 1, 2 and 13, 14 revealed stereochemically relevant differences which are not observed for the other pairs of isomers. Copyright (C) 2008 John Wiley & Sons, Ltd.},
	keywords = {CONFORMATIONAL-ANALYSIS; SEMIEMPIRICAL METHODS; IONIZATION; ELECTRON-IMPACT; SPECTROMETRIC FRAGMENTATION; ARYL MIGRATION; TRIVALENT PHOSPHORUS; TRANS HEXAHYDROINDANES; IMPACT-INDUCED FRAGMENTATION; PHOSPHORUS-CONTAINING HETEROCYCLES},
	year = {2008},
	eissn = {1097-0231},
	pages = {1519-1527},
	orcid-numbers = {Fülöp, Ferenc/0000-0003-1066-5287}
}

@article{MTMT:1083281,
	title = {Synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid Derivatives Via Ugi Reactions},
	url = {https://m2.mtmt.hu/api/publication/1083281},
	author = {Schuster, Ildikó and Sztojkov-Ivanov, Anita and Lázár, László and Fülöp, Ferenc},
	doi = {10.2174/157017807780414226},
	journal-iso = {LETT ORG CHEM},
	journal = {LETTERS IN ORGANIC CHEMISTRY},
	volume = {4},
	unique-id = {1083281},
	issn = {1570-1786},
	abstract = {The three-component Ugi reactions of 3,4-dihydroisoquinolines, isocyanides and acids furnished 2-acyl-N-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Chiral, nonracemic acids induced only poor diastercoselectivities in the condensations. Hydrolysis of the Ugi carboxamides gave the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids, which due to their ready ability to undergo racemization, were obtained as racemic mixtures or with low enantiomeric excesses.},
	year = {2007},
	eissn = {1875-6255},
	pages = {102-108},
	orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287}
}