TY - JOUR AU - Varga, Adorján AU - Makszin, Lilla AU - Bufa, Anita AU - Sipos, Dávid AU - Kása, Péter AU - Pál, Szilárd AU - Rosenstiel, Philip AU - Sommer, Felix AU - Kocsis, Béla AU - Péterfi, Zoltán TI - Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 13 PY - 2023 PG - 15 SN - 2235-2988 DO - 10.3389/fcimb.2023.1041384 UR - https://m2.mtmt.hu/api/publication/33588242 ID - 33588242 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Kocsis, Béla AU - Sipos, Dávid AU - Kása, Péter AU - Vigvári, Szabolcs József AU - Pál, Szilárd AU - Dembrovszky, Fanni AU - Borbásné Farkas, Kornélia AU - Péterfi, Zoltán TI - How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 11 PY - 2021 PG - 11 SN - 2235-2988 DO - 10.3389/fcimb.2021.657320 UR - https://m2.mtmt.hu/api/publication/32056248 ID - 32056248 N1 - Department of Medical Microbiology and Immunology, University of Pécs Clinical Centre, Pécs, Hungary Department of Internal Medicine – Department of Infectology, University of Pécs Clinical Centre, Pécs, Hungary Institute of Pharmaceutical Technology and Biopharmacy, University of Pécs, Faculty of Pharmacy, Pécs, Hungary Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary Institute of Bioanalysis, University of Pécs Medical School, Pécs, Hungary Cited By :17 Export Date: 23 April 2024 Correspondence Address: Varga, A.; Department of Medical Microbiology and Immunology, Hungary LA - English DB - MTMT ER - TY - GEN AU - Ferenczi, Krisztina AU - Vörös-Horváth, Barbara AU - Kása, Péter AU - Nagy, Sándor AU - Széchenyi, Aleksandar AU - Pál, Szilárd AU - Hódi, Klára TI - A nanonizálás hatása a keményítőszemcsék dezintegráns hatására PY - 2019 UR - https://m2.mtmt.hu/api/publication/30882388 ID - 30882388 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Kocsis, Béla AU - Sipos, Dávid AU - Vigvári, Szabolcs József AU - Kása, Péter AU - Pál, Szilárd AU - Mikó, Éva AU - Szereday, László AU - Bechtolsheim, F. AU - Péterfi, Zoltán TI - Treatment options of Clostridium difficile infection: our latest experiences with fecal microbiota transplant JF - CLINICAL CHEMISTRY AND LABORATORY MEDICINE J2 - CLIN CHEM LAB MED VL - 56 PY - 2018 IS - 9 SP - eA133 EP - eA133 SN - 1434-6621 UR - https://m2.mtmt.hu/api/publication/30600970 ID - 30600970 LA - English DB - MTMT ER - TY - JOUR AU - Hegyesi, Diána AU - Markus, Thommes AU - Peter, Kleinebudde AU - Sovány, Tamás AU - Kása, Péter AU - Kelemen, András AU - Hódi, Klára AU - Regdon, Géza (ifj.) TI - Preparation and physicochemical characterization of matrix pellets containing APIs with different solubility via extrusion process JF - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY J2 - DRUG DEV IND PHARM VL - 43 PY - 2017 IS - 3 SP - 458 EP - 464 PG - 7 SN - 0363-9045 DO - 10.1080/03639045.2016.1261150 UR - https://m2.mtmt.hu/api/publication/3140460 ID - 3140460 N1 - Funding Agency and Grant Number: Gedeon Richter Ltd. Funding text: We would like to thank Richter Gedeon Ltd., Colorcon Ltd., and FMC Corporation for providing the active agent and the excipients, and special thanks to Gedeon Richter Ltd., who supported the experimental work in Dusseldorf. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary Gedeon Richter Ltd., Budapest, Hungary Department of Biochemical and Chemical Engineering, Chair of Solids Process Engineering, Technical University Dortmund, Dortmund, Germany Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Düsseldorf, Germany Evonik Nutrition & Care GmbH Magyarországi Fióktelepe, Budapest, Hungary Department of Applied Informatics, University of Szeged, Szeged, Hungary Cited By :1 Export Date: 5 October 2020 CODEN: DDIPD Correspondence Address: Regdon, G.; Department of Pharmaceutical Technology, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., Hungary; email: geza.regdon@pharm.u-szeged.hu Chemicals/CAS: enalapril maleate, 76095-16-4; ethyl cellulose, 9004-57-3; hydrochlorothiazide, 58-93-5; microcrystalline cellulose, 39394-43-9, 51395-75-6; Drug Implants Manufacturers: richter gedeon, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Jójárt, I AU - Kása, Péter AU - Kelemen, András AU - Hódi, Klára TI - Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 21 PY - 2016 IS - 3 SP - 321 EP - 327 PG - 7 SN - 1083-7450 DO - 10.3109/10837450.2014.1003654 UR - https://m2.mtmt.hu/api/publication/2810589 ID - 2810589 LA - English DB - MTMT ER - TY - JOUR AU - Papós, Kitti AU - Kása, Péter AU - Ilić, Ilija AU - Blatnik-Urek, Sandra AU - Regdon, Géza (ifj.) AU - Srčič, Stane AU - Hódi, Klára AU - Sovány, Tamás TI - Effect of the surface free energy of materials on the lamination tendency of bilayer tablets JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 496 PY - 2015 IS - 2 SP - 609 EP - 613 PG - 5 SN - 0378-5173 DO - 10.1016/j.ijpharm.2015.10.061 UR - https://m2.mtmt.hu/api/publication/2966264 ID - 2966264 AB - Abstract Dosage forms with fixed dose combinations of drugs is a frequent and advantageous mode of administration, but their production involves a number of technological problems. Numerous interactions in a homogeneous vehicle may be avoided through the use of layered tablets. The mechanical properties of these dosage forms depend on numerous process parameters and material characteristics. The aim of the present study was a detailed investigation of the relationships between the surface characteristics and deformation properties of tableting materials and the tendency of bilayer tablets to undergo lamination. Bilayer tablets were compressed from unlubricated materials with different plastic-elastic properties and surface free energies according to a mixed 2 and 3-level half-replicated factorial design. The results revealed that the surface characteristics play the main role in the lamination of layered tablets and the effect of the plastic-elastic behavior cannot be interpreted without a knowledge of these properties. LA - English DB - MTMT ER - TY - JOUR AU - Fenyvesi, Ferenc AU - Kónya, Zoltán AU - Rázga, Zsolt AU - Vecsernyés, Miklós AU - Kása, Péter AU - Hódi, Klára AU - Bácskay, Ildikó TI - Investigation of the Cytotoxic Effects of Titanate Nanotubes on Caco-2 Cells JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 15 PY - 2014 IS - 4 SP - 858 EP - 861 PG - 4 SN - 1530-9932 DO - 10.1208/s12249-014-0115-x UR - https://m2.mtmt.hu/api/publication/2573578 ID - 2573578 AB - Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery. LA - English DB - MTMT ER - TY - JOUR AU - Oláh, Ildikó AU - Kása, Péter AU - Regdon, Géza (ifj.) AU - Hódi, Klára AU - Sovány, Tamás TI - Kalcium/D3-vitamin tartalmú szájban diszpergálódó tabletták optimalizálása kísérlettervezéses és PAT módszerekkel JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 58 PY - 2014 IS - S1 SP - 112 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/2701382 ID - 2701382 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szepes, Anikó AU - Révész, Piroska AU - Bajdik, János AU - Kása, Péter AU - Neményi, Miklós AU - Pap, Roland AU - Kovács, Attila József AU - Hódi, Klára TI - Characterization and utilization of starches extracted from Florencia and waxy maize hybrids for tablet formulation: compaction behaviour and tablet properties JF - AMERICAN JOURNAL OF PLANT SCIENCES (AJPS) J2 - AM J PLANT SCI VL - 5 PY - 2014 SP - 787 EP - 798 PG - 12 SN - 2158-2742 DO - 10.4236/ajps.2014.56093 UR - https://m2.mtmt.hu/api/publication/2562122 ID - 2562122 LA - English DB - MTMT ER - TY - JOUR AU - Hegyesi, Diána AU - M., Thommes AU - P., Kleinebudde AU - Sovány, Tamás AU - Kása, Péter AU - Kelemen, András AU - Hódi, Klára AU - Regdon, Géza (ifj.) TI - Preparation and characterization of matrix pellets via extrusion process JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 50 PY - 2013 IS - S1 SN - 0928-0987 UR - https://m2.mtmt.hu/api/publication/2418706 ID - 2418706 LA - English DB - MTMT ER - TY - JOUR AU - Jójárt, Imre AU - Kelemen, András AU - Kása, Péter AU - Hódi, Klára TI - Tracking of the post-compressional behaviour of chewing gum tablets JF - COMPOSITES PART B-ENGINEERING J2 - COMPOS PART B-ENG VL - 49 PY - 2013 SP - 1 EP - 5 PG - 5 SN - 1359-8368 DO - 10.1016/j.compositesb.2013.01.003 UR - https://m2.mtmt.hu/api/publication/2274682 ID - 2274682 AB - The elasticity and elastic recovery of chewing gum powder were tested in this work. Powder rheological tests (flowability and compressibility) showed that direct compression is a suitable method for the preparation of chewing gum tablets. The advantages of this method relative to preparation by extrusion are economic: a reduced processing time, fewer manufacturing steps, less equipment, less process validation and reduced labour costs. A very important property of a chewing gum tablet is the chewability, which depends on the elasticity of the product. This was tested by breaking strength measurements and study of the deformation process. For a good chewable tablet, the authors suggest application of a compression force of 5 kN. © 2013 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Kása, Péter AU - Jójárt, Imre AU - Kelemen, András AU - Hódi, Klára TI - Formulation study of directly compressible chewable polymers containing ascorbic acid JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 18 PY - 2013 IS - 2 SP - 384 EP - 389 PG - 6 SN - 1083-7450 DO - 10.3109/10837450.2011.646426 UR - https://m2.mtmt.hu/api/publication/1884753 ID - 1884753 LA - English DB - MTMT ER - TY - JOUR AU - Sovány, Tamás AU - Papos, K AU - Kása, Péter AU - Ilic, I AU - Srcic, S AU - Hódi, Klára TI - Application of Physicochemical Properties and Process Parameters in the Development of a Neural Network Model for Prediction of Tablet Characteristics JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 14 PY - 2013 IS - 2 SP - 511 EP - 516 PG - 6 SN - 1530-9932 DO - 10.1208/s12249-013-9932-6 UR - https://m2.mtmt.hu/api/publication/2440606 ID - 2440606 LA - English DB - MTMT ER - TY - CONF AU - Sovány, Tamás AU - Oláh, Ildikó AU - Kása, Péter AU - Hódi, Klára TI - Application of PAT methods in the development and quality contol of orally disintegrating tablets T2 - 3rd World Conference on Physico-Chemical Methods in Drug Discovery and Development PY - 2013 SP - 29 EP - 29 PG - 1 UR - https://m2.mtmt.hu/api/publication/2473715 ID - 2473715 LA - English DB - MTMT ER - TY - JOUR AU - Hamedelniel, EI AU - Bajdik, J AU - Kása, Péter AU - Hódi, Klára TI - Study of the influence of alkalizing components on matrix pellets prepared by extrusion/spheronization JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 17 PY - 2012 IS - 2 SP - 204 EP - 211 PG - 8 SN - 1083-7450 DO - 10.3109/10837450.2010.531734 UR - https://m2.mtmt.hu/api/publication/2045181 ID - 2045181 LA - English DB - MTMT ER - TY - GEN AU - Hegyesi, Diána AU - Kása, Péter AU - Hódi, Klára AU - Regdon, Géza (ifj.) TI - Mátrix típusú pelletek formulálása faktoriális kísérlettervezés alkalmazásával. PY - 2012 UR - https://m2.mtmt.hu/api/publication/2209127 ID - 2209127 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Jójárt, Imre AU - Sovány, Tamás AU - Hódi, Klára AU - Kása, Péter TI - Study of the behaviour of magnesium stearate with different specific surface areas on the surface of particles during mixing JF - JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY J2 - J ADHES SCI TECHNOL VL - 26 PY - 2012 IS - 24 SP - 2737 EP - 2744 PG - 8 SN - 0169-4243 DO - 10.1080/01694243.2012.701481 UR - https://m2.mtmt.hu/api/publication/1999883 ID - 1999883 LA - English DB - MTMT ER - TY - JOUR AU - Korbely, Anita AU - Kelemen, András AU - Kása, Péter AU - Hódi, Klára TI - Effects of Processing on the Release Profiles of Matrix Systems Containing 5-Aminosalicylic Acid JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 13 PY - 2012 IS - 4 SP - 1341 EP - 1347 PG - 7 SN - 1530-9932 DO - 10.1208/s12249-012-9861-9 UR - https://m2.mtmt.hu/api/publication/2099429 ID - 2099429 AB - The aim of this study was to investigate the influence of different processing methods on the profiles of 5-aminosalicylic acid dissolution from controlled-release matrix systems based on Eudragit(R) RL and Eudragit(R) RS water-insoluble polymers. The pure polymers and their mixtures were studied as matrix formers using different processing methods, i.e., direct compression, wet granulation of the active ingredient with the addition of polymer(s) to the external phase, wet granulation with water, and wet granulation with aqueous dispersions. In comparison with the directly compressed tablets, tablets made by wet granulation with water demonstrated a 6-19% increase in final drug dissolution, whereas when polymers were applied in the external phase during compression, a 0-13% decrease was observed in the amount of drug released. Wet granulation with aqueous polymer dispersions delayed the release of the drug; this was especially marked (a 54-56% decrease in drug release) in compositions, which contained a high amount of Eudragit RL 30D. The release profiles were mostly described by the Korsmeyer- Peppas model or the Hopfenberg model. LA - English DB - MTMT ER - TY - JOUR AU - Soica, CM AU - Dehelean, CA AU - Peev, C AU - Aluas, M AU - Zupkó, István AU - Kása, Péter AU - Alexa, E TI - Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines JF - NATURAL PRODUCT RESEARCH J2 - NAT PROD RES VL - 26 PY - 2012 IS - 10 SP - 968 EP - 974 PG - 7 SN - 1478-6419 DO - 10.1080/14786419.2010.545352 UR - https://m2.mtmt.hu/api/publication/1972159 ID - 1972159 AB - Betulin and betulinic acid are pentacyclic triterpenes present in the bark of the birch tree and other vegetal sources. Quantitatively, in birch bark betulin is more significant than betulinic acid; therefore, birch can be a large and feasible source of raw material for betulin extraction. Betulin can be used as extracted or, after chemical modification, as a starting compound for its acid, betulinic acid, with both substances possessing various interesting pharmacological properties. The purpose of this study is to analyse the betulin and betulinic acid content of a birch tree bark extract, as well as its cytotoxic activity. The extraction was done using a Soxhlet extractor and chloroform/dichlormethane/methanol (1 : 1 : 1) as solvent. The betulin and betulinic acid content of the extract was estimated using standards of pure betulin and betulinic acid, by thermal analysis as opposed to pure substance (thermogravimetric and differential thermal analysis). The extract and the main compounds were also analysed by NMR. The results indicated a high amount of betulin in the final extract (up to 50%), and an important quantity of betulinic acid: over 3%. The cytotoxic activity indicated a high proliferation inhibition for the birch tree extract but was still comparable with betulinic acid and betulin. LA - English DB - MTMT ER -