@article{MTMT:34763930,
	title = {Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties},
	url = {https://m2.mtmt.hu/api/publication/34763930},
	author = {Farkas, Gyula and Nagy, Sándor and Dévay, Attila and Széchenyi, Aleksandar and Pál, Szilárd},
	doi = {10.3390/pharmaceutics16030405},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {34763930},
	issn = {1999-4923},
	abstract = {The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have been developed to examine flowability, including static and dynamic methods applying empirical studies and up-to-date chaos theory; however, the newest methods seem only to be powerful with the supplementation of empirical principles. Our experiments try to refine both the technique of analysis and the methods, by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model that combined empirical observations and chaos theory on a geometrical basis, thus finding new characteristics regarding the flow properties of pellets and granules that could be relevant for drug developers. Our findings indicate that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical multiparticular preparations. Furthermore, this study confirms that integrating chaos theory and empirical observations in a time-dependent dynamic model provides a comprehensive understanding of particle flow behavior, pivotal for optimizing manufacturing processes.},
	keywords = {Flow properties; flow time; flow curve; conical section; static angle of repose},
	year = {2024},
	eissn = {1999-4923},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:32907484,
	title = {Cocrystals of tuberculosis antibiotics : Challenges and missed opportunities},
	url = {https://m2.mtmt.hu/api/publication/32907484},
	author = {Salem, Ala' and Khanfar, Esam and Nagy, Sándor and Széchenyi, Aleksandar},
	doi = {10.1016/j.ijpharm.2022.121924},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {623},
	unique-id = {32907484},
	issn = {0378-5173},
	abstract = {Cocrystals have been extensively used to improve the physicochemical properties and bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis medications are among those commonly reported. This review provides a summary of the tuberculosis antibiotic cocrystals reported in the literature, providing the main results on current tuberculosis medications utilized in cocrystals. Moreover, anti-tuberculosis cocrystals limitations and advantages are described, including evidence for enhanced solubility, stability and effect. Opportunities to enhance anti-tuberculosis medications and fixed dose combinations using cocrystals are given. Several cocrystal pairs are suggested to enhance the effectiveness of anti-tuberculosis drugs.},
	keywords = {Solubility; Cocrystal; multidrug-resistant; Anti-tuberculosis; Drug-drug cocrystal},
	year = {2022},
	eissn = {1873-3476},
	orcid-numbers = {Khanfar, Esam/0000-0001-5260-7937; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:31646675,
	title = {Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control},
	url = {https://m2.mtmt.hu/api/publication/31646675},
	author = {Salem, Ala' and Hagymási, A. and Vörös-Horváth, Barbara and Šafarik, T. and Balić, T. and Szabó, Péter and Gősi, F. and Nagy, Sándor and Pál, Szilárd and Kunsági-Máté, Sándor and Széchenyi, Aleksandar},
	doi = {10.1016/j.ejps.2020.105599},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {156},
	unique-id = {31646675},
	issn = {0928-0987},
	year = {2021},
	eissn = {1879-0720},
	orcid-numbers = {Szabó, Péter/0000-0003-0827-3583; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:31905073,
	title = {Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals},
	url = {https://m2.mtmt.hu/api/publication/31905073},
	author = {Salem, Ala' and Takácsi-Nagy, Anna Erzsébet and Nagy, Sándor and Hagymási, Alexandra and Gősi, Fruzsina and Vörös-Horváth, Barbara and Balić, Tomislav and Pál, Szilárd and Széchenyi, Aleksandar},
	doi = {10.3390/pharmaceutics13020277},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {13},
	unique-id = {31905073},
	issn = {1999-4923},
	abstract = {Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine.},
	keywords = {COCRYSTALS; High-pressure homogenization; Sulfamethazine; 4-aminosalicylic acid; high-power ultrasound; nano-drugs},
	year = {2021},
	eissn = {1999-4923},
	orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:31347571,
	title = {First online operation of TRIGA-TRAP},
	url = {https://m2.mtmt.hu/api/publication/31347571},
	author = {Grund, J. and Asai, M. and Blaum, K. and Block, M. and Chenmarev, S. and Düllmann, C.E. and Eberhardt, K. and Lohse, S. and Nagame, Y. and Nagy, Sándor and Naubereit, P. and van, de Laar J.J.W. and Schneider, F. and Sato, T.K. and Sato, N. and Simonovski, D. and Tsukada, K. and Wendt, K.},
	doi = {10.1016/j.nima.2020.164013},
	journal-iso = {NUCL INSTRUM METH A},
	journal = {NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT},
	volume = {972},
	unique-id = {31347571},
	issn = {0168-9002},
	year = {2020},
	eissn = {1872-9576}
}

@article{MTMT:31613161,
	title = {Targeted delivery of essential oils for pharmaceutical applications},
	url = {https://m2.mtmt.hu/api/publication/31613161},
	author = {Széchenyi, Aleksandar and Vörös-Horváth, Barbara and Nagy, Sándor and Das, S. and Kőszegi, Tamás and Horváth, Györgyi and Balázs, Viktória Lilla and Varga, A. and Kocsis, Béla and Pál, Szilárd},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {90},
	unique-id = {31613161},
	issn = {0001-6659},
	year = {2020},
	eissn = {1587-1495},
	pages = {76-76},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551; Horváth, Györgyi/0000-0001-5344-0294}
}

@article{MTMT:31613607,
	title = {Application of nanotechnology in formulation of tioconazole and tea tree essential oil for onychomycosis topical treatment},
	url = {https://m2.mtmt.hu/api/publication/31613607},
	author = {Vörös-Horváth, Barbara and Nagy, Sándor and Das, Sourav and Kőszegi, Tamás and Pál, Szilárd and Széchenyi, Aleksandar},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {90},
	unique-id = {31613607},
	issn = {0001-6659},
	year = {2020},
	eissn = {1587-1495},
	pages = {150-150},
	orcid-numbers = {Das, Sourav/0000-0002-3753-9689; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:31677449,
	title = {Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment},
	url = {https://m2.mtmt.hu/api/publication/31677449},
	author = {Vörös-Horváth, Barbara and Das, Sourav and Salem, Ala' and Nagy, Sándor and Böszörményi, Andrea and Kőszegi, Tamás and Pál, Szilárd and Széchenyi, Aleksandar},
	doi = {10.3390/molecules25235544},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {25},
	unique-id = {31677449},
	issn = {1420-3049},
	year = {2020},
	eissn = {1420-3049},
	orcid-numbers = {Das, Sourav/0000-0002-3753-9689; Böszörményi, Andrea/0000-0003-3982-7059; Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@misc{MTMT:30882361,
	title = {Nano-sized anti-tuberculosis multi-drug co-crystals},
	url = {https://m2.mtmt.hu/api/publication/30882361},
	author = {Salem, Ala' and F., Gosi and Nagy, Sándor and Pál, Szilárd and Széchenyi, Aleksandar},
	unique-id = {30882361},
	year = {2019},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@misc{MTMT:30882388,
	title = {A nanonizálás hatása a keményítőszemcsék dezintegráns hatására},
	url = {https://m2.mtmt.hu/api/publication/30882388},
	author = {Ferenczi, Krisztina and Vörös-Horváth, Barbara and Kása, Péter and Nagy, Sándor and Széchenyi, Aleksandar and Pál, Szilárd and Hódi, Klára},
	unique-id = {30882388},
	year = {2019},
	orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Széchenyi, Aleksandar/0000-0001-9207-2551; Hódi, Klára/0000-0002-0794-1423}
}

@misc{MTMT:30882284,
	title = {Teafaolajban oldott tiokonazol tartalmú pickering emulziók előállítása és alkalmazása körömgomba helyi kezelésére},
	url = {https://m2.mtmt.hu/api/publication/30882284},
	author = {Vörös-Horváth, Barbara and Nagy, Sándor and Balázs, Viktória Lilla and Pál, Szilárd and Széchenyi, Aleksandar},
	unique-id = {30882284},
	year = {2019},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@misc{MTMT:30884878,
	title = {Anaerob Bacteroides fragilis felhasználása módosított mezoporózusos szilika nanoanyagok (metronidazol) direkt bioautográfiás kioldódás vizsgálatára},
	url = {https://m2.mtmt.hu/api/publication/30884878},
	author = {Nagy, Sándor and Varga, Adorján and Kocsis, Béla and Pál, Szilárd and Mohammad, Reza Sazegar and Széchenyi, Aleksandar},
	unique-id = {30884878},
	year = {2019},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:30403170,
	title = {Reliability of the Hansen Solubility Parameters as Co-Crystal Formation Prediction Tool.},
	url = {https://m2.mtmt.hu/api/publication/30403170},
	author = {Salem, Ala' and Nagy, Sándor and Pál, Szilárd and Széchenyi, Aleksandar},
	doi = {10.1016/j.ijpharm.2019.01.007},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {558},
	unique-id = {30403170},
	issn = {0378-5173},
	abstract = {Pharmaceutical co-crystals present an opportunity to improve the solubility of conventional active pharmaceutical ingredients (APIs). Despite advances in co-crystal screening, the rational design of even the chemically simplest co-crystals remains challenging. Hansen solubility parameters (HSPs) have previously been used as a tool to predict co-crystal formation using only the chemical structure. The aim of this study was to validate the use of HSPs as a tool to predict co-crystal formation, analyse its limitations and examine the previously set Δδ inclusion cut-off value. A total of 109 co-formers of carbamazepine, caffeine and theophylline were used as a training set. Sixteen different descriptors were examined. An additional 72 co-formers of piroxicam and nicotinamide were used to test the methods and new cut-off values. The established cut-off value (8.18 MPa0.5) despite being similar to the previously reported value (7 MPa0.5), offered no real advantage over the previously reported value. Our results suggest the use of the modified radius (Ra) method of calculating the solubility difference, which had higher sensitivity of 90% compared to 86% for the previously reported method and cut-off value to indicate co-crystal formation as well as a lower miss and false omission rates.},
	keywords = {Eutectics; Screening; miscibility; Group contribution method; Hansen solubility parameters (HSPs); pharmaceutical co-crystals; predicting co-crystal formation},
	year = {2019},
	eissn = {1873-3476},
	pages = {319-327},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:3310246,
	title = {Application of solid nanoparticle as emulsifiers and surface modifiers in controlled drug delivery},
	url = {https://m2.mtmt.hu/api/publication/3310246},
	author = {Széchenyi, Aleksandar and Vörös-Horváth, Barbara and Safarik, T and Sándori, D and Nagy, Sándor and Pál, Szilárd},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {87},
	unique-id = {3310246},
	issn = {0001-6659},
	year = {2017},
	eissn = {1587-1495},
	pages = {109-110},
	orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551}
}

@article{MTMT:3119939,
	title = {Influence of barium sulfate X-ray imaging contrast material on properties of floating drug delivery tablets.},
	url = {https://m2.mtmt.hu/api/publication/3119939},
	author = {Diós, Péter and Szigeti, Krisztián and Budán, Ferenc Csaba and Pocsik, M and Veres, Dániel and Máthé, Domokos and Pál, Szilárd and Dévay, Attila and Nagy, Sándor},
	doi = {10.1016/j.ejps.2016.09.034},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {95},
	unique-id = {3119939},
	issn = {0928-0987},
	abstract = {The objective of the study was to reveal the influence of necessarily added barium sulfate (BaSO4) X-ray contrast material on floating drug delivery tablets. Based on literature survey, a chosen floating tablet composition was determined containing HPMC and carbopol 943P as matrix polymers. One-factor factorial design with five levels was created for evaluation of BaSO4 (X1) effects on experimental parameters of tablets including: floating lag time, total floating time, swelling-, erosion-, dissolution-, release kinetics parameters and X-ray detected volume changes of tablets. Applied concentrations of BaSO4 were between 0 and 20.0% resulting in remarkable alteration of experimental parameters related especially to flotation. Drastic deterioration of floating lag time and total floating time could be observed above 15.0% BaSO4. Furthermore, BaSO4 showed to increase the integrity of tablet matrix by reducing eroding properties. A novel evaluation of dissolutions from floating drug delivery systems was introduced, which could assess the quantity of drug dissolved from dosage form in floating state. In the cases of tablets containing 20.0% BaSO4, only the 40% of total API amount could be dissolved in floating state. In vitro fine resolution X-ray CT imagings were performed to study the volume change and the voxel distributions as a function of HU attenuations by histogram analysis of the images. X-ray detected relative volume change results did not show significant difference between samples. After 24h, all tablets containing BaSO4 could be segmented, which highlighted the fact that enough BaSO4 remained in the tablets for their identification.},
	year = {2016},
	eissn = {1879-0720},
	pages = {46-53},
	orcid-numbers = {Veres, Dániel/0000-0002-9687-3556}
}

@article{MTMT:3006232,
	title = {Multiparametric luminescent cell viability assay in toxicology models. A critical evaluation},
	url = {https://m2.mtmt.hu/api/publication/3006232},
	author = {Sali, Nikolett and Nagy, Sándor and Poór, Miklós and Kőszegi, Tamás},
	doi = {10.1016/j.vascn.2016.01.004},
	journal-iso = {J PHARMACOL TOXICOL METH},
	journal = {JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS},
	volume = {79},
	unique-id = {3006232},
	issn = {1056-8719},
	year = {2016},
	eissn = {1873-488X},
	pages = {45-54}
}

@CONFERENCE{MTMT:2929738,
	title = {Hidrofil mátrixképző polimerek alkalmazhatósága efferveszcens úszó készítményekben},
	url = {https://m2.mtmt.hu/api/publication/2929738},
	author = {Diós, Péter and Nagy, Sándor and Bognár, Vivien and Pál, Szilárd and Dévay, Attila},
	booktitle = {I. Cholnoky László Szakkollégiumi Szimpózium},
	unique-id = {2929738},
	abstract = {Módosított hatóanyag-leadású készítmények alapos 
		megtervezésével különböző biofarmáciai igényeknek 
		megfelelő hatóanyag-felszabadulású rendszerek készíthetők. 
		Ezen készítmények előállítása során a 
		hatóanyag-leadás módosítását speciális segédanyagok és/vagy 
		különleges technológiai eljárások 
		segítségével érhetjük el. A gasztroretentív rendszerek 
		alkalmazásának célja a készítmények gyomorban 
		való tartózkodási idejének meghosszabbítása.
		A gasztroretentív rendszerek leggyakrabban alkalmazott 
		technológiai megvalósítása az úszó hatóanyag-
		leadó rendszerek (FDDSs). Ezen úszó rendszerek gyomor 
		retenciós idejének megnövelését azok lecsökkent 
		átlagsűrűsége révén érhető el. A szakirodalom az úszó 
		készítményeken belül élesen elkülöníti az 
		efferveszcens és nem-efferveszcens úszó rendszereket. 
		Az előadás célja, hogy bemutassa a gyógyszertechnológiai 
		gyakorlatban, az iparban és magisztrálisan 
		egyaránt leggyakrabban használt hét hidrofil mátrixképző 
		polimer efferveszcens úszótablettákban való 
		alkalmazhatóságát. Az elkészített tabletták összetételei csak 
		az alkalmazott polimerekben különböznek. 
		Alkalmazott hidrofil mátrixképzők: hidroxipropil-
		metilcellulóz (HPMC), metilcellulóz (MC), hidroxietil-
		cellulóz (HEC), karmellóz-nátrium (CMC-Na), kismértékben 
		szubsztituált hidroxipropilcellulóz (L-HPC), 
		nátrium-alginát, karbomer (Carbopol 934P).
		A kísérlet során elvégzett vizsgálatok: az úszás eléréséhez 
		szükséges idő (tlag) meghatározása és a 
		hatóanyag 24 órás kioldódás vizsgálata.
		A vizsgálati minták eredményei között jelentős különbségek 
		mutatkoztak. Egyes minták teljes 
		hatóanyagtartalma 24 órás vizsgálat során sem tudott 
		felszabadulni, míg több esetben már akár egy órát 
		követően teljes hatóanyag kioldódás és gyors duzzadás volt 
		tapasztalható.},
	year = {2015},
	pages = {x}
}

@article{MTMT:2924040,
	title = {Preformulation studies and optimization of sodium alginate based floating drug delivery system for eradication of Helicobacter pylori},
	url = {https://m2.mtmt.hu/api/publication/2924040},
	author = {Diós, Péter and Nagy, Sándor and Pál, Szilárd and Pernecker, Tivadar and Kocsis, Béla and Budán, Ferenc Csaba and Horváth, Ildikó and Szigeti, Krisztián and Bölcskei, Kata and Máthé, Domokos and Dévay, Attila},
	doi = {10.1016/j.ejpb.2015.07.020},
	journal-iso = {EUR J PHARM BIOPHARM},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS},
	volume = {96},
	unique-id = {2924040},
	issn = {0939-6411},
	abstract = {The aim of this study was to design a local, floating, mucoadhesive drug delivery system containing metronidazole for Helicobacter pylori eradication. Face-centered central composite design (with three factors, in three levels) was used for evaluation and optimization of in vitro floating and dissolution studies. Sodium alginate (X1), low substituted hydroxypropyl cellulose (L-HPC B1, X2) and sodium bicarbonate (X3) concentrations were the independent variables in the development of effervescent floating tablets. All tablets showed acceptable physicochemical properties. Statistical analysis revealed that tablets with 5.00 % sodium alginate, 38.63 % L-HPC B1 and 8.45 % sodium bicarbonate content showed promising in vitro floating and dissolution properties for further examinations. Optimized floating tablets expressed remarkable floating force. Their in vitro dissolution studies were compared with two commercially available non-floating metronidazole products and then microbiologically detected dissolution, ex vivo detachment force, rheological mucoadhesion studies and compatibility studies were carried out. Remarkable similarity (f1, f2) between in vitro spectrophotometrically and microbiologically detected dissolutions was found. Studies revealed significant ex vivo mucoadhesion of optimized tablets, which was considerably increased by L-HPC. In vivo X-ray CT studies of optimized tablets showed 8 h gastroretention in rats represented by an animation prepared by special CT technique.},
	year = {2015},
	eissn = {1873-3441},
	pages = {196-206}
}

@article{MTMT:2807473,
	title = {Influence of different types of low substituted hydroxypropyl cellulose on tableting, disintegration, and floating behaviour of floating drug delivery systems},
	url = {https://m2.mtmt.hu/api/publication/2807473},
	author = {Diós, Péter and Pernecker, Tivadar and Nagy, Sándor and Pál, Szilárd and Dévay, Attila},
	doi = {10.1016/j.jsps.2014.09.001},
	journal-iso = {SAUDI PHARM J},
	journal = {SAUDI PHARMACEUTICAL JOURNAL},
	volume = {23},
	unique-id = {2807473},
	issn = {1319-0164},
	abstract = {Abstract The object of the present study is to evaluate the effect of application of low-substituted hydroxypropyl cellulose (L-HPC) 11 and B1 as excipients promoting floating in gastroretentive tablets. Directly compressed tablets were formed based on experimental design. Face-centred central composite design was applied with two factors and 3 levels, where amount of sodium alginate (X1) and L-HPC (X2) were the numerical factors. Applied types of L-HPCs and their 1:1 mixture were included in a categorical factor (X3). Studied parameters were floating lag time, floating time, floating force, swelling behaviour of tablets and dissolution of paracetamol, which was used as a model active substance. Due to their physical character, L-HPCs had different water uptake and flowability. Lower flowability was observed and lower water uptake after 60 minutes at L-HPC 11 compared to L-HPC B1. Shorter floating times were detected at L-HPC 11 and L-HPC mixtures with 0.5% content of sodium alginate, whereas alginate was the only significant factor. Evaluating results of drug release and swelling studies on floating tablets revealed correlation, which can serve to help to understand the mechanism of action of L-HPCs in the field development of gastroretentive dosage forms.},
	keywords = {DISINTEGRATION; Sodium alginate; Floating force; Gastroretentive; Floating tablets; Low substituted hydroxypropyl cellulose},
	year = {2015},
	eissn = {2213-7475},
	pages = {658-666}
}

@misc{MTMT:2929726,
	title = {Nátrium-alginát alapú efferveszcens úszótabletták in vitro és in vivo gyógyszertechnológiai és biofarmáciai vizsgálata és optimalizálása},
	url = {https://m2.mtmt.hu/api/publication/2929726},
	author = {Diós, Péter and Budán, Ferenc and Nagy, Sándor and Horváth, Ildikó and Szigeti, Krisztián and Máthé, Domokos and Dévay, Attila},
	unique-id = {2929726},
	abstract = {A módosított hatóanyag-leadású készítmények azon terápiás 
		rendszerek, melyek hatóanyag-felszabadulásának idejét, 
		helyét, típusát, mechanizmusát valamely módon módosítják egy 
		meghatározott terápiás cél elérése érdekében. A terápiás cél 
		a hatóanyag megfelelő biohasznosulása révén valósul meg. A 
		gasztroretentív készítmények a módosított hatóanyag-leadású 
		rendszerek részeként a gyomorban való tartózkodási idejüket 
		hosszabbítják meg, melynek céljából számos 
		gyógyszertechnológiai megoldást fejlesztettek ki: úszó-, 
		expanzív-, nagysűrűségű- és mukoadhéziós rendszereket. 
		Azon készítményeket nevezzük úszó hatóanyag-leadó 
		rendszereknek, melyek adagolásukat követően, a gyomorban 
		bizonyos idő elteltével a gyomornedv felületén történő 
		úszásra képesek lecsökkent sűrűségük miatt. Az úszó 
		rendszerek hosszú gyomor retenciós ideje lehetőséget adhat 
		egy szabályozott, nyújtott hatóanyag-leadású készítmény 
		kifejlesztésére. A terápiás cél lehet a gyomor lokális 
		terápiája, illetve a bélrendszer elérését megelőző nyújtott 
		hatóanyag kioldódás.
		Kísérleteinkben metronidazolt alkalmaztunk helyi antimikrobás 
		kezelés céljából, melyek során úszó és dezintegrálódó 
		hatóanyag-leadású készítmény optimalizálását végeztük el, 
		melyből megfelelő úszási kinetikával rendelkezve, közel egy 
		óra alatt szabadul fel a teljes hatóanyag-tartalom. Az 
		összetételeket háromfaktoros központi kompozíciós 
		kísérletterv alkalmazásával határoztuk meg. Az optimálisnak 
		talált összetételű készítményt kísérleti patkányban bárium-
		szulfát kontrasztanyag mellett in vivo röntgen/CT-s 
		képalkotással vizsgáltuk a Cromed kft közreműködésével.},
	year = {2014}
}