@article{MTMT:33563214, title = {Sigma − 1 receptor activation as a new option for the treatment of glaucoma in preclinical models}, url = {https://m2.mtmt.hu/api/publication/33563214}, author = {Fekete, Andrea and Tran, Ngoc Minh and Besztercei, Balázs and Török, György and Medveczki, Tímea and Takácsi-Nagy, Anna Erzsébet and Gasull, Xavier and Szabó, Attila and Kovács, Illés and Hodrea, Judit}, doi = {10.1111/j.1755-3768.2022.15344}, journal-iso = {ACTA OPHTHALMOL}, journal = {ACTA OPHTHALMOLOGICA}, volume = {100}, unique-id = {33563214}, issn = {1755-375X}, year = {2022}, eissn = {1755-3768}, orcid-numbers = {Fekete, Andrea/0000-0002-0210-153X; Tran, Ngoc Minh/0000-0002-6925-0871; Medveczki, Tímea/0000-0002-3618-6690; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Szabó, Attila/0000-0001-7321-9861; Kovács, Illés/0000-0001-5763-0482; Hodrea, Judit/0000-0002-6388-4021} } @article{MTMT:32909641, title = {Sigma-1 receptor aktiváció, mint a glaukóma kezelésének új lehetősége preklinikai modellekben}, url = {https://m2.mtmt.hu/api/publication/32909641}, author = {Hodrea, Judit and Tran, Ngoc Minh and Besztercei, Balazs and Török, György and Medveczki, Tímea and Takácsi-Nagy, Anna Erzsébet and Xavier, Gasull and Szabó, Attila and Kovács, Illés and Fekete, Andrea}, journal-iso = {SZEMÉSZET}, journal = {SZEMÉSZET}, volume = {159}, unique-id = {32909641}, issn = {0039-8101}, year = {2022}, pages = {46-47}, orcid-numbers = {Hodrea, Judit/0000-0002-6388-4021; Tran, Ngoc Minh/0000-0002-6925-0871; Medveczki, Tímea/0000-0002-3618-6690; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Szabó, Attila/0000-0001-7321-9861; Kovács, Illés/0000-0001-5763-0482; Fekete, Andrea/0000-0002-0210-153X} } @misc{MTMT:33685814, title = {Assessment of eye irritation as the first step of an intraocular pressure-lowering eye drop formulation}, url = {https://m2.mtmt.hu/api/publication/33685814}, author = {Tran, Ngoc Minh and Takácsi-Nagy, Anna Erzsébet and Medveczki, Tímea and Csősz, Éva and Kovács, Illés and Clyne, Megan and Szabó, Attila and Fekete, Andrea and Hodrea, Judit}, unique-id = {33685814}, year = {2022}, orcid-numbers = {Tran, Ngoc Minh/0000-0002-6925-0871; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Medveczki, Tímea/0000-0002-3618-6690; Kovács, Illés/0000-0001-5763-0482; Szabó, Attila/0000-0001-7321-9861; Fekete, Andrea/0000-0002-0210-153X; Hodrea, Judit/0000-0002-6388-4021} } @article{MTMT:33082969, title = {The Importance of Pine Species in the Ethnomedicine of Transylvania (Romania)}, url = {https://m2.mtmt.hu/api/publication/33082969}, author = {Papp, Nóra and Purger, Dragica and Czigle, Szilvia and Czégényi, Dóra Andrea and Stranczinger, Szilvia and Tóth, Mónika Margit and Dénes, Tünde and Kocsis, Marianna and Takácsi-Nagy, Anna Erzsébet and Filep, Rita}, doi = {10.3390/plants11182331}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {11}, unique-id = {33082969}, year = {2022}, eissn = {2223-7747}, orcid-numbers = {Purger, Dragica/0000-0003-2480-0777; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @article{MTMT:32534460, title = {The effect of pH adjusted electrolytes on capillary isoelectric focusing assessed by high-resolution dynamic computer simulation.}, url = {https://m2.mtmt.hu/api/publication/32534460}, author = {Takácsi-Nagy, Anna Erzsébet and Kilár, Ferenc and Thormann, Wolfgang}, doi = {10.1002/elps.202100367}, journal-iso = {ELECTROPHORESIS}, journal = {ELECTROPHORESIS}, volume = {43}, unique-id = {32534460}, issn = {0173-0835}, abstract = {The effect of the composition of electrolytes on capillary IEF is assessed for systems with carrier ampholytes covering 2 pH units and with catholytes of decreased pH, anolytes of increased pH and both electrode solutions with adjusted pH values. For electrolytes composed of formic acid as anolyte and ammonium hydroxide as catholyte, simulation is demonstrated to provide the expected IEF system in which analytes with pI values within the formed pH gradient are focused and become immobile. Addition of formic acid to the catholyte results in the formation of an isotachophoretic zone structure that migrates towards the cathode. With ammonium hydroxide added to the anolyte migration occurs towards the anode. In the two cases, all carrier components and amphoteric analytes migrate isotachophoretically as cations or anions, respectively. The data reveal that mM amounts of a counter ion are sufficient to convert an IEF pattern into an ITP system. With increased amounts of the added counter ion, the overall length of the migrating zone structure shrinks, the range of the pH gradient changes, and the migration rate increases. The studied examples indicate that systems of this type reported in the literature should be classified as ITP and not IEF. When both electrolytes are titrated, a non-uniform background electrolyte composed of formic acid and ammonium hydroxide is established in which analytes migrate according to local pH and conductivity without forming IEF or ITP zone structures. Simulation data are in qualitative agreement with previously published experimental data. This article is protected by copyright. All rights reserved.}, keywords = {simulation; Electrolytes; Isoelectric Focusing; Carrier ampholytes; isotachophoresis}, year = {2022}, eissn = {1522-2683}, pages = {669-678}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Kilár, Ferenc/0000-0001-5737-5514} } @article{MTMT:31805804, title = {Meibom-mirigy-diszfunkció és a száraz szem = [Meibomian gland dysfunction and dry eye: Diagnosis and treatment]. Diagnosztikai és kezelési lehetőségek}, url = {https://m2.mtmt.hu/api/publication/31805804}, author = {Kovács, Balázs and Láng, Boglárka and Takácsi-Nagy, Anna Erzsébet and Horváth, Györgyi and Czakó, Cecilia Nóra and Csorba, Anita and Kiss, Huba and Szalai, Irén and Nagy, Zoltán Zsolt and Kovács, Illés}, doi = {10.1556/650.2021.31958}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {162}, unique-id = {31805804}, issn = {0030-6002}, abstract = {Összefoglaló. A szárazszem-panaszok hátterében gyakran áll Meibom-mirigy-diszfunkció, melynek felismerése kiemelten fontos a hatékony kezelés érdekében. A Meibom-mirigyek kóros működése miatt a termelt lipid nem oszlik el megfelelően a szemfelszínen, így a könnyfilm párolgása fokozódik. A könnytermelési zavar következtében szárazszem-panaszok alakulnak ki, melyek a hagyományos könnypótló kezelésre rendszerint csak átmenetileg javulnak. A Meibom-mirigy-diszfunkciót gyakran kíséri a szemhéjszél Demodex-atka-fertőzése - az atka eradikálása szükséges a mirigyek működésének helyreállításához és ezáltal a panaszok megszüntetéséhez. A Meibom-mirigy-diszfunkció a leggyakrabban enyhe formában jelentkezik; a terápia ilyenkor a beteg által is elvégezhető szemhéjtisztításból áll, míg a gyógyszeres kezelés csak az előrehaladottabb, kifejezett gyulladással járó formákban szükséges. Az összefoglaló áttekinti a Meibom-mirigy-diszfunkció klinikai jeleivel és kezelésével kapcsolatos legfontosabb tudnivalókat, különös tekintettel a Demodex-fertőzés felismerésére és kezelésére vonatkozóan. Orv Hetil. 2021; 162(2): 43-51. Summary. The onset of dry eye complaints is often a result of Meibomian gland dysfunction and its diagnosis is essential for effective treatment. In the case of Meibomian gland dysfunction, there is an increased evaporation of the tear film due to the abnormal secretion of lipids that cannot spread on the ocular surface. The treatment of dry eye complaints associated with Meibomian gland dysfunction with tear supplementation is usually ineffective and only results in an intermittent relief of complaints. Meibomian gland dysfunction is often associated with Demodex infestation of the eyelids, and eradicating the mites is essential to re-establish normal meibum production and thus, decreasing ocular complaints. In most cases, Meibomian gland dysfunction is mild, and the treatment of these forms is based on ocular hygiene performed by the patient, while only more advanced forms with inflammatory processes require pharmacologic treatment. This review summarizes the most important knowledge on the clinical signs and treatment of Meibomian gland dysfunction with particular attention to the diagnosis and treatment of ocular Demodex infection. Orv Hetil. 2021; 162(2): 43-51.}, keywords = {dry eye; száraz szem; meibomian gland dysfunction; Demodex mites; Demodex atka; Meibom-mirigy-diszfunkció}, year = {2021}, eissn = {1788-6120}, pages = {43-51}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Horváth, Györgyi/0000-0001-5344-0294; Czakó, Cecilia Nóra/0000-0001-9424-7853; Csorba, Anita/0000-0002-3256-9440; Kiss, Huba/0000-0002-8885-6334; Szalai, Irén/0000-0001-9245-4285; Nagy, Zoltán Zsolt/0000-0002-7330-0464; Kovács, Illés/0000-0001-5763-0482} } @article{MTMT:31905073, title = {Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals}, url = {https://m2.mtmt.hu/api/publication/31905073}, author = {Salem, Ala' and Takácsi-Nagy, Anna Erzsébet and Nagy, Sándor and Hagymási, Alexandra and Gősi, Fruzsina and Vörös-Horváth, Barbara and Balić, Tomislav and Pál, Szilárd and Széchenyi, Aleksandar}, doi = {10.3390/pharmaceutics13020277}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {13}, unique-id = {31905073}, issn = {1999-4923}, abstract = {Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine.}, keywords = {COCRYSTALS; High-pressure homogenization; Sulfamethazine; 4-aminosalicylic acid; high-power ultrasound; nano-drugs}, year = {2021}, eissn = {1999-4923}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:31151492, title = {Gyulladáscsökkentő, levendula illóolaj tartalmú készítmény formulálása, technológiai vizsgálata}, url = {https://m2.mtmt.hu/api/publication/31151492}, author = {Gampel, Zsófia and Takácsi-Nagy, Anna Erzsébet}, journal-iso = {GYÓGYSZERÉSZET}, journal = {GYÓGYSZERÉSZET}, volume = {64}, unique-id = {31151492}, issn = {0017-6036}, year = {2020}, pages = {27-33} } @article{MTMT:31613499, title = {The development of a semi-solid formulation containing natural extracts as a hand-sanitizer preparation}, url = {https://m2.mtmt.hu/api/publication/31613499}, author = {Lendvai, B. and Nmar, F. and Kocsis, Béla and Horváth, Györgyi and Pál, Szilárd and Takácsi-Nagy, Anna Erzsébet}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {90}, unique-id = {31613499}, issn = {0001-6659}, year = {2020}, eissn = {1587-1495}, pages = {127-128}, orcid-numbers = {Horváth, Györgyi/0000-0001-5344-0294; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @article{MTMT:33603593, title = {Kakaóvaj tartalmú, egyedi előiratú kenőcs eltérő formulálási technikáinak hatása a készítmény stabilitására}, url = {https://m2.mtmt.hu/api/publication/33603593}, author = {Székely, Adrienn and Takácsi-Nagy, Anna Erzsébet}, journal-iso = {GYÓGYSZERÉSZET}, journal = {GYÓGYSZERÉSZET}, volume = {64}, unique-id = {33603593}, issn = {0017-6036}, year = {2020}, pages = {344-348}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @article{MTMT:31613591, title = {The development of a semi-solid formulation containing cinnamon essential oil as a handsanitizer preparation}, url = {https://m2.mtmt.hu/api/publication/31613591}, author = {Takácsi-Nagy, Anna Erzsébet and Székely, A. and Pál, Szilárd}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {90}, unique-id = {31613591}, issn = {0001-6659}, year = {2020}, eissn = {1587-1495}, pages = {144-144}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @article{MTMT:31155717, title = {Stability testing of semisolid individual preparations containing cacao butter}, url = {https://m2.mtmt.hu/api/publication/31155717}, author = {Székely, A. and Pál, Szilárd and Takácsi-Nagy, Anna Erzsébet}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {88}, unique-id = {31155717}, issn = {0001-6659}, year = {2018}, eissn = {1587-1495}, pages = {118-118}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @article{MTMT:3310244, title = {Pickering emulsion of tre tree oil in water, stabilized with silica nanoparticles for onychomycosis topical treatment}, url = {https://m2.mtmt.hu/api/publication/3310244}, author = {Vörös-Horváth, Barbara and Bárdonicsek, N and Takácsi-Nagy, Anna Erzsébet and Pál, Sz and Széchenyi, Aleksandar}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {87}, unique-id = {3310244}, issn = {0001-6659}, year = {2017}, eissn = {1587-1495}, pages = {139}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Széchenyi, Aleksandar/0000-0001-9207-2551} } @mastersthesis{MTMT:3406190, title = {Dynamics of isoelectric focusing}, url = {https://m2.mtmt.hu/api/publication/3406190}, author = {Takácsi-Nagy, Anna Erzsébet}, publisher = {PTE}, unique-id = {3406190}, year = {2017}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @article{MTMT:3106405, title = {Modeling of formation and prevention of a pure water zone in capillary isoelectric focusing with narrow pH range carrier ampholytes}, url = {https://m2.mtmt.hu/api/publication/3106405}, author = {Takácsi-Nagy, Anna Erzsébet and Kilár, Ferenc and Thormann, Wolfgang}, doi = {10.1002/elps.201600314}, journal-iso = {ELECTROPHORESIS}, journal = {ELECTROPHORESIS}, volume = {38}, unique-id = {3106405}, issn = {0173-0835}, year = {2017}, eissn = {1522-2683}, pages = {677-688}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Kilár, Ferenc/0000-0001-5737-5514} } @article{MTMT:2501652, title = {Internalization and cytotoxicity assays of transferrin complexes into stem cell-like glioblastoma cells}, url = {https://m2.mtmt.hu/api/publication/2501652}, author = {Gálicza, Judit and Éva, Fischer-Fodor and Takácsi-Nagy, Anna Erzsébet and Vargová, Andrea and Albert, Beáta and Lányi, Szabolcs and Kilár, Ferenc}, journal-iso = {STUD UNIV BABES-BOLYAI CHEM}, journal = {STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA}, volume = {2013}, unique-id = {2501652}, issn = {1224-7154}, year = {2013}, eissn = {2065-9520}, pages = {33-42}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Kilár, Ferenc/0000-0001-5737-5514} } @article{MTMT:2043575, title = {Effect of electrolyte pH on CIEF with narrowpH range ampholytes}, url = {https://m2.mtmt.hu/api/publication/2043575}, author = {Páger, Csilla and Vargová, Andrea and Takácsi-Nagy, Anna Erzsébet and Dörnyei, Ágnes and Kilár, Ferenc}, doi = {10.1002/elps.201200175}, journal-iso = {ELECTROPHORESIS}, journal = {ELECTROPHORESIS}, volume = {33}, unique-id = {2043575}, issn = {0173-0835}, abstract = {Capillary isoelectric focusing of components following sequential injection of ampholytes and the sample zone offers unique advantages for analysis. The most important one of these is the efficient separation of amphoteric compounds having isoelectric points (pIs) outside the pH range of the ampholytes applied, but the resolution of the components can be increased by an adequate setup in the injection protocol. In this study, the effect of the pH of the anolyte and catholyte on the selectivity and speed of isoelectric focusing was investigated. Changes in the pH values significantly influenced the resolution and the length of the pH gradient, while changes in the charge-state of components were also observed. Three ampholyte solutions (from different suppliers) covering only 2 pH units were used for the analyses of substituted nitrophenol dyes in uncoated capillary. With appropriate setup the components, with pIs not covered by the ampholyte pH range, migrated in charged state outside the pH gradient. This phenomenon is preferable for coupling isoelectric focusing to mass spectrometry detection, by evading the undesirable ion suppression effect of ampholytes.}, year = {2012}, eissn = {1522-2683}, pages = {3269-3275}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Dörnyei, Ágnes/0000-0002-6552-8522; Kilár, Ferenc/0000-0001-5737-5514} } @article{MTMT:1761123, title = {Sampling strategies for capillary isoelectric focusing with electroosmotic zone mobilization assessed by high-resolution dynamic computer simulation}, url = {https://m2.mtmt.hu/api/publication/1761123}, author = {Takácsi-Nagy, Anna Erzsébet and Kilár, Ferenc and Páger, Csilla and A Mosher, Richard and Thormann, Wolfgang}, doi = {10.1002/elps.201100525}, journal-iso = {ELECTROPHORESIS}, journal = {ELECTROPHORESIS}, volume = {33}, unique-id = {1761123}, issn = {0173-0835}, year = {2012}, eissn = {1522-2683}, pages = {970-980}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Kilár, Ferenc/0000-0001-5737-5514} } @{MTMT:1752149, title = {Isoelectric focusing coupled to mass spectrometry for bioanalysis}, url = {https://m2.mtmt.hu/api/publication/1752149}, author = {Kilár, Ferenc and Páger, Csilla and Dörnyei, Ágnes and Vargová, Andrea and Takácsi-Nagy, Anna Erzsébet and Thormann, Wolfgang}, booktitle = {CECE 2011 - 8th International Interdisciplinary Meeting on Bioanalysis}, unique-id = {1752149}, year = {2011}, pages = {28}, orcid-numbers = {Kilár, Ferenc/0000-0001-5737-5514; Dörnyei, Ágnes/0000-0002-6552-8522; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} } @{MTMT:1612403, title = {Capillary Isoelectric Focusing Combined with MS Detection}, url = {https://m2.mtmt.hu/api/publication/1612403}, author = {Kilár, Ferenc and Páger, Csilla and Vargová, Andrea and Takácsi-Nagy, Anna Erzsébet and Thormann, Wolfgang}, booktitle = {36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, (HPLC 2011)}, unique-id = {1612403}, abstract = {Capillary isoelectric focusing in presence of electroosmosis with sequential injection of carrier ampholytes and sample was found to be suitable for mass spectrometry detection. The separate injection of the sample and the ampholytes provides good condition to suppress and overcome the undesirable effect of the presence of ampholytes in mass spectrometry. By the appropriate selection of ampholyte solutions, whose pH range not necessarily covers the pI values of the analytes, the migration of the components can be controlled, and the impact of the ampholytes on mass spectrometric detection is decreased. The unique applicability of this setup is shown by testing several parameters, such as, the application of volatile electrolyte solutions, the type of the ampholytes, the order and the number of the ampholyte and sample zones. Broad and narrow pH range ampholytes were applied in experiments using uncoated capillaries with different length for the analyses of substituted nitrophenol dyes to achieve optimal conditions for the mass spectrometric detection. Although, the sample components are not leaving the pH gradient, due to the decrease in the ampholyte concentration at the position of the components, and because the sample components migrate in charged state, the ionization is more effective for mass spectrometry detection. Results with model calculations confirmed the mechanism of the process in the isoelectric focusing using one or two ampholyte zones before and/or after the sample zone. The work was supported by grant OTKA-NKTH-NI-68863 and by project SROP-4.2.2/08/1/2008-0011.}, year = {2011}, pages = {72}, orcid-numbers = {Kilár, Ferenc/0000-0001-5737-5514; Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136} }