TY - JOUR AU - Fekete, Andrea AU - Tran, Ngoc Minh AU - Besztercei, Balázs AU - Török, György AU - Medveczki, Tímea AU - Takácsi-Nagy, Anna Erzsébet AU - Gasull, Xavier AU - Szabó, Attila AU - Kovács, Illés AU - Hodrea, Judit TI - Sigma − 1 receptor activation as a new option for the treatment of glaucoma in preclinical models JF - ACTA OPHTHALMOLOGICA J2 - ACTA OPHTHALMOL VL - 100 PY - 2022 SN - 1755-375X DO - 10.1111/j.1755-3768.2022.15344 UR - https://m2.mtmt.hu/api/publication/33563214 ID - 33563214 N1 - WoS:hiba:000946564000463 2023-12-31 14:43 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Hodrea, Judit AU - Tran, Ngoc Minh AU - Besztercei, Balazs AU - Török, György AU - Medveczki, Tímea AU - Takácsi-Nagy, Anna Erzsébet AU - Xavier, Gasull AU - Szabó, Attila AU - Kovács, Illés AU - Fekete, Andrea TI - Sigma-1 receptor aktiváció, mint a glaukóma kezelésének új lehetősége preklinikai modellekben JF - SZEMÉSZET J2 - SZEMÉSZET VL - 159 PY - 2022 IS - Suppl. 1 SP - 46 EP - 47 PG - 2 SN - 0039-8101 UR - https://m2.mtmt.hu/api/publication/32909641 ID - 32909641 LA - English DB - MTMT ER - TY - GEN AU - Tran, Ngoc Minh AU - Takácsi-Nagy, Anna Erzsébet AU - Medveczki, Tímea AU - Csősz, Éva AU - Kovács, Illés AU - Clyne, Megan AU - Szabó, Attila AU - Fekete, Andrea AU - Hodrea, Judit TI - Assessment of eye irritation as the first step of an intraocular pressure-lowering eye drop formulation PY - 2022 UR - https://m2.mtmt.hu/api/publication/33685814 ID - 33685814 N1 - {poszter} LA - English DB - MTMT ER - TY - JOUR AU - Papp, Nóra AU - Purger, Dragica AU - Czigle, Szilvia AU - Czégényi, Dóra Andrea AU - Stranczinger, Szilvia AU - Tóth, Mónika Margit AU - Dénes, Tünde AU - Kocsis, Marianna AU - Takácsi-Nagy, Anna Erzsébet AU - Filep, Rita TI - The Importance of Pine Species in the Ethnomedicine of Transylvania (Romania) JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 11 PY - 2022 IS - 18 PG - 22 SN - 2223-7747 DO - 10.3390/plants11182331 UR - https://m2.mtmt.hu/api/publication/33082969 ID - 33082969 N1 - Funding Agency and Grant Number: OTKA (Hungarian Scientific Research Fund) [K 127944]; Ministry of Education, Science, Research and Sport of the Slovak Republic [VEGA 1/0226/22] Funding text: This research was funded by OTKA (Hungarian Scientific Research Fund, K 127944) (N.P.) and the Ministry of Education, Science, Research and Sport of the Slovak Republic grants (VEGA 1/0226/22) (S.C.). LA - English DB - MTMT ER - TY - JOUR AU - Takácsi-Nagy, Anna Erzsébet AU - Kilár, Ferenc AU - Thormann, Wolfgang TI - The effect of pH adjusted electrolytes on capillary isoelectric focusing assessed by high-resolution dynamic computer simulation. JF - ELECTROPHORESIS J2 - ELECTROPHORESIS VL - 43 PY - 2022 IS - 5-6 SP - 669 EP - 678 PG - 10 SN - 0173-0835 DO - 10.1002/elps.202100367 UR - https://m2.mtmt.hu/api/publication/32534460 ID - 32534460 N1 - Funding Agency and Grant Number: Swiss NSF [TaMOP-4.2.2, D-15/1/KONV-2015-0015, NKFIH K-125275] Funding text: This work was supported by TaMOP-4.2.2.D-15/1/KONV-2015-0015, NKFIH K-125275, and the Swiss NSF. AB - The effect of the composition of electrolytes on capillary IEF is assessed for systems with carrier ampholytes covering 2 pH units and with catholytes of decreased pH, anolytes of increased pH and both electrode solutions with adjusted pH values. For electrolytes composed of formic acid as anolyte and ammonium hydroxide as catholyte, simulation is demonstrated to provide the expected IEF system in which analytes with pI values within the formed pH gradient are focused and become immobile. Addition of formic acid to the catholyte results in the formation of an isotachophoretic zone structure that migrates towards the cathode. With ammonium hydroxide added to the anolyte migration occurs towards the anode. In the two cases, all carrier components and amphoteric analytes migrate isotachophoretically as cations or anions, respectively. The data reveal that mM amounts of a counter ion are sufficient to convert an IEF pattern into an ITP system. With increased amounts of the added counter ion, the overall length of the migrating zone structure shrinks, the range of the pH gradient changes, and the migration rate increases. The studied examples indicate that systems of this type reported in the literature should be classified as ITP and not IEF. When both electrolytes are titrated, a non-uniform background electrolyte composed of formic acid and ammonium hydroxide is established in which analytes migrate according to local pH and conductivity without forming IEF or ITP zone structures. Simulation data are in qualitative agreement with previously published experimental data. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Balázs AU - Láng, Boglárka AU - Takácsi-Nagy, Anna Erzsébet AU - Horváth, Györgyi AU - Czakó, Cecilia Nóra AU - Csorba, Anita AU - Kiss, Huba AU - Szalai, Irén AU - Nagy, Zoltán Zsolt AU - Kovács, Illés TI - Meibom-mirigy-diszfunkció és a száraz szem = [Meibomian gland dysfunction and dry eye: Diagnosis and treatment]. Diagnosztikai és kezelési lehetőségek TS - Diagnosztikai és kezelési lehetőségek JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2021 IS - 2 SP - 43 EP - 51 PG - 9 SN - 0030-6002 DO - 10.1556/650.2021.31958 UR - https://m2.mtmt.hu/api/publication/31805804 ID - 31805804 AB - Összefoglaló. A szárazszem-panaszok hátterében gyakran áll Meibom-mirigy-diszfunkció, melynek felismerése kiemelten fontos a hatékony kezelés érdekében. A Meibom-mirigyek kóros működése miatt a termelt lipid nem oszlik el megfelelően a szemfelszínen, így a könnyfilm párolgása fokozódik. A könnytermelési zavar következtében szárazszem-panaszok alakulnak ki, melyek a hagyományos könnypótló kezelésre rendszerint csak átmenetileg javulnak. A Meibom-mirigy-diszfunkciót gyakran kíséri a szemhéjszél Demodex-atka-fertőzése - az atka eradikálása szükséges a mirigyek működésének helyreállításához és ezáltal a panaszok megszüntetéséhez. A Meibom-mirigy-diszfunkció a leggyakrabban enyhe formában jelentkezik; a terápia ilyenkor a beteg által is elvégezhető szemhéjtisztításból áll, míg a gyógyszeres kezelés csak az előrehaladottabb, kifejezett gyulladással járó formákban szükséges. Az összefoglaló áttekinti a Meibom-mirigy-diszfunkció klinikai jeleivel és kezelésével kapcsolatos legfontosabb tudnivalókat, különös tekintettel a Demodex-fertőzés felismerésére és kezelésére vonatkozóan. Orv Hetil. 2021; 162(2): 43-51. Summary. The onset of dry eye complaints is often a result of Meibomian gland dysfunction and its diagnosis is essential for effective treatment. In the case of Meibomian gland dysfunction, there is an increased evaporation of the tear film due to the abnormal secretion of lipids that cannot spread on the ocular surface. The treatment of dry eye complaints associated with Meibomian gland dysfunction with tear supplementation is usually ineffective and only results in an intermittent relief of complaints. Meibomian gland dysfunction is often associated with Demodex infestation of the eyelids, and eradicating the mites is essential to re-establish normal meibum production and thus, decreasing ocular complaints. In most cases, Meibomian gland dysfunction is mild, and the treatment of these forms is based on ocular hygiene performed by the patient, while only more advanced forms with inflammatory processes require pharmacologic treatment. This review summarizes the most important knowledge on the clinical signs and treatment of Meibomian gland dysfunction with particular attention to the diagnosis and treatment of ocular Demodex infection. Orv Hetil. 2021; 162(2): 43-51. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Salem, Ala' AU - Takácsi-Nagy, Anna Erzsébet AU - Nagy, Sándor AU - Hagymási, Alexandra AU - Gősi, Fruzsina AU - Vörös-Horváth, Barbara AU - Balić, Tomislav AU - Pál, Szilárd AU - Széchenyi, Aleksandar TI - Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 13 PY - 2021 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics13020277 UR - https://m2.mtmt.hu/api/publication/31905073 ID - 31905073 AB - Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine. LA - English DB - MTMT ER - TY - JOUR AU - Gampel, Zsófia AU - Takácsi-Nagy, Anna Erzsébet TI - Gyulladáscsökkentő, levendula illóolaj tartalmú készítmény formulálása, technológiai vizsgálata JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 64 PY - 2020 IS - 1 SP - 27 EP - 33 PG - 7 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/31151492 ID - 31151492 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lendvai, B. AU - Nmar, F. AU - Kocsis, Béla AU - Horváth, Györgyi AU - Pál, Szilárd AU - Takácsi-Nagy, Anna Erzsébet TI - The development of a semi-solid formulation containing natural extracts as a hand-sanitizer preparation JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 90 PY - 2020 IS - 2-3 SP - 127 EP - 128 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/31613499 ID - 31613499 LA - English DB - MTMT ER - TY - JOUR AU - Székely, Adrienn AU - Takácsi-Nagy, Anna Erzsébet TI - Kakaóvaj tartalmú, egyedi előiratú kenőcs eltérő formulálási technikáinak hatása a készítmény stabilitására JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 64 PY - 2020 IS - 6 SP - 344 EP - 348 PG - 5 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/33603593 ID - 33603593 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Takácsi-Nagy, Anna Erzsébet AU - Székely, A. AU - Pál, Szilárd TI - The development of a semi-solid formulation containing cinnamon essential oil as a handsanitizer preparation JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 90 PY - 2020 IS - 2-3 SP - 144 EP - 144 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/31613591 ID - 31613591 LA - English DB - MTMT ER - TY - JOUR AU - Székely, A. AU - Pál, Szilárd AU - Takácsi-Nagy, Anna Erzsébet TI - Stability testing of semisolid individual preparations containing cacao butter JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 88 PY - 2018 IS - 3 SP - 118 EP - 118 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/31155717 ID - 31155717 LA - English DB - MTMT ER - TY - JOUR AU - Vörös-Horváth, Barbara AU - Bárdonicsek, N AU - Takácsi-Nagy, Anna Erzsébet AU - Pál, Sz AU - Széchenyi, Aleksandar TI - Pickering emulsion of tre tree oil in water, stabilized with silica nanoparticles for onychomycosis topical treatment JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 87 PY - 2017 IS - 3-4 SP - 139 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/3310244 ID - 3310244 LA - English DB - MTMT ER - TY - THES AU - Takácsi-Nagy, Anna Erzsébet TI - Dynamics of isoelectric focusing PB - Pécsi Tudományegyetem PY - 2017 SP - 113 UR - https://m2.mtmt.hu/api/publication/3406190 ID - 3406190 LA - English DB - MTMT ER - TY - JOUR AU - Takácsi-Nagy, Anna Erzsébet AU - Kilár, Ferenc AU - Thormann, Wolfgang TI - Modeling of formation and prevention of a pure water zone in capillary isoelectric focusing with narrow pH range carrier ampholytes JF - ELECTROPHORESIS J2 - ELECTROPHORESIS VL - 38 PY - 2017 IS - 5 SP - 677 EP - 688 PG - 12 SN - 0173-0835 DO - 10.1002/elps.201600314 UR - https://m2.mtmt.hu/api/publication/3106405 ID - 3106405 N1 - Funding Agency and Grant Number: Swiss National Science Foundation; [TAMOP-4.2.2.D-15/1/KONV-2015-0015]; [OTKA K-100667] Funding text: This work was supported by TAMOP-4.2.2.D-15/1/KONV-2015-0015, OTKA K-100667 and the Swiss National Science Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Gálicza, Judit AU - Éva, Fischer-Fodor AU - Takácsi-Nagy, Anna Erzsébet AU - Vargová, Andrea AU - Albert, Beáta AU - Lányi, Szabolcs AU - Kilár, Ferenc TI - Internalization and cytotoxicity assays of transferrin complexes into stem cell-like glioblastoma cells JF - STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA J2 - STUD UNIV BABES-BOLYAI CHEM VL - 2013 PY - 2013 IS - 3 SP - 33 EP - 42 PG - 10 SN - 1224-7154 UR - https://m2.mtmt.hu/api/publication/2501652 ID - 2501652 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - Páger, Csilla AU - Vargová, Andrea AU - Takácsi-Nagy, Anna Erzsébet AU - Dörnyei, Ágnes AU - Kilár, Ferenc TI - Effect of electrolyte pH on CIEF with narrowpH range ampholytes JF - ELECTROPHORESIS J2 - ELECTROPHORESIS VL - 33 PY - 2012 IS - 22 SP - 3269 EP - 3275 PG - 7 SN - 0173-0835 DO - 10.1002/elps.201200175 UR - https://m2.mtmt.hu/api/publication/2043575 ID - 2043575 N1 - Export Date: 27 January 2024; CODEN: ELCTD AB - Capillary isoelectric focusing of components following sequential injection of ampholytes and the sample zone offers unique advantages for analysis. The most important one of these is the efficient separation of amphoteric compounds having isoelectric points (pIs) outside the pH range of the ampholytes applied, but the resolution of the components can be increased by an adequate setup in the injection protocol. In this study, the effect of the pH of the anolyte and catholyte on the selectivity and speed of isoelectric focusing was investigated. Changes in the pH values significantly influenced the resolution and the length of the pH gradient, while changes in the charge-state of components were also observed. Three ampholyte solutions (from different suppliers) covering only 2 pH units were used for the analyses of substituted nitrophenol dyes in uncoated capillary. With appropriate setup the components, with pIs not covered by the ampholyte pH range, migrated in charged state outside the pH gradient. This phenomenon is preferable for coupling isoelectric focusing to mass spectrometry detection, by evading the undesirable ion suppression effect of ampholytes. LA - English DB - MTMT ER - TY - JOUR AU - Takácsi-Nagy, Anna Erzsébet AU - Kilár, Ferenc AU - Páger, Csilla AU - A Mosher, Richard AU - Thormann, Wolfgang TI - Sampling strategies for capillary isoelectric focusing with electroosmotic zone mobilization assessed by high-resolution dynamic computer simulation JF - ELECTROPHORESIS J2 - ELECTROPHORESIS VL - 33 PY - 2012 IS - 6 SP - 970 EP - 980 PG - 11 SN - 0173-0835 DO - 10.1002/elps.201100525 UR - https://m2.mtmt.hu/api/publication/1761123 ID - 1761123 N1 - Export Date: 27 January 2024; CODEN: ELCTD LA - English DB - MTMT ER - TY - CHAP AU - Kilár, Ferenc AU - Páger, Csilla AU - Dörnyei, Ágnes AU - Vargová, Andrea AU - Takácsi-Nagy, Anna Erzsébet AU - Thormann, Wolfgang ED - Foret, Frantisek TI - Isoelectric focusing coupled to mass spectrometry for bioanalysis T2 - CECE 2011 - 8th International Interdisciplinary Meeting on Bioanalysis PB - [Hiányzó kiadó] CY - Brno SN - 9788090495906 PY - 2011 SP - 28 UR - https://m2.mtmt.hu/api/publication/1752149 ID - 1752149 LA - English DB - MTMT ER - TY - CHAP AU - Kilár, Ferenc AU - Páger, Csilla AU - Vargová, Andrea AU - Takácsi-Nagy, Anna Erzsébet AU - Thormann, Wolfgang ED - Felinger, A TI - Capillary Isoelectric Focusing Combined with MS Detection T2 - 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, (HPLC 2011) PB - Hungarian Society for Separation Sciences CY - Budapest SN - 9789638933508 PY - 2011 SP - 72 UR - https://m2.mtmt.hu/api/publication/1612403 ID - 1612403 AB - Capillary isoelectric focusing in presence of electroosmosis with sequential injection of carrier ampholytes and sample was found to be suitable for mass spectrometry detection. The separate injection of the sample and the ampholytes provides good condition to suppress and overcome the undesirable effect of the presence of ampholytes in mass spectrometry. By the appropriate selection of ampholyte solutions, whose pH range not necessarily covers the pI values of the analytes, the migration of the components can be controlled, and the impact of the ampholytes on mass spectrometric detection is decreased. The unique applicability of this setup is shown by testing several parameters, such as, the application of volatile electrolyte solutions, the type of the ampholytes, the order and the number of the ampholyte and sample zones. Broad and narrow pH range ampholytes were applied in experiments using uncoated capillaries with different length for the analyses of substituted nitrophenol dyes to achieve optimal conditions for the mass spectrometric detection. Although, the sample components are not leaving the pH gradient, due to the decrease in the ampholyte concentration at the position of the components, and because the sample components migrate in charged state, the ionization is more effective for mass spectrometry detection. Results with model calculations confirmed the mechanism of the process in the isoelectric focusing using one or two ampholyte zones before and/or after the sample zone. The work was supported by grant OTKA-NKTH-NI-68863 and by project SROP-4.2.2/08/1/2008-0011. LA - English DB - MTMT ER -