TY - JOUR AU - Farkas, Gyula AU - Nagy, Sándor AU - Dévay, Attila AU - Széchenyi, Aleksandar AU - Pál, Szilárd TI - Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 16 PY - 2024 IS - 3 PG - 18 SN - 1999-4923 DO - 10.3390/pharmaceutics16030405 UR - https://m2.mtmt.hu/api/publication/34763930 ID - 34763930 N1 - Export Date: 12 April 2024 Correspondence Address: Pál, S.; Institute of Pharmaceutical Technology and Biopharmacy, Rókus Str. 2, Hungary; email: szilard.pal@aok.pte.hu AB - The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have been developed to examine flowability, including static and dynamic methods applying empirical studies and up-to-date chaos theory; however, the newest methods seem only to be powerful with the supplementation of empirical principles. Our experiments try to refine both the technique of analysis and the methods, by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model that combined empirical observations and chaos theory on a geometrical basis, thus finding new characteristics regarding the flow properties of pellets and granules that could be relevant for drug developers. Our findings indicate that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical multiparticular preparations. Furthermore, this study confirms that integrating chaos theory and empirical observations in a time-dependent dynamic model provides a comprehensive understanding of particle flow behavior, pivotal for optimizing manufacturing processes. LA - English DB - MTMT ER - TY - JOUR AU - Šafranko, S. AU - Janđel, K. AU - Kovačević, M. AU - Stanković, A. AU - Dutour, Sikirić M. AU - Mandić, Š. AU - Széchenyi, Aleksandar AU - Glavaš, Obrovac L. AU - Leventić, M. AU - Strelec, I. AU - Aladić, K. AU - Jokić, S. TI - A Facile Synthetic Approach toward Obtaining N-Doped Carbon Quantum Dots from Citric Acid and Amino Acids, and Their Application in Selective Detection of Fe(III) Ions JF - CHEMOSENSORS J2 - CHEMOSENSORS VL - 11 PY - 2023 IS - 4 PG - 22 SN - 2227-9040 DO - 10.3390/chemosensors11040205 UR - https://m2.mtmt.hu/api/publication/33806312 ID - 33806312 LA - English DB - MTMT ER - TY - JOUR AU - Samardžić, Mirela AU - Peršić, Mateja AU - Széchenyi, Aleksandar AU - Jozanović, Marija AU - Pukleš, Iva AU - Budetić, Mateja TI - Development of the New Sensor Based on Functionalized Carbon Nanomaterials for Promethazine Hydrochloride Determination. JF - SENSORS J2 - SENSORS-BASEL VL - 23 PY - 2023 IS - 5 PG - 11 SN - 1424-8220 DO - 10.3390/s23052641 UR - https://m2.mtmt.hu/api/publication/33695774 ID - 33695774 N1 - Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8/A, Osijek, 31000, Croatia Doctoral School of Chemistry, University of Pécs, Ifjúság útja, Pécs, 7624, Hungary Export Date: 20 March 2023 Correspondence Address: Budetić, M.; Department of Chemistry, Cara Hadrijana 8/A, Croatia; email: mbudetic@kemija.unios.hr AB - Promethazine hydrochloride (PM) is a widely used drug so its determination is important. Solid-contact potentiometric sensors could be an appropriate solution for that purpose due to their analytical properties. The aim of this research was to develop solid-contact sensor for potentiometric determination of PM. It had a liquid membrane containing hybrid sensing material based on functionalized carbon nanomaterials and PM ions. The membrane composition for the new PM sensor was optimized by varying different membrane plasticizers and the content of the sensing material. The plasticizer was selected based on calculations of Hansen solubility parameters (HSP) and experimental data. The best analytical performances were obtained using a sensor with 2-nitrophenyl phenyl ether (NPPE) as the plasticizer and 4% of the sensing material. It had a Nernstian slope (59.4 mV/decade of activity), a wide working range (6.2 × 10-7 M-5.0 × 10-3 M), a low limit of detection (1.5 × 10-7 M), fast response time (6 s), low signal drift (-1.2 mV/h), and good selectivity. The working pH range of the sensor was between 2 and 7. The new PM sensor was successfully used for accurate PM determination in a pure aqueous PM solution and pharmaceutical products. For that purpose, the Gran method and potentiometric titration were used. LA - English DB - MTMT ER - TY - JOUR AU - Balić, Tomislav AU - Paurević, Marija AU - Počkaj, Marta AU - Medvidović-Kosanović, Martina AU - Goman, Dominik AU - Széchenyi, Aleksandar AU - Preisz, Zsolt AU - Kunsági-Máté, Sándor TI - Influence of Aliphatic Chain Length on Structural, Thermal and Electrochemical Properties of n-alkylene Benzyl Alcohols : A Study of the Odd-Even Effect JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 12 PG - 20 SN - 1420-3049 DO - 10.3390/molecules27123781 UR - https://m2.mtmt.hu/api/publication/32907495 ID - 32907495 AB - The century-old, well-known odd-even effect phenomenon is still a very attractive and intriguing topic in supramolecular and nano-scale organic chemistry. As a part of our continuous efforts in the study of supramolecular chemistry, we have prepared three novel aromatic alcohols (1,2-bis[2-(hydroxymethyl)phenoxy]butylene (Do4OH), 1,2-bis[2-(hydroxymethyl)phenoxy]pentylene (Do5OH) and 1,2-bis[2-(hydroxymethyl)phenoxy]hexylene (Do6OH)) and determined their crystal and molecular structures by single-crystal X-ray diffraction. In all compounds, two benzyl alcohol groups are linked by an aliphatic chain of different lengths (CH2)n; n = 4, 5 and 6. The major differences in the molecular structures were found in the overall planarity of the molecules and the conformation of the aliphatic chain. Molecules with an even number of CH2 groups tend to be planar with an all-trans conformation of the aliphatic chain, while the odd-numbered molecule is non-planar, with partial gauche conformation. A direct consequence of these structural differences is visible in the melting points-odd-numbered compounds of a particular series display systematically lower melting points. Crystal and molecular structures were additionally studied by the theoretical calculations and the melting points were correlated with packing density and the number of CH2 groups. The results have shown that the generally accepted rule, higher density = higher stability = higher melting point, could not be applied to these compounds. It was found that the denser packaging causes an increase in the percentage of repulsive H‧‧‧H interactions, thereby reducing the stability of the crystal, and consequently, the melting points. Another interesting consequence of different molecular structures is their electrochemical and antioxidative properties-a non-planar structure displays the highest oxidation peak of hydroxyl groups and moderate antioxidant activity. LA - English DB - MTMT ER - TY - JOUR AU - Bálint, Gábor AU - Vörös-Horváth, Barbara AU - Széchenyi, Aleksandar TI - Omicron : increased transmissibility and decreased pathogenicity JF - SIGNAL TRANSDUCTION AND TARGETED THERAPY J2 - SIGNAL TRANSDUCT TAR VL - 7 PY - 2022 IS - 1 PG - 3 SN - 2095-9907 DO - 10.1038/s41392-022-01009-8 UR - https://m2.mtmt.hu/api/publication/32819183 ID - 32819183 N1 - Megosztott első szerzőség Research Highlight LA - English DB - MTMT ER - TY - JOUR AU - Budetić, Mateja AU - Samardžić, Mirela AU - Bubnjar, Karlo AU - Dandić, Andrea AU - Živković, Pavo AU - Széchenyi, Aleksandar AU - Kiss, László TI - A new sensor for direct potentiometric determination of thiabendazole in fruit peels using the Gran method JF - FOOD CHEMISTRY J2 - FOOD CHEM VL - 392 PY - 2022 PG - 26 SN - 0308-8146 DO - 10.1016/j.foodchem.2022.133290 UR - https://m2.mtmt.hu/api/publication/32843480 ID - 32843480 LA - English DB - MTMT ER - TY - JOUR AU - Dandic, Andrea AU - Novak, Ivana AU - Jozanović, Marija AU - Pukleš, Iva AU - Széchenyi, Aleksandar AU - Budetic, Mateja AU - Samardzic, Mirela TI - A New, MWCNT-Based, Solid-State Thiabendazole-Selective Sensor JF - SENSORS J2 - SENSORS-BASEL VL - 22 PY - 2022 IS - 10 PG - 12 SN - 1424-8220 DO - 10.3390/s22103785 UR - https://m2.mtmt.hu/api/publication/32894547 ID - 32894547 AB - Direct potentiometric measurements using solid-state sensors have a great potential for thiabendazole (TBZ) determination, considering simplicity, accuracy, and low cost. Modifying the sensing material of the sensor with multi-walled carbon nanotubes (MWCNTs) leads to improved analytical properties of the sensor. In this study, a new potentiometric solid-state sensor for TBZ determination, based on MWCNTs modified with a sulfate group, and TBZ ion as sensing material was developed. The sensor exhibited a Nernstian response for TBZ (60.4 mV/decade of activity) in a working range between 8.6 x 10(-7) and 1.0 x 10(-3) M. The detection limit for TBZ was 6.2 x 10(-7) M. The response time of the sensor for TBZ was 8 s, and its signal drift was only 1.7 mV/h. The new sensor is applicable for direct potentiometric determination of TBZ in complex real samples, such as fruit peel. The accuracy of TBZ determination is confirmed using the standard addition method. LA - English DB - MTMT ER - TY - JOUR AU - Dandić, Andrea AU - Rajkovača, Katarina AU - Jozanović, Marija AU - Pukleš, Iva AU - Széchenyi, Aleksandar AU - Budetić, Mateja AU - Samardžić, Mirela TI - Review of characteristics and analytical methods for determination of indomethacin JF - REVIEWS IN ANALYTICAL CHEMISTRY J2 - REV ANAL CHEM VL - 41 PY - 2022 IS - 1 SP - 34 EP - 62 PG - 29 SN - 0793-0135 DO - 10.1515/revac-2022-0032 UR - https://m2.mtmt.hu/api/publication/32593111 ID - 32593111 LA - English DB - MTMT ER - TY - CHAP AU - Filotás, Nóra AU - Helt, Réka AU - Hencz, Alexandra Júlia AU - Tenzlinger, Kristóf AU - Odry, Ákos AU - Odry, Péter AU - Széchenyi, Aleksandar AU - Karádi, Zoltán György AU - Tóth, Attila AU - Vizvári, Zoltán Ákos AU - Pál, József ED - Tóth, Attila ED - Vizvári, Zoltán Ákos TI - Bioimpedancia mérő plate fejlesztése hipoxiás és hiperoxiás állapotok vizsgálatára sejtkultúrákban T2 - Orvosbiológiai kérdések - multidiszciplináris, bioimpedancia alapú válaszok PB - Pécsi Tudományegyetem CY - Pécs SN - 9789634299349 PY - 2022 SP - 104 EP - 114 PG - 11 UR - https://m2.mtmt.hu/api/publication/32733052 ID - 32733052 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Hencz, Alexandra Júlia AU - Szilágyi, Gábor AU - Győrfi, Nina Rubina AU - Tenzlinger, Kristóf AU - Odry, Ákos AU - Odry, Péter AU - Széchenyi, Aleksandar AU - Karádi, Zoltán AU - Tóth, Attila AU - Vizvári, Zoltán Ákos AU - Pál, József ED - Tóth, Attila ED - Vizvári, Zoltán Ákos TI - Grafén és indium-ón-oxid elektródák összehasonlítása alacsony frekvenciás elektromos impedancia spektroszkópia mérésekkel T2 - Orvosbiológiai kérdések - multidiszciplináris, bioimpedancia alapú válaszok PB - Pécsi Tudományegyetem CY - Pécs SN - 9789634299349 PY - 2022 SP - 115 EP - 123 PG - 9 UR - https://m2.mtmt.hu/api/publication/32733167 ID - 32733167 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Nádasdi, Lili AU - Maczkó, Gergő AU - Győrfi, Nina Rubina AU - Tenzlinger, Kristóf AU - Odry, Ákos AU - Odry, Péter AU - Széchenyi, Aleksandar AU - Karádi, Zoltán AU - Tóth, Attila AU - Pál, József AU - Vizvári, Zoltán Ákos ED - Tóth, Attila ED - Vizvári, Zoltán Ákos TI - Saját fejlesztésű bioimpedancia mérőelektród előkészítése és validálása tumorsejtek mérésére T2 - Orvosbiológiai kérdések - multidiszciplináris, bioimpedancia alapú válaszok PB - Pécsi Tudományegyetem CY - Pécs SN - 9789634299349 PY - 2022 SP - 124 EP - 133 PG - 10 UR - https://m2.mtmt.hu/api/publication/32733333 ID - 32733333 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Salem, Ala' AU - Khanfar, Esam AU - Nagy, Sándor AU - Széchenyi, Aleksandar TI - Cocrystals of tuberculosis antibiotics : Challenges and missed opportunities JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 623 PY - 2022 PG - 16 SN - 0378-5173 DO - 10.1016/j.ijpharm.2022.121924 UR - https://m2.mtmt.hu/api/publication/32907484 ID - 32907484 AB - Cocrystals have been extensively used to improve the physicochemical properties and bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis medications are among those commonly reported. This review provides a summary of the tuberculosis antibiotic cocrystals reported in the literature, providing the main results on current tuberculosis medications utilized in cocrystals. Moreover, anti-tuberculosis cocrystals limitations and advantages are described, including evidence for enhanced solubility, stability and effect. Opportunities to enhance anti-tuberculosis medications and fixed dose combinations using cocrystals are given. Several cocrystal pairs are suggested to enhance the effectiveness of anti-tuberculosis drugs. LA - English DB - MTMT ER - TY - CHAP AU - Varga, Réka AU - Berta, Kiara AU - Győrfi, Nina Rubina AU - Tenzlinger, Kristóf AU - Odry, Ákos AU - Odry, Péter AU - Széchenyi, Aleksandar AU - Karádi, Zoltán AU - Tóth, Attila AU - Pál, József AU - Vizvári, Zoltán Ákos ED - Tóth, Attila ED - Vizvári, Zoltán Ákos TI - Grafénnel bevont mérőeszköz fejlesztése “sötét” neuronok vizsgálatára elektromos impedancia (EIS) mérés segítségével T2 - Orvosbiológiai kérdések - multidiszciplináris, bioimpedancia alapú válaszok PB - Pécsi Tudományegyetem CY - Pécs SN - 9789634299349 PY - 2022 SP - 134 EP - 143 PG - 10 UR - https://m2.mtmt.hu/api/publication/32733357 ID - 32733357 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Vörös-Horváth, Barbara AU - Zivkovic, Pavo AU - Bánfai, Krisztina AU - Bovári-Biri, Judit AU - Pongrácz, Judit AU - Bálint, Gábor AU - Pál, Szilárd AU - Széchenyi, Aleksandar TI - Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection JF - ACS OMEGA J2 - ACS OMEGA VL - 7 PY - 2022 IS - 4 SP - 3240 EP - 3253 PG - 14 SN - 2470-1343 DO - 10.1021/acsomega.1c05149 UR - https://m2.mtmt.hu/api/publication/32623813 ID - 32623813 AB - The COVID-19 virus is spread by pulmonary droplets. Its high infectivity is caused by the high-affinity binding of the viral spike protein to the ACE2 receptors on the surface of respiratory epithelial cell membranes. The proper hydration of nasal mucosa plays an essential role in defense of bacterial and viral infections. Therefore, a nasal formulation, which can moisture the nasal mucosa and contains the ACE2 receptor inhibitor, can reduce the risk of COVID-19 infection. This article presents a systematic study of the preparation of chitosan hydrogels with dicarboxylic acids (malic and glutaric acid) and their detailed characterization (Fourier transform infrared spectroscopy, deter-mination of cross-linking efficiency, rheological studies, thermal analysis, and swelling kinetics). The results confirm that chemically cross-linked chitosan hydrogels can be synthesized using malic or glutaric acid without additives or catalysts. The adsorption capacity of hydrogels for three different ACE2 inhibitors, as APIs, has also been investigated. The API content of hydrogels and their mucoadhesive property can provide an excellent basis to use the hydrogels for the development of a nasal formulation in order to reduce the risk of SARS-CoV 2 infection. LA - English DB - MTMT ER - TY - CHAP AU - Berta, Kiara AU - Varga, Reka AU - Győrfi, Nina Rubina AU - Tenzlinger, Kristof AU - Odry, Ákos AU - Odry, Péter AU - Széchenyi, Aleksandar AU - Karádi, Zoltán György AU - Tóth, Attila AU - Vizvári, Zoltán Ákos AU - Pál, József ED - Szakál, Anikó TI - The development of graphene coated measuring plate for the investigation of “dark” neurons with electrical impedance spectrum (EIS) measurement T2 - 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021 PB - IEEE CY - Budapest CY - Piscataway (NJ) SN - 9781728195438 PY - 2021 SP - 000159 EP - 000164 PG - 6 DO - 10.1109/SACI51354.2021.9465541 UR - https://m2.mtmt.hu/api/publication/32120818 ID - 32120818 N1 - Export Date: 11 January 2024 LA - English DB - MTMT ER - TY - CHAP AU - Filotas, Nora AU - Helt, Reka AU - Hencz, Alexandra Júlia AU - Tenzlinger, Kristof AU - Odry, Ákos AU - Odry, Péter AU - Karádi, Zoltán György AU - Vizvári, Zoltán Ákos AU - Tóth, Attila AU - Győrfi, Nina Rubina AU - Széchenyi, Aleksandar AU - Pál, József ED - Szakál, Anikó TI - Development of a Bioimpedance Measuring Plate for the Study of Hypoxic and Hyperoxic Conditions in Cell Cultures T2 - 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021 PB - IEEE CY - Budapest CY - Piscataway (NJ) SN - 9781728195438 PY - 2021 SP - 153 EP - 158 PG - 6 DO - 10.1109/SACI51354.2021.9465616 UR - https://m2.mtmt.hu/api/publication/32120790 ID - 32120790 N1 - Conference code: 171067 Export Date: 26 February 2024 Funding details: European Commission, EC, KA-2019-19/PTE-AOK Funding text 1: This research was funded by project EFOP-3.6.3-VEKOP-16-2017-00009 co-financed by the European Union, KA-2019-19/PTE-AOK. LA - English DB - MTMT ER - TY - CHAP AU - Hencz, Alexandra Júlia AU - Szilagyi, Gabor AU - Győrfi, Nina Rubina AU - Tenzlinger, Kristof AU - Széchenyi, Aleksandar AU - Odry, Ákos AU - Odry, Péter AU - Karádi, Zoltán György AU - Vizvári, Zoltán Ákos AU - Tóth, Attila AU - Pál, József ED - Szakál, Anikó TI - Comparative electrical impedance spectroscopy study of graphene and indium tin oxide electrodes during low frequency measurements T2 - 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021 PB - IEEE CY - Budapest CY - Piscataway (NJ) SN - 9781728195438 PY - 2021 SP - 000147 EP - 000152 PG - 6 DO - 10.1109/SACI51354.2021.9465546 UR - https://m2.mtmt.hu/api/publication/32120814 ID - 32120814 N1 - Institute of Physiology, Medical School Univeristy of Pecs, Pecs, Hungary Medical School Univeristy of Pecs, Department of Biochemistry and Medical Chemistry, Pecs, Hungary Institute of Pharmaceutical Technology and Biopharmacy of Information Technology, Faculty of Pharmacy University of Pecs, Pecs, Hungary Faculty of Engineering University of Szeged, Szeged, Hungary Institute of Information Technologyl University of Dunaujvaros, Dunaujvaros, Hungary Faculty of Engineering and Information Technology University of Pecs, Department of Environmental Engineering, Pecs, Hungary Conference code: 171067 Export Date: 26 February 2024 Funding text 1: This research was funded by project EFOP-3.6.3-VEKOP-16-2017-00009, GINOP-2.3.2-15-2016-00049, EFOP-3.6.1-16-2016-00004, KA-2019-19/PTE-AOK. LA - English DB - MTMT ER - TY - JOUR AU - Jukić, Ivana AU - Kolobarić, Nikolina AU - Stupin, Ana AU - Matić, Anita AU - Kozina, Nataša AU - Mihaljević, Zrinka AU - Mihalj, Martina AU - Šušnjara, Petar AU - Stupin, Marko AU - Ćurić, Željka Breškić AU - Selthofer-Relatić, Kristina AU - Kibel, Aleksandar AU - Lukinac, Anamarija AU - Kolar, Luka AU - Kralik, Gordana AU - Kralik, Zlata AU - Széchenyi, Aleksandar AU - Jozanović, Marija AU - Galović, Olivera AU - Medvidović-Kosanović, Martina AU - Drenjančević, Ines TI - Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 10 PY - 2021 IS - 7 PG - 31 SN - 2076-3921 DO - 10.3390/antiox10071037 UR - https://m2.mtmt.hu/api/publication/32152322 ID - 32152322 LA - English DB - MTMT ER - TY - CHAP AU - Nadasdi, Lili AU - Maczko, Gergo AU - Győrfi, Nina Rubina AU - Tenzlinger, Kristof AU - Odry, Ákos AU - Odry, Péter AU - Széchenyi, Aleksandar AU - Karádi, Zoltán György AU - Pál, József AU - Tóth, Attila AU - Vizvári, Zoltán Ákos ED - Szakál, Anikó TI - Preparation and Validation of Self-developed Bioimpedance Electrode Array for Measurement of Tumor Cells T2 - 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021 PB - IEEE CY - Budapest CY - Piscataway (NJ) SN - 9781728195438 PY - 2021 SP - 000129 EP - 000134 PG - 6 DO - 10.1109/SACI51354.2021.9465598 UR - https://m2.mtmt.hu/api/publication/32120811 ID - 32120811 N1 - Conference code: 171067 Export Date: 26 February 2024 Funding details: European Commission, EC Funding text 1: This research was funded by project a EFOP-3.6.3-VEKOP-16-2017-00009 co-financed by the European Union. LA - English DB - MTMT ER - TY - JOUR AU - Šafranko, Silvija AU - Stanković, Anamarija AU - Hajra, Sugato AU - Kim, Hoe-Joon AU - Strelec, Ivica AU - Dutour-Sikirić, Maja AU - Weber, Igor AU - Bosnar, Maja H. AU - Grbčić, Petra AU - Pavelić, Sandra K. AU - Széchenyi, Aleksandar AU - Mishra, Yogendra K. AU - Jerković, Igor AU - Jokić, Stela TI - Preparation of Multifunctional N-Doped Carbon Quantum Dots from Citrus clementina Peel: Investigating Targeted Pharmacological Activities and the Potential Application for Fe3+ Sensing JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 9 PG - 18 SN - 1424-8247 DO - 10.3390/ph14090857 UR - https://m2.mtmt.hu/api/publication/32188208 ID - 32188208 N1 - Faculty of Food Technology Osijek, University of Osijek, Franje Kuhača 18, Osijek, 31000, Croatia Department of Chemistry, University of Osijek, Ulica cara Hadrijana 8/A, Osijek, 31000, Croatia Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, 42988, South Korea Division of Physical Chemistry, Ruđer Bošković Institute, Zagreb, 10000, Croatia Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, 10000, Croatia Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, 10000, Croatia Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, Rijeka, 51000, Croatia Faculty of Health Studies, University of Rijeka, Viktora Cara Emina 5, Rijeka, 51000, Croatia Institute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, Pécs, H-7624, Hungary Mads Clausen Institute, NanoSYD, University of Southern Denmark, Alsion 2, Sønderborg, 6400, Denmark Department of Organic Chemistry, Faculty of Chemistry and Technology, University of Split, Ru ¯dera Boškovića 35, Split, 21000, Croatia Export Date: 13 September 2021 Correspondence Address: Jerković, I.; Department of Organic Chemistry, Ru ¯dera Boškovića 35, Croatia; email: igor@ktf-split.hr Correspondence Address: Jokić, S.; Faculty of Food Technology Osijek, Franje Kuhača 18, Croatia; email: sjokic@ptfos.hr AB - Carbon quantum dots (CQDs) have recently emerged as innovative theranostic nanomaterials, enabling fast and effective diagnosis and treatment. In this study, a facile hydrothermal approach for N-doped biomass-derived CQDs preparation from Citrus clementina peel and amino acids glycine (Gly) and arginine (Arg) has been presented. The gradual increase in the N-dopant (amino acids) nitrogen content increased the quantum yield of synthesized CQDs. The prepared CQDs exhibited good biocompatibility, stability in aqueous, and high ionic strength media, similar optical properties, while differences were observed regarding the structural and chemical diversity, and biological and antioxidant activity. The antiproliferative effect of CQD@Gly against pancreatic cancer cell lines (CFPAC-1) was observed. At the same time, CQD@Arg has demonstrated the highest quantum yield and antioxidant activity by DPPH scavenging radical method of 81.39 ± 0.39% and has been further used for the ion sensing and cellular imaging of cancer cells. The obtained results have demonstrated selective response toward Fe3+ detection, with linear response ranging from 7.0 µmol dm−3 to 50.0 µmol dm−3 with R2 = 0.9931 and limit of detection (LOD) of 4.57 ± 0.27 µmol dm−3. This research could be a good example of sustainable biomass waste utilization with potential for biomedical analysis and ion sensing applications. LA - English DB - MTMT ER -