TY - JOUR AU - Lőrincz, Csanád Endre AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Varga, Csaba AU - Szabó, Renáta TI - Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 3 SP - 560 SN - 2227-9059 DO - 10.3390/biomedicines12030560 UR - https://m2.mtmt.hu/api/publication/34742326 ID - 34742326 AB - Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS. LA - English DB - MTMT ER - TY - CONF AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Physical activity induced protection in TNBS rat colitis: focus on NETosis PY - 2023 SP - ISBN 978-615-6203-02-1 UR - https://m2.mtmt.hu/api/publication/34136600 ID - 34136600 LA - English DB - MTMT ER - TY - JOUR AU - Almási, Nikoletta AU - Török, Szilvia AU - Al-Awar, Amin AU - Veszelka, Médea AU - Király, László AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 8 PG - 11 SN - 2076-3921 DO - 10.3390/antiox12081531 UR - https://m2.mtmt.hu/api/publication/34081631 ID - 34081631 N1 - Funding Agency and Grant Number: This research was supported by GINOP PLUSZ-2.1.1-21-2022-00189.; GINOP; [PLUSZ-2.1.1-21-2022-00189] Funding text: This research was supported by GINOP PLUSZ-2.1.1-21-2022-00189. AB - Inflammatory bowel diseases (IBDs) are autoimmune disorders of the gut. It is increasingly clear that voluntary exercise (VE) may exert protection against IBDs, but the exact background mechanism needs to be elucidated. In the present study, we aimed to investigate the possible role of NETosis and the antioxidant peroxiredoxin (Prdx) enzyme family in VE-induced protection. Wistar Han rats were randomly divided into two groups: sedentary (SED) and VE. After the 6-week voluntary wheel running, animals were treated with 2,4,6-trinitrobenzene sulphonic acid (TNBS) as a model of colitis. Here, we found that VE significantly decreased inflammation and ulceration of the colon in the VE TNBS group compared with SED TNBS. We also found that VE significantly decreased the expression of protein arginine deiminase 4 (PAD4) and myeloperoxidase (MPO), and markedly reduced citrullinated histone H3 (citH3) compared with SED TNBS. Furthermore, VE caused a significant increase in the levels of Prdx6 in the control and TNBS groups. Taken together, we found that a prior 6-week VE effectively reduces inflammation in TNBS-induced colitis, and we suggest that the protective effect of VE may be mediated via the inhibition of NETosis and upregulation of Prdx6 antioxidant. LA - English DB - MTMT ER - TY - CHAP AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Sugár, Anna AU - Neuperger, Patrícia AU - Szebeni, Gábor AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Almási, Nikoletta AU - Veszelka, Médea AU - Török, Szilvia AU - Varga, Csaba AU - Szabó, Renáta ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - A PCOS gyulladásos hátterének vizsgálata és terápiás megközelítése T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 16 EP - 16 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136606 ID - 34136606 LA - English DB - MTMT ER - TY - CHAP AU - Kiss, Viktória AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Nagy, András Levente AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - Effects of lifestyle on adipokine pattern changes in stroke-prone spontaneously hypertensive rat model T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 34 EP - 34 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136657 ID - 34136657 LA - English DB - MTMT ER - TY - CHAP AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Sugár, Anna AU - Nagy, András AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patrícia AU - Szebeni, Gábor AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - Examination of imatinib-induced cardiotoxicity in a rat model T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 57 EP - 57 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136645 ID - 34136645 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Nagy, András Levente AU - Török, Szilvia AU - Veszelka, Médea AU - Almási, Nikoletta AU - Varga, Csaba TI - The Interplay of Lifestyle and Adipokines in the Non-Obese Stroke-Prone Spontaneously Hypertensive Rats JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 7 PG - 13 SN - 2076-3921 DO - 10.3390/antiox12071450 UR - https://m2.mtmt.hu/api/publication/34071290 ID - 34071290 N1 - Funding Agency and Grant Number: [2019-1.1.1-PIACI-KFI-2019-00226]; [GINOP-PLUSZ-2.3.1-21-2022-00083] Funding text: The study was supported by the 2019-1.1.1-PIACI-KFI-2019-00226 grant and GINOP-PLUSZ-2.3.1-21-2022-00083. AB - Although the morphological features and functions of adipose tissue are well-described in obesity-prone animal models, less information is available on animals such as the stroke-prone spontaneously hypertensive (SHRSP) strain with cardiovascular abnormalities, which is not characterized by excessive adiposity. Our aim was to focus on lifestyle-induced (type of diet and physical exercise) effects on adipokine profile and lipid peroxidation in SHRSP rats. In our study, male Wistar-kyoto (control) and SHRSP rats were used. SHRSP rats were fed either standard chow or a high-fat diet with 40% fat content (HFD). One group of the animals was placed into cages fitted with a running-wheel; thus, the dietary and training period started at the same time and lasted for 12 weeks. At the end of the experimental period, adiponectin, leptin, omentin, and chemerin concentrations were determined from adipose tissue and serum. Besides adipokines, malondialdehyde (MDA) levels were also measured. Twelve weeks of HFD significantly decreased adiponectin and omentin concentrations of both adipose tissue and serum, which were ameliorated by physical exercise. Serum leptin, chemerin, and MDA values were elevated in HFD groups; however, physical exercise was able to mitigate these adverse changes. Our results underpin the crosstalk between lifestyle changes and dysfunctional adipose tissue in SHRSP rats. LA - English DB - MTMT ER - TY - JOUR AU - Török, Szilvia AU - Almási, Nikoletta AU - Veszelka, Médea AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Protective Effects of H2S Donor Treatment in Experimental Colitis: A Focus on Antioxidants JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 5 PG - 11 SN - 2076-3921 DO - 10.3390/antiox12051025 UR - https://m2.mtmt.hu/api/publication/34007150 ID - 34007150 N1 - Cited By :1 Export Date: 11 October 2023 Correspondence Address: Török, S.; Department of Physiology, Hungary; email: tszilvia@bio.u-szeged.hu Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: This research was supported by the ÚNKP-22-4-SZTE-525 (Szilvia Török) New National Excellence Program of the Ministry for Culture and Innovation from the Source of the National Research, Development and Innovation Fund. AB - Inflammatory bowel diseases (IBD) are chronic, inflammatory disorders of the gastrointestinal (GI) system, which have become a global disease over the past few decades. It has become increasingly clear that oxidative stress plays a role in the pathogenesis of IBD. Even though several effective therapies exist against IBD, these might have serious side effects. It has been proposed that hydrogen sulfide (H2S), as a novel gasotransmitter, has several physiological and pathological effects on the body. Our present study aimed to investigate the effects of H2S administration on antioxidant molecules in experimental rat colitis. As a model of IBD, 2,4,6-trinitrobenzenesulfonic acid (TNBS) was used intracolonically (i.c.) to induce colitis in male Wistar–Hannover rats. Animals were orally treated (2 times/day) with H2S donor Lawesson’s reagent (LR). Our results showed that H2S administration significantly decreased the severity of inflammation in the colons. Furthermore, LR significantly suppressed the level of oxidative stress marker 3-nitrotyrosine (3-NT) and caused a significant elevation in the levels of antioxidant GSH, Prdx1, Prdx6, and the activity of SOD compared to TNBS. In conclusion, our results suggest that these antioxidants may offer potential therapeutic targets and H2S treatment through the activation of antioxidant defense mechanisms and may provide a promising strategy against IBD. LA - English DB - MTMT ER - TY - CHAP AU - Török, Szilvia AU - Almási, Nikoletta AU - Veszelka, Médea AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - The effect of H2S treatment on the antioxidant system in a colitis model T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 78-615-6203-02-1 UR - https://m2.mtmt.hu/api/publication/34136601 ID - 34136601 LA - English DB - MTMT ER - TY - CHAP AU - Veszelka, Médea AU - Almási, Nikoletta AU - Török, Szilvia AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Bódi, Nikolett AU - Szabó, Renáta AU - Börzsei, Denise AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - Resveratrol hatásának vizsgálata IBD patkánymodellben T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 67 EP - 67 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136566 ID - 34136566 LA - English DB - MTMT ER - TY - GEN AU - Almási, Nikoletta AU - Török, Szilvia AU - Al-Awar, Amin AU - Veszelka, Médea AU - Baráth, D AU - Pósa, Anikó AU - Kupai, Krisztina AU - Varga, Csaba TI - The protective effect of voluntary exercise is mediated by the inhibition of NETosis and upregulation of Prdx6 in TNBS-induced rat colitis PY - 2022 UR - https://m2.mtmt.hu/api/publication/33116005 ID - 33116005 LA - English DB - MTMT ER - TY - CHAP AU - Pósa, Anikó AU - Szabó, Renáta AU - Börzsei, Denise AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Varga, Csaba ED - Dela, F. ED - Piacentini, M.F. ED - Helge, J.W. ED - Calvo Lluch, Á. ED - Sáez, E. ED - Pareja Blanco, F. ED - Tsolakidis, E. TI - Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat testis T2 - 27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE PB - European College of Sport Science CY - Köln SN - 9783981841459 PY - 2022 UR - https://m2.mtmt.hu/api/publication/33569027 ID - 33569027 LA - English DB - MTMT ER - TY - GEN AU - Pósa, Anikó AU - Szabó, Renáta AU - Börzsei, Denise AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Nadin, Zelma Lesi AU - Szász, András AU - Varga, Csaba TI - Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat model PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568963 ID - 33568963 LA - English DB - MTMT ER - TY - JOUR AU - Börzsei, Denise AU - Sebestyén, Judith AU - Szabó, Renáta AU - Lesi, Zelma Nadin AU - Pálszabo, Andrea AU - Pálszabó , Patrícia AU - Szász, András AU - Priksz, Dániel AU - Juhász, Béla AU - Veszelka, Médea AU - Turcsán, Zsolt AU - Deim, Zoltán AU - Varga, Csaba AU - Pósa, Anikó TI - Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations JF - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY J2 - OXID MED CELL LONGEV VL - 2022 PY - 2022 PG - 8 SN - 1942-0900 DO - 10.1155/2022/7911222 UR - https://m2.mtmt.hu/api/publication/32911781 ID - 32911781 N1 - Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, 6726, Hungary South-Pest Hospital Centre, National Institute for Infectology and Haematology, Department of Burns and Plastic Surgery, Budapest, 1097, Hungary Institution of Physical Education and Sport Sciences, Faculty of Education, University of Szeged, Szeged, 6725, Hungary Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary Gulyás János És Társa Ltd., Felgyő6645, Hungary Export Date: 18 January 2023 Correspondence Address: Pósa, A.; Department of Physiology, Hungary; email: paniko@bio.u-szeged.hu Chemicals/CAS: glutathione, 70-18-8; heme oxygenase, 9059-22-7; resveratrol, 501-36-0; polyphenol, 37331-26-3; Antioxidants; Glutathione; Heme Oxygenase (Decyclizing); NF-kappa B; Polyphenols; Resveratrol; Stilbenes; Tumor Necrosis Factor-alpha LA - English DB - MTMT ER - TY - JOUR AU - Börzsei, Denise AU - Szabó, Renáta AU - Lesi, Zelma Nadin AU - Pálszabó, Andrea AU - Pálszabó, Patrícia AU - Szász, András AU - Pósa, Anikó AU - Varga, Csaba TI - A testmozgás andrológiai vonatkozásai: a mérsékelt úszás véd az izoproterenol által kiváltott here- és spermium-rendellenességekkel szemben patkányokban JF - MAGYAR SPORTTUDOMÁNYI SZEMLE J2 - M SPORTTUD SZLE VL - 23 PY - 2022 IS - 2 SP - 37 EP - 37 PG - 1 SN - 1586-5428 UR - https://m2.mtmt.hu/api/publication/32893539 ID - 32893539 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Börzsei, Denise AU - Szabó, Renáta AU - Pálszabó, Andrea AU - Priksz, Dániel AU - Varga, Csaba AU - Pósa, Anikó ED - Dela, F. ED - Piacentini, M.F. ED - Helge, J.W. ED - Calvo Lluch, Á. ED - Sáez, E. ED - Pareja Blanco, F. ED - Tsolakidis, E. TI - Exercise-mitigated, gender-based differences in aging rat heart T2 - 27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE PB - European College of Sport Science CY - Köln SN - 9783981841459 PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568999 ID - 33568999 LA - English DB - MTMT ER - TY - GEN AU - Börzsei, Denise AU - Szabó, Renáta AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Nadin, Zelma Lesi AU - Szász, András AU - Varga, Csaba AU - Pósa, Anikó TI - Cardiometabolic effects mediated by endocannabinoids in estrogen-depleted rat model PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568950 ID - 33568950 LA - English DB - MTMT ER - TY - JOUR AU - Kupai, Krisztina AU - Török, Szilvia AU - Várkonyi, Ákos AU - Csonka, Á AU - Almási, Nikoletta AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila AU - Valkusz, Zsuzsanna AU - Pósa, Anikó AU - Varga, Csaba TI - Fehérjék poszttranszlációs módosításának szerepe 1-es típusú diabetes mellitusban [ Role of post-translational modifications of proteins in experimental type 1 diabetes] JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 30 PY - 2022 IS - Suppl. 2 SP - 62 EP - 63 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/33089323 ID - 33089323 LA - Hungarian DB - MTMT ER - TY - GEN AU - Veszelka, Médea AU - Almási, Nikoletta AU - Török, Szilvia AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Pósa, Anikó AU - Varga, Csaba TI - Resveratrol supplementation ameliorates TNBS colitis in rats PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568908 ID - 33568908 LA - English DB - MTMT ER - TY - JOUR AU - Pálszabó, Andrea AU - Szabó, Renáta AU - Börzsei, Denise AU - Pálszabó, Patrícia AU - Lesi, Zelma Nadin AU - Szász, András AU - Pósa, Anikó AU - Varga, Csaba TI - Rekreációs testmozgás hatása a szívben történő fehérje expresszióra idős patkányokban JF - MAGYAR SPORTTUDOMÁNYI SZEMLE J2 - M SPORTTUD SZLE VL - 23 PY - 2022 IS - 2 SP - 76 EP - 76 PG - 1 SN - 1586-5428 UR - https://m2.mtmt.hu/api/publication/32893536 ID - 32893536 LA - Hungarian DB - MTMT ER -