@article{MTMT:34742326,
	title = {Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation},
	url = {https://m2.mtmt.hu/api/publication/34742326},
	author = {Lőrincz, Csanád Endre and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Varga, Csaba and Szabó, Renáta},
	doi = {10.3390/biomedicines12030560},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {12},
	unique-id = {34742326},
	abstract = {Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS.},
	year = {2024},
	eissn = {2227-9059},
	pages = {560},
	orcid-numbers = {Varga, Csaba/0000-0002-2678-665X}
}

@CONFERENCE{MTMT:34136600,
	title = {Physical activity induced protection in TNBS rat colitis: focus on NETosis},
	url = {https://m2.mtmt.hu/api/publication/34136600},
	author = {Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	unique-id = {34136600},
	year = {2023},
	pages = {ISBN 978-615-6203-02-1},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:34081631,
	title = {Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants},
	url = {https://m2.mtmt.hu/api/publication/34081631},
	author = {Almási, Nikoletta and Török, Szilvia and Al-Awar, Amin and Veszelka, Médea and Király, László and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	doi = {10.3390/antiox12081531},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34081631},
	abstract = {Inflammatory bowel diseases (IBDs) are autoimmune disorders of the gut. It is increasingly clear that voluntary exercise (VE) may exert protection against IBDs, but the exact background mechanism needs to be elucidated. In the present study, we aimed to investigate the possible role of NETosis and the antioxidant peroxiredoxin (Prdx) enzyme family in VE-induced protection. Wistar Han rats were randomly divided into two groups: sedentary (SED) and VE. After the 6-week voluntary wheel running, animals were treated with 2,4,6-trinitrobenzene sulphonic acid (TNBS) as a model of colitis. Here, we found that VE significantly decreased inflammation and ulceration of the colon in the VE TNBS group compared with SED TNBS. We also found that VE significantly decreased the expression of protein arginine deiminase 4 (PAD4) and myeloperoxidase (MPO), and markedly reduced citrullinated histone H3 (citH3) compared with SED TNBS. Furthermore, VE caused a significant increase in the levels of Prdx6 in the control and TNBS groups. Taken together, we found that a prior 6-week VE effectively reduces inflammation in TNBS-induced colitis, and we suggest that the protective effect of VE may be mediated via the inhibition of NETosis and upregulation of Prdx6 antioxidant.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136606,
	title = {A PCOS gyulladásos hátterének vizsgálata és terápiás megközelítése},
	url = {https://m2.mtmt.hu/api/publication/34136606},
	author = {Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Sugár, Anna and Neuperger, Patrícia and Szebeni, Gábor and Bagyánszki, Mária and Barta, Bence Pál and Almási, Nikoletta and Veszelka, Médea and Török, Szilvia and Varga, Csaba and Szabó, Renáta},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136606},
	year = {2023},
	pages = {16-16},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136657,
	title = {Effects of lifestyle on adipokine pattern changes in stroke-prone spontaneously hypertensive rat model},
	url = {https://m2.mtmt.hu/api/publication/34136657},
	author = {Kiss, Viktória and Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Nagy, András Levente and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136657},
	year = {2023},
	pages = {34-34},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136645,
	title = {Examination of imatinib-induced cardiotoxicity in a rat model},
	url = {https://m2.mtmt.hu/api/publication/34136645},
	author = {Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Sugár, Anna and Nagy, András and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patrícia and Szebeni, Gábor and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136645},
	year = {2023},
	pages = {57-57},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:34071290,
	title = {The Interplay of Lifestyle and Adipokines in the Non-Obese Stroke-Prone Spontaneously Hypertensive Rats},
	url = {https://m2.mtmt.hu/api/publication/34071290},
	author = {Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Nagy, András Levente and Török, Szilvia and Veszelka, Médea and Almási, Nikoletta and Varga, Csaba},
	doi = {10.3390/antiox12071450},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34071290},
	abstract = {Although the morphological features and functions of adipose tissue are well-described in obesity-prone animal models, less information is available on animals such as the stroke-prone spontaneously hypertensive (SHRSP) strain with cardiovascular abnormalities, which is not characterized by excessive adiposity. Our aim was to focus on lifestyle-induced (type of diet and physical exercise) effects on adipokine profile and lipid peroxidation in SHRSP rats. In our study, male Wistar-kyoto (control) and SHRSP rats were used. SHRSP rats were fed either standard chow or a high-fat diet with 40% fat content (HFD). One group of the animals was placed into cages fitted with a running-wheel; thus, the dietary and training period started at the same time and lasted for 12 weeks. At the end of the experimental period, adiponectin, leptin, omentin, and chemerin concentrations were determined from adipose tissue and serum. Besides adipokines, malondialdehyde (MDA) levels were also measured. Twelve weeks of HFD significantly decreased adiponectin and omentin concentrations of both adipose tissue and serum, which were ameliorated by physical exercise. Serum leptin, chemerin, and MDA values were elevated in HFD groups; however, physical exercise was able to mitigate these adverse changes. Our results underpin the crosstalk between lifestyle changes and dysfunctional adipose tissue in SHRSP rats.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:34007150,
	title = {Protective Effects of H2S Donor Treatment in Experimental Colitis: A Focus on Antioxidants},
	url = {https://m2.mtmt.hu/api/publication/34007150},
	author = {Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	doi = {10.3390/antiox12051025},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34007150},
	abstract = {Inflammatory bowel diseases (IBD) are chronic, inflammatory disorders of the gastrointestinal (GI) system, which have become a global disease over the past few decades. It has become increasingly clear that oxidative stress plays a role in the pathogenesis of IBD. Even though several effective therapies exist against IBD, these might have serious side effects. It has been proposed that hydrogen sulfide (H2S), as a novel gasotransmitter, has several physiological and pathological effects on the body. Our present study aimed to investigate the effects of H2S administration on antioxidant molecules in experimental rat colitis. As a model of IBD, 2,4,6-trinitrobenzenesulfonic acid (TNBS) was used intracolonically (i.c.) to induce colitis in male Wistar–Hannover rats. Animals were orally treated (2 times/day) with H2S donor Lawesson’s reagent (LR). Our results showed that H2S administration significantly decreased the severity of inflammation in the colons. Furthermore, LR significantly suppressed the level of oxidative stress marker 3-nitrotyrosine (3-NT) and caused a significant elevation in the levels of antioxidant GSH, Prdx1, Prdx6, and the activity of SOD compared to TNBS. In conclusion, our results suggest that these antioxidants may offer potential therapeutic targets and H2S treatment through the activation of antioxidant defense mechanisms and may provide a promising strategy against IBD.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136601,
	title = {The effect of H2S treatment on the antioxidant system in a colitis model},
	url = {https://m2.mtmt.hu/api/publication/34136601},
	author = {Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136601},
	year = {2023},
	pages = {78-615-6203-02-1},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136566,
	title = {Resveratrol hatásának vizsgálata IBD patkánymodellben},
	url = {https://m2.mtmt.hu/api/publication/34136566},
	author = {Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Bódi, Nikolett and Szabó, Renáta and Börzsei, Denise and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136566},
	year = {2023},
	pages = {67-67},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Bódi, Nikolett/0000-0002-9774-1387; Varga, Csaba/0000-0002-2678-665X}
}

@misc{MTMT:33116005,
	title = {The protective effect of voluntary exercise is mediated by the inhibition of NETosis and upregulation of Prdx6 in TNBS-induced rat colitis},
	url = {https://m2.mtmt.hu/api/publication/33116005},
	author = {Almási, Nikoletta and Török, Szilvia and Al-Awar, Amin and Veszelka, Médea and Baráth, D and Pósa, Anikó and Kupai, Krisztina and Varga, Csaba},
	unique-id = {33116005},
	year = {2022},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Pósa, Anikó/0000-0003-2167-2888; Kupai, Krisztina/0000-0002-0644-1718; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:33569027,
	title = {Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat testis},
	url = {https://m2.mtmt.hu/api/publication/33569027},
	author = {Pósa, Anikó and Szabó, Renáta and Börzsei, Denise and Andrea, Pálszabó and Patrícia, Pálszabó and Varga, Csaba},
	booktitle = {27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE},
	unique-id = {33569027},
	year = {2022},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@misc{MTMT:33568963,
	title = {Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat model},
	url = {https://m2.mtmt.hu/api/publication/33568963},
	author = {Pósa, Anikó and Szabó, Renáta and Börzsei, Denise and Andrea, Pálszabó and Patrícia, Pálszabó and Nadin, Zelma Lesi and Szász, András and Varga, Csaba},
	unique-id = {33568963},
	year = {2022},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:32911781,
	title = {Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations},
	url = {https://m2.mtmt.hu/api/publication/32911781},
	author = {Börzsei, Denise and Sebestyén, Judith and Szabó, Renáta and Lesi, Zelma Nadin and Pálszabo, Andrea and Pálszabó , Patrícia and Szász, András and Priksz, Dániel and Juhász, Béla and Veszelka, Médea and Turcsán, Zsolt and Deim, Zoltán and Varga, Csaba and Pósa, Anikó},
	doi = {10.1155/2022/7911222},
	journal-iso = {OXID MED CELL LONGEV},
	journal = {OXIDATIVE MEDICINE AND CELLULAR LONGEVITY},
	volume = {2022},
	unique-id = {32911781},
	issn = {1942-0900},
	year = {2022},
	eissn = {1942-0994},
	orcid-numbers = {Börzsei, Denise/0000-0002-7899-9374; Szabó, Renáta/0000-0001-7881-2082; Priksz, Dániel/0000-0002-5818-4557; Veszelka, Médea/0000-0003-2037-3288; Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888}
}

@article{MTMT:32893539,
	title = {A testmozgás andrológiai vonatkozásai: a mérsékelt úszás véd az izoproterenol által kiváltott here- és spermium-rendellenességekkel szemben patkányokban},
	url = {https://m2.mtmt.hu/api/publication/32893539},
	author = {Börzsei, Denise and Szabó, Renáta and Lesi, Zelma Nadin and Pálszabó, Andrea and Pálszabó, Patrícia and Szász, András and Pósa, Anikó and Varga, Csaba},
	journal-iso = {M SPORTTUD SZLE},
	journal = {MAGYAR SPORTTUDOMÁNYI SZEMLE},
	volume = {23},
	unique-id = {32893539},
	issn = {1586-5428},
	year = {2022},
	pages = {37-37},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:33568999,
	title = {Exercise-mitigated, gender-based differences in aging rat heart},
	url = {https://m2.mtmt.hu/api/publication/33568999},
	author = {Börzsei, Denise and Szabó, Renáta and Pálszabó, Andrea and Priksz, Dániel and Varga, Csaba and Pósa, Anikó},
	booktitle = {27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE},
	unique-id = {33568999},
	year = {2022},
	orcid-numbers = {Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888}
}

@misc{MTMT:33568950,
	title = {Cardiometabolic effects mediated by endocannabinoids in estrogen-depleted rat model},
	url = {https://m2.mtmt.hu/api/publication/33568950},
	author = {Börzsei, Denise and Szabó, Renáta and Andrea, Pálszabó and Patrícia, Pálszabó and Nadin, Zelma Lesi and Szász, András and Varga, Csaba and Pósa, Anikó},
	unique-id = {33568950},
	year = {2022},
	orcid-numbers = {Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888}
}

@article{MTMT:33089323,
	title = {Fehérjék poszttranszlációs módosításának szerepe 1-es típusú diabetes mellitusban [ Role of post-translational modifications of proteins in experimental type 1 diabetes]},
	url = {https://m2.mtmt.hu/api/publication/33089323},
	author = {Kupai, Krisztina and Török, Szilvia and Várkonyi, Ákos and Csonka, Á and Almási, Nikoletta and Várkonyi, Tamás and Lengyel, Csaba Attila and Valkusz, Zsuzsanna and Pósa, Anikó and Varga, Csaba},
	journal-iso = {DIABETOLOGIA HUNGARICA},
	journal = {DIABETOLOGIA HUNGARICA},
	volume = {30},
	unique-id = {33089323},
	issn = {1217-372X},
	year = {2022},
	eissn = {2560-0168},
	pages = {62-63},
	orcid-numbers = {Kupai, Krisztina/0000-0002-0644-1718; Almási, Nikoletta/0000-0002-7371-5272; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067; Valkusz, Zsuzsanna/0000-0003-1928-6160; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@misc{MTMT:33568908,
	title = {Resveratrol supplementation ameliorates TNBS colitis in rats},
	url = {https://m2.mtmt.hu/api/publication/33568908},
	author = {Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Pósa, Anikó and Varga, Csaba},
	unique-id = {33568908},
	year = {2022},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:32893536,
	title = {Rekreációs testmozgás hatása a szívben történő fehérje expresszióra idős patkányokban},
	url = {https://m2.mtmt.hu/api/publication/32893536},
	author = {Pálszabó, Andrea and Szabó, Renáta and Börzsei, Denise and Pálszabó, Patrícia and Lesi, Zelma Nadin and Szász, András and Pósa, Anikó and Varga, Csaba},
	journal-iso = {M SPORTTUD SZLE},
	journal = {MAGYAR SPORTTUDOMÁNYI SZEMLE},
	volume = {23},
	unique-id = {32893536},
	issn = {1586-5428},
	year = {2022},
	pages = {76-76},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}