@article{MTMT:31783191, title = {A nagy tisztaságú klór-dioxid oldattal történő eredményes kezelés tudományos magyarázata}, url = {https://m2.mtmt.hu/api/publication/31783191}, author = {Kály-Kullai, Kristóf and Gyökérné Wittmann, Mária and Noszticzius, Z and Rosivall, László}, journal-iso = {GYÓGYSZERÉSZ TOVÁBBKÉPZÉS}, journal = {GYÓGYSZERÉSZ TOVÁBBKÉPZÉS}, volume = {14}, unique-id = {31783191}, issn = {1788-9049}, year = {2020}, pages = {245-248}, orcid-numbers = {Rosivall, László/0000-0002-9809-3879} } @article{MTMT:31304529, title = {Can chlorine dioxide prevent the spreading of coronavirus or other viral infections? Medical hypotheses}, url = {https://m2.mtmt.hu/api/publication/31304529}, author = {Kály-Kullai, Kristóf and Gyökérné Wittmann, Mária and Noszticzius, Zoltán and Rosivall, László}, doi = {10.1556/2060.2020.00015}, journal-iso = {PHYSIOL INT}, journal = {PHYSIOLOGY INTERNATIONAL}, volume = {107}, unique-id = {31304529}, issn = {2498-602X}, year = {2020}, eissn = {2677-0164}, pages = {1-11}, orcid-numbers = {Rosivall, László/0000-0002-9809-3879} } @article{MTMT:3392676, title = {Reactions of iodate with iodine in concentrated sulfuric acid. Formation of I(+3) and I(+1) compounds}, url = {https://m2.mtmt.hu/api/publication/3392676}, author = {Schmitz, G and Noszticzius, Zoltán and Holló, Gábor and Gyökérné Wittmann, Mária and Furrow, SD}, doi = {10.1016/j.cplett.2017.10.055}, journal-iso = {CHEM PHYS LETT}, journal = {CHEMICAL PHYSICS LETTERS}, volume = {691}, unique-id = {3392676}, issn = {0009-2614}, abstract = {The absorption spectra in a large range of concentrations show that the reactions of iodate with iodine in 96% sulfuric acid produce (IO) HSO4, I-3(+) and I-5(+), just like in the pure 100% acid. We discovered that, in 96% H2SO4, these reactions also produce I2O which is not formed in the pure acid. I2O is an important intermediate of reactions in diluted sulfuric acid, including the Bray-Liebhafsky reaction, but it had never been observed directly because of its very high reactivity. The equilibrium constants of the reactions producing these four compounds were determined. (C) 2017 Elsevier B.V. All rights reserved.}, keywords = {KINETICS; HYDROGEN-PEROXIDE; Ion-selective electrodes; Briggs-Rauscher reaction; Disproportionation; hypoiodous acid; POTENTIAL RESPONSE; MONITORING OSCILLATING REACTIONS; BIOGENIC IODINE; ATMOSPHERIC IODINE}, year = {2018}, eissn = {1873-4448}, pages = {44-50}, orcid-numbers = {Holló, Gábor/0000-0001-9920-4801} } @article{MTMT:3184605, title = {Platinum as a HOI/I2 Redox Electrode and Its Mixed Potential in the Oscillatory Briggs−Rauscher Reaction}, url = {https://m2.mtmt.hu/api/publication/3184605}, author = {Holló, Gábor and Kály-Kullai, Kristóf and Lawson, Thuy B and Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Muntean, Norbert and Furrow, Stanley D and Schmitz, Guy}, doi = {10.1021/acs.jpca.6b10243}, journal-iso = {J PHYS CHEM A}, journal = {JOURNAL OF PHYSICAL CHEMISTRY A}, volume = {121}, unique-id = {3184605}, issn = {1089-5639}, year = {2017}, eissn = {1520-5215}, pages = {429-439}, orcid-numbers = {Holló, Gábor/0000-0001-9920-4801} } @article{MTMT:3309625, title = {Hogyan ellenőrizhető egy ismeretlen klór-dioxid termék tisztasága?}, url = {https://m2.mtmt.hu/api/publication/3309625}, author = {Noszticzius, Zoltán and Bezur, László and Gerencsér, Ákos and Holló, Gábor and Kály-Kullai, Kristóf and Lawson, Thuy and Megyesi, Marianna and Varga, Bozsana and Gyökérné Wittmann, Mária}, journal-iso = {MAGYAR FOGORVOS}, journal = {MAGYAR FOGORVOS: A MAGYAR ORVOSI KAMARA FOGORVOSI TAGOZATÁNAK LAPJA}, volume = {2017}, unique-id = {3309625}, issn = {1216-2213}, year = {2017}, pages = {132-137}, orcid-numbers = {Holló, Gábor/0000-0001-9920-4801} } @article{MTMT:2743898, title = {HOI versus HOIO Selectivity of a Molten-type AgI Electrode}, url = {https://m2.mtmt.hu/api/publication/2743898}, author = {Holló, Gábor and Kály-Kullai, Kristóf and Lawson, Thuy B and Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Muntean, Norbert and Furrow, Stanley D and Schmitz, Guy}, doi = {10.1021/jp504052w}, journal-iso = {J PHYS CHEM A}, journal = {JOURNAL OF PHYSICAL CHEMISTRY A}, volume = {118}, unique-id = {2743898}, issn = {1089-5639}, year = {2014}, eissn = {1520-5215}, pages = {4670-4679}, orcid-numbers = {Holló, Gábor/0000-0001-9920-4801} } @{MTMT:2803233, title = {Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide}, url = {https://m2.mtmt.hu/api/publication/2803233}, author = {Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Megyesi, M and Volford, A}, unique-id = {2803233}, year = {2013} } @book{MTMT:2803231, title = {Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide}, url = {https://m2.mtmt.hu/api/publication/2803231}, author = {Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Megyesi, M and Volford, A}, unique-id = {2803231}, year = {2013} } @article{MTMT:2499103, title = {Chlorine Dioxide Is a Size-Selective Antimicrobial Agent}, url = {https://m2.mtmt.hu/api/publication/2499103}, author = {Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Beregvari, Z and Kiss, István and Rosivall, László and Szegedi, J}, doi = {10.1371/journal.pone.0079157}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {8}, unique-id = {2499103}, issn = {1932-6203}, abstract = {Background / Aims: ClO2, the so-called "ideal biocide", could also be applied as an antiseptic if it was understood why the solution killing microbes rapidly does not cause any harm to humans or to animals. Our aim was to find the source of that selectivity by studying its reaction-diffusion mechanism both theoretically and experimentally. Methods: ClO2 permeation measurements through protein membranes were performed and the time delay of ClO2 transport due to reaction and diffusion was determined. To calculate ClO2 penetration depths and estimate bacterial killing times, approximate solutions of the reaction-diffusion equation were derived. In these calculations evaporation rates of ClO2 were also measured and taken into account. Results: The rate law of the reaction-diffusion model predicts that the killing time is proportional to the square of the characteristic size (e. g. diameter) of a body, thus, small ones will be killed extremely fast. For example, the killing time for a bacterium is on the order of milliseconds in a 300 ppm ClO2 solution. Thus, a few minutes of contact time (limited by the volatility of ClO2) is quite enough to kill all bacteria, but short enough to keep ClO2 penetration into the living tissues of a greater organism safely below 0.1 mm, minimizing cytotoxic effects when applying it as an antiseptic. Additional properties of ClO2, advantageous for an antiseptic, are also discussed. Most importantly, that bacteria are not able to develop resistance against ClO2 as it reacts with biological thiols which play a vital role in all living organisms. Conclusion: Selectivity of ClO2 between humans and bacteria is based not on their different biochemistry, but on their different size. We hope initiating clinical applications of this promising local antiseptic.}, keywords = {MECHANISMS; PROTEIN; OXIDATION; TOXICITY; HYDROGEN-PEROXIDE; HYPOCHLOROUS ACID; Disinfectants; ANTISEPTICS; GLUTATHIONE SULFONAMIDE; MYELOPEROXIDASE-DERIVED OXIDANTS}, year = {2013}, eissn = {1932-6203}, orcid-numbers = {Kiss, István/0000-0003-4287-143X; Rosivall, László/0000-0002-9809-3879} } @techreport{MTMT:2777271, title = {Demonstrating that chlorine dioxide is a size-selective antimicrobial agent and high purity ClO2 can be used as a local antiseptic}, url = {https://m2.mtmt.hu/api/publication/2777271}, author = {Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Zoltán, Beregvári and István, Kiss and Rosivall, László and János, Szegedi}, editor = {arXiv, org}, unique-id = {2777271}, abstract = {Background / Aims ClO2, the so-called “ideal biocide”, could also be applied as an antiseptic if it was understood why the solution’s rapid killing of microbes does not cause any harm to humans or to animals. Our aim was to study both theoretically and experim entally its reaction-diffusion mechanism to find the source of that selectivity. Methods ClO2 permeation measurements through protein membranes were performed and the time delay of ClO2 transport due to reaction and diffusion was determined. To calculate ClO2 penetration depths and estimate bacterial killing times, approximate solutions of the reaction-diffusion equation were derived. Additionally, as a preliminary test, three patients with infected wounds were treated with a 300 ppm high purity ClO 2 solution and the healing process was documented. Results The rate law of the reaction-diffusion model predicts that the killing time is proportional to the square of the characteristic size (e.g. diameter) of a body, thus, small ones will be killed extremely fast. For example, the killing time for a bacterium is on the order of milliseconds in a 300 ppm ClO 2 solution. Thus, the few minutes of contact time (owing to the volatility of ClO2) is quite enough to kill all bacteria, but short enough to keep ClO2 penetration into the living tissues safely below 0.1 mm, minimizing cytotoxic effects. Pictures of successful wound healings confirm these considerations. Various properties of ClO2, advantageous for an antiseptic, are also discussed. Most importantly, bacteria are not able to develop resistance against ClO2 as it reacts with biological thiols which play a vital role in a ll living organisms. Conclusion Selectivity of ClO2 between humans and bacteria is based not on their different biochemistry, but on their different size. Preliminary clinical results encourage further research with this promising local antiseptic.}, year = {2013}, orcid-numbers = {Rosivall, László/0000-0002-9809-3879} } @article{MTMT:2210869, title = {Measurement of Hypoiodous Acid Concentration by a Novel Type Iodide Selective Electrode and a New Method To Prepare HOI. Monitoring HOI Levels in the Briggs-Rauscher Oscillatory Reaction}, url = {https://m2.mtmt.hu/api/publication/2210869}, author = {Muntean, Norbert and Lawson Bich, Thuy and Kály-Kullai, Kristóf and Gyökérné Wittmann, Mária and Noszticzius, Zoltán and Onel, L and Furrow, SD}, doi = {10.1021/jp3015673}, journal-iso = {J PHYS CHEM A}, journal = {JOURNAL OF PHYSICAL CHEMISTRY A}, volume = {116}, unique-id = {2210869}, issn = {1089-5639}, abstract = {A new type of iodide selective electrode prepared by dipping a silver wire into molten silver iodide is reported. The electrode was calibrated for silver and iodide ions and the measured electromotive force for various Ag+ and I- concentrations was close to the theoretical within a few millivolts. Besides Ag+ and I- ions, however, the electrode also responds to hypoiodous acid. Thus, the electrode was calibrated for HOT as well, and for that purpose a new method of hypoiodous acid preparation was developed. To explain the close to Nemstian electrode response for HOI and also the effect of hydrogen ion and iodine concentration on that response, the corrosion potential theory suggested earlier by Noszticzius et al. was modified and developed further. Following oscillations in the Briggs-Rauscher reaction with the new electrode the potential crosses the "solubility limit potential" (SLP) of silver iodide. Potentials below SLP are controlled by the concentration of I-, but potentials above SLP are corrosion potentials determined by the concentration of HOI. Finally, the measured HOI oscillations are compared with calculated ones simulated by a model by Furrow et al.}, keywords = {MODEL; MECHANISM; SYSTEMS; KINETICS; HYDROLYSIS; HYDROGEN-PEROXIDE; Acetone; CO2 EVOLUTION; POTENTIAL RESPONSE; DIIODOMALONIC ACID}, year = {2012}, eissn = {1520-5215}, pages = {6630-6642} } @{MTMT:2803189, title = {Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide}, url = {https://m2.mtmt.hu/api/publication/2803189}, author = {Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Megyesi, M and Volford, A}, unique-id = {2803189}, year = {2012} } @article{MTMT:1401921, title = {Univerzális fegyver a mikrobák ellen? A hipertiszta klór-dioxid}, url = {https://m2.mtmt.hu/api/publication/1401921}, author = {Noszticzius, Zoltán and Rosivall, László and Gyökérné Wittmann, Mária}, journal-iso = {TERMÉSZET VILÁGA}, journal = {TERMÉSZET VILÁGA}, volume = {141}, unique-id = {1401921}, issn = {0040-3717}, year = {2010}, pages = {154-157}, orcid-numbers = {Rosivall, László/0000-0002-9809-3879} } @article{MTMT:1401797, title = {Micropatterned Polyvinyl Butyral Membrane for Acid-Base Diodes}, url = {https://m2.mtmt.hu/api/publication/1401797}, author = {Roszol, László and Lawson Bich, Thuy and Koncz, Viktória Anna and Noszticzius, Zoltán and Gyökérné Wittmann, Mária and Sarkadi, Tamás and Koppa, Pál}, doi = {10.1021/jp106773y}, journal-iso = {J PHYS CHEM B}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, volume = {114}, unique-id = {1401797}, issn = {1520-6106}, abstract = {Until now, polyvinyl alcohol (PVA) gel cylinders have been used in electrolyte diodes as a connecting element between the acidic and alkaline reservoirs. In this paper, a new connecting element is reported: a breath figure templated polyvinyl butyral (PVB) membrane prepared with dip-coating from a dichloromethane solution of the polymer in a humid atmosphere. The procedure gives a 1.5-2 mu m thick membrane with a hexagonal pattern, the average characteristic length of which is 1 mu m. After an acidic etching, it was found to be a good connecting element. The voltage-current characteristics and dynamic properties of PVA and PVB were measured and compared. The PVB membrane has a faster response to voltage changes than the PVA gel, but in both cases, there was a slow drift in the current that prevented it from reaching a steady state. Reproducible characteristics can be obtained, however, after the current reaches a well-defined quasi-steady state.}, keywords = {ACIDS; Gels; DICHLOROMETHANE; steady state; PVA-gel; Dynamic property; Current voltage characteristics; Electrolyte diode; Voltage-current characteristics; Voltage change; Thick membranes; Templated; Quasi-steady state; Polyvinyl butyral; Polyvinyl alcohol gels; Micropatterned; Humid atmospheres; Hexagonal pattern; Dip coating; Dichloromethane solutions; Characteristic length; Breath figures; Acid base}, year = {2010}, eissn = {1520-5207}, pages = {13718-13725} } @article{MTMT:1315743, title = {Negative salt effect in an acid-base diode: Simulations and experiments}, url = {https://m2.mtmt.hu/api/publication/1315743}, author = {Roszol, László and Várnai, A and Lorántfy, B and Noszticzius, Zoltán and Gyökérné Wittmann, Mária}, doi = {10.1063/1.3292001}, journal-iso = {J CHEM PHYS}, journal = {JOURNAL OF CHEMICAL PHYSICS}, volume = {132}, unique-id = {1315743}, issn = {0021-9606}, abstract = {The paper describes a new phenomenon discovered in the electrolytic analog of a semiconductor diode. As an example, the phenomenon is studied in the 0.1M KOH–0.1M HCl diode where the alkaline and the acidic reservoirs are connected by a hydrogel cylinder. First the traditional, so-called positive salt effect is discussed. In that case some salt is added to the alkaline reservoir of a reverse biased electrolyte diode and as a result, close to a critical concentration of the added salt the electric current increases sharply. The so-called negative salt effect appears as a suppression of the positive one. It is shown by numerical simulations, by approximate analytical formulae, and also by experiments that the high current caused by the salt contamination in the alkaline reservoir can be mostly suppressed by relatively small salt concentrations in the acidic reservoir. Thus a straightforward application of the negative salt effect would be the sensitive detection of nonhydrogen cations in an acidic medium (eg., in ion chromatography)}, year = {2010}, eissn = {1089-7690} } @article{MTMT:1315789, title = {Reply to the “Comment on ‘Mechanistic Investigations on the Belousov-Zhabotinsky Reaction with Oxalic Acid Substrate. 2. Measuring and Modeling the Oxalic Acid-Bromine Chain Reaction and Simulating the Complete Oscillatory System’”}, url = {https://m2.mtmt.hu/api/publication/1315789}, author = {Gyökérné Wittmann, Mária and Noszticzius, Zoltán}, doi = {10.1021/jp100570k}, journal-iso = {J PHYS CHEM A}, journal = {JOURNAL OF PHYSICAL CHEMISTRY A}, volume = {114}, unique-id = {1315789}, issn = {1089-5639}, year = {2010}, eissn = {1520-5215}, pages = {3742-3742} } @article{MTMT:1315114, title = {Iodomalonic Acid as an Anti-Inhibitor in the Resorcinol Inhibited Briggs-Rauscher Reaction}, url = {https://m2.mtmt.hu/api/publication/1315114}, author = {Lawson Bich, Thuy and Fulop, J and Gyökérné Wittmann, Mária and Noszticzius, Zoltán and Muntean, Norbert and Szabó, Gabriella Stefánia and Onel, L}, doi = {10.1021/jp907364a}, journal-iso = {J PHYS CHEM A}, journal = {JOURNAL OF PHYSICAL CHEMISTRY A}, volume = {113}, unique-id = {1315114}, issn = {1089-5639}, abstract = {It was found that the inhibitory effect of resorcinol is less pronounced if it is added in a later stage of the Briggs-Rauscher reaction, which indicates that all accumulating intermediate-most probably iodomalonic acid-can suppress the inhibition. In fact, when iodomalonic acid was added to the reaction mixture, the inhibitory period was shortened considerably even at micromolar levels of the iodomalonic acid concentration. Moreover, iodomalonic acid call accelerate the rate of the reaction when applied in the same low concentrations, suggesting that it can be an autocatalytic intermediate of the Briggs-Rauscher reaction.}, keywords = {MODEL; MECHANISM; antioxidants; MALONIC-ACID; OSCILLATING SYSTEM; CO2 EVOLUTION}, year = {2009}, eissn = {1520-5215}, pages = {14095-14098}, orcid-numbers = {Szabó, Gabriella Stefánia/0000-0002-7083-9106} } @article{MTMT:1315115, title = {Reaction Routes Leading to CO2 and CO in the Briggs-Rauscher Oscillator: Analogies between the Oscillatory BR and BZ Reactions}, url = {https://m2.mtmt.hu/api/publication/1315115}, author = {Muntean, Norbert and Szabó, Gabriella Stefánia and Gyökérné Wittmann, Mária and Lawson Bich, Thuy and Fulop, J and Noszticzius, Zoltán and Onel, L}, doi = {10.1021/jp905239w}, journal-iso = {J PHYS CHEM A}, journal = {JOURNAL OF PHYSICAL CHEMISTRY A}, volume = {113}, unique-id = {1315115}, issn = {1089-5639}, abstract = {With Fenton-type experiments, it is shown that the intense CO2/CO evolution in the Briggs-Rauscher (BR) reaction is due to decarboxylation/decarbonylation of organic free radicals. The metal ion applied in the Fenton-type experiments was Fe2+ or Ti3+ or Mn2+ combined with H2O2 or S2O82- as a peroxide, whereas the organic substrate was malonic acid (MA) or a H mixture of MA and iodomalonic acid (IMA). Experiments with a complete BR system applying MA or the MA/IMA mixture indicate that practically all CO2 and CO comes from IMA. The decarboxylation/decarbonylation mechanisms of various iodomalonyl radicals can be analogous to that of the bromomalonyl radicals studied already in the Belousov-Zhabotinsky (BZ) reaction, It is found that an intense CO2/CO evolution requires the simultaneous presence of H2O2, IO3-, Mn2+, and IMA. It is suggested that the critical first step of this complex reaction takes place in the coordination sphere of Mn2+. That first step can initiate a chain reaction where organic and hydroperoxyl radicals are the chain carriers. A chain reaction was already found in a BZ oscillator as well. Therefore, the analogies between the BR and BZ oscillators are due to the fact that in both mechanisms, free radicals and, in most cases, also transition-metal complexes play an important role.}, keywords = {MODEL; SYSTEM; MECHANISM; INHIBITION; SUBSTRATE; EVOLUTION; antioxidants; MALONIC-ACID; BELOUSOV-ZHABOTINSKY REACTION; CARBON-MONOXIDE}, year = {2009}, eissn = {1520-5215}, pages = {9102-9108}, orcid-numbers = {Szabó, Gabriella Stefánia/0000-0002-7083-9106} } @{MTMT:1130687, title = {Preparing a fluid containing pure chlorine dioxide, involves transporting chlorine dioxide generated by synthesis, across a pore-free polymeric membrane, via selective permeation, into fluid target medium}, url = {https://m2.mtmt.hu/api/publication/1130687}, author = {Noszticzius, Zoltán and Balogh, S and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Megyesi, M and Volford, A}, unique-id = {1130687}, year = {2009} } @{MTMT:1317674, title = {Permeation Method and Apparatus for Preparing Fluids Containing High Purity Chlorine Dioxide}, url = {https://m2.mtmt.hu/api/publication/1317674}, author = {Noszticzius, Zoltán and Balogh, S. and Gyökérné Wittmann, Mária and Kály-Kullai, Kristóf and Megyesi, M and Volford, András}, unique-id = {1317674}, year = {2008} }