TY - JOUR AU - Kovács, Ervin AU - Szepesi Kovács, Dénes AU - Mucsi, Zoltán TI - Láthatóvá tenni a ráksejteket. Új festék a mikroszkópos tumordiagnosztikábanLáthatóvá tenni a ráksejteket/ Új festék a mikroszkópos tumordiagnosztikában JF - TERMÉSZET VILÁGA J2 - TERMÉSZET VILÁGA VL - 154 PY - 2023 IS - 6 SP - 259 EP - 263 PG - 5 SN - 0040-3717 UR - https://m2.mtmt.hu/api/publication/34016504 ID - 34016504 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Chiovini, Balázs AU - Müller, Dalma AU - Tóth, Estilla Zsófia AU - Fülöp, Anna AU - Ábrányi-Balogh, Péter AU - Wittner, Lucia AU - Várady, György AU - Farkas, Ödön AU - Turczel, Gábor AU - Katona, Gergely AU - Győrffy, Balázs AU - Keserű, György Miklós AU - Mucsi, Zoltán AU - Rózsa J., Balázs AU - Kovács, Ervin TI - Synthesis and Application of Two-Photon Active Fluorescent Rhodol Dyes for Antibody Conjugation and In Vitro Cell Imaging JF - ACS OMEGA J2 - ACS OMEGA VL - 8 PY - 2023 IS - 25 SP - 22836 EP - 22843 PG - 8 SN - 2470-1343 DO - 10.1021/acsomega.3c01796 UR - https://m2.mtmt.hu/api/publication/34015800 ID - 34015800 LA - English DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Kontra, Bence AU - Chiovini, Balázs AU - Müller, Dalma AU - Tóth, Estilla Zsófia AU - Ábrányi-Balogh, Péter AU - Wittner, Lucia AU - Várady, György AU - Turczel, Gábor AU - Farkas, Ödön AU - Owen, Michael Christopher AU - Katona, Gergely AU - Győrffy, Balázs AU - Keserű, György Miklós AU - Mucsi, Zoltán AU - Rózsa J., Balázs AU - Kovács, Ervin TI - Effective Synthesis, Development and Application of a Highly Fluorescent Cyanine Dye for Antibody Conjugation and Microscopy Imaging JF - ORGANIC & BIOMOLECULAR CHEMISTRY J2 - ORG BIOMOL CHEM VL - 21 PY - 2023 IS - 44 SP - 8829 EP - 8836 PG - 8 SN - 1477-0520 DO - 10.1039/D3OB01471A UR - https://m2.mtmt.hu/api/publication/34205650 ID - 34205650 AB - An asymmetric cyanine-type fluorescent dye was designed and synthesized via a versatile, multi-step process, aiming to conjugate with an Her2+ receptor specific antibody by an azide-alkyne click reaction. The aromaticity and the excitation and relaxation energetics of the fluorophore were characterized by computational methods. The synthesized dye exhibited excellent fluorescence properties for confocal microscopy, offering efficient applicability in in vitro imaging due to its merits such as a high molar absorption coefficient (36 816 M-1 cm-1), excellent brightness, optimal wavelength (627 nm), larger Stokes shift (26 nm) and appropriate photostability compared to cyanines. The conjugated cyanine-trastuzumab was constructed via an effective, metal-free, strain-promoted azide-alkyne click reaction leading to a regulated number of dyes being conjugated. This novel cyanine-labelled antibody was successfully applied for in vitro confocal imaging and flow cytometry of Her2+ tumor cells. An azido cyanine dye was synthesized and characterized by computational and experimental techniques and applied in tumor cell imaging. LA - English DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Hajdu, Imre AU - Mészáros, Gergely AU - Wittner, Lucia AU - Meszéna, Domokos AU - Tóth, Estilla Zsófia AU - Hegedűs, Zita AU - Randelovic, Ivan AU - Tóvári, József AU - Szabó, Tímea AU - Szilágyi, Bence AU - Milen, Mátyás AU - Keserű, György Miklós AU - Ábrányi-Balogh, Péter TI - Synthesis and characterization of new fluorescent boro-β-carboline dyes JF - RSC ADVANCES J2 - RSC ADV VL - 11 PY - 2021 IS - 21 SP - 12802 EP - 12807 PG - 6 SN - 2046-2069 DO - 10.1039/D1RA02132J UR - https://m2.mtmt.hu/api/publication/31951354 ID - 31951354 N1 - Research Centre for Natural Sciences, Medicinal Chemistry Research Group, Budapest, POB 286, Hungary Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1521, Hungary Research Centre for Natural Sciences, Comparative Psychophysiology Research Group, Budapest, POB 286, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, POB 278, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, 1085, Hungary National Institute of Oncology, Department of Experimental Pharmacology, POB 21, Budapest, 1525, Hungary Egis Pharmaceuticals Plc., Directorate of Drug Substance Development, POB 100, Budapest, 1475, Hungary Export Date: 30 August 2021 CODEN: RSCAC Correspondence Address: Keserű, G.M.; Research Centre for Natural Sciences, POB 286, Hungary; email: keseru.gyorgy@ttk.hu LA - English DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Keserű, György Miklós AU - Ábrányi-Balogh, Péter TI - Application of Boroisoquinoline Fluorophores as Chemodosimeters for Fluoride Ion and Pd (0) JF - MATERIALS J2 - MATERIALS VL - 13 PY - 2020 IS - 1 SP - 199 SN - 1996-1944 DO - 10.3390/ma13010199 UR - https://m2.mtmt.hu/api/publication/31038453 ID - 31038453 LA - English DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Kormos, Attila AU - Demeter, Orsolya AU - Dancsó, András AU - Keserű, György Miklós AU - Milen, Mátyás AU - Ábrányi-Balogh, Péter TI - Synthesis and fluorescent properties of boroisoquinolines, a new family of fluorophores JF - RSC ADVANCES J2 - RSC ADV VL - 8 PY - 2018 IS - 67 SP - 38598 EP - 38605 PG - 8 SN - 2046-2069 DO - 10.1039/c8ra08241c UR - https://m2.mtmt.hu/api/publication/30340445 ID - 30340445 N1 - Export Date: 7 December 2018 Funding Agency and Grant Number: Hungarian Academy of Sciences; Hungarian Science Foundation [OTKA PD124598] Funding text: P. A.-B. is grateful for the postdoctoral fellowship of the Hungarian Academy of Sciences and the Hungarian Science Foundation (OTKA PD124598). LA - English DB - MTMT ER -