TY - JOUR AU - Kardos, Julianna AU - Héja, László AU - Jemnitz, Katalin AU - Kovacs, R AU - Palkovits, Miklós TI - The nature of early astroglial protection-Fast activation and signaling.. Fast activation and signaling TS - Fast activation and signaling JF - PROGRESS IN NEUROBIOLOGY: AN INTERNATIONAL REVIEW JOURNAL J2 - PROG NEUROBIOL VL - 153 PY - 2017 SP - 86 EP - 99 PG - 14 SN - 0301-0082 DO - 10.1016/j.pneurobio.2017.03.005 UR - https://m2.mtmt.hu/api/publication/3209058 ID - 3209058 N1 - Journal Article; Review; Research Support, Non-U.S. Gov't --- összevonáskor átvett szöveg --- doi: 10.1016/j.pneurobio.2017.03.005. [Epub ahead of print] Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :4 Export Date: 22 July 2019 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :8 Export Date: 15 April 2020 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :8 Export Date: 22 April 2020 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :9 Export Date: 29 May 2020 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :12 Export Date: 31 July 2020 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 21 September 2020 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 17 March 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 29 March 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Funding Agency and Grant Number: ERA-Chemistry grant [OTKA102166]; [KMR_12-1-2012-0112] Funding text: We gratefully thank Dr Orsolya Toke for her critical comments and careful editing of the manuscript as well as professor Ferenc Hajos for the tripartite synapse photocopy shown in Fig. 3. Financial support by the KMR_12-1-2012-0112 and ERA-Chemistry OTKA102166 grants are greatly acknowledged. Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 6 April 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 7 April 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 20 April 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :14 Export Date: 5 May 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Institute of Neurophysiology, Charité – Universitätsmedizin, Berlin, Germany Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary Cited By :15 Export Date: 14 September 2021 CODEN: PGNBA Correspondence Address: Kardos, J.; Research Centre for Natural Sciences, H‐1117 Budapest, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; ammonia, 14798-03-9, 51847-23-5, 7664-41-7; calcium ion, 14127-61-8; carrier protein, 80700-39-6; estradiol, 50-28-2; glutamate ammonia ligase, 9023-70-5; glutamate dehydrogenase, 9001-46-1; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; raloxifene, 82640-04-8, 84449-90-1; succinic acid, 110-15-6; tamoxifen, 10540-29-1; gamma-Aminobutyric Acid; Glutamic Acid; Succinic Acid AB - Our present review is focusing on the uniqueness of balanced astroglial signaling. The balance of excitatory and inhibitory signaling within the CNS is mainly determined by sharp synaptic transients of excitatory glutamate (Glu) and inhibitory gamma- aminobutyrate (GABA) acting on the sub-second timescale. Astroglia is involved in excitatory chemical transmission by taking up i) Glu through neurotransmitter-sodium transporters, ii) K+ released due to presynaptic action potential generation, and iii) water keeping osmotic pressure. Glu uptake-coupled Na+ influx may either ignite long-range astroglial Ca2+ transients or locally counteract over-excitation via astroglial GABA release and increased tonic inhibition. Imbalance of excitatory and inhibitory drives is associated with a number of disease conditions, including prevalent traumatic and ischaemic injuries or the emergence of epilepsy. Therefore, when addressing the potential of early therapeutic intervention, astroglial signaling functions combating progress of Glu excitotoxicity is of critical importance. We suggest, that excitotoxicity is linked primarily to over-excitation induced by the impairment of astroglial Glu uptake and/or GABA release. Within this framework, we discuss the acute alterations of Glu- cycling and metabolism and conjecture the therapeutic promise of regulation. We also confer the role played by key carrier proteins and enzymes as well as their interplay at the molecular, cellular, and organ levels. Moreover, based on our former studies, we offer potential prospect on the emerging theme of astroglial succinate sensing in course of Glu excitotoxicity. LA - English DB - MTMT ER -