@article{MTMT:3201077,
	title = {Synthesis and in vitro investigation of potential antiproliferative monosaccharide-D-secoestrone bioconjugates},
	url = {https://m2.mtmt.hu/api/publication/3201077},
	author = {Bodnár, Brigitta and Mernyák, Erzsébet and Szabó, Johanna and Wölfling, János and Schneider, Gyula and Zupkó, István and Kupihár, Zoltán and Kovács, Lajos},
	doi = {10.1016/j.bmcl.2017.03.029},
	journal-iso = {BIOORG MED CHEM LETT},
	journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS},
	volume = {27},
	unique-id = {3201077},
	issn = {0960-894X},
	abstract = {The syntheses of monosaccharide–D-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-D-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC). The antiproliferative activities of the conjugates were investigated in vitro against a panel of human adherent cancer cell lines (HeLa, A2780 and MCF-7) by means of MTT assays. The protected D-glucose-containing D-secoestrone oxime bioconjugate (24b) proved to be the most effective with an IC50 value in the low micromolar range against A2780 cell line. © 2017 Elsevier Ltd},
	year = {2017},
	eissn = {1464-3405},
	pages = {1938-1942},
	orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817; Wölfling, János/0000-0002-3037-309X; Zupkó, István/0000-0003-3243-5300; Kupihár, Zoltán/0000-0001-5499-7617; Kovács, Lajos/0000-0002-0331-3980}
}