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PACAP-deficient male mice have several morphological, biochemical, behavioral defects and show disturbed signaling in spermatogenesis affecting fertility in PACAP KO mice. Reproductive functions such as fertility, mating and maternal behaviors have been widely investigated, but no immune analyses are available regarding the testicular immune-privileged environment in male PACAP-deficient mice.Therefore, we performed detailed immunophenotyping of testicular immune cells and investigated the expression of TIM-3 and PD-1 immune-checkpoint molecules of immune cells together with the detection of Galectin-9 and perforin. We investigated the percentage of numerous immune cell populations in the testis of wild-type and PACAP-deficient mice.We demonstrated a significant increase in the frequency of testicular CD8+ T cells together with the decrease of Treg cell number obtained from PACAP KO mice compared to wild-type mice. Investigating immune-checkpoint receptors, only PD-1 showed a significantly decreased expression in CD8+ T cells in PACAP KO mice compared to wild-type suggesting an impaired PD-1/PD-L1 pathway. Regarding TIM-3 expression, we did not find any significant difference between the investigated groups.We hypothesize that these local changes may result in an immune activation with disturbed testicular immunoregulation in PACAP KO mice, however, determining the exact function requires further investigations. Our data further support the view that besides a systemic immune tolerance, localized active immunosuppression is involved in the regulation of testicular immune privilege.", "subjects" : [ { "otype" : "Classification", "mtid" : 10558, "link" : "/api/classification/10558", "label" : "Jelátvitel (sejtek között)", "published" : true, "snippet" : true } ], "fundings" : [ { "otype" : "Funding", "mtid" : 1982352, "link" : "/api/funding/1982352", "label" : "(3.6.2-16-2017-00008) Támogató: EFOP", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1982353, "link" : "/api/funding/1982353", "label" : "(-3.6.1-16-2016-00004) Támogató: EFOP", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1982354, "link" : "/api/funding/1982354", "label" : "(NAP-2017-1.2.1-NKP-2017-00002)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1982355, "link" : "/api/funding/1982355", "label" : "GINOP(2.3.2-15-2016-00050)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1982356, "link" : "/api/funding/1982356", "label" : "NKFIH(K119759)", "published" : false, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 908, "link" : "/api/keyword/908", "label" : "NEUROPEPTIDE", "published" : true, "oldId" : 908, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2013, "link" : "/api/keyword/2013", "label" : "PACAP", "published" : true, "oldId" : 2013, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1441152, "link" : "/api/keyword/1441152", "label" : "PD-1", "published" : true, "oldId" : 1441152, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1453506, "link" : "/api/keyword/1453506", "label" : "PD-L1", "published" : true, "oldId" : 1453506, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1493320, "link" : "/api/keyword/1493320", "label" : "Galectin-9", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1493321, "link" : "/api/keyword/1493321", "label" : "TIM-3", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-20", "oaFree" : true, "oaLink" : "https://doi.org/10.1111/aji.13212", "citationCount" : 5, "citationCountUnpublished" : 0, "citationCountWoOther" : 5, "independentCitCountWoOther" : 1, "nationalOriginCitationCount" : 4, "foreignEditionCitationCount" : 5, "doiCitationCount" : 5, "wosCitationCount" : 5, "scopusCitationCount" : 5, "wosScopusCitationCount" : 5, "wosScopusCitationCountWoOther" : 5, "wosScopusIndependentCitationCount" : 1, "wosScopusIndependentCitationCountWoOther" : 1, "independentCitationCount" : 1, "selfCitationCount" : 4, "unhandledCitationCount" : 0, "citingPubCount" : 5, "independentCitingPubCount" : 1, "citingPubCountWoOther" : 5, "independentCitingPubCountWoOther" : 1, "unhandledCitingPubCount" : 0, "citedPubCount" : 7, "citedCount" : 7, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10864579, "link" : "/api/sjrrating/10864579", "label" : "sjr:Q1 (2020) Scopus - Obstetrics and Gynecology AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 1046-7408 1600-0897", "listPos" : 38, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2729, "link" : "/api/classificationexternal/2729", "label" : "Scopus - Obstetrics and Gynecology", "published" : true, "oldId" : 2729, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2020-02-11T07:02:12.370+0000", "directInstitutesForSort" : "Anatómiai Intézet (PTE / ÁOK); MTA-PTE PACAP Kutatócsoport (PTE / KCS); Orvosi Mikrobiológiai és Immunitástani Intézet (PTE / ÁOK); Reproduktív és tumor immunológiai kutatócsoport (PTE / SZKK)", "ownerAuthorCount" : 5, "ownerInstituteCount" : 20, "directInstituteCount" : 4, "authorCount" : 5, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30914524", "label" : "Meggyes M et al. 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