TY - JOUR AU - Kardos, Julianna AU - Héja, László AU - Simon, Ágnes AU - Jablonkai, István AU - Kovács, Richárd AU - Jemnitz, Katalin TI - Copper signalling: causes and consequences JF - CELL COMMUNICATION AND SIGNALING J2 - CELL COMM SIGN VL - 16 PY - 2018 IS - 1 PG - 21 SN - 1478-811X DO - 10.1186/s12964-018-0277-3 UR - https://m2.mtmt.hu/api/publication/30317831 ID - 30317831 N1 - Journal Article; Review Funding Agency and Grant Number: [KMR_12-1-2012-0112 TRANSRAT]; [VEKOP-2.1.1-15-2016-00156]; [OTKA K124558] Funding text: This work was supported by grants KMR_12-1-2012-0112 TRANSRAT, VEKOP-2.1.1-15-2016-00156 and OTKA K124558. Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany Cited By :28 Export Date: 6 April 2021 Correspondence Address: Kardos, J.; Functional Pharmacology Research Group, Magyar Tudósok körútja 2, Hungary; email: kardos.julianna@ttk.mta.hu Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany Cited By :28 Export Date: 7 April 2021 Correspondence Address: Kardos, J.; Functional Pharmacology Research Group, Magyar Tudósok körútja 2, Hungary; email: kardos.julianna@ttk.mta.hu Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany Cited By :37 Export Date: 29 July 2021 Correspondence Address: Kardos, J.; Functional Pharmacology Research Group, Magyar Tudósok körútja 2, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; captopril, 62571-86-2; clioquinol, 130-26-7, 8057-20-3; copper, 15158-11-9, 7440-50-8; disulfiram, 97-77-8; elesclomol, 488832-69-5; glutathione, 70-18-8; metformin, 1115-70-4, 657-24-9; penicillamine, 2219-30-9, 52-67-5; tetrathiomolybdic acid, 13718-35-9, 16330-92-0; trientine, 112-24-3, 38260-01-4; Copper Funding details: Hungarian Scientific Research Fund, OTKA, K124558 Funding text 1: This work was supported by grants KMR_12-1-2012-0112 TRANSRAT, VEKOP-2.1.1-15-2016-00156 and OTKA K124558. AB - Copper-containing enzymes perform fundamental functions by activating dioxygen (O-2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O-2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism. LA - English DB - MTMT ER -