{ "labelLang" : "hun", "responseDate" : "2024-03-29 06:07", "paging" : { "last" : true, "first" : true, "totalPages" : 1, "totalElements" : 1, "totalUncutElements" : 1, "totalEstimatedElements" : 1, "size" : 10, "number" : 1, "numberOfElements" : 1, "sort" : [ { "direction" : "DESC", "property" : "publishedYear", "ascending" : false }, { "direction" : "ASC", "property" : "firstAuthor", "ascending" : true } ] }, "content" : [ { "otype" : "JournalArticle", "mtid" : 2988827, "status" : "VALIDATED", "published" : true, "unhandledTickets" : 0, "oldTimestamp" : "2018-10-02T08:54:25.000+0000", "deleted" : false, "oldId" : 2988827, "lastRefresh" : "2024-03-22T14:08:00.805+0000", "lastModified" : "2023-11-22T15:21:44.336+0000", "created" : "2015-12-30T16:30:47.000+0000", "creator" : { "otype" : "Author", "mtid" : 10001431, "link" : "/api/author/10001431", "label" : "Héja László (Neurokémia)", "familyName" : "Héja", "givenName" : "László", "published" : true, "oldId" : 10001431, "snippet" : true }, "lastDuplumOK" : "2024-03-03T18:47:51.858+0000", "lastDuplumSearch" : "2024-03-03T18:47:51.858+0000", "validated" : "2023-11-22T15:21:44.594+0000", "validator" : { "otype" : "Admin", "mtid" : 10013962, "link" : "/api/admin/10013962", "label" : "Vasvari Lilian (MTMT Központ, admin)", "familyName" : "Vasvari", "givenName" : "Lilian", "published" : true, "oldId" : 10013962, "snippet" : true }, "tempLockers" : [ { "otype" : "Admin", "mtid" : 10073918, "link" : "/api/admin/10073918", "label" : "Kovács Marcell (MTMT Közp., admin)", "familyName" : "Kovács", "givenName" : "Marcell", "published" : true, "snippet" : true } ], "tempLocked" : "2024-03-22T13:59:27.989+0000", "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Ma, X", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 6943570, "link" : "/api/authorship/6943570", "label" : "Ma, X", "listPosition" : 1, "share" : 0.1, "first" : true, "last" : false, "familyName" : "Ma", "givenName" : "X", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881697, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943571, "link" : "/api/authorship/6943571", "label" : "Lubin, H", "listPosition" : 2, "share" : 0.1, "first" : false, "last" : false, "familyName" : "Lubin", "givenName" : "H", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881696, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943572, "link" : "/api/authorship/6943572", "label" : "Ioja, E [Ioja, Enikő (biokémia), szerző] Szerves Kémiai Intézet (TTK); Funkcionális Farmakológiai Csoport (HRN TTK / SZKI)", "listPosition" : 3, "share" : 0.1, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10044684, "link" : "/api/author/10044684", "label" : "Ioja Enikő (biokémia)", "familyName" : "Ioja", "givenName" : "Enikő", "published" : true, "oldId" : 10044684, "snippet" : true }, "familyName" : "Ioja", "givenName" : "E", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881695, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943573, "link" : "/api/authorship/6943573", "label" : "Kekesi, O [Kékesi, Orsolya Sára (Kémia), szerző] Szerves Kémiai Intézet (TTK); Funkcionális Farmakológiai Csoport (HRN TTK / SZKI)", "listPosition" : 4, "share" : 0.1, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10022479, "link" : "/api/author/10022479", "label" : "Kékesi Orsolya Sára (Kémia)", "familyName" : "Kékesi", "givenName" : "Orsolya Sára", "published" : true, "oldId" : 10022479, "snippet" : true }, "familyName" : "Kekesi", "givenName" : "O", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881694, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943574, "link" : "/api/authorship/6943574", "label" : "Simon, A [Simon, Ágnes (Fehérjék számítóg...), szerző] Funkcionális Farmakológiai Csoport (HRN TTK / SZKI); Szerves Kémiai Intézet (HRN TTK)", "listPosition" : 5, "share" : 0.1, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10000213, "link" : "/api/author/10000213", "label" : "Simon Ágnes (Fehérjék számítógépes elemzése)", "familyName" : "Simon", "givenName" : "Ágnes", "published" : true, "oldId" : 10000213, "snippet" : true }, "familyName" : "Simon", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881693, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943575, "link" : "/api/authorship/6943575", "label" : "Apati, A [Apáti, Ágota (Őssejt kutatás), szerző] Enzimológiai Intézet (TTK)", "listPosition" : 6, "share" : 0.1, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10027529, "link" : "/api/author/10027529", "label" : "Apáti Ágota (Őssejt kutatás)", "familyName" : "Apáti", "givenName" : "Ágota", "published" : true, "oldId" : 10027529, "snippet" : true }, "familyName" : "Apati", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881692, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943576, "link" : "/api/authorship/6943576", "label" : "Orban, TI [Orbán, Tamás I. (Molekuláris sejtb...), szerző] Enzimológiai Intézet (TTK)", "listPosition" : 7, "share" : 0.1, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10000148, "link" : "/api/author/10000148", "label" : "Orbán Tamás I. (Molekuláris sejtbiológia)", "familyName" : "Orbán", "givenName" : "Tamás I.", "published" : true, "oldId" : 10000148, "snippet" : true }, "familyName" : "Orban", "givenName" : "TI", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881691, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943577, "link" : "/api/authorship/6943577", "label" : "Heja, L [Héja, László (Neurokémia), szerző] Szerves Kémiai Intézet (TTK); Funkcionális Farmakológiai Csoport (HRN TTK / SZKI)", "listPosition" : 8, "share" : 0.1, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10001431, "link" : "/api/author/10001431", "label" : "Héja László (Neurokémia)", "familyName" : "Héja", "givenName" : "László", "published" : true, "oldId" : 10001431, "snippet" : true }, "familyName" : "Heja", "givenName" : "L", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881690, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943578, "link" : "/api/authorship/6943578", "label" : "Kardos, J ✉ [Kardos, Julianna (Neurokémia, az id...), szerző] Szerves Kémiai Intézet (TTK); Funkcionális Farmakológiai Csoport (HRN TTK / SZKI)", "listPosition" : 9, "share" : 0.1, "first" : false, "last" : false, "corresponding" : true, "author" : { "otype" : "Author", "mtid" : 10001101, "link" : "/api/author/10001101", "label" : "Kardos Julianna (Neurokémia, az idegi jelátvitel molekuláris mechanizmusai)", "familyName" : "Kardos", "givenName" : "Julianna", "published" : true, "oldId" : 10001101, "snippet" : true }, "familyName" : "Kardos", "givenName" : "J", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881689, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 6943579, "link" : "/api/authorship/6943579", "label" : "Marko, IE ✉", "listPosition" : 10, "share" : 0.1, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Marko", "givenName" : "IE", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 22881688, "snippet" : true } ], "title" : "Straightforward and effective synthesis of gamma-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 1048362, "link" : "/api/publicationidentifier/1048362", "label" : "DOI: 10.1016/j.bmcl.2015.11.100", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "10.1016/j.bmcl.2015.11.100", "realUrl" : "https://doi.org/10.1016/j.bmcl.2015.11.100", "published" : false, "oldId" : 1272190, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1048364, "link" : "/api/publicationidentifier/1048364", "label" : "REAL: 32533", "source" : { "otype" : "SwordSource", "mtid" : 36, "link" : "/api/publicationsource/36", "label" : "REAL", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "REAL", "nameEng" : "REAL", "linkPattern" : "http://real.mtak.hu/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 36, "snippet" : true }, "oaType" : "CLOSED", "oaFree" : false, "validState" : "NO", "idValue" : "32533", "realUrl" : "http://real.mtak.hu/32533", "published" : false, "oldId" : 1288634, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1048360, "link" : "/api/publicationidentifier/1048360", "label" : "WoS: 000367329700035", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000367329700035", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000367329700035", "published" : false, "oldId" : 1700208, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1048361, "link" : "/api/publicationidentifier/1048361", "label" : "Scopus: 84952935630", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "84952935630", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84952935630", "published" : false, "oldId" : 1700202, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1048363, "link" : "/api/publicationidentifier/1048363", "label" : "PubMed: 26706177", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "26706177", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26706177&dopt=Abstract", "published" : false, "oldId" : 1272191, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 741, "link" : "/api/journal/741", "label" : "BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 0960-894X 1464-3405", "pIssn" : "0960-894X", "eIssn" : "1464-3405", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 741, "snippet" : true }, "volume" : "26", "issue" : "2", "firstPage" : "417", "lastPage" : "423", "firstPageOrInternalIdForSort" : "417", "pageLength" : 7, "publishedYear" : 2016, "abstractText" : "Supply of major metabolites such as gamma-aminobutyric acid (GABA), beta-alanine and taurine is an essential instrument that shapes signalling, proper cell functioning and survival in the brain and peripheral organs. This background motivates the synthesis of novel classes of compounds regulating their selective transport through various fluid-organ barriers via the low-affinity gamma-aminobutyric acid (GABA) transporter subtype 2 (GAT2). Natural and synthetic spirocyclic compounds or therapeutics with a range of structures and biological activity are increasingly recognised in this regard. Based on pre-validated GABA transport activity, straightforward and efficient synthesis method was developed to provide an azaspiro[4.5]decane scaffold, holding a variety of charge, substituent and 3D constrain of spirocyclic amine. Investigation of the azaspiro[4.5]decane scaffold in cell lines expressing the four GABA transporter subtypes led to the discovery of a subclass of a GAT2-selective compounds with acyl-substituted azaspiro[4.5]decane core.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10575, "link" : "/api/classification/10575", "label" : "Biokémia és molekuláris biológia", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10293, "link" : "/api/classification/10293", "label" : "Kémiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2015, "packet" : "109799", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "CLOSED", "oaCheckDate" : "2024-03-22", "oaFree" : false, "oaByAuthor" : { "otype" : "Author", "mtid" : 10001431, "link" : "/api/author/10001431", "label" : "Héja László (Neurokémia)", "familyName" : "Héja", "givenName" : "László", "published" : true, "oldId" : 10001431, "snippet" : true }, "citationCount" : 7, "citationCountUnpublished" : 0, "citationCountWoOther" : 7, "independentCitCountWoOther" : 5, "nationalOriginCitationCount" : 2, "foreignEditionCitationCount" : 6, "doiCitationCount" : 7, "wosCitationCount" : 7, "scopusCitationCount" : 6, "wosScopusCitationCount" : 7, "wosScopusCitationCountWoOther" : 7, "wosScopusIndependentCitationCount" : 5, "wosScopusIndependentCitationCountWoOther" : 5, "independentCitationCount" : 5, "selfCitationCount" : 2, "unhandledCitationCount" : 0, "citingPubCount" : 7, "independentCitingPubCount" : 5, "citingPubCountWoOther" : 7, "independentCitingPubCountWoOther" : 5, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10954991, "link" : "/api/sjrrating/10954991", "label" : "sjr:Q1 (2016) Scopus - Pharmaceutical Science BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 0960-894X 1464-3405", "listPos" : 37, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3003, "link" : "/api/classificationexternal/3003", "label" : "Scopus - Pharmaceutical Science", "published" : true, "oldId" : 3003, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2016-03-29T15:32:45.000+0000", "publishDate" : "2015-12-30T16:32:45.000+0000", "directInstitutesForSort" : "Enzimológiai Intézet (TTK); Funkcionális Farmakológiai Csoport (HRN TTK / SZKI); Szerves Kémiai Intézet (HRN TTK); Szerves Kémiai Intézet (TTK)", "ownerAuthorCount" : 7, "ownerInstituteCount" : 60, "directInstituteCount" : 4, "authorCount" : 10, "contributorCount" : 0, "hasQualityFactor" : true, "tempLockerIds" : [ 10073918 ], "link" : "/api/publication/2988827", "label" : "Ma X et al. Straightforward and effective synthesis of gamma-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.. (2016) BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 0960-894X 1464-3405 26 2 417-423", "template" : "