https://m2.mtmt.hu/hun2024-03-29 02:22truetrue11111011DESCpublishedYearfalseASCfirstAuthortrueJournalArticle2972585APPROVEDtrueUniversity Medical Center of the Johannes Gutenberg University Mainz, Institute of Physiology, Mainz, Germany
Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Acton, ACT, Australia
Cited By :38
Export Date: 6 April 2021
CODEN: GLIAE
Correspondence Address: Kirischuk, S.; University Medical Center of the Johannes Gutenberg University Mainz, Germany; email: brian.billups@anu.edu.au02018-10-02T08:54:25.000+0000false29725852024-02-18T05:08:57.393+00002021-04-06T00:46:00.153+00002015-11-21T15:03:33.000+0000true10001431HéjaLászló
/api/author/10001431
Authortrue10001431truefalsetrue2424
/api/publicationtype/24
PublicationType1true24JournalArticletrue1134514Survey papertrue2424
/api/publicationtype/24
PublicationType1true24JournalArticle
/api/subtype/1134514
Összefoglaló cikkSubType102true1134514true1
/api/category/1
Categorytrue1Kirischuk, SAstrocyte sodium signaling and the regulation of neurotransmissiontruetrue
/api/journal/1719
REVIEWEDtruefalse1719false1719true0894-14911098-1136JournalFOREIGN6410165516661655122016The transmembrane Na+ concentration gradient is an important source of energy required not only to enable the generation of action potentials in excitable cells, but also for various transmembrane transporters both in excitable and non-excitable cells, like astrocytes. One of the vital functions of astrocytes in the central nervous system (CNS) is to regulate neurotransmitter concentrations in the extracellular space. Most neurotransmitters in the CNS are removed from the extracellular space by Na+ -dependent neurotransmitter transporters (NeuTs) expressed both in neurons and astrocytes. Neuronal NeuTs control mainly phasic synaptic transmission, i.e., synaptically induced transient postsynaptic potentials, while astrocytic NeuTs contribute to the termination of phasic neurotransmission and modulate the tonic tone, i.e., the long-lasting activation of extrasynaptic receptors by neurotransmitter that has diffused out of the synaptic cleft. Consequently, local intracellular Na+ ([Na+ ]i ) transients occurring in astrocytes, for example via the activation of ionotropic neurotransmitter receptors, can affect the driving force for neurotransmitter uptake, in turn modulating the spatio-temporal profiles of neurotransmitter levels in the extracellular space. As some NeuTs are close to thermodynamic equilibrium under resting conditions, an increase in astrocytic [Na+ ]i can stimulate the direct release of neurotransmitter via NeuT reversal. In this review we discuss the role of astrocytic [Na+ ]i changes in the regulation of uptake/release of neurotransmitters. It is emphasized that an activation of one neurotransmitter system, including either its ionotropic receptor or Na+ -coupled co-transporter, can strongly influence, or even reverse, other Na+ -dependent NeuTs, with potentially significant consequences for neuronal communication. GLIA 2015.2015293353truetruetruefalsetruefalseCLOSED2024-02-18falsetrue10001431HéjaLászló
/api/author/10001431
Authortrue10001431710686046761555359595151638071636860044D1false10001431falsefalsefalse2016-02-20T07:18:34.000+00002015-11-22T07:18:34.000+0000Funkcionális Farmakológiai Csoport (HRN TTK / SZKI); Szerves Kémiai Intézet (TTK)215240trueLanguage10002
/api/language/10002
AngolEnglishtrue2truePersonAuthorship6831416
/api/authorship/6831416
10.25truefalseKirischukStruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalse22414970truePersonAuthorship6831417
/api/authorship/6831417
20.25falsefalseAuthor10001431
/api/author/10001431
HéjaLászlótrue10001431trueHejaLtruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalse22414969truePersonAuthorship6831418
/api/authorship/6831418
30.25falsefalseAuthor10001101
/api/author/10001101
KardosJuliannatrue10001101trueKardosJtruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalse22414968truePersonAuthorship6831419
/api/authorship/6831419
40.25falsetrueBillupsBtruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalse22414967truePublicationIdentifier1037096
/api/publicationidentifier/1037096
falseIDENTICAL10.1002/glia.22943https://doi.org/10.1002/glia.22943false1252616truePublicationIdentifier1037098
/api/publicationidentifier/1037098
CLOSEDfalseNO46011http://real.mtak.hu/46011false1523713truePublicationIdentifier1037094
/api/publicationidentifier/1037094
falseIDENTICAL000384932800006https://www.webofscience.com/wos/woscc/full-record/000384932800006false1514006truePublicationIdentifier1037095
/api/publicationidentifier/1037095
falseIDENTICAL84984999080http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84984999080false1700200truePublicationIdentifier1037097
/api/publicationidentifier/1037097
falseIDENTICAL26566753http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26566753&dopt=Abstractfalse1252617trueClassification12125
/api/classification/12125
truetrueClassification12215
/api/classification/12215
truetrueSjrRating10919822
/api/sjrrating/10919822
70.1journalRatingType10002
/api/ratingtype/10002
sjrtruetrueClassificationExternal2804
/api/classificationexternal/2804
true2804trueD1DIRECTtruetrue
/api/publication/2972585
<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Kirischuk, S </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001431"> <a href="/gui2/?type=authors&mode=browse&sel=10001431" target="_blank">Heja, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001101"> <a href="/gui2/?type=authors&mode=browse&sel=10001101" target="_blank">Kardos, J</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Billups, B </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2972585" mtid="2972585" target="_blank">Astrocyte sodium signaling and the regulation of neurotransmission</a></div> <div class="pub-info"> <span class="journal-title">GLIA</span> <span class="journal-volume">64</span> : <span class="journal-issue">10</span> <span class="page"> pp. 1655-1666. , 12 p. </span> <span class="year">(2016)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/glia.22943" target="_blank" href="https://doi.org/10.1002/glia.22943"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:black" title="46011" target="_blank" href="http://real.mtak.hu/46011"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000384932800006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000384932800006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84984999080" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84984999080"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26566753" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26566753&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2972585 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 71</span> | Független: 63 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 55 | Scopus jelölt: 53 | WoS/Scopus jelölt: 59 | DOI jelölt: 61 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Kirischuk S
</span>
;
<span class="author-name" mtid="10001431"><a
href="/gui2/?type=authors&mode=browse&sel=10001431" target="_blank">Heja L
(<span class="authorship-author-name">Héja László</span>
<span class="authorAux-mtmt"> Neurokémia</span>)
</a>
</span>
<span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Szerves Kémiai Intézet; <span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/Funkcionális Farmakológiai Csoport</span>
;
<span class="author-name" mtid="10001101"><a
href="/gui2/?type=authors&mode=browse&sel=10001101" target="_blank">Kardos J
(<span class="authorship-author-name">Kardos Julianna</span>
<span class="authorAux-mtmt"> Neurokémia, az idegi jelátvitel molekuláris mec...</span>)
</a>
</span>
<span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Szerves Kémiai Intézet; <span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/Funkcionális Farmakológiai Csoport</span>
;
<span class="author-name" >Billups B
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;2972585" target="_blank">Astrocyte sodium signaling and the regulation of neurotransmission</a></div> <div> <span class="journal-title">GLIA</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0894-1491">0894-1491</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1098-1136">1098-1136</a>)</span>:
<span class="journal-volume">64</span> <span class="journal-issue">10</span>
<span class="page">
pp 1655-1666
</span> <span class="year">(2016)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
Angol
| </span>
<span class="identifiers">
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="10.1002/glia.22943" target="_blank" href="https://doi.org/10.1002/glia.22943">
DOI
</a>
</span>
<span class="id identifier oa_CLOSED" title=" Zárt
">
<a style="color:black" title="46011" target="_blank" href="http://real.mtak.hu/46011">
REAL
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="000384932800006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000384932800006">
WoS
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="84984999080" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84984999080">
Scopus
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="26566753" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26566753&dopt=Abstract">
PubMed
</a>
</span>
</span>
<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 71</span>
| Független: 63
| Függő: 8
| Nem jelölt: 0
| WoS jelölt: 55
| Scopus jelölt: 53
| WoS/Scopus jelölt: 59
| DOI jelölt: 61
</div>
<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;2972585&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 4
</a>
</div>
<div class="mtid"><span class="long-pub-mtid">Közlemény: 2972585</span>
| <span class="status-data status-APPROVED"> Nyilvános
</span>
<span class="oldId">Régi azonosító: 2972585</span> |
Forrás Idéző
| <span class="type-subtype">Folyóiratcikk
( Összefoglaló cikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">MEDLINE</span>
</div>
<div class="lastModified">Utolsó módosítás: 2021.04.06. 02:46 Héja László (MTA TTK SZKI admin5)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: University Medical Center of the Johannes Gutenberg University Mainz, Institute of Physiology, Mainz, Germany
Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Acton, ACT...</pre>
</div></div>