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Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry
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The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Cabrele, C </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, TA</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Reiser, O </span> <span class="author-type"> </span> ; <span class="author-name" > Berlicki, Ł ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2817673" mtid="2817673" target="_blank">Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF MEDICINAL CHEMISTRY</span> <span class="journal-volume">57</span> : <span class="journal-issue">23</span> <span class="page"> pp. 9718-9739. , 22 p. </span> <span class="year">(2014)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1021/jm5010896" target="_blank" href="https://doi.org/10.1021/jm5010896"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000346321200002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000346321200002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84918498601" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84918498601"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25207470" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25207470&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="4777" target="_blank" href="http://publicatio.bibl.u-szeged.hu/4777"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2817673 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 263</span> | Független: 245 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 226 | Scopus jelölt: 237 | WoS/Scopus jelölt: 244 | DOI jelölt: 240 (Nem nyilvános: 2) </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Cabrele C </span> ; <span class="author-name" mtid="10001168"><a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek TA (<span class="authorship-author-name">Martinek Tamás</span> <span class="authorAux-mtmt"> Gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerkémiai Intézet">GYKI</span>/MTA-SZTE Lendület Peptidfoldamer Kutatócsoport</span> ; <span class="author-name" >Reiser O </span> ; <span class="author-name" >Berlicki Ł ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;2817673" target="_blank">Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry</a></div> <div> <span class="journal-title">JOURNAL OF MEDICINAL CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0022-2623">0022-2623</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1520-4804">1520-4804</a>)</span>: <span class="journal-volume">57</span> <span class="journal-issue">23</span> <span class="page"> pp 9718-9739 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1021/jm5010896" target="_blank" href="https://doi.org/10.1021/jm5010896"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000346321200002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000346321200002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84918498601" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84918498601"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25207470" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25207470&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="4777" target="_blank" href="http://publicatio.bibl.u-szeged.hu/4777"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 263</span> | Független: 245 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 226 | Scopus jelölt: 237 | WoS/Scopus jelölt: 244 | DOI jelölt: 240 (Nem nyilvános: 2) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2817673&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2817673</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 2817673</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2024.02.27. 15:19 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>