TY  - JOUR
AU  - Cabrele, C
AU  - Martinek, Tamás
AU  - Reiser, O
AU  - Berlicki, Ł
TI  - Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry
JF  - JOURNAL OF MEDICINAL CHEMISTRY
J2  - J MED CHEM
VL  - 57
PY  - 2014
IS  - 23
SP  - 9718
EP  - 9739
PG  - 22
SN  - 0022-2623
DO  - 10.1021/jm5010896
UR  - https://m2.mtmt.hu/api/publication/2817673
ID  - 2817673
AB  - The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.
LA  - English
DB  - MTMT
ER  -