TY  - JOUR
AU  - László, Eszter
AU  - Kiss, Péter
AU  - Horváth-Opper, Gabriella
AU  - Szakály, Péter
AU  - Tamás, Andrea
AU  - Reglődi, Dóra
TI  - The effects of pituitary adenylate cyclase activating polypeptide in renal ischemia/reperfusion.
JF  - ACTA BIOLOGICA HUNGARICA (1983-2018)
J2  - ACTA BIOL HUNG
VL  - 65
PY  - 2014
IS  - 4
SP  - 369
EP  - 378
PG  - 10
SN  - 0236-5383
DO  - 10.1556/ABiol.65.2014.4.1
UR  - https://m2.mtmt.hu/api/publication/2788820
ID  - 2788820
AB  - Pituitary adenylate cyclase activating polypeptide (PACAP ) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycin- and cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusion-induced kidney injury and gives a brief summary about the results published in this area.
LA  - English
DB  - MTMT
ER  -