TY  - JOUR
AU  - Borbély, Emőke
AU  - Horváth, János
AU  - Furdan, Szabina
AU  - Bozsó, Zsolt
AU  - Penke, Botond
AU  - Fülöp, Lívia
TI  - Simultaneous changes of spatial memory and spine density after intrahippocampal administration of fibrillar abeta1-42 to the rat brain
JF  - BIOMED RESEARCH INTERNATIONAL
J2  - BIOMED RES INT
VL  - 2014
PY  - 2014
PG  - 9
SN  - 2314-6133
DO  - 10.1155/2014/345305
UR  - https://m2.mtmt.hu/api/publication/2755872
ID  - 2755872
AB  - Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAbeta) peptide represents one of the most frequently used models, mimicking Abeta deposits in the brain. In our experiment synthetic fAbeta1-42 peptide was administered to rat hippocampus. The effect of the Abeta peptide on spatial memory and dendritic spine density was studied. The fAbeta1-42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAbeta1-42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Abeta-triggered neurodegeneration processes.
LA  - English
DB  - MTMT
ER  -