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The decrease of blood catalase with age was greater in males (b = 0.084 MU/1 year) than in females (b = -0.016 MU/1 year). The screening of 3300 healthy citizens for hypocatalasemia yielded six families (0.18%), and three families were identified out of 1630 clinic patients. These nine families revealed 37 hypocatalasemic patients with 57.5 ± 11.7 MU/I mean and S.D. of blood catalase activity. 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