TY  - JOUR
AU  - Szolnoki, Éva Tünde
AU  - Hetényi, Anasztázia
AU  - Mándity, István
AU  - Fülöp, Ferenc
AU  - Martinek, Tamás
TI  - Foldameric β-H18/20P mixed helix stabilized by head-to-tail contacts: A way to higher-order structures Foldameric-H18/20P Mixed Helix Stabilized by Head-to-Tail Contacts: A Way to Higher-Order Structures
JF  - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
J2  - EUR J ORG CHEM
VL  - 2013
PY  - 2013
IS  - 17
SP  - 3555
EP  - 3559
PG  - 5
SN  - 1434-193X
DO  - 10.1002/ejoc.201201633
UR  - https://m2.mtmt.hu/api/publication/2347492
ID  - 2347492
N1  - Funding Agency and Grant Number: European Union (EU) (COST Action) [CM0803]; Hungarian Research Foundation [OTKA PD83600, K83882]; Hungarian Academy of Sciences [LP-2011-009]; Gedeon Richter Centennial Foundation\n Funding text: This work was supported by the European Union (EU) (COST Action CM0803), the Hungarian Research Foundation (OTKA PD83600 and K83882), and the Hungarian Academy of Sciences (Lendulet programme, LP-2011-009). E. S. acknowleges support by the Gedeon Richter Centennial Foundation.\n
WoS:hiba:000320036300015 2019-12-11 20:24 cím nem egyezik
Funding Agency and Grant Number: European Union (EU) (COST Action)European Union (EU) [CM0803]; Hungarian Research FoundationOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [OTKA PD83600, K83882]; Hungarian Academy of SciencesHungarian Academy of Sciences [LP-2011-009]; Gedeon Richter Centennial Foundation
            Funding text: This work was supported by the European Union (EU) (COST Action CM0803), the Hungarian Research Foundation (OTKA PD83600 and K83882), and the Hungarian Academy of Sciences (Lendulet programme, LP-2011-009). E. S. acknowleges support by the Gedeon Richter Centennial Foundation.
AB  - Peptidic foldamers are known to exhibit increased diversity in the periodic secondary-structure space in comparison with their natural counterparts, but their higher-order self-organization has been studied less thoroughly. In theory, large-diameter peptide foldamer helices have the capability of self-recognition through axial helix-helix interactions (e.g., head-to-tail), but this phenomenon has previously been observed in only one instance. In this article we report on the discovery of the largest-diameter β-peptidic mixed helix to date, the H18/20P helix. Its formation is solvent-dependent and its folding occurs cooperatively through head-to-tail self-assembly in solution. These findings suggest that axial helix-helix interactions can serve as a new mode for the formation of tertiary/quaternary structures for peptide foldamers, which also show higher-order structural diversity than natural proteins. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
LA  - English
DB  - MTMT
ER  -