TY  - JOUR
AU  - Háznagyné Radnai, Erzsébet
AU  - Balogh, Ágnes
AU  - Czigle, Szilvia
AU  - Máthé, Imre
AU  - Hohmann, Judit
AU  - Blazsó, Gábor
TI  - Antiinflammatory activities of Hungarian Stachys species and their iridoids
JF  - PHYTOTHERAPY RESEARCH
J2  - PHYTOTHER RES
VL  - 26
PY  - 2012
IS  - 4
SP  - 505
EP  - 509
PG  - 5
SN  - 0951-418X
DO  - 10.1002/ptr.3582
UR  - https://m2.mtmt.hu/api/publication/1853438
ID  - 1853438
N1  - Department of Pharmacognosy, University of Szeged, Eötvös 6, H-6720 Szeged, Hungary            
            Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös 6, H-6720 Szeged, Hungary            
            Department of Pharmacognosy and Botany, Comenius University, Odbojárov 10, SK-83232 Bratislava, Slovakia            
            Institute of Ecology and Botany, Hungarian Academy of Sciences, Alkotmány u. 2, H-2163 Vácrátõt, Hungary            
            Cited By :38            
            Export Date: 27 April 2021            
            CODEN: PHYRE            
            Correspondence Address: Háznagy-Radnai, E.; Department of Pharmacognosy, Eötvös 6, H-6720 Szeged, Hungary; email: haznagy.radnai@pharm.u-szeged.hu
AB  - The antiinflammatory activities of aqueous extracts prepared from the aerial parts of ten Hungarian Stachys species were investigated in vivo in the carrageenan-induced paw oedema test after intraperitoneal and oral administration to rats. Some of the extracts were found to display significant antiphlogistic effects when administered intraperitoneally and orally; in particular, the extracts of S. alpina, S. germanica, S. officinalis and S. recta demonstrated high activity following intraperitoneal administration. At the same dose of 5.0mg/kg, these extracts exhibited similar or greater potency than that of the positive control diclofenac-Na. The main iridoids present in the investigated extracts, ajugoside, aucubin, acetylharpagide, harpagide and harpagoside, were also assayed in the same test, and high dose-dependent antiphlogistic effects were recorded for aucubin and harpagoside. These results led to the conclusion that most probably iridoids are responsible for the antiinflammatory effect of Stachys species, but other active constituents or their synergism must also be implicated in the antiinflammatory effect. © 2011 John Wiley & Sons, Ltd.
LA  - English
DB  - MTMT
ER  -