TY  - JOUR
AU  - Szolnoki, Éva Tünde
AU  - Hetényi, Anasztázia
AU  - Martinek, Tamás
AU  - Szakonyi, Zsolt
AU  - Fülöp, Ferenc
TI  - Self-association-driven transition of the β-peptidic H12 helix to the H18 helix
JF  - ORGANIC & BIOMOLECULAR CHEMISTRY
J2  - ORG BIOMOL CHEM
VL  - 10
PY  - 2012
IS  - 2
SP  - 255
EP  - 259
PG  - 5
SN  - 1477-0520
DO  - 10.1039/c1ob06627g
UR  - https://m2.mtmt.hu/api/publication/1842289
ID  - 1842289
AB  - Various patterns of foldameric oligomers formed by trans-ABHC ((1S,2S,3S, 5S)-2-amino-6,6-dimethylbicyclo-[3.3.1]heptane-3-carboxylic acid) and beta(3)-hSer residues were studied. NMR, ECD and molecular modelling demonstrated that octameric and nonameric sequences with multiple i-i+3 ABHC pair repulsions attain the beta-H18 helix in CD3OH. As a close relative of the alpha-helix, this helix type is stabilized by i-i+4 backbone H-bond interactions. The formation of the beta-H18 helix was found to be solvent-and concentration-dependent. Upon dilution, the beta-H18 -> beta-H12 helix transition was revealed by concentration-dependent ECD, DOSY-NMR and TEM measurements.
LA  - English
DB  - MTMT
ER  -