TY  - JOUR
AU  - Mándity, István
AU  - Fülöp, Lívia
AU  - Vass, Elemér
AU  - Tóth, Gábor
AU  - Martinek, Tamás
AU  - Fülöp, Ferenc
TI  - Building β-Peptide H10/12 Foldamer Helices with Six-Membered Cyclic Side-Chains: Fine-Tuning of Folding and Self-Assembly
JF  - ORGANIC LETTERS
J2  - ORG LETT
VL  - 12
PY  - 2010
IS  - 23
SP  - 5584
EP  - 5587
PG  - 4
SN  - 1523-7060
DO  - 10.1021/ol102494m
UR  - https://m2.mtmt.hu/api/publication/1412123
ID  - 1412123
AB  - The ability of the beta-peptidic H10/12 helix to tolerate side-chains containing six-membered alicyclic rings was studied. cis-2-Aminocyclohex-3-ene carboxylic acid (cis-ACHEC) res dues afforded H10/12 helix formation with alternating backbone configuration. Conformational polymorphism was observed for the alternating cis-ACHC hexamer, where chemical exchange takes place between the major left-handed H10/12 helix and a minor folded conformation. The hydrophobically driven self-assembly was achieved for the cis-ACHC-containing helix which was observed as vesicles similar to 100 nm in diameter.
LA  - English
DB  - MTMT
ER  -