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Chemicals/CAS: galectin 1, 258495-34-0; tyrosine, 16870-43-2, 55520-40-6, 60-18-4; Asialoglycoproteins; Galectin 1; Glycoproteins; Peptides; Recombinant Proteins; Tyrosine, 55520-40-6; alpha-Fetoproteins; asialofetuin
Funding Agency and Grant Number: Hungarian Academy of Sciences; Hungarian Scientific Research Fund [K 69047, PD 75938]; NKTH-OTKA [CK 78188]; OTKA NF [69316]\n Funding text: A.H. and T.A.M. acknowledge the award of Janos Bolyai Research Fellowships by the Hungarian Academy of Sciences. This work was supported by grants from the Hungarian Scientific Research Fund (OTKA K 69047, PD 75938, NKTH-OTKA CK 78188, and OTKA NF 69316).\n
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Galectin-1-Asialofetuin Interaction Is Inhibited by Peptides Containing the Tyr-Xxx-Tyr Motif Acting on the Glycoprotein
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Galectin-1 (Gal-1), a ubiquitous P-galactoside-binding protein expressed by various normal and pathological tissues, has been implicated in cancer and autoimmune/inflammatory diseases in consequence of its regulatory role in adhesion, cell viability, proliferation, and angiogenesis. The functions of Gal-1 depend on its affinity for P-galactoside-containing glycoconjugates; accordingly, the inhibition of sugar binding blocks its functions, hence promising potential therapeutic tools. The Tyr-Xxx-Tyr peptide motifs have been reported to be glycomimetic sequences, mainly on the basis of their inhibitory effect on the Gal-1-asialofetuin (ASF) interaction. However, the results regarding the efficacy of the Tyr-Xxx-Tyr motif as a glycomimetic inhibitor are still controversial. The present STD and trNOE NMR experiments reveal that the Tyr-Xxx-Tyr peptides studied do not bind to Gal-1, whereas their binding to ASF is clearly detected. N-15,H-1 HSQC titrations with N-15-labeled Gal-1 confirm the absence of any peptide-Gal-1 interaction. These data indicate that the Tyr-Xxx-Tyr peptides tested in this work are not glycomimetics as they interact with ASF via an unrevealed molecular linkage.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001147"> <a href="/gui2/?type=authors&mode=browse&sel=10001147" target="_blank">Hetenyi, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10025381"> <a href="/gui2/?type=authors&mode=browse&sel=10025381" target="_blank">Vaczi, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10034564"> <a href="/gui2/?type=authors&mode=browse&sel=10034564" target="_blank">Szolnoki, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013040"> <a href="/gui2/?type=authors&mode=browse&sel=10013040" target="_blank">Fajka-Boja, R</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10025373"> <a href="/gui2/?type=authors&mode=browse&sel=10025373" target="_blank">Tubak, V</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008944"> <a href="/gui2/?type=authors&mode=browse&sel=10008944" target="_blank">Monostori, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, TA ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1321061" mtid="1321061" target="_blank">Galectin-1-Asialofetuin Interaction Is Inhibited by Peptides Containing the Tyr-Xxx-Tyr Motif Acting on the Glycoprotein</a></div> <div class="pub-info"> <span class="journal-title">CHEMBIOCHEM</span> <span class="journal-volume">11</span> : <span class="journal-issue">2</span> <span class="page"> pp. 228-234. , 7 p. </span> <span class="year">(2010)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/cbic.200900502" target="_blank" href="https://doi.org/10.1002/cbic.200900502"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="36260" target="_blank" href="http://real.mtak.hu/36260"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000274341000013" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000274341000013"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="76649093581" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-76649093581"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="19938027" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19938027&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="http://onlinelibrary.wiley.com/doi/10.1002/cbic.200900502/pdf" target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbic.200900502/pdf"> Egyéb URL </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="7552" target="_blank" href="http://publicatio.bibl.u-szeged.hu/7552"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1321061 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 8 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt: 8 | WoS/Scopus jelölt: 8 | DOI jelölt: 8 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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;
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<span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1321061" target="_blank">Galectin-1-Asialofetuin Interaction Is Inhibited by Peptides Containing the Tyr-Xxx-Tyr Motif Acting on the Glycoprotein</a></div> <div> <span class="journal-title">CHEMBIOCHEM</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1439-4227">1439-4227</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1439-7633">1439-7633</a>)</span>:
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1321061</span>
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<span class="oldId">Régi azonosító: 1321061</span> |
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<div class="lastModified">Utolsó módosítás: 2023.09.19. 00:02 MTMT API (MTMT API user, admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Chemicals/CAS: galectin 1, 258495-34-0; tyrosine, 16870-43-2, 55520-40-6, 60-18-4; Asialoglycoproteins; Galectin 1; Glycoproteins; Peptides; Recombinant Proteins; Tyrosine, 55520-40-6; alpha-Fetoproteins; asialofetuin
Funding Agency and Grant Number: Hungarian Academy of Sciences; Hungarian Scientific Research Fund [K 69047, PD 75938]; NKTH-OTKA [CK 78188]; OTKA NF [69316]\n Funding text: A.H. ...</pre>
</div></div>