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Human GCs \nwere isolated from\npreovulatory follicular fluid aspirated from 22 women undergoing \nin vitro\nfertilization at the University Women's Hospital of Tubingen. \nThe production of\nprogesterone and E(2) was measured in the presence and absence \nof acetylcholine, \ncarbachol, atropine, luteinizing hormone (LH) or follicle-\nstimulating hormone\n(FSH) using radioimmunoassay. Statistical analysis of the data \nwas performed by\nANOVA and Newman-Keuls test. Administration of acetylcholine or \ncarbachol (10(-5)\nM) resulted in a significant increase in P and E(2) secretion. \nThis response was \nspecifically blocked by the muscarinic receptor antagonist \natropine. Similarly,\ncarbachol resulted in a significant increase in P and E(2) \noutput, though the\nresponse to it was somewhat reduced when compared to that evoked \nby\nacetylcholine. Acetylcholine did not show any additive effect on \nLH-stimulated P \nsecretion, while it augmented the stimulatory effect of FSH on P \nrelease. In\ncontrast, carbachol markedly diminished the stimulatory effect \nof LH on P\nsecretion, while it caused no change in FSH-induced P output. \nWhen administered\ntogether, acetylcholine did not modify the stimulatory effect of \nFSH on E(2)\nsecretion, however, it markedly elevated LH-induced E(2) output. \nSimilar to this,\ncarbachol significantly increased LH-induced E(2) release, \nhowever it decreased\nFSH-stimulated E(2) secretion. We suggest that acetylcholine has \na direct\nmodulatory effect on gonadotropin-stimulated steroid production \nof GCs, an effect\nthat is mediated via muscarinic receptors. This effect may have \na physiological\nrole in the regulation of GC function during the menstrual \ncycle.", "subjects" : [ { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2009, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-16", "oaFree" : false, "oaByAuthor" : { "otype" : "Admin", "mtid" : 10045349, "link" : "/api/admin/10045349", "label" : "Fekete Rita (PTE GYTK admin 5)", "familyName" : "Fekete", "givenName" : "Rita", "published" : true, "oldId" : 10045349, "snippet" : true }, "citationCount" : 25, "citationCountUnpublished" : 0, "citationCountWoOther" : 24, "independentCitCountWoOther" : 21, "nationalOriginCitationCount" : 2, "foreignEditionCitationCount" : 24, "doiCitationCount" : 24, "wosCitationCount" : 23, "scopusCitationCount" : 24, "wosScopusCitationCount" : 24, "wosScopusCitationCountWoOther" : 24, "wosScopusIndependentCitationCount" : 21, "wosScopusIndependentCitationCountWoOther" : 21, "independentCitationCount" : 22, "selfCitationCount" : 3, "unhandledCitationCount" : 0, "citingPubCount" : 25, "independentCitingPubCount" : 22, "citingPubCountWoOther" : 24, "independentCitingPubCountWoOther" : 21, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 6114723, "link" : "/api/sjrrating/6114723", "label" : "sjr:Q2 (2001) Scopus - Obstetrics and Gynecology GYNECOLOGIC AND OBSTETRIC INVESTIGATION 0378-7346 1423-002X", "listPos" : 52, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2729, "link" : "/api/classificationexternal/2729", "label" : "Scopus - Obstetrics and Gynecology", "published" : true, "oldId" : 2729, "snippet" : true }, "ranking" : "Q2", "calculation" : "DIRECT", "published" : true, "oldId" : 6114723, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "inSelectedPubs" : "10044260", "userChangeableUntil" : "2015-10-26T08:28:55.000+0000", "publishDate" : "2012-08-27T08:37:15.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 4, "ownerInstituteCount" : 22, "directInstituteCount" : 0, "authorCount" : 5, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/1176836", "label" : "Kornya L et al. 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