TY  - JOUR
AU  - Schuster, Ildikó
AU  - Sztojkov-Ivanov, Anita
AU  - Lázár, László
AU  - Fülöp, Ferenc
TI  - Synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid Derivatives Via Ugi Reactions
JF  - LETTERS IN ORGANIC CHEMISTRY
J2  - LETT ORG CHEM
VL  - 4
PY  - 2007
IS  - 2
SP  - 102
EP  - 108
PG  - 7
SN  - 1570-1786
DO  - 10.2174/157017807780414226
UR  - https://m2.mtmt.hu/api/publication/1083281
ID  - 1083281
N1  - Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary.
AB  - The three-component Ugi reactions of 3,4-dihydroisoquinolines, isocyanides and acids furnished 2-acyl-N-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Chiral, nonracemic acids induced only poor diastercoselectivities in the condensations. Hydrolysis of the Ugi carboxamides gave the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids, which due to their ready ability to undergo racemization, were obtained as racemic mixtures or with low enantiomeric excesses.
LA  - English
DB  - MTMT
ER  -