@article{MTMT:1083281, title = {Synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid Derivatives Via Ugi Reactions}, url = {https://m2.mtmt.hu/api/publication/1083281}, author = {Schuster, Ildikó and Sztojkov-Ivanov, Anita and Lázár, László and Fülöp, Ferenc}, doi = {10.2174/157017807780414226}, journal-iso = {LETT ORG CHEM}, journal = {LETTERS IN ORGANIC CHEMISTRY}, volume = {4}, unique-id = {1083281}, issn = {1570-1786}, abstract = {The three-component Ugi reactions of 3,4-dihydroisoquinolines, isocyanides and acids furnished 2-acyl-N-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Chiral, nonracemic acids induced only poor diastercoselectivities in the condensations. Hydrolysis of the Ugi carboxamides gave the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids, which due to their ready ability to undergo racemization, were obtained as racemic mixtures or with low enantiomeric excesses.}, year = {2007}, eissn = {1875-6255}, pages = {102-108}, orcid-numbers = {Lázár, László/0000-0002-2135-8496; Fülöp, Ferenc/0000-0003-1066-5287} }