TY - JOUR AU - Balić, Tomislav AU - Paurević, Marija AU - Počkaj, Marta AU - Medvidović-Kosanović, Martina AU - Goman, Dominik AU - Széchenyi, Aleksandar AU - Preisz, Zsolt AU - Kunsági-Máté, Sándor TI - Influence of Aliphatic Chain Length on Structural, Thermal and Electrochemical Properties of n-alkylene Benzyl Alcohols : A Study of the Odd-Even Effect JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 12 PG - 20 SN - 1420-3049 DO - 10.3390/molecules27123781 UR - https://m2.mtmt.hu/api/publication/32907495 ID - 32907495 AB - The century-old, well-known odd-even effect phenomenon is still a very attractive and intriguing topic in supramolecular and nano-scale organic chemistry. As a part of our continuous efforts in the study of supramolecular chemistry, we have prepared three novel aromatic alcohols (1,2-bis[2-(hydroxymethyl)phenoxy]butylene (Do4OH), 1,2-bis[2-(hydroxymethyl)phenoxy]pentylene (Do5OH) and 1,2-bis[2-(hydroxymethyl)phenoxy]hexylene (Do6OH)) and determined their crystal and molecular structures by single-crystal X-ray diffraction. In all compounds, two benzyl alcohol groups are linked by an aliphatic chain of different lengths (CH2)n; n = 4, 5 and 6. The major differences in the molecular structures were found in the overall planarity of the molecules and the conformation of the aliphatic chain. Molecules with an even number of CH2 groups tend to be planar with an all-trans conformation of the aliphatic chain, while the odd-numbered molecule is non-planar, with partial gauche conformation. A direct consequence of these structural differences is visible in the melting points-odd-numbered compounds of a particular series display systematically lower melting points. Crystal and molecular structures were additionally studied by the theoretical calculations and the melting points were correlated with packing density and the number of CH2 groups. The results have shown that the generally accepted rule, higher density = higher stability = higher melting point, could not be applied to these compounds. It was found that the denser packaging causes an increase in the percentage of repulsive H‧‧‧H interactions, thereby reducing the stability of the crystal, and consequently, the melting points. Another interesting consequence of different molecular structures is their electrochemical and antioxidative properties-a non-planar structure displays the highest oxidation peak of hydroxyl groups and moderate antioxidant activity. LA - English DB - MTMT ER - TY - JOUR AU - Bognár, Balázs AU - Lemli, Beáta AU - Kőrösi, László Tamás AU - Mohamed Ameen, Hiba Farooq AU - Derdák, Diána AU - Isbera, Mostafa AU - Preisz, Zsolt AU - Úr, Györgyi AU - Pápayné Sár, Cecília AU - Kunsági-Máté, Sándor AU - Kálai, Tamás TI - Szemelvények a PTE GyTK Szerves és Gyógyszerkémiai Intézetének újabb (2013-2021) kutatási eredményeiből JF - MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-) J2 - MAGY KÉM FOLY KÉM KÖZL VL - 128 PY - 2022 IS - 2 SP - 68 EP - 78 PG - 11 SN - 1418-9933 DO - 10.24100/MKF.2022.02.68 UR - https://m2.mtmt.hu/api/publication/33090440 ID - 33090440 LA - Hungarian DB - MTMT ER - TY - BOOK ED - Kajos, Luca Fanni ED - Bali, Cintia ED - Preisz, Zsolt ED - Szabó, Rebeka TI - X. JUBILEUMI INTERDISZCIPLINÁRIS DOKTORANDUSZ KONFERENCIA 2021 TANULMÁNYKÖTET = 10th JUBILEE INTERDISCIPLINARY DOCTORAL CONFERENCE 2021 CONFERENCE BOOK PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs PY - 2022 SP - 872 SN - 9789634298199 UR - https://m2.mtmt.hu/api/publication/32646528 ID - 32646528 N1 - A kötet a konferencián elhangzott előadásanyagok lektorált változatát tartalmazza. (2023.04.26. Boros A.) LA - English DB - MTMT ER - TY - THES AU - Preisz, Zsolt TI - A metotrexát és egyes analogonjainak másodlagos kölcsönhatásai és antioxidáns tulajdonságai PY - 2022 SP - 71 UR - https://m2.mtmt.hu/api/publication/33685148 ID - 33685148 LA - Hungarian DB - MTMT ER - TY - BOOK ED - Kajos, Luca Fanni ED - Bali, Cintia ED - Preisz, Zsolt ED - Polgár, Petra Ibolya ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám ED - Szabó, Rebeka TI - 10th Jubilee Interdisciplinary Doctoral Conference : Book of Abstracts = 10. Jubileumi Interdiszciplináris Doktorandusz Konferencia : Absztraktkötet PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs PY - 2021 SP - 347 SN - 9789634298205 UR - https://m2.mtmt.hu/api/publication/32526207 ID - 32526207 LA - English DB - MTMT ER - TY - JOUR AU - Preisz, Zsolt AU - Kunsági-Máté, Sándor TI - Effect of methotrexate and its photodegradation products on the temperature induced denaturation of human serum albumin JF - SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY J2 - SPECTROCHIM ACTA A VL - 245 PY - 2021 PG - 5 SN - 1386-1425 DO - 10.1016/j.saa.2020.118905 UR - https://m2.mtmt.hu/api/publication/31604212 ID - 31604212 LA - English DB - MTMT ER - TY - JOUR AU - Preisz, Zsolt AU - Nagymihaly, Zoltan AU - Kollár, László AU - Kálai, Tamás AU - Kunsági-Máté, Sándor TI - Weak Interactions of the Isomers of Phototrexate and Two Cavitand Derivatives JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 19 PG - 11 SN - 1661-6596 DO - 10.3390/ijms221910764 UR - https://m2.mtmt.hu/api/publication/32396707 ID - 32396707 AB - The interactions of two conformers of newly synthesized photoswitchable azobenzene analogue of methotrexate, called Phototrexate, with two cavitand derivatives, have been investigated in dimethyl sulfoxide medium. Photoluminescence methods have been applied to determine the complex stabilities and the related enthalpy and entropy changes associated to the complex formation around room temperature. Results show opposite temperature dependence of complex stabilities. The structure of the upper rims of the host molecules and the reordered solvent structure were identified as the background of the opposite tendencies of temperature dependence at molecular level. These results can support the therapeutic application of the photoswitchable phototrexate, because the formation of inclusion complexes is a promising method to regulate the pharmacokinetics of drug molecules. LA - English DB - MTMT ER - TY - CHAP AU - Preisz, Zsolt ED - Molnár, Dániel ED - Molnár , Dóra TI - A metotrexát és fotodegradációs termékeinek hatása a humán szérum albumin hődenaturációjára T2 - XXIV. Tavaszi Szél Konferencia 2021: Absztrakt kötet PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786155586996 PY - 2021 SP - 496 EP - 496 PG - 1 UR - https://m2.mtmt.hu/api/publication/32217277 ID - 32217277 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Preisz, Zsolt AU - Hartvig, Nóra AU - Bognár, Balázs AU - Kálai, Tamás AU - Kunsági-Máté, Sándor TI - Comparative EPR Study on the Scavenging Effect of Methotrexate with the Isomers of Its Photoswitchable Derivative JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 7 PG - 10 SN - 1424-8247 DO - 10.3390/ph14070665 UR - https://m2.mtmt.hu/api/publication/32102470 ID - 32102470 LA - English DB - MTMT ER - TY - JOUR AU - Preisz, Zsolt AU - Bognár, Balázs AU - Kálai, Tamás AU - Kollár, László AU - Kunsági-Máté, Sándor TI - Some Interactions of the Novel Photoswitchable Compound Phototrexate JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 300 EP - 301 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.300-301 UR - https://m2.mtmt.hu/api/publication/32634855 ID - 32634855 LA - English DB - MTMT ER -