https://m2.mtmt.hu/ eng 2026-10-06 05:39 false true 2 12 12 20 10 1 10 DESC publishedYear false ASC firstAuthor true JournalArticle 34175360 APPROVED true 0 false 2026-05-23T06:19:14.802+0000 2024-02-15T12:35:22.347+0000 2023-10-04T20:28:42.889+0000 true 10068186 Jezsó Bálint /api/author/10068186 Author true 2026-02-18T11:58:40.645+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-04T10:42:03.166+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mózner, Orsolya Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop true true /api/journal/10041705 REVIEWED true false 10041705 false 10041705 true 2077-0375 Journal FOREIGN 13 10 822 822 14 2023 The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, residing in a structurally unresolved cytoplasmic region (a.a. 354–367) of ABCG2 on the function and trafficking of this protein. A cluster of four lysines (K357–360) and the phosphorylation of a threonine (T362) residue in this region have been previously suggested to significantly affect the cellular fate of ABCG2. Here, we report that the naturally occurring K360del variant in human cells increased ABCG2 plasma membrane expression and accelerated cellular trafficking. The variable alanine replacements of the neighboring lysines had no significant effect on transport function, and the apical localization of ABCG2 in polarized cells has not been altered by any of these mutations. Moreover, in contrast to previous reports, we found that the phosphorylation-incompetent T362A, or the phosphorylation-mimicking T362E variants in this loop had no measurable effects on the function or expression of ABCG2. Molecular dynamics simulations indicated an increased mobility of the mutant variants with no major effects on the core structure of the protein. These results may help to decipher the potential role of this unstructured region within this transporter. Funding 2033093 /api/funding/2033093 false true Funding 2033094 /api/funding/2033094 false true Funding 2033095 /api/funding/2033095 false true Funding 2033096 /api/funding/2033096 false true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/membranes13100822 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 Q2 false 1241938 false false false 2023-11-02T14:40:37.792+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Biokémiai Tanszék (ELTE / TTK / Bio_I); Doktori Iskola (SE); Enzimológiai Intézet (TTK) 9 46 4 11 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 110179649 /api/authorship/110179649 1 0.091 true false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179650 /api/authorship/110179650 2 0.091 false false false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179651 /api/authorship/110179651 3 0.091 false false false Author 10054127 /api/author/10054127 Bartos Zsuzsa true 10054127 true Bartos Zsuzsa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179652 /api/authorship/110179652 4 0.09090909 false false false Gergely Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179653 /api/authorship/110179653 5 0.09090909 false false false Szabó Kata Sára true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179654 /api/authorship/110179654 6 0.091 false false false Author 10068186 /api/author/10068186 Jezsó Bálint true true Jezsó Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179655 /api/authorship/110179655 7 0.091 false false false Author 10027670 /api/author/10027670 Telbisz Ágnes Mária true 10027670 true Telbisz Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179656 /api/authorship/110179656 8 0.09090909 false false false Author 10015754 /api/author/10015754 Várady György true 10015754 true Várady György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179657 /api/authorship/110179657 9 0.091 false false false Author 10010446 /api/author/10010446 Homolya László true 10010446 true Homolya László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179658 /api/authorship/110179658 10 0.091 false false true Author 10015687 /api/author/10015687 Hegedűs Tamás true 10015687 true Hegedűs Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110179659 /api/authorship/110179659 11 0.091 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24459299 /api/publicationidentifier/24459299 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/membranes13100822 https://doi.org/10.3390/membranes13100822 false true PublicationIdentifier 24891258 /api/publicationidentifier/24891258 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001095372000001 https://www.webofscience.com/wos/woscc/full-record/001095372000001 true true PublicationIdentifier 24632892 /api/publicationidentifier/24632892 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85175065302 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175065302 false true PublicationIdentifier 24711226 /api/publicationidentifier/24711226 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37887994 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37887994&dopt=Abstract false true SjrRating 11361967 /api/sjrrating/11361967 113 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1501 /api/classificationexternal/1501 true 1501 true Q2 DIRECT true true /api/publication/34175360 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Zsuzsa (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gergely Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó Kata Sára </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068186"><a href="/gui2/?type=authors&mode=browse&sel=10068186" target="_blank">Jezsó Bálint (<span class="authorship-author-name">Jezsó Bálint</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027670"><a href="/gui2/?type=authors&mode=browse&sel=10027670" target="_blank">Telbisz Ágnes (<span class="authorship-author-name">Telbisz Ágnes Mária</span> <span class="authorAux-mtmt"> Biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya László (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs Tamás ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34175360" target="_blank">Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop</a></div> <div> <span class="journal-title">MEMBRANES (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0375">2077-0375</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">10</span> <span class="page"> Paper 822. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/membranes13100822" target="_blank" href="https://doi.org/10.3390/membranes13100822"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001095372000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001095372000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175065302" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175065302"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37887994" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37887994&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Filtration and Separation&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Process Chemistry and Technology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34175360&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34175360</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFIH-K-128123) Funder: NRDIO, (K127961) Funder: NRDIO, (K137610), (KDP-1017403) </div> <div class="lastModified">Last Modified: 2024.02.15. 13:35 Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:42 Andrea Vándor (VA, admin) </div> </div></div> JournalArticle 33061607 APPROVED true National Institute of Locomotor Diseases and Disabilities, Frankel Leo str. 38-40, Budapest, 1023, Hungary Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary Section of Rheumatology and Physiotherapy, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary Export Date: 9 February 2023 CODEN: CEMLB Correspondence Address: Pálinkás, M.; National Institute of Locomotor Diseases and Disabilities, Frankel Leo str. 38-40, Hungary; email: mrpalinkas@gmail.com Correspondence Address: Poór, G.; Section of Rheumatology and Physiotherapy, Hungary; email: poor.gyula@orfi.hu Funding details: Semmelweis Egyetem, EFOP-3.6.3, VEKOP-16–2017-00009 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K-128011 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Innovációs és Technológiai Minisztérium Funding text 1: Open access funding provided by Semmelweis University. This study has been supported by grants from Hungarian National Development and Innovation Office (NKFIH K-128011 to Gy.V.), FIEK_16-1-2016-0005 (B.S.), and VEKOP-2.1.1-15-2016-00117 (Gy.V.). O.M. was supported by the KDP doctoral scholarship from the Ministry for Innovation and Technology (National Research, Development and Innovation Fund). B.Z. was supported by the Predoctoral Fellowship Grant of Semmelweis University (EFOP-3.6.3.-VEKOP-16–2017-00009). 0 false 2026-07-31T15:16:18.074+0000 2026-01-26T10:54:41.517+0000 2022-08-23T09:20:46.340+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-04-01T12:36:36.432+0000 2026-04-01T12:36:36.432+0000 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:17:19.306+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Pálinkás, M. Genetic polymorphisms and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia true true /api/journal/10000722 REVIEWED true false 10000722 false 10000722 true 1591-8890 1591-9528 Journal FOREIGN 23 4 1277 1284 1277 8 2023 Gout is a common crystal induced disease of high personal and social burden, characterised by severe arthritis and comorbidity if untreated. Impaired function of ABCG2 transporter is causative in gout and may be responsible for renal-overload type hyperuricemia. Despite its importance, there is limited information on how clinical parameters correlate with protein expression and that with genetic changes. Urate and clinical parameters of 78 gouty patients and healthy controls were measured among standardised circumstances from a Hungarian population. ABCG2 membrane expression of red blood cells was determined by flow cytometry-based method and SNPs of this protein were analysed by TaqMan-based qPCR. The prevalence of ABCG2 functional polymorphisms in gouty and control patients were 32.1 and 13.7%, respectively. Most common SNP was Q141K while one sample with R236X, R383C and the lately described M71V were found in the gouty population. These polymorphisms showed strong linkage with decreased protein expression while the latter was also associated with higher fractional urate excretion (FUE) and urinary urate excretion (UUE). This study firstly evaluated ABCG2 protein expression in a clinically defined gouty population while also proving its associations between ABCG2 genetic changes and renal-overload hyperuricemia. The paper also highlighted relations between ABCG2 SNPs, gout susceptibility and disease severity characterised by an early onset disease with frequent flares and tophi formation. Funding 2016873 /api/funding/2016873 false true Funding 2016874 /api/funding/2016874 false true Funding 2016875 /api/funding/2016875 false true Funding 2016876 /api/funding/2016876 false true Funding 2016877 /api/funding/2016877 false true true 2022 true true true false true false NONE 2026-07-31 false 8 0 8 6 2 8 7 8 6 8 8 6 6 6 2 0 8 6 8 6 0 5 5 Q1 false 10000283,1241938,10015754,10071451 false false false 2022-11-21T10:28:15.441+0000 Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Doktori Iskola (SE); Enzimológiai Intézet (TTK); Reumatológiai és Immunológiai Klinika (SE / KKP) 9 55 4 12 0 true 10066925 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103195106 /api/authorship/103195106 1 0.083 true false true Author 10084525 /api/author/10084525 Pálinkás Márton true true Pálinkás M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195107 /api/authorship/103195107 2 0.083 false false false Author 10040526 /api/author/10040526 Szabó Edit Zsuzsanna true 10040526 true Szabó E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195108 /api/authorship/103195108 3 0.083 false false false Author 10071451 /api/author/10071451 Kulin Anna true true Kulin A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195109 /api/authorship/103195109 4 0.083 false false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195110 /api/authorship/103195110 5 0.083333336 false false false Rásonyi R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195111 /api/authorship/103195111 6 0.083333336 false false false Author 10103065 /api/author/10103065 Juhász Péter true true Juhász P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195112 /api/authorship/103195112 7 0.083333336 false false false Nagy K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195113 /api/authorship/103195113 8 0.083 false false false Author 10015754 /api/author/10015754 Várady György true 10015754 true Várady G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195114 /api/authorship/103195114 9 0.083333336 false false false Vörös D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195115 /api/authorship/103195115 10 0.083 false false false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195116 /api/authorship/103195116 11 0.083 false false false Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103195117 /api/authorship/103195117 12 0.083 false true true Author 10000283 /api/author/10000283 Poór Gyula true 10000283 true Poór G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21607269 /api/publicationidentifier/21607269 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s10238-022-00848-7 https://doi.org/10.1007/s10238-022-00848-7 false true PublicationIdentifier 21607270 /api/publicationidentifier/21607270 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000837490200002 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/api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true Q1 DIRECT true true /api/publication/33061607 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10084525"><a href="/gui2/?type=authors&mode=browse&sel=10084525" target="_blank">Pálinkás M. ✉ (<span class="authorship-author-name">Pálinkás Márton</span> <span class="authorAux-mtmt"> Reumatológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Clinical Center of the Semmelweis University">CCSU</span>/Clinic for Rheumatology and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040526"><a href="/gui2/?type=authors&mode=browse&sel=10040526" target="_blank">Szabó E. (<span class="authorship-author-name">Szabó Edit Zsuzsanna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071451"><a href="/gui2/?type=authors&mode=browse&sel=10071451" target="_blank">Kulin A. (<span class="authorship-author-name">Kulin Anna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner O. (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rásonyi R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103065"><a href="/gui2/?type=authors&mode=browse&sel=10103065" target="_blank">Juhász P. (<span class="authorship-author-name">Juhász Péter</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Clinical Center of the Semmelweis University">CCSU</span>/Clinic for Rheumatology and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagy K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady G. (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vörös D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó B. (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi B. (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000283"><a href="/gui2/?type=authors&mode=browse&sel=10000283" target="_blank">Poór G. ✉ (<span class="authorship-author-name">Poór Gyula</span> <span class="authorAux-mtmt"> Reumatológia, osteológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis University">SU</span>/<span title="Clinical Center of the Semmelweis University">CCSU</span>/Clinic for Rheumatology and Immunology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33061607" target="_blank">Genetic polymorphisms and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia</a></div> <div> <span class="journal-title">CLINICAL AND EXPERIMENTAL MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1591-8890">1591-8890</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1591-9528">1591-9528</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">4</span> <span class="page"> pp 1277-1284 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s10238-022-00848-7" target="_blank" href="https://doi.org/10.1007/s10238-022-00848-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000837490200002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000837490200002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85135757853" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85135757853"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35939175" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35939175&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 6 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 8 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;8 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33061607&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33061607</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (NKFIH K-128011), (FIEK_16-1-2016-0005), (VEKOP-2.1.1-15-2016-00117), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP </div> <div class="lastModified">Last Modified: 2026.01.26. 11:54 Anna Mária Kósáné Holecz (SE_KK_Reumatológia_Admin5_KHAM, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:17 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: National Institute of Locomotor Diseases and Disabilities, Frankel Leo str. 38-40, Budapest, 1023, Hungary Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary Section of Rheumatology and Physiotherapy, Department of ...</pre> </div></div> JournalArticle 32156982 APPROVED true 0 false 2026-09-11T10:40:19.440+0000 2025-02-25T22:57:37.743+0000 2021-08-25T14:40:42.424+0000 true 10073889 Mózner Orsolya /api/author/10073889 Author true 2026-02-02T09:01:23.878+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mózner, Orsolya Modulation of the Human Erythroid Plasma Membrane Calcium Pump (PMCA4b) Expression by Polymorphic Genetic Variants true true /api/journal/10041705 REVIEWED true false 10041705 false 10041705 true 2077-0375 Journal FOREIGN 11 8 586 586 10 2021 In the human ATP2B4 gene, coding for the plasma membrane calcium pump PMCA4b, a minor haplotype results in the decreased expression of this membrane protein in erythroid cells. The presence of this haplotype and the consequently reduced PMCA4b expression have been suggested to affect red blood cell hydration and malaria susceptibility. By using dual-luciferase reporter assays, we have localized the erythroid-specific regulatory region within the haplotype of the ATP2B4 gene, containing predicted GATA1 binding sites that are affected by SNPs in the minor haplotype. Our results show that, in human erythroid cells, the regulation of ATP2B4 gene expression is significantly affected by GATA1 expression, and we document the role of specific SNPs involved in predicted GATA1 binding. Our findings provide a mechanistic explanation at the molecular level for the reduced erythroid-specific PMCA4b expression in carriers of ATP2B4 gene polymorphic variants. Funding 2007284 /api/funding/2007284 false true true 2021 true true true false true false GOLD 2026-09-11 true https://doi.org/10.3390/membranes11080586 7 0 7 5 1 7 7 7 5 7 7 5 5 5 2 0 7 5 7 5 0 3 3 Q2 false 10073889,1241938 false false false 2021-09-05T12:05:20.018+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Doktori Iskola (SE); Enzimológiai Intézet (TTK) 3 32 3 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 97181674 /api/authorship/97181674 1 0.333 true false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97181675 /api/authorship/97181675 2 0.333 true false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 97181676 /api/authorship/97181676 3 0.333 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 19161177 /api/publicationidentifier/19161177 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/membranes11080586 https://doi.org/10.3390/membranes11080586 false true PublicationIdentifier 19313969 /api/publicationidentifier/19313969 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000689454400001 https://www.webofscience.com/wos/woscc/full-record/000689454400001 true true PublicationIdentifier 19161179 /api/publicationidentifier/19161179 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85112639733 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85112639733 false true PublicationIdentifier 19313975 /api/publicationidentifier/19313975 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34436349 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34436349&dopt=Abstract true true SjrRating 11202038 /api/sjrrating/11202038 104 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1501 /api/classificationexternal/1501 true 1501 true Q2 DIRECT true true /api/publication/32156982 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka<sup>*</sup> (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32156982" target="_blank">Modulation of the Human Erythroid Plasma Membrane Calcium Pump (PMCA4b) Expression by Polymorphic Genetic Variants</a></div> <div> <span class="journal-title">MEMBRANES (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0375">2077-0375</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">8</span> <span class="page"> Paper 586. 10 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/membranes11080586" target="_blank" href="https://doi.org/10.3390/membranes11080586"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000689454400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000689454400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85112639733" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85112639733"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34436349" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34436349&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Process Chemistry and Technology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Filtration and Separation&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 5 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32156982&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32156982</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (1017403) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2025.02.25. 23:57 Gusztáv Ladányi (MTMT API user, admin) </div> </div></div> JournalArticle 30924863 VALIDATED true 0 false 2026-05-19T13:54:18.079+0000 2022-12-12T14:09:51.225+0000 2019-11-19T14:49:37.905+0000 true 10015745 Enyedi Ágnes /api/author/10015745 Author true 10015745 5385285 2026-02-02T10:30:38.612+0000 2026-02-02T10:30:38.911+0000 Author 10015745 /api/author/10015745 Enyedi Ágnes true 10015745 true SUSPECT 2025-03-20T20:04:30.661+0000 2026-02-02T10:30:38.857+0000 2021-02-17T10:33:02.688+0000 true 10020110 Farkas Andrea /api/admin/10020110 Admin true 10020110 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hegedűs, L. Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions true true /api/journal/15628 REVIEWED true false 15628 false 15628 true 0065-2598 2214-8019 Journal FOREIGN 1131 93 129 93 37 2020 Plasma membrane Ca2+ transport ATPases (PMCA1-4, ATP2B1-4) are responsible for removing excess Ca2+ from the cell in order to keep the cytosolic Ca2+ ion concentration at the low level essential for normal cell function. While these pumps take care of cellular Ca2+ homeostasis they also change the duration and amplitude of the Ca2+ signal and can create Ca2+ gradients across the cell. This is accomplished by generating more than twenty PMCA variants each having the character – fast or slow response, long or short memory, distinct interaction partners and localization signals – that meets the specific needs of the particular cell-type in which they are expressed. It has become apparent that these pumps are essential to normal tissue development and their malfunctioning can be linked to different pathological conditions such as certain types of neurodegenerative and heart diseases, hearing loss and cancer. In this chapter we summarize the complexity of PMCA regulation and function under normal and pathological conditions with particular attention to recent developments of the field. © Springer Nature Switzerland AG 2020. 2019 true true true false true false NONE 2026-05-19 false 22 0 22 20 3 22 22 21 16 22 22 20 20 20 2 0 22 20 22 20 0 30 30 Q2 false 10015745,10029020,10015749 false false false 2020-02-17T15:09:15.010+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK); II. Sz. 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<span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó B. (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015749"><a href="/gui2/?type=authors&mode=browse&sel=10015749" target="_blank">Pászty K. (<span class="authorship-author-name">Pászty Katalin</span> <span class="authorAux-mtmt"> Biokémia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029020"><a href="/gui2/?type=authors&mode=browse&sel=10029020" target="_blank">Padányi R. (<span class="authorship-author-name">Padányi Rita</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035825"><a href="/gui2/?type=authors&mode=browse&sel=10035825" target="_blank">Varga K. (<span class="authorship-author-name">Varga Karolina</span> <span class="authorAux-mtmt"> kémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Penniston J.T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015745"><a href="/gui2/?type=authors&mode=browse&sel=10015745" target="_blank">Enyedi Á. ✉ (<span class="authorship-author-name">Enyedi Ágnes</span> <span class="authorAux-mtmt"> Biokémia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30924863" target="_blank">Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions</a></div> <div> <span class="journal-title">ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0065-2598">0065-2598</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2214-8019">2214-8019</a>)</span>: <span class="journal-volume">1131</span> <span class="page"> pp 93-129 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/978-3-030-12457-1_5" target="_blank" href="https://doi.org/10.1007/978-3-030-12457-1_5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000539038900005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000539038900005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074100841" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074100841"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31646508" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31646508&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 22</span> | Independent citation: 20 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 21 | Number of citations in Scopus:&nbsp;16 | WoS/Scopus assigned:&nbsp;22 | Number of citations with DOI:&nbsp;22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30924863&sort=publishedYear,desc&sort=title"> Number of cited publications: 30 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30924863</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing Suspect | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="duplumMark">Duplum marked: </div> <div class="lastModified">Last Modified: 2022.12.12. 15:09 Anna Sághi-Keszthelyi (SE_KK_Admin5_SKA, admin) </div> </div></div> JournalArticle 31240593 VALIDATED true Research Centre for Natural Sciences, Institute of Enzymology, Budapest, Hungary South-Pest Hospital Centre, National Institute of Hematology and Infectious Diseases, Laboratory of Molecular and Cytogenetics, Budapest, Hungary Cited By :9 Export Date: 20 October 2022 CODEN: BCPCA Correspondence Address: Sarkadi, B.; Research Centre for Natural Sciences, Rm. D2.03A, Magyar tudósok körútja 2., Hungary; email: sarkadi.balazs@ttk.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; clemastine, 15686-51-8; cobalt chloride, 1332-82-7, 7646-79-9; colchicine, 64-86-8; dexamethasone, 50-02-2; docetaxel, 114977-28-5; etoposide, 33419-42-0, 433304-61-1; flavopiridol, 131740-09-5, 146426-40-6; gemcitabine, 103882-84-4; hydrocortisone, 50-23-7; methylprednisolone, 6923-42-8, 83-43-2; mitoxantrone, 65271-80-9, 70476-82-3; paclitaxel, 33069-62-4; sodium ion, 17341-25-2; valproic acid, 1069-66-5, 99-66-1; vinblastine, 865-21-4; vorinostat, 149647-78-9; epidermal growth factor receptor, 79079-06-4; ABCG2 protein, human; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; CRISPR-Associated Protein 9; EGFR protein, human; ErbB Receptors; Neoplasm Proteins 0 false 2026-08-28T06:13:36.354+0000 2022-02-17T10:41:01.403+0000 2020-03-13T10:29:04.657+0000 true 1241938 Sarkadi Balázs /api/author/1241938 Author true 1241938 2026-08-28T06:12:31.585+0000 2020-04-29T10:26:12.040+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2024-03-22T13:59:27.989+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kovacsics, Daniella Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cells true true /api/journal/686 REVIEWED true false 686 false 686 true 0006-2952 1873-2968 Journal FOREIGN 175 113865 113865 14 2020 Expression of the ABCG2 multidrug transporter is a marker of cancer stem cells and a predictor of recurrent malignant disease. Understanding how human ABCG2 expression is modulated by pharmacotherapy is crucial in guiding therapeutic recommendations and may aid rational drug development. Genome edited reporter cells are useful in investigating gene regulation and visualizing protein activity in live cells but require precise targeting to preserve native regulatory regions. Here, we describe a fluorescent reporter assay that allows the noninvasive assessment of ABCG2 regulation in human lung adenocarcinoma cells. Using CRISPR-Cas9 gene editing coupled with homology-directed repair, we targeted an eGFP coding sequence to the translational start site of ABCG2, generating ABCG2 knock-out and in situ tagged ABCG2 reporter cells. Using the engineered cell lines, we show that ABCG2 is upregulated by a number of anti-cancer medications, HDAC inhibitors, hypoxia-mimicking agents and glucocorticoids, supporting a model in which ABCG2 is under the control of a general stress response. To our knowledge, this is the first description of a fluorescent reporter assay system designed to follow the endogenous regulation of a human ABC transporter in live cells. 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AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125776 /api/authorship/91125776 8 0.06666667 false false false Author 10040185 /api/author/10040185 Németh Eszter true 10040185 true Németh Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125777 /api/authorship/91125777 9 0.06666667 false false false Author 10067874 /api/author/10067874 Fóthi Ábel true true Fóthi Ábel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125778 /api/authorship/91125778 10 0.06666667 false false false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125779 /api/authorship/91125779 11 0.06666667 false false false Author 10026660 /api/author/10026660 Szüts Dávid true 10026660 true Szüts Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125780 /api/authorship/91125780 12 0.06666667 false false false Author 10015754 /api/author/10015754 Várady György true 10015754 true Várady György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125781 /api/authorship/91125781 13 0.06666667 false false false Author 10000148 /api/author/10000148 Orbán Tamás I. true 10000148 true Orbán Tamás I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125782 /api/authorship/91125782 14 0.06666667 false false false Author 10027529 /api/author/10027529 Apáti Ágota true 10027529 true Apáti Ágota true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91125783 /api/authorship/91125783 15 0.06666667 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi Balázs true false false AuthorshipType 1 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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081239314&doi=10.1016%2Fj.bcp.2020.113865&partnerID=40&md5=afefff71d23d9f62a822daeacb925b74 false true Classification 10575 /api/classification/10575 true true Keyword 8268 /api/keyword/8268 true 8268 true Keyword 19546 /api/keyword/19546 true 19546 true Keyword 1431489 /api/keyword/1431489 true 1431489 true Keyword 1815917 /api/keyword/1815917 true true Keyword 1995227 /api/keyword/1995227 true true SjrRating 10750627 /api/sjrrating/10750627 82 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/31240593 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10058367"><a href="/gui2/?type=authors&mode=browse&sel=10058367" target="_blank">Kovacsics Daniella (<span class="authorship-author-name">Kovacsics Daniella</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027530"><a href="/gui2/?type=authors&mode=browse&sel=10027530" target="_blank">Brózik Anna<sup>*</sup> (<span class="authorship-author-name">Brózik Anna</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034873"><a href="/gui2/?type=authors&mode=browse&sel=10034873" target="_blank">Tihanyi Borbála (<span class="authorship-author-name">Tihanyi Borbála</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043362"><a href="/gui2/?type=authors&mode=browse&sel=10043362" target="_blank">Matula Zsolt (<span class="authorship-author-name">Matula Zsolt</span> <span class="authorAux-mtmt"> Őssejt-biológia, Genetika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Borsy Adrienn </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mészáros Nikolett </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040526"><a href="/gui2/?type=authors&mode=browse&sel=10040526" target="_blank">Szabó Edit (<span class="authorship-author-name">Szabó Edit Zsuzsanna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040185"><a href="/gui2/?type=authors&mode=browse&sel=10040185" target="_blank">Németh Eszter (<span class="authorship-author-name">Németh Eszter</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067874"><a href="/gui2/?type=authors&mode=browse&sel=10067874" target="_blank">Fóthi Ábel (<span class="authorship-author-name">Fóthi Ábel</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_413</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026660"><a href="/gui2/?type=authors&mode=browse&sel=10026660" target="_blank">Szüts Dávid (<span class="authorship-author-name">Szüts Dávid</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000148"><a href="/gui2/?type=authors&mode=browse&sel=10000148" target="_blank">Orbán Tamás I (<span class="authorship-author-name">Orbán Tamás I.</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027529"><a href="/gui2/?type=authors&mode=browse&sel=10027529" target="_blank">Apáti Ágota (<span class="authorship-author-name">Apáti Ágota</span> <span class="authorAux-mtmt"> Őssejt kutatás</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31240593" target="_blank">Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cells</a></div> <div> <span class="journal-title">BIOCHEMICAL PHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0006-2952">0006-2952</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-2968">1873-2968</a>)</span>: <span class="journal-volume">175</span> <span class="page"> Paper 113865. 14 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.bcp.2020.113865" target="_blank" href="https://doi.org/10.1016/j.bcp.2020.113865"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000527350300011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000527350300011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85081239314" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85081239314"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32142727" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32142727&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081239314&doi=10.1016%2Fj.bcp.2020.113865&partnerID=40&md5=afefff71d23d9f62a822daeacb925b74" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081239314&doi=10.1016%2Fj.bcp.2020.113865&partnerID=40&md5=afefff71d23d9f62a822daeacb925b74"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 17</span> | Independent citation: 15 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 15 | Number of citations in Scopus:&nbsp;17 | WoS/Scopus assigned:&nbsp;17 | Number of citations with DOI:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31240593&sort=publishedYear,desc&sort=title"> Number of cited publications: 15 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31240593</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2022.02.17. 11:41 Zsolt Matula (Őssejt-biológia, Genetika) </div> <div class="lockedBy">Centrally managed 2024.03.22. 14:59 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Research Centre for Natural Sciences, Institute of Enzymology, Budapest, Hungary South-Pest Hospital Centre, National Institute of Hematology and Infectious Diseases, Laboratory of Molecular and Cytogenetics, Budapest, Hungary Cited By :9 Export Date: 20 October 2022 CODEN: BCPCA ...</pre> </div></div> JournalArticle 30745945 VALIDATED true Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudosok krt. 2, Budapest, 1117, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, Budapest, 1094, Hungary Cited By :16 Export Date: 10 February 2024 CODEN: CMLSF Correspondence Address: Sarkadi, B.; Institute of Enzymology, Magyar Tudosok krt. 2, Hungary; email: sarkadi@biomembrane.hu Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3; ABCG2 protein, human; Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily G, Member 2; Neoplasm Proteins 0 false 2026-06-01T16:23:29.973+0000 2024-04-03T10:18:18.524+0000 2019-07-24T09:18:56.493+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 2025-03-12T14:31:09.416+0000 2025-03-12T14:31:09.416+0000 2021-02-22T10:03:13.946+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2021-07-22T08:23:41.874+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2024-03-22T13:59:27.989+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Zámbó, B. Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter true true /api/journal/11507 REVIEWED true false 11507 false 11507 true 1420-682X 1420-9071 Journal FOREIGN 77 2 365 378 365 14 2020 The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics; thus the relatively frequent polymorphic and mutant ABCG2 variants in the population may significantly alter disease conditions and pharmacological effects. Low-level or non-functional ABCG2 expression may increase individual drug toxicity, reduce cancer drug resistance, and result in hyperuricemia and gout. In the present work we have studied the cellular expression, trafficking, and function of nine naturally occurring polymorphic and mutant variants of ABCG2. A comprehensive analysis of the membrane localization, transport, and ATPase activity, as well as retention and degradation in intracellular compartments was performed. Among the examined variants, R147W and R383C showed expression and/or protein folding defects, indicating that they could indeed contribute to ABCG2 functional deficiency. These studies and the applied methods should significantly promote the exploration of the medical effects of these personal variants, promote potential therapies, and help to elucidate the specific role of the affected regions in the folding and function of the ABCG2 protein. © 2019, The Author(s). Funding 2000629 /api/funding/2000629 false true true true 2019 true true true false true false GREEN 2026-06-01 true https://real.mtak.hu/103927 22 0 22 11 8 22 22 22 21 22 22 11 11 11 11 0 22 11 22 11 0 16 16 D1 false 10073889,10010446,10035824,1241938,10027670 false false false 2019-10-22T09:19:49.794+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK) 9 41 2 9 0 true 10073918 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 87608783 /api/authorship/87608783 1 0.11111111 true false false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608784 /api/authorship/87608784 2 0.11111111 true false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608785 /api/authorship/87608785 3 0.11111111 false false false Author 10054127 /api/author/10054127 Bartos Zsuzsa true 10054127 true Bartos Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608786 /api/authorship/87608786 4 0.11111111 false false false Author 10035824 /api/author/10035824 Török György true 10035824 true Török G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608787 /api/authorship/87608787 5 0.11111111 false false false Author 10015754 /api/author/10015754 Várady György true 10015754 true Várady G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608788 /api/authorship/87608788 6 0.11111111 false false false Author 10027670 /api/author/10027670 Telbisz Ágnes Mária true 10027670 true Telbisz Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608789 /api/authorship/87608789 7 0.11111111 false false false Author 10010446 /api/author/10010446 Homolya László true 10010446 true Homolya L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608790 /api/authorship/87608790 8 0.11111111 false false false Author 10000148 /api/author/10000148 Orbán Tamás I. true 10000148 true Orbán T.I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87608791 /api/authorship/87608791 9 0.11111111 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 15739295 /api/publicationidentifier/15739295 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s00018-019-03186-2 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/api/classificationexternal/1313 true 1313 true D1 DIRECT true true /api/publication/30745945 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó B. (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner O.<sup>*</sup> (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Z. (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035824"><a href="/gui2/?type=authors&mode=browse&sel=10035824" target="_blank">Török G. (<span class="authorship-author-name">Török György</span> <span class="authorAux-mtmt"> Biofizika, Sejt- és fejlődésbiológia,</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady G. (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027670"><a href="/gui2/?type=authors&mode=browse&sel=10027670" target="_blank">Telbisz Á. (<span class="authorship-author-name">Telbisz Ágnes Mária</span> <span class="authorAux-mtmt"> Biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya L. (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000148"><a href="/gui2/?type=authors&mode=browse&sel=10000148" target="_blank">Orbán T.I. (<span class="authorship-author-name">Orbán Tamás I.</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi B. ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30745945" target="_blank">Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter</a></div> <div> <span class="journal-title">CELLULAR AND MOLECULAR LIFE SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-682X">1420-682X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-9071">1420-9071</a>)</span>: <span class="journal-volume">77</span> <span class="journal-issue">2</span> <span class="page"> pp 365-378 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00018-019-03186-2" target="_blank" href="https://doi.org/10.1007/s00018-019-03186-2"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="103927" target="_blank" href="https://real.mtak.hu/103927"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000511711100012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000511711100012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85068190642" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85068190642"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31254042" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31254042&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 22</span> | Independent citation: 11 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 22 | Number of citations in Scopus:&nbsp;21 | WoS/Scopus assigned:&nbsp;22 | Number of citations with DOI:&nbsp;22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30745945&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30745945</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus (kolacsek2011.ris, 2019-07-24)</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP </div> <div class="lastModified">Last Modified: 2024.04.03. 12:18 Marcell Kovács (MTMT Közp., admin) </div> <div class="lockedBy">Centrally managed 2024.03.22. 14:59 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudosok krt. 2, Budapest, 1117, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, Budapest, 1094, Hungary Cited By :16 Export Date: 10 February 2024 CODE...</pre> </div></div> JournalArticle 30924895 VALIDATED true Funding Agency and Grant Number: National Research, Development, and Innovation Office [NKFI-127961]; OTKA/NKFIHOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 128123, NK 115375, FIEK_16-1-2016-0005]; Hungarian Ministry for Innovation and Technology [UNKP-19-3-I-SE-15, UNKP-19-2-I-BME-380] Funding text: This research was funded by National Research, Development, and Innovation Office, grant number NKFI-127961, (T.H.) OTKA/NKFIH grant_K 128123 (L.H.), OTKA/NKFIH grant NK 115375 (B.S.) and FIEK_16-1-2016-0005 (B.S. and L.H.). Z.B. and O.M. were supported by grants UNKP-19-3-I-SE-15 (Z.B.) and UNKP-19-2-I-BME-380 (O.M.) from the Hungarian Ministry for Innovation and Technology. 0 false 2026-05-19T13:54:11.831+0000 2021-05-10T09:52:50.712+0000 2019-11-19T15:35:36.252+0000 true 10010446 Homolya László /api/author/10010446 Author true 10010446 2026-03-03T10:42:44.625+0000 2026-03-03T10:42:44.625+0000 2021-02-23T08:29:35.982+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2021-05-10T09:52:50.724+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10003133 /api/admin/10003133 Boros Annamária true 10003133 true 2022-07-08T10:16:39.536+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Mózner, Orsolya Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism. true true /api/journal/10051562 REVIEWED true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 8 10 1215 1215 15 2019 The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells. Variants of the ABCG2 transporter, affecting cellular processing and trafficking, have been shown to cause gout and increased drug toxicity. In this paper, we overview the key cellular pathways involved in the processing and trafficking of large membrane proteins, focusing on ABC transporters. We discuss the information available for disease-causing polymorphic variants and selected mutations of ABCG2, causing increased degradation and impaired travelling of the transporter to the plasma membrane. In addition, we provide a detailed in silico analysis of an as yet unrecognized loop region of the ABCG2 protein, in which a recently discovered mutation may actually promote ABCG2 membrane expression. We suggest that post-translational modifications in this unstructured loop at the cytoplasmic surface of the protein may have special influence on ABCG2 processing and trafficking. true 2019 true true true false true false GOLD 2026-05-19 true https://doi.org/10.3390/cells8101215 26 0 26 20 3 26 26 25 21 26 26 20 20 20 6 0 26 20 26 20 0 18 18 false 10073889,1241938 false false false 2019-12-06T07:45:43.390+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK); MTA-SE Molekuláris Biofizikai Kutatócsoport (SE / AOK / I / BSI) 6 35 3 6 0 true 10003133 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88804641 /api/authorship/88804641 1 0.16666667 true false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88804642 /api/authorship/88804642 2 0.16666667 false false false Author 10054127 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class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Zsuzsa (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya László (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs Tamás ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/MTA-SE Molekuláris Biofizikai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30924895" target="_blank">Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism.</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">10</span> <span class="page"> Paper 1215. 15 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells8101215" target="_blank" href="https://doi.org/10.3390/cells8101215"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="7967" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/7967"> SE Repozitórium </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="103410" target="_blank" href="http://real.mtak.hu/103410"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000497336400104" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000497336400104"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85084933719" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85084933719"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31597297" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31597297&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 26</span> | Independent citation: 20 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 25 | Number of citations in Scopus:&nbsp;21 | WoS/Scopus assigned:&nbsp;26 | Number of citations with DOI:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30924895&sort=publishedYear,desc&sort=title"> Number of cited publications: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30924895</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2021.05.10. 11:52 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> <div class="lockedBy">Centrally managed 2022.07.08. 12:16 Annamária Boros (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Research, Development, and Innovation Office [NKFI-127961]; OTKA/NKFIHOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 128123, NK 115375, FIEK_16-1-2016-0005]; Hungarian Ministry for Innovation and Technology [UNKP-19-3-I-SE-15, UNKP-19-2-I-BME-380] Funding text: This research was funded by National Research, Development, and Innovation ...</pre> </div></div> JournalArticle 31432864 VALIDATED true 0 false 2025-09-16T08:56:17.958+0000 2023-01-12T10:54:29.327+0000 2020-08-26T10:09:54.045+0000 true 10015754 Várady György /api/author/10015754 Author true 10015754 2025-07-07T13:14:44.179+0000 2025-07-07T13:14:44.179+0000 2022-09-12T11:32:44.986+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:17:19.306+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Várady, György Potential Diagnostic Application of the Quantitative Assessment of Red Blood Cell Membrane Protein Expression true 20077761 false false /api/journal/20077761 2689-9663 Journal true FOREIGN false true 3 2 1024 1024 5 2019 Funding 2017591 /api/funding/2017591 false true Funding 2017592 /api/funding/2017592 false true Funding 2017593 /api/funding/2017593 false true true true 2020 true true true false true false GOLD 2025-09-16 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 false false false false 2020-11-24T11:09:54.988+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK); MTA Természettudományi Kutatóközpont; Országos Reumatológiai és Fizioterápiás Intézet 8 55 4 8 0 false 10066925 10067876 Language 10002 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/api/publicationidentifier/20715753 PlainSource 39 /api/publicationsource/39 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Teljes dokumentum Full text @@@ true true 39 true IDENTICAL https://austinpublishinggroup.com/thrombosis-haemostasis/fulltext/thrombosis-v3-id1024.pdf https://austinpublishinggroup.com/thrombosis-haemostasis/fulltext/thrombosis-v3-id1024.pdf false true Classification 10575 /api/classification/10575 true true /api/publication/31432864 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040526"><a href="/gui2/?type=authors&mode=browse&sel=10040526" target="_blank">Szabó Edit (<span class="authorship-author-name">Szabó Edit Zsuzsanna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071451"><a href="/gui2/?type=authors&mode=browse&sel=10071451" target="_blank">Kulin Anna (<span class="authorship-author-name">Kulin Anna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil">MTA Research Centre for Natural Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084525"><a href="/gui2/?type=authors&mode=browse&sel=10084525" target="_blank">Pálinkás Márton (<span class="authorship-author-name">Pálinkás Márton</span> <span class="authorAux-mtmt"> Reumatológia, molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000283"><a href="/gui2/?type=authors&mode=browse&sel=10000283" target="_blank">Poór Gyula (<span class="authorship-author-name">Poór Gyula</span> <span class="authorAux-mtmt"> Reumatológia, osteológia, molekuláris biológia</span>) </a> </span> <span class="author-affil">Országos Reumatológiai és Fizioterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31432864" target="_blank">Potential Diagnostic Application of the Quantitative Assessment of Red Blood Cell Membrane Protein Expression</a></div> <div> <span class="journal-title">THROMBOSIS AND HAEMOSTASIS: RESEARCH</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2689-9663">2689-9663</a>)</span>: <span class="journal-volume">3</span> <span class="journal-issue">2</span> <span class="page"> Paper 1024. 5 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://austinpublishinggroup.com/thrombosis-haemostasis/fulltext/thrombosis-v3-id1024.pdf" target="_blank" href="https://austinpublishinggroup.com/thrombosis-haemostasis/fulltext/thrombosis-v3-id1024.pdf"> Full text </a> </span> </span> <div class="mtid"><span class="long-pub-mtid">Publication: 31432864</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K115375) Funder: HSRF, (K128011) Funder: HSRF, (FIEK-16-1-2016-0005) </div> <div class="lastModified">Last Modified: 2023.01.12. 11:54 Márton Pálinkás (Reumatológia, molekuláris biológia) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:17 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> </div></div> Thesis 30764866 VALIDATED true 0 false 2025-05-09T17:02:24.615+0000 2025-05-09T16:00:56.751+0000 2019-08-14T06:36:08.629+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2025-05-09T16:00:56.308+0000 2025-05-09T16:00:56.308+0000 2025-05-09T16:00:56.754+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin true Admin 10067876 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class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of Ph. D. Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30764866" target="_blank">Membránfehérjék vizsgálata vörösvértesteken, a kapcsolódó genetikai variánsok azonosítása és jellemzése</a></div> <div> </div> <div class="thesis-cons"> Témavezető(k): <span class="consultantAuthor"><b>Sarkadi Balázs</b> <span class="authorAux-mtmt">biofizika</span> </span> </div> <div class="applicationYear"> <span class="applicationYear">Dissertation submission year: 2018</span> , <span class="acceptanceYear">Accepted: 2019 </span> </div> <div class="publishedYear">Published/defended: 2019 </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: Hungarian | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.14753/SE.2019.2259" target="_blank" href="https://doi.org/10.14753/SE.2019.2259"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="7466" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/7466"> SE Repozitórium </a> </span> </span> <div class="mtid"><span class="long-pub-mtid">Publication: 30764866</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Thesis ( PhD ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.05.09. 18:00 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Temporarily locked 2025.05.09. 18:00 Gusztáv Ladányi (MTMT API user, admin) </div> </div></div> JournalArticle 3370208 VALIDATED true Boglárka Zámbó, Zsuzsa Bartos, László Homolya and Balázs Sarkadi contributed equally to this work. 0 2018-08-23T22:21:24.000+0000 false 3370208 2026-05-25T12:50:11.973+0000 2023-07-07T10:15:11.090+0000 2018-05-11T09:15:36.000+0000 true 10000283 Poór Gyula /api/author/10000283 Author true 10000283 2026-03-03T11:44:40.650+0000 2026-03-03T11:44:40.650+0000 2021-02-22T10:12:52.135+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2021-05-12T08:43:32.225+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:17:19.306+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Zámbó, B Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 8 1 7487 7487 13 2018 The ABCG2 membrane protein is a key xeno- and endobiotic transporter, modulating the absorption and metabolism of pharmacological agents and causing multidrug resistance in cancer. ABCG2 is also involved in uric acid elimination and its impaired function is causative in gout. Analysis of ABCG2 expression in the erythrocyte membranes of healthy volunteers and gout patients showed an enrichment of lower expression levels in the patients. By genetic screening based on protein expression, we found a relatively frequent, novel ABCG2 mutation (ABCG2-M71V), which, according to cellular expression studies, causes reduced protein expression, although with preserved transporter capability. Molecular dynamics simulations indicated a stumbled dynamics of the mutant protein, while ABCG2-M71V expression in vitro could be corrected by therapeutically relevant small molecules. These results suggest that personalized medicine should consider this newly discovered ABCG2 mutation, and genetic analysis linked to protein expression provides a new tool to uncover clinically important mutations in membrane proteins. © 2018 The Author(s). 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left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó B (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Z<sup>*</sup> (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner O (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040526"><a href="/gui2/?type=authors&mode=browse&sel=10040526" target="_blank">Szabó E (<span class="authorship-author-name">Szabó Edit Zsuzsanna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady G (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000283"><a href="/gui2/?type=authors&mode=browse&sel=10000283" target="_blank">Poór G (<span class="authorship-author-name">Poór Gyula</span> <span class="authorAux-mtmt"> Reumatológia, osteológia, molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084525"><a href="/gui2/?type=authors&mode=browse&sel=10084525" target="_blank">Pálinkás M (<span class="authorship-author-name">Pálinkás Márton</span> <span class="authorAux-mtmt"> Reumatológia, molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036963"><a href="/gui2/?type=authors&mode=browse&sel=10036963" target="_blank">Andrikovics H (<span class="authorship-author-name">Andrikovics Hajnalka</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Transzfúziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs T (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya L<sup>**</sup> (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi B ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3370208" target="_blank">Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper 7487. 13 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-018-25695-z" target="_blank" href="https://doi.org/10.1038/s41598-018-25695-z"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="6003" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/6003"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000431763700020" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000431763700020"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="91789" target="_blank" href="http://real.mtak.hu/91789"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85046959544" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85046959544"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29749379" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29749379&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="PMC5945641" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945641"> Pubmed Central </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 25</span> | Independent citation: 15 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 23 | Number of citations in Scopus:&nbsp;24 | WoS/Scopus assigned:&nbsp;25 | Number of citations with DOI:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3370208&sort=publishedYear,desc&sort=title"> Number of cited publications: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3370208</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3370208</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (FIEK_16-1-2016-0005) </div> <div class="lastModified">Last Modified: 2023.07.07. 12:15 Andrea Vándor (VA, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:17 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Boglárka Zámbó, Zsuzsa Bartos, László Homolya and Balázs Sarkadi contributed equally to this work.</pre> </div></div>