@misc{MTMT:35431401, title = {A TRIGLICERID, ILLETVE A FENOFIBRÁT KEZELÉS HATÁSÁNAK VIZSGÁLATA AORTA-VENA CAVA SHUNTTEL KIALAKÍTOTT VOLUMENTERHELÉSES PATKÁNY SZÍV MODELLBEN}, url = {https://m2.mtmt.hu/api/publication/35431401}, isbn = {9786156457523}, author = {Árva, Hédi and Huliák, Ildikó and Szűcs, Gergő and Csont, Tamás Bálint and Matejka, Zsombor and Csontné Kiricsi, Mónika}, unique-id = {35431401}, year = {2024}, orcid-numbers = {Szűcs, Gergő/0000-0003-1874-2718; Csont, Tamás Bálint/0000-0001-5792-2768; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:34687262, title = {Preparation, characterization and in vitro evaluation of the antimicrobial and antitumor activity of MnOx nanoparticles}, url = {https://m2.mtmt.hu/api/publication/34687262}, author = {Rónavári, Andrea and Ochirkhuyag, Altantuya and Igaz, Nóra and Szerencsés, Bettina and Ballai, Gergő and Huliák, Ildikó and Bocz, Csenge and Kovács, Ákos and Pfeiffer, Ilona and Csontné Kiricsi, Mónika and Kónya, Zoltán}, doi = {10.1016/j.colsurfa.2024.133528}, journal-iso = {COLLOID SURFACE A}, journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS}, volume = {688}, unique-id = {34687262}, issn = {0927-7757}, year = {2024}, eissn = {1873-4359}, orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Ochirkhuyag, Altantuya/0000-0001-6495-7360; Igaz, Nóra/0000-0003-1580-4397; Pfeiffer, Ilona/0000-0003-0680-7596; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Kónya, Zoltán/0000-0002-9406-8596} } @article{MTMT:34147665, title = {Medicinal-Chemistry-Driven Approach to 2-Substituted Benzoxazole–Estradiol Chimeras: Synthesis, Anticancer Activity, and Early ADME Profile}, url = {https://m2.mtmt.hu/api/publication/34147665}, author = {Kovács, Ferenc and Huliák, Ildikó and Árva, Hédi and Csontné Kiricsi, Mónika and Erdős, Dóra and Kocsis, Marianna and Takács, Gergely and Balogh, György Tibor and Nagyné Frank, Éva}, doi = {10.1002/cmdc.202300352}, journal-iso = {CHEMMEDCHEM}, journal = {CHEMMEDCHEM}, volume = {18}, unique-id = {34147665}, issn = {1860-7179}, abstract = {The efficient synthesis of novel estradiol‐based A‐ring‐fused oxazole derivatives, which can be considered as benzoxazole‐steroid domain‐integrated hybrids containing a common benzene structural motif, is described. The target compounds were prepared from steroidal 2‐aminophenol precursors by heterocycle formation or functional group interconversion (FGI) strategies. According to 2D projection‐based t‐distributed stochastic neighbor embedding (t‐SNE), the novel molecules were proved to represent a new chemical space among steroid drugs. They were characterized based on critical physicochemical parameters using in silico and experimental data. The performance of the compounds to inhibit cell proliferation was tested on four human cancer cell lines and non‐cancerous cells. Further examinations were performed to reveal IC50 and lipophilic ligand efficiency (LLE) values, cancer cell selectivity, and apoptosis‐triggering features. Pharmacological tests and LLE metric revealed that some derivatives, especially the 2‐(4‐ethylpiperazin‐1‐yl)oxazole derivative exhibit strong anticancer activity and trigger the apoptosis of cancer cells with relatively low promiscuity risk similarly to the structurally most closely‐related and intensively studied anticancer agent, 2‐methoxy‐estradiol.}, year = {2023}, eissn = {1860-7187}, orcid-numbers = {Csontné Kiricsi, Mónika/0000-0002-8416-2052; Balogh, György Tibor/0000-0003-3347-1880; Nagyné Frank, Éva/0000-0002-1332-0551} } @article{MTMT:34070423, title = {Semi-synthetic dihydrotestosterone derivatives modulate inherent multidrug resistance and sensitize colon cancer cells to chemotherapy}, url = {https://m2.mtmt.hu/api/publication/34070423}, author = {Nagy, Ferenc István and Gopisetty, Mohana Krishna and Huliák, Ildikó and Nagyné Frank, Éva and Csontné Kiricsi, Mónika}, journal-iso = {FEBS OPEN BIO}, journal = {FEBS OPEN BIO}, volume = {13}, unique-id = {34070423}, issn = {2211-5463}, year = {2023}, eissn = {2211-5463}, pages = {66-66}, orcid-numbers = {Gopisetty, Mohana Krishna/0000-0002-4310-3478; Nagyné Frank, Éva/0000-0002-1332-0551; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:33634274, title = {Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy}, url = {https://m2.mtmt.hu/api/publication/33634274}, author = {Nagy, Ferenc István and Adamecz, Dóra Izabella and Baji, Ádám and Kiricsi, Ágnes and Huliák, Ildikó and Rónavári, Andrea and Kónya, Zoltán and Nagyné Frank, Éva and Gopisetty, Mohana Krishna and Csontné Kiricsi, Mónika}, doi = {10.3390/pharmaceutics15020584}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {15}, unique-id = {33634274}, issn = {1999-4923}, abstract = {Multidrug resistance (MDR) is a serious hurdle to successful cancer therapy. Here, we examined the efficiency of novel semi-synthetic dihydrotestosterone derivatives, more specifically androstano-arylpyrimidines in inhibiting the efflux activity of ATP-binding cassette (ABC) transporters and sensitizing inherently MDR colon cancer cells to various chemotherapy drugs. Using the Rhodamine123 accumulation assay, we evaluated the efflux activity of cancer cells following treatments with androstano-arylpyrimidines. We found that acetylated compounds were capable of attenuating the membrane efflux of inherently MDR cells; however, deacetylated counterparts were ineffective. To delineate the possible molecular mechanisms underlying these unique activities of androstano-arylpyrimidines, the degree of apoptosis induction was assessed by AnnexinV-based assays, both upon the individual as well as by steroid and chemotherapy agent combination treatments. Five dihydrotestosterone derivatives applied in combination with Doxorubicin or Epirubicin triggered massive apoptosis in MDR cells, and these combinations were more efficient than chemotherapy drugs together with Verapamil. Furthermore, our results revealed that androstano-arylpyrimidines induced significant endoplasmic reticulum stress (ER stress) but did not notably modulate ABC transporter expression. Therefore, ER stress triggered by acetylated androstano-arylpyrimidines is probably involved in the mechanism of efflux pump inhibition and drug sensitization which can be targeted in future drug developments to defeat inherently multidrug-resistant cancer.}, year = {2023}, eissn = {1999-4923}, orcid-numbers = {Adamecz, Dóra Izabella/0000-0002-1883-9600; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Nagyné Frank, Éva/0000-0002-1332-0551; Gopisetty, Mohana Krishna/0000-0002-4310-3478; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @misc{MTMT:35431263, title = {METABOLIKUS SZABÁLYOZÓ GÉNEK EXPRESSZIÓS VIZSGÁLATA PATKÁNYMODELLBEN}, url = {https://m2.mtmt.hu/api/publication/35431263}, isbn = {9786158205481}, author = {Árva, Hédi and Huliák, Ildikó and Leprán, István and Csontné Kiricsi, Mónika}, unique-id = {35431263}, year = {2022}, orcid-numbers = {Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @mastersthesis{MTMT:32474165, title = {Tumor-asszociált miofibroblasztok genetikai, epigenetikai, transzkripciós és funkcionális jellemzői [Genetic, epigenetic, transcriptional and functional comparison of tumor-associated and adjacent normal myofibroblasts]}, url = {https://m2.mtmt.hu/api/publication/32474165}, author = {Huliák, Ildikó}, doi = {10.14232/phd.10787}, publisher = {SZTE}, unique-id = {32474165}, year = {2021} } @article{MTMT:30350391, title = {Genetic, epigenetic and transcriptional comparison of esophagus tumor‑associated and adjacent normal myofibroblasts}, url = {https://m2.mtmt.hu/api/publication/30350391}, author = {Huliák, Ildikó and Bodai, László and Czepán, Mátyás and Kovács, Dávid and Szabó, Anikó and Tiszlavicz, László and Lázár, György ifj and Rakonczay, Zoltán and Hegyi, Péter and Boros, Imre Miklós and Csontné Kiricsi, Mónika}, doi = {10.3892/or.2018.6909}, journal-iso = {ONCOL REP}, journal = {ONCOLOGY REPORTS}, volume = {41}, unique-id = {30350391}, issn = {1021-335X}, abstract = {Myofibroblasts (MFs) are present in healthy tissues and are also key components of the tumor microenvironment. In the present study a comparative analysis of MFs obtained from various gastrointestinal tumor tissues and from tumor‑adjacent normal tissues of cancer patients was performed, with the aim to evaluate differences in MF morphology, gene expression profile and function. The goal was to correlate the observed morphological and functional variations with the underlying genetic and epigenetic backgrounds. The mutation frequency of MFs was assessed by next generation sequencing. The transcript levels of cancer‑specific genes were determined by TaqMan array and quantitative polymerase chain reaction. Epigenetic modifications were analyzed by immunocytochemistry and western blotting. The migratory capacity of MFs was assessed by scratch assay, whereas matrix metalloproteinase expression and activity were obtained by quantitative polymerase chain reaction and zymography. The results of the present study demonstrate that MFs were present in an increased number and with altered morphology in tumor samples compared with the healthy tissue. Although the detected number of mutations in tumor‑associated and normal tissue‑derived MFs did not differ markedly, shifts in the level of specific acetylated and methylated histone proteins, namely decreased levels of trimethylated H3K9 and acetylated H4K16 were demonstrated in tumor‑associated MFs. Transcript levels of several tumor‑specific genes involved in metastasis, regulation of cellular growth, apoptosis, as well as in hypoxia‑angiogenesis were altered in tumor‑derived MF cultures. Increased mRNA levels were obtained and activity of matrix metalloproteases in tumor‑derived MFs and these cells also exhibited a higher migratory capacity compared with the normal MFs. In summary, the results of the present study indicate that tumor‑associated MFs display an altered phenotype compared with healthy tissue derived counterparts. The results imply that epigenetic rather than genetic alterations are associated with the development of the distinct expressional and functional features, which define this MF phenotype in the tumor microenvironment.}, year = {2019}, eissn = {1791-2431}, pages = {839-852}, orcid-numbers = {Bodai, László/0000-0001-8411-626X; Kovács, Dávid/0000-0002-5706-5126; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978; Rakonczay, Zoltán/0000-0002-1499-3416; Hegyi, Péter/0000-0003-0399-7259; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @CONFERENCE{MTMT:3414115, title = {Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage}, url = {https://m2.mtmt.hu/api/publication/3414115}, author = {Borsos, Barbara Nikolett and Huliák, Ildikó and Majoros, Hajnalka and Újfaludi, Zsuzsanna and Gyenis, Ákos and Pukler, Peter and Boros, Imre Miklós and Pankotai, Tibor}, booktitle = {9th Central European Genome Stability and Dynamics Meeting}, unique-id = {3414115}, year = {2018}, orcid-numbers = {Majoros, Hajnalka/0000-0003-2020-971X; Újfaludi, Zsuzsanna/0000-0003-4738-0963; Boros, Imre Miklós/0000-0001-8504-9687; Pankotai, Tibor/0000-0001-9810-5465} } @CONFERENCE{MTMT:3333842, title = {Beyond Initiation: Human P53 Plays Role in Transcription Elongation}, url = {https://m2.mtmt.hu/api/publication/3333842}, author = {Borsos, Barbara Nikolett and Majoros, Hajnalka and Huliák, Ildikó and Újfaludi, Zsuzsanna and Boros, Imre Miklós and Pankotai, Tibor}, booktitle = {Ubiquitin and SUMO: From molecular mechanisms to system-wide responses}, unique-id = {3333842}, year = {2017}, pages = {95}, orcid-numbers = {Majoros, Hajnalka/0000-0003-2020-971X; Újfaludi, Zsuzsanna/0000-0003-4738-0963; Boros, Imre Miklós/0000-0001-8504-9687; Pankotai, Tibor/0000-0001-9810-5465} }