TY - BOOK AU - Árva, Hédi AU - Huliák, Ildikó AU - Szűcs, Gergő AU - Csont, Tamás Bálint AU - Matejka, Zsombor AU - Csontné Kiricsi, Mónika TI - A TRIGLICERID, ILLETVE A FENOFIBRÁT KEZELÉS HATÁSÁNAK VIZSGÁLATA AORTA-VENA CAVA SHUNTTEL KIALAKÍTOTT VOLUMENTERHELÉSES PATKÁNY SZÍV MODELLBEN PY - 2024 SN - 9786156457523 UR - https://m2.mtmt.hu/api/publication/35431401 ID - 35431401 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Besleaga, Iuliana AU - Raptova, Renata AU - Stoica, Alexandru-Constantin AU - Milunović, Miljan N.M. AU - Zalibera, Michal AU - Bai, Ruoli AU - Igaz, Nóra AU - Reynisson, Johannes AU - Csontné Kiricsi, Mónika AU - Enyedy, Éva Anna AU - Rapta, P. AU - Hamel, Ernest AU - Arion, Vladimir TI - Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? JF - DALTON TRANSACTIONS J2 - DALTON T VL - 53 PY - 2024 IS - 29 SP - 12349 EP - 12369 PG - 21 SN - 1477-9226 DO - 10.1039/D4DT01469C UR - https://m2.mtmt.hu/api/publication/35081780 ID - 35081780 AB - Quite recently we discovered that copper(II) complexes with isomeric morpholine-thiosemicarbazone (morph-TSCs) hybrid ligands show good cytotoxicity in cancer cells and that the molecular target responsible for this activity might be... LA - English DB - MTMT ER - TY - JOUR AU - Molnár-Gáspár, Renáta AU - Nógrádi-Halmi, Dóra AU - Demján, Virág AU - Diószegi, Petra AU - Igaz, Nóra AU - Vincze, Anna AU - Pipicz, Márton AU - Csontné Kiricsi, Mónika AU - Vécsei, László AU - Csont, Tamás Bálint TI - Kynurenic acid protects against ischemia/reperfusion injury by modulating apoptosis in cardiomyocytes JF - APOPTOSIS J2 - APOPTOSIS VL - 29 PY - 2024 IS - 9-10 SP - 1483 EP - 1498 PG - 16 SN - 1360-8185 DO - 10.1007/s10495-024-02004-w UR - https://m2.mtmt.hu/api/publication/35176616 ID - 35176616 N1 - RG, VD and DNH were supported by the New National Excellence Program of the Ministry of Human Capacities (ÚNKP-22-5-SZTE-562, ÚNKP-19-3-SZTE-47, ÚNKP-20-2-SZTE-64) AB - Acute myocardial infarction, often associated with ischemia/reperfusion injury (I/R), is a leading cause of death worldwide. Although the endogenous tryptophan metabolite kynurenic acid (KYNA) has been shown to exert protection against I/R injury, its mechanism of action at the cellular and molecular level is not well understood yet. Therefore, we examined the potential involvement of antiapoptotic mechanisms, as well as N-methyl-D-aspartate (NMDA) receptor modulation in the protective effect of KYNA in cardiac cells exposed to simulated I/R (SI/R). KYNA was shown to attenuate cell death induced by SI/R dose-dependently in H9c2 cells or primary rat cardiomyocytes. Analysis of morphological and molecular markers of apoptosis (i.e., membrane blebbing, apoptotic nuclear morphology, DNA double-strand breaks, activation of caspases) revealed considerably increased apoptotic activity in cardiac cells undergoing SI/R. The investigated apoptotic markers were substantially improved by treatment with the cytoprotective dose of KYNA. Although cardiac cells were shown to express NMDA receptors, another NMDA antagonist structurally different from KYNA was unable to protect against SI/R-induced cell death. Our findings provide evidence that the protective effect of KYNA against SI/R-induced cardiac cell injury involves antiapoptotic mechanisms, that seem to evoke independently of NMDA receptor signaling. LA - English DB - MTMT ER - TY - JOUR AU - Rónavári, Andrea AU - Ochirkhuyag, Altantuya AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Ballai, Gergő AU - Huliák, Ildikó AU - Bocz, Csenge AU - Kovács, Ákos AU - Pfeiffer, Ilona AU - Csontné Kiricsi, Mónika AU - Kónya, Zoltán TI - Preparation, characterization and in vitro evaluation of the antimicrobial and antitumor activity of MnOx nanoparticles JF - COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS J2 - COLLOID SURFACE A VL - 688 PY - 2024 SN - 0927-7757 DO - 10.1016/j.colsurfa.2024.133528 UR - https://m2.mtmt.hu/api/publication/34687262 ID - 34687262 LA - English DB - MTMT ER - TY - CONF AU - Adamecz, Dóra Izabella AU - Petra, Bicskei AU - Árva, Hédi AU - Igaz, Nóra AU - Veres, Éva AU - Rónavári, Andrea AU - Gácser, Attila AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - The possible modulatory effects of metal nanoparticles on macrophage polarization in co-culture T2 - Abstracts for the 47th FEBS Congress PY - 2023 UR - https://m2.mtmt.hu/api/publication/34154600 ID - 34154600 LA - English DB - MTMT ER - TY - CONF AU - Veres, Éva AU - Szilovics, Zóra AU - Adamecz, Dóra Izabella AU - Gergő, Svorenj AU - Buzás, Krisztina AU - Csontné Kiricsi, Mónika AU - Gácser, Attila ED - Wolf, Holnthoner ED - Edit, Buzas ED - Metka, Lenassi ED - Maja, Kosanović TI - Examination of the interaction between oral squamous cell carcinoma and Candida species at the level of extracellular vesicles T2 - Small New World 2.0 PB - Medical University of Graz C1 - Graz SN - 9788690562602 PY - 2023 SP - 101 EP - 101 PG - 1 UR - https://m2.mtmt.hu/api/publication/35417440 ID - 35417440 LA - English DB - MTMT ER - TY - CONF AU - Igaz, Nóra AU - Szőke, Krisztina AU - Bocz, Csenge AU - Kovács, Dávid AU - Rónavári, Andrea AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Buhala, Andrea AU - Vizler, Csaba AU - Tiszlavicz, László AU - Rázga, Zsolt AU - Hideghéty, Katalin AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors T2 - FAMÉ 2023 PY - 2023 SP - 75 EP - 76 PG - 2 UR - https://m2.mtmt.hu/api/publication/34154565 ID - 34154565 LA - English DB - MTMT ER - TY - BOOK ED - Kónya, Zoltán ED - Csontné Kiricsi, Mónika TI - A Magyar Tudományos Akadémia Analítikai és Környezetkémiai Bizottságának 11. Környezetkémiai Szimpóziuma. (2023) PY - 2023 SP - 19 SN - 9789633069547 UR - https://m2.mtmt.hu/api/publication/34205216 ID - 34205216 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Ferenc AU - Huliák, Ildikó AU - Árva, Hédi AU - Csontné Kiricsi, Mónika AU - Erdős, Dóra AU - Kocsis, Marianna AU - Takács, Gergely AU - Balogh, György Tibor AU - Nagyné Frank, Éva TI - Medicinal-Chemistry-Driven Approach to 2-Substituted Benzoxazole–Estradiol Chimeras: Synthesis, Anticancer Activity, and Early ADME Profile JF - CHEMMEDCHEM J2 - CHEMMEDCHEM VL - 18 PY - 2023 IS - 22 PG - 9 SN - 1860-7179 DO - 10.1002/cmdc.202300352 UR - https://m2.mtmt.hu/api/publication/34147665 ID - 34147665 N1 - Department of Molecular and Analytical Chemistry, University of Szeged, Dóm tér 7–8, Szeged, 6720, Hungary Department of Biochemistry and Molecular Biology, Doctoral School of Biology, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, 1111, Hungary Mcule.com Kft., Bartók Béla út 105–113, Budapest, 1115, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. 9, Budapest, 1085, Hungary Export Date: 13 October 2023 CODEN: CHEMG Correspondence Address: Frank, É.; Department of Molecular and Analytical Chemistry, Dóm tér 7–8, Hungary; email: frank@chem.u-szeged.hu Correspondence Address: Balogh, G.T.; Department of Chemical and Environmental Process Engineering, Műegyetem rkp. 3, Hungary; email: balogh.gyorgy.tibor@semmelwies.hu AB - The efficient synthesis of novel estradiol‐based A‐ring‐fused oxazole derivatives, which can be considered as benzoxazole‐steroid domain‐integrated hybrids containing a common benzene structural motif, is described. The target compounds were prepared from steroidal 2‐aminophenol precursors by heterocycle formation or functional group interconversion (FGI) strategies. According to 2D projection‐based t‐distributed stochastic neighbor embedding (t‐SNE), the novel molecules were proved to represent a new chemical space among steroid drugs. They were characterized based on critical physicochemical parameters using in silico and experimental data. The performance of the compounds to inhibit cell proliferation was tested on four human cancer cell lines and non‐cancerous cells. Further examinations were performed to reveal IC50 and lipophilic ligand efficiency (LLE) values, cancer cell selectivity, and apoptosis‐triggering features. Pharmacological tests and LLE metric revealed that some derivatives, especially the 2‐(4‐ethylpiperazin‐1‐yl)oxazole derivative exhibit strong anticancer activity and trigger the apoptosis of cancer cells with relatively low promiscuity risk similarly to the structurally most closely‐related and intensively studied anticancer agent, 2‐methoxy‐estradiol. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Ferenc István AU - Gopisetty, Mohana Krishna AU - Huliák, Ildikó AU - Nagyné Frank, Éva AU - Csontné Kiricsi, Mónika TI - Semi-synthetic dihydrotestosterone derivatives modulate inherent multidrug resistance and sensitize colon cancer cells to chemotherapy JF - FEBS OPEN BIO J2 - FEBS OPEN BIO VL - 13 PY - 2023 IS - S2 SP - 66 EP - 66 PG - 1 SN - 2211-5463 UR - https://m2.mtmt.hu/api/publication/34070423 ID - 34070423 LA - English DB - MTMT ER -