TY - JOUR AU - Szinger, Dávid AU - Berki, Tímea AU - Drenjančević, Ines AU - Samardzic, Senka AU - Zelić, Marija AU - Sikora, Magdalena AU - Požgain, Arlen AU - Markovics, Ákos AU - Borbásné Farkas, Kornélia AU - Németh, Péter AU - Böröcz, Katalin TI - Raising Epidemiological Awareness : Assessment of Measles/MMR Susceptibility in Highly Vaccinated Clusters within the Hungarian and Croatian Population-A Sero-Surveillance Analysis JF - VACCINES (BASEL) J2 - VACCINES-BASEL VL - 12 PY - 2024 IS - 5 PG - 23 SN - 2076-393X DO - 10.3390/vaccines12050486 UR - https://m2.mtmt.hu/api/publication/34878179 ID - 34878179 N1 - Department of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, Pécs, 7624, Hungary Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia Scientific Centre for Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia Department of Public Health, Teaching Institute of Public Health for The Osijek-Baranja County, Osijek, 31000, Croatia Department of Microbiology, Parasitology and Clinical Laboratory Diagnostics, Medical Faculty of Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia Department of General and Physical Chemistry, Faculty of Natural Sciences, University of Pécs, Pécs, 7622, Hungary Department of Bioanalysis, Medical School, University of Pécs, Szigeti u. 12, Pécs, 7643, Hungary Export Date: 5 June 2024 Correspondence Address: Böröcz, K.; Department of Immunology and Biotechnology, Hungary; email: borocz.katalin@pte.hu AB - Perceptions of the complete eradication of vaccine-preventable diseases such as measles, mumps, and rubella (MMR) may foster complacency and compromise vaccination efforts. Decreased measles vaccination rates during the COVID-19 pandemic have heightened the risk of outbreaks, even in adequately vaccinated populations. To address this, we have aligned with ECDC recommendations, leveraging previous cross-border sero-epidemiological assessments between Pécs, Hungary, and Osijek, Croatia, to identify latent risk groups and uncover potential parallels between our nations. Testing 2680 Hungarian and 1764 Croatian serum samples for anti-MMR IgG via ELISAs revealed anti-measles seropositivity ratios below expectations in Croatian cohorts aged ~20-30 (75.7%), ~30-40 (77.5%) and ~40-50 years (73.3%). Similarly, Hungarian samples also showed suboptimal seropositivity ratios in the ~30-40 (80.9%) and ~40-50 (87.3%) age groups. Considering mumps- and rubella-associated seropositivity trends, in both examined populations, individuals aged ~30-50 years exhibited the highest vulnerability. Additionally, we noted congruent seropositivity trends across both countries, despite distinct immunization and epidemiological contexts. Therefore, we propose expanding research to encompass the intricate dynamics of vaccination, including waning long-term immunity. This understanding could facilitate targeted interventions and bolster public awareness. Our findings underscore persistent challenges in attaining robust immunity against measles despite vaccination endeavors. LA - English DB - MTMT ER - TY - JOUR AU - Böröcz, Katalin AU - Samardžić, Senka AU - Drenjančević, Ines AU - Markovics, Ákos AU - Berki, Tímea AU - Németh, Péter TI - Dynamic Features of Herd Immunity: Similarities in Age-Specific Anti-Measles Seroprevalence Data between Two Countries of Different Epidemiological History JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 11 PY - 2022 IS - 4 PG - 8 SN - 2077-0383 DO - 10.3390/jcm11041145 UR - https://m2.mtmt.hu/api/publication/32699595 ID - 32699595 LA - English DB - MTMT ER - TY - JOUR AU - Böröcz, Katalin AU - Markovics, Ákos AU - Csizmadia, Zsuzsanna AU - Najbauer, József AU - Berki, Tímea AU - Németh, Péter TI - Imported Infections Versus Herd Immunity Gaps; A Didactic Demonstration of Compartment Models Through the Example of a Minor Measles Outbreak in Hungary JF - SOUTHEASTERN EUROPEAN MEDICAL JOURNAL J2 - SOUTHEAST EUR MED J VL - 5 PY - 2021 IS - 1 SP - 1 EP - 16 PG - 16 SN - 2459-9484 UR - https://m2.mtmt.hu/api/publication/31996319 ID - 31996319 LA - English DB - MTMT ER - TY - JOUR AU - Böröcz, Katalin AU - Csizmadia, Zsuzsanna AU - Markovics, Ákos AU - Borbásné Farkas, Kornélia AU - Najbauer, József AU - Berki, Tímea AU - Németh, Péter TI - Application of a fast and cost-effective ‘three-in-one’ MMR ELISA as a tool for surveying anti-MMR humoral immunity: the Hungarian experience JF - EPIDEMIOLOGY AND INFECTION J2 - EPIDEMIOL INFECT VL - 148 PY - 2020 PG - 12 SN - 0950-2688 DO - 10.1017/S0950268819002280 UR - https://m2.mtmt.hu/api/publication/31164687 ID - 31164687 LA - English DB - MTMT ER - TY - JOUR AU - Böröcz, Katalin AU - Csizmadia, Zsuzsanna AU - Markovics, Ákos AU - Meszaros, V AU - Borbásné Farkas, Kornélia AU - Telek, Vivien AU - Varga, V AU - Maloba, GO AU - Bodó, Kornélia AU - Najbauer, József AU - Berki, Tímea AU - Németh, Péter TI - Development of a robust and standardized immunoserological assay for detection of anti-measles IgG antibodies in human sera. JF - JOURNAL OF IMMUNOLOGICAL METHODS J2 - J IMMUNOL METHODS VL - 464 PY - 2019 SP - 1 EP - 8 PG - 8 SN - 0022-1759 DO - 10.1016/j.jim.2018.07.009 UR - https://m2.mtmt.hu/api/publication/3401786 ID - 3401786 AB - Because of measles outbreaks there is a need for continuous monitoring of immunological protection against infection at population level. For such monitoring to be feasible, a cost-effective, reliable and high-throughput assay is necessary. Herein we describe an ELISA protocol for assessment of anti-measles antibody levels in human serum samples that fulfills the above criteria and is easily adaptable by various laboratories. A serum bank of anonymous patient sera was established (N>3000 samples). Sera were grouped based on measles immunization schedules and/or changes in vaccine components since the introduction of the first measles vaccine in Hungary in 1969. Newly designed ELISA was performed by using Siemens BEP 2000 Advance System and data were confirmed using commercially available kits. Our indirect ELISA was compared to indirect immunfluoresence and to anti-measles nucleocapsid (N) monoclonal antibody-based sandwich ELISA. The results obtained are in high agreement with the confirmatory methods, and reflect measles vaccination history in Hungary ranging from pre-vaccination era, through the initial period of measles vaccination, to present. Based on measurement of 1985 sera, the highest ratio of low/questionable antibody level samples was detected in cluster '1978-1987' (~25.4%), followed by cluster '1969-1977' (~15.4%).Our assay is suitable for assessment of anti-measles immunity in a large cohort of subjects. The assay is cost-effective, allows high-throughput screening and has superior signal-to-noise ratio. This assay can serve as a first step in assessment of the effectiveness of all three components of the MMR vaccine. LA - English DB - MTMT ER - TY - JOUR AU - Markovics, Ákos AU - Kovács, Barna TI - Optical Ammonia Sensors for Environmental Applications JF - ANALYTICAL LETTERS J2 - ANAL LETT VL - 47 PY - 2014 IS - 3 SP - 465 EP - 477 PG - 13 SN - 0003-2719 DO - 10.1080/00032719.2013.843188 UR - https://m2.mtmt.hu/api/publication/2777546 ID - 2777546 AB - Triphenyl-methane based indicators bromophenol blue and bromocresol green were immobilized in ormosil sol-gel films prepared from phenyl-triethoxysilane in order to prepare colorimetric ammonia sensors. The sensing layers contained different molar ratios of the indicators, in this way-depending on the pKa values of the indicators-sensors with tailored dynamic ranges could be fabricated. Adsorption based immobilization was also used for the fabrication of chemical layers immersing anodized aluminum films in aqueous solutions of the indicators. Simultaneous immobilization of the indicators was considerably effortful on the anodized aluminum film, compared with the sol-gel film; therefore, the significant temperature dependency of the sensor response was used to shift the dynamic range. The effect of an ionic liquid additive was also investigated to increase the lifetime of these sensors. All sensors were tested spectrophotometrically, although a simple reflection based read-out device was also constructed using two light emitting diodes as light sources and two photodiodes as detectors. The device did not produce a concentration dependent signal but gave a digital yes or no (1 or 0) indicating that ammonia concentrations had reached a preset level. © 2014 Copyright Taylor and Francis Group, LLC. LA - English DB - MTMT ER - TY - THES AU - Markovics, Ákos TI - Új típusú rétegek optikai ammónia érzékelőkhöz PY - 2013 SP - 105 UR - https://m2.mtmt.hu/api/publication/33771485 ID - 33771485 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Markovics, Ákos AU - Kovács, Barna TI - Fabrication of optical chemical ammonia sensors using anodized alumina supports and sol–gel method JF - TALANTA J2 - TALANTA VL - 109 PY - 2013 IS - 0 SP - 101 EP - 106 PG - 6 SN - 0039-9140 DO - 10.1016/j.talanta.2013.01.054 UR - https://m2.mtmt.hu/api/publication/2241729 ID - 2241729 N1 - Funding Agency and Grant Number: Developing Competitiveness of Universities in the South Transdanubian Region [SROP-4.2.1.B-10/2/KONV-2010-0002] Funding text: The work was partly supported by "Developing Competitiveness of Universities in the South Transdanubian Region" (Grant no. SROP-4.2.1.B-10/2/KONV-2010-0002). AB - In this comparative study, the fabrication and the sensing properties of various reflectometric optical ammonia gas sensors are described. In the first set of experiments the role of the support material was investigated on four different sensor membranes. Two of them were prepared by the adsorption of bromocresol green indicator on anodized aluminum plates. The applied anodizing voltages were 12 V and 24 V, which resulted in different dynamic ranges and response times for gaseous ammonia. The sol–gel method was used for the preparation of the other batch of sensors. These layers were coated on anodized aluminum plates (24 V) and on standard microscope cover glasses. In spite of the identical sensing chemistry, slightly different response times were measured merely because of the aluminum surface porosity. Gas molecules can remain entrapped in the pores, which results in delayed recovery time. On the other hand, the porous oxide film provides excellent adhesion, making the anodized aluminum an attractive support for the sol–gel layer. LA - English DB - MTMT ER - TY - CHAP AU - Gouveia, C AU - Markovics, Ákos AU - Baptista, J M AU - Kovács, Barna AU - Jorge, P A S ED - Orlando, Frazao TI - Measurement of CO2 using refractometric fiber optic sensors. 3rd WSEAS International Conference on Sensors and Signals, SENSIG'10, 3rd WSEAS International Conference on Materials Science, MATERIALS'10 TS - 3rd WSEAS International Conference on Sensors and Signals, SENSIG'10, 3rd WSEAS International Conference on Materials Science, MATERIALS'10 T2 - Advances in Sensors, Signals and Materials - 3rd WSEAS International Conference on Sensors and Signals, SENSIG'10, 3rd WSEAS International Conference on Materials Science, MATERIALS'10 PB - World Scientific and Engineering Academy and Society (WSEAS) CY - Faro SN - 9789604742486 PY - 2010 SP - 169 EP - 173 PG - 5 UR - https://m2.mtmt.hu/api/publication/1748381 ID - 1748381 AB - An indicator free optical fiber sensor for determination of carbon dioxide is presented. The sensing layer is based on the acid-basic equilibrium of phenol and of its derivative p-nitro-phenol that, in the presence of CO2, are prone to protonation introducing refractive index changes. The new sensitive layer is characterized and tested in different refractometric fiber optic sensor configurations. Using a fiber based interferometric setup, a CO 2 dependent refractive index change of ∼0.05 RIU is observed, in the 10%-90% CO2 concentration range, demonstrating the membrane viability. Preliminary results are presented for an all-fiber LPG-based carbon dioxide sensor. LA - English DB - MTMT ER - TY - JOUR AU - Kasik, Ivan AU - Mrazek, Jan AU - Podrazky, Ondrej AU - Seidl, Miroslav AU - Aubrecht, Jan AU - Tobiska, Petr AU - Pospisilova, Marie AU - Matejec, Vlastimil AU - Kovács, Barna AU - Markovics, Ákos AU - Szili, Mónika TI - Fiber-optic detection of chlorine in water JF - SENSORS AND ACTUATORS B-CHEMICAL J2 - SENSOR ACTUAT B CHEM VL - 139 PY - 2009 IS - 1 SP - 139 EP - 142 PG - 4 SN - 0925-4005 DO - 10.1016/j.snb.2008.10.064 UR - https://m2.mtmt.hu/api/publication/1608446 ID - 1608446 N1 - Institute of Photonics and Electronics ASCR, v.v.i., Chaberska 57, 182 51 Prague 8, Czech Republic Faculty of Science, University of Pecs, Ifjusag utja 6, H-7624 Pecs, Hungary Cited By :20 Export Date: 17 January 2024 CODEN: SABCE Correspondence Address: Kasik, I.; Institute of Photonics and Electronics ASCR, v.v.i., Chaberska 57, 182 51 Prague 8, Czech Republic; email: kasik@ufe.cz AB - Monitoring of the chlorine content represents important issue of the control of water quality. Crucial points of this control are detection of low chlorine concentrations around 1 ppm and reversibility of chemical reactions between strong oxidation agent, chlorine and opto-chemical transducers used for the detection. This paper deals with fiber-optic detection of chlorine in water by using a commercially available absorption transducer o-phenylenediamine (o-PDA) electrochemically immobilized onto fiber-optic substrates coated with Indium-Tin-Oxide (ITO). Sensitive layers of the absorption transducer o-PDA were prepared electrochemically by cyclic voltammetry. The layers were applied onto declad segments of polymer-clad silica fibers coated with a thin conductive ITO layer making the electrochemical deposition possible. Prepared detection elements were exposed to aqueous solutions of chlorine of various concentrations and spectral response and time response curves were measured. Oxidized sensitive layers were regenerated chemically by using a solution of sodium thiosulfate. A limit of detection of chlorine in water of about 0.14 ppm has been achieved, making the detection of chlorine in water within the hygienic limits feasible. LA - English DB - MTMT ER -