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Doctoral School of Biology, University of Szeged, Szeged, Hungary
Institute of Biophysics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary
Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
HUN-REN Biophysical Virology Research Group, Budapest, Hungary
Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary
Export Date: 27 March 2024
Correspondence Address: Juhász, G.; HUN-REN Biological Research Centre Szeged, Temesvari krt. 62, Hungary; email: juhasz.gabor@brc.hu
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10025119"> <a href="/gui2/?type=authors&mode=browse&sel=10025119" target="_blank">Laczkó-Dobos, Hajnalka</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10064022"> <a href="/gui2/?type=authors&mode=browse&sel=10064022" target="_blank">Bhattacharjee, Arindam</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10069500"> <a href="/gui2/?type=authors&mode=browse&sel=10069500" target="_blank">Maddali, Asha Kiran</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032015"> <a href="/gui2/?type=authors&mode=browse&sel=10032015" target="_blank">Kincses, András</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10081548"> <a href="/gui2/?type=authors&mode=browse&sel=10081548" target="_blank">Abuammar, Hussein</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011600"> <a href="/gui2/?type=authors&mode=browse&sel=10011600" target="_blank">Sebők-Nagy, Krisztina</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10007583"> <a href="/gui2/?type=authors&mode=browse&sel=10007583" target="_blank">Páli, Tibor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10009032"> <a href="/gui2/?type=authors&mode=browse&sel=10009032" target="_blank">Dér, András</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015687"> <a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs, Tamás</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10024943"> <a href="/gui2/?type=authors&mode=browse&sel=10024943" target="_blank">Csordás, Gábor</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34724664" mtid="34724664" target="_blank">PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion</a></div> <div class="pub-info"> <span class="journal-title">AUTOPHAGY</span> <span class="journal-volume">0</span> <span class="page"> p. 0 </span> <span class="year">(2024)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1080/15548627.2024.2322493" target="_blank" href="https://doi.org/10.1080/15548627.2024.2322493"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001180966000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001180966000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85187160275" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85187160275"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38411137" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38411137&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:34724664 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Published </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" mtid="10025119"><a
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(<span class="authorship-author-name">Laczkó-Dobos Hajnalka</span>
<span class="authorAux-mtmt"> fejlődésgenetika</span>)
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Genetics</span>
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<span class="author-name" mtid="10064022"><a
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<span class="authorAux-mtmt"> Genetics</span>)
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Genetics</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Genetics</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Biophysics</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Genetics</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Biophysics</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Biophysics</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Biophysics</span>
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<span class="author-name" mtid="10015687"><a
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<span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/HUN-REN-SE Biophysical Virology Research Group</span>
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<span class="author-name" mtid="10024943"><a
href="/gui2/?type=authors&mode=browse&sel=10024943" target="_blank">Csordás Gábor
(<span class="authorship-author-name">Csordás Gábor</span>
<span class="authorAux-mtmt"> genetika</span>)
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Genetics</span>
;
<span class="author-name" mtid="10000590"><a
href="/gui2/?type=authors&mode=browse&sel=10000590" target="_blank">Juhász Gábor ✉
(<span class="authorship-author-name">Juhász Gábor</span>
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<span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Institute of Genetics</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34724664" target="_blank">PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion</a></div> <div> <span class="journal-title">AUTOPHAGY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8627">1554-8627</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8635">1554-8635</a>)</span>:
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Number of cited publications: 1
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<div class="mtid"><span class="long-pub-mtid">Publication: 34724664</span>
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<div class="funder"> (LP2023-6), (BO-00/761/21), (BO-00/870/23), (K127961) Funder: NRDIO, (K146634), (PD128280), (PD143268), (KKP129797) Funder: NRDIO, (PD135587), (SHE-19314-004/2019) </div>
<div class="lastModified">Last Modified: 2024.03.19. 13:41 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary
Doctoral School of Biology, University of Szeged, Szeged, Hungary
Institute of Biophysics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary
Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary ...</pre>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;33731782" target="_blank">Plasma membrane Ca2+ pump isoform 4 function in cell migration and cancer metastasis</a></div> <div> <span class="journal-title">JOURNAL OF PHYSIOLOGY-LONDON</span>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Basu, S. </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015687"> <a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs, T.</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Kurgan, L. ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34163279" mtid="34163279" target="_blank">CoMemMoRFPred: Sequence-based Prediction of MemMoRFs by Combining Predictors of Intrinsic Disorder, MoRFs and Disordered Lipid-binding Regions</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF MOLECULAR BIOLOGY</span> <span class="journal-volume">435</span> : <span class="journal-issue">21</span> <span class="page"> Paper: 168272 , 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.jmb.2023.168272" target="_blank" href="https://doi.org/10.1016/j.jmb.2023.168272"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001083627600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001083627600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85171535617" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85171535617"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37709009" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37709009&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:34163279 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/ELKH-SE Biophysical Virology Research Group</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34163279" target="_blank">CoMemMoRFPred: Sequence-based Prediction of MemMoRFs by Combining Predictors of Intrinsic Disorder, MoRFs and Disordered Lipid-binding Regions</a></div> <div> <span class="journal-title">JOURNAL OF MOLECULAR BIOLOGY</span>
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<div class="lastModified">Last Modified: 2023.11.03. 08:41 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 17 November 2023
CODEN: JMOBA
Correspondence Address: Kurgan, L.; Department of Computer Science, 401 West Main Street, Room E4225, United States; email: lkurgan@vcu.edu</pre>
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Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop
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The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, residing in a structurally unresolved cytoplasmic region (a.a. 354–367) of ABCG2 on the function and trafficking of this protein. A cluster of four lysines (K357–360) and the phosphorylation of a threonine (T362) residue in this region have been previously suggested to significantly affect the cellular fate of ABCG2. Here, we report that the naturally occurring K360del variant in human cells increased ABCG2 plasma membrane expression and accelerated cellular trafficking. The variable alanine replacements of the neighboring lysines had no significant effect on transport function, and the apical localization of ABCG2 in polarized cells has not been altered by any of these mutations. Moreover, in contrast to previous reports, we found that the phosphorylation-incompetent T362A, or the phosphorylation-mimicking T362E variants in this loop had no measurable effects on the function or expression of ABCG2. Molecular dynamics simulations indicated an increased mobility of the mutant variants with no major effects on the core structure of the protein. These results may help to decipher the potential role of this unstructured region within this transporter.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10073889"> <a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner, Orsolya</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10053932"> <a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó, Boglárka</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10054127"> <a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos, Zsuzsa</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Gergely, Anna </span> <span class="author-type"> </span> ; <span class="author-name" > Szabó, Kata Sára </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10068186"> <a href="/gui2/?type=authors&mode=browse&sel=10068186" target="_blank">Jezsó, Bálint</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027670"> <a href="/gui2/?type=authors&mode=browse&sel=10027670" target="_blank">Telbisz, Ágnes</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015754"> <a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady, György</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10010446"> <a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya, László</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015687"> <a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs, Tamás ✉</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34175360" mtid="34175360" target="_blank">Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop</a></div> <div class="pub-info"> <span class="journal-title">MEMBRANES (BASEL)</span> <span class="journal-volume">13</span> : <span class="journal-issue">10</span> <span class="page"> Paper: 822 , 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/membranes13100822" target="_blank" href="https://doi.org/10.3390/membranes13100822"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001095372000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001095372000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175065302" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175065302"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37887994" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37887994&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:34175360 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Published </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Zsuzsa (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> PhD hallgató</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ; <span class="author-name" >Gergely Anna </span> ; <span class="author-name" >Szabó Kata Sára </span> ; <span class="author-name" mtid="10068186"><a href="/gui2/?type=authors&mode=browse&sel=10068186" target="_blank">Jezsó Bálint (<span class="authorship-author-name">Jezsó Bálint</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Biochemistry</span> ; <span class="author-name" mtid="10027670"><a href="/gui2/?type=authors&mode=browse&sel=10027670" target="_blank">Telbisz Ágnes (<span class="authorship-author-name">Telbisz Ágnes Mária</span> <span class="authorAux-mtmt"> Biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya László (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs Tamás ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;34175360" target="_blank">Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop</a></div> <div> <span class="journal-title">MEMBRANES (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0375">2077-0375</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">10</span> <span class="page"> Paper 822. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/membranes13100822" target="_blank" href="https://doi.org/10.3390/membranes13100822"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001095372000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001095372000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175065302" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175065302"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37887994" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37887994&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34175360&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34175360</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFIH-K-128123) Funder: NRDIO, (K127961) Funder: NRDIO, (K137610), (KDP-1017403) </div> <div class="lastModified">Last Modified: 2024.02.15. 13:35 Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) </div> </div></div>
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Synergistic Inhibitory Effect of Quercetin and Cyanidin-3O-Sophoroside on ABCB1
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The human ABCB1 (P-glycoprotein, Pgp) protein is an active exporter expressed in the plasma membrane of cells forming biological barriers. In accordance with its broad substrate spectrum and tissue expression pattern, it affects the pharmacokinetics of numerous chemotherapeutic drugs and it is involved in unwanted drug–drug interactions leading to side effects or toxicities. When expressed in tumor tissues, it contributes to the development of chemotherapy resistance in malignancies. Therefore, the understanding of the molecular details of the ligand–ABCB1 interactions is of crucial importance. In a previous study, we found that quercetin (QUR) hampers both the transport and ATPase activity of ABCB1, while cyandin-3O-sophroside (C3S) stimulates the ATPase activity and causes only a weak inhibition of substrate transport. In the current study, when QUR and C3S were applied together, both a stronger ATPase inhibition and a robust decrease in substrate transport were observed, supporting their synergistic ABCB1 inhibitory effect. Similar to cyclosporine A, a potent ABCB1 inhibitor, co-treatment with QUR and C3S shifted the conformational equilibrium to the “inward-facing” conformer of ABCB1, as it was detected by the conformation-selective UIC2 mAb. To gain deeper insight into the molecular details of ligand–ABCB1 interactions, molecular docking experiments and MD simulations were also carried out. Our in silico studies support that QUR and C3S can bind simultaneously to ABCB1. The most favourable ligand–ABCB1 interaction is obtained when C3S binds to the central substrate binding site and QUR occupies the “access tunnel”. Our results also highlight that the strong ABCB1 inhibitory effect of the combined treatment with QUR and C3S may be exploited in chemotherapy protocols for the treatment of multidrug-resistant tumors or for improving drug delivery through pharmacological barriers.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10090173"> <a href="/gui2/?type=authors&mode=browse&sel=10090173" target="_blank">Singh, Kuljeet</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Patil, Rajesh B. </span> <span class="author-type"> </span> ; <span class="author-name" > Patel, Vikas </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032955"> <a href="/gui2/?type=authors&mode=browse&sel=10032955" target="_blank">Remenyik, Judit</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015687"> <a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs, Tamás</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000653"> <a href="/gui2/?type=authors&mode=browse&sel=10000653" target="_blank">Goda, Katalin ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34077112" mtid="34077112" target="_blank">Synergistic Inhibitory Effect of Quercetin and Cyanidin-3O-Sophoroside on ABCB1</a></div> <div class="pub-info"> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-volume">24</span> : <span class="journal-issue">14</span> <span class="page"> Paper: 11341 , 24 p. </span> <span class="year">(2023)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms241411341" target="_blank" href="https://doi.org/10.3390/ijms241411341"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001038603500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001038603500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85165937457" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85165937457"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37511101" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37511101&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:34077112 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10090173"><a href="/gui2/?type=authors&mode=browse&sel=10090173" target="_blank">Singh Kuljeet (<span class="authorship-author-name">Singh Kuljeet</span> <span class="authorAux-mtmt"> Drug resistance, cancer biology, ABC transporters</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biophysics and Cell Biology; 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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Soya, N. </span> <span class="author-type"> </span> ; <span class="author-name" > Xu, H. </span> <span class="author-type"> </span> ; <span class="author-name" > Roldan, A. </span> <span class="author-type"> </span> ; <span class="author-name" > Yang, Z. </span> <span class="author-type"> </span> ; <span class="author-name" > Ye, H. </span> <span class="author-type"> </span> ; <span class="author-name" > Jiang, F. </span> <span class="author-type"> </span> ; <span class="author-name" > Premchandar, A. </span> <span class="author-type"> </span> ; <span class="author-name" > Veit, G. </span> <span class="author-type"> </span> ; <span class="author-name" > Cole, S.P.C. </span> <span class="author-type"> </span> ; <span class="author-name" > Kappes, J. </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34257929" mtid="34257929" target="_blank">Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling</a></div> <div class="pub-info"> <span class="journal-title">NATURE COMMUNICATIONS</span> <span class="journal-volume">14</span> : <span class="journal-issue">1</span> <span class="page"> Paper: 6868 , 21 p. </span> <span class="year">(2023)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41467-023-42586-8" target="_blank" href="https://doi.org/10.1038/s41467-023-42586-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001091497000012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001091497000012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175197724" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175197724"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37891162" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37891162&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:34257929 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Soya N. </span> ; <span class="author-name" >Xu H. </span> ; <span class="author-name" >Roldan A. </span> ; <span class="author-name" >Yang Z. </span> ; <span class="author-name" >Ye H. </span> ; <span class="author-name" >Jiang F. </span> ; <span class="author-name" >Premchandar A. </span> ; <span class="author-name" >Veit G. </span> ; <span class="author-name" >Cole S.P.C. </span> ; <span class="author-name" >Kappes J. </span> ; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedüs T. (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/ELKH-SE Biophysical Virology Research Group</span> ; <span class="author-name" >Lukacs G.L. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;34257929" target="_blank">Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling</a></div> <div> <span class="journal-title">NATURE COMMUNICATIONS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-1723">2041-1723</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-1723">2041-1723</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">1</span> <span class="page"> Paper 6868. 21 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41467-023-42586-8" target="_blank" href="https://doi.org/10.1038/s41467-023-42586-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001091497000012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001091497000012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175197724" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175197724"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37891162" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37891162&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34257929&sort=publishedYear,desc&sort=title"> Number of cited publications: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34257929</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2023.11.06. 13:22 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> </div></div>
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Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1
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Cystic fibrosis (CF) is a frequent genetic disease in Caucasians that is caused by the deletion of F508 (DF508) in the nucleotide binding domain 1 (NBD1) of the CF transmembrane conductance regulator (CFTR). The DF508 compromises the folding energetics of the NBD1, as well as the folding of three other CFTR domains. Combination of FDA approved corrector molecules can efficiently but incompletely rescue the DF508-CFTR folding and stability defect. Thus, new pharmacophores that would reinstate the wildtype-like conformational stability of the DF508-NBD1 would be highly beneficial. The most prominent molecule, 5-bromoindole-3-acetic acid (BIA) that can thermally stabilize the NBD1 has low potency and efficacy. To gain insights into the NBD1 (un)folding dynamics and BIA binding site localization, we combined molecular dynamics (MD) simulations, atomic force spectroscopy (AFM) and hydrogendeuterium exchange (HDX) experiments. We found that the NBD1 a-subdomain with three adjacent strands from the b-subdomain plays an important role in early folding steps, when crucial non-native interactions are formed via residue F508. Our AFM and HDX experiments showed that BIA associates with this a-core region and increases the resistance of the DF508-NBD1 against mechanical unfolding, a phenomenon that could be exploited in future developments of folding correctors. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10029020"> <a href="/gui2/?type=authors&mode=browse&sel=10029020" target="_blank">Padányi, Rita</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10062898"> <a href="/gui2/?type=authors&mode=browse&sel=10062898" target="_blank">Farkas, Bianka<sup>*</sup></a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10010378"> <a href="/gui2/?type=authors&mode=browse&sel=10010378" target="_blank">Tordai, Hedvig</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10064582"> <a href="/gui2/?type=authors&mode=browse&sel=10064582" target="_blank">Kiss, Bálint</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Grubmüller, Helmut </span> <span class="author-type"> </span> ; <span class="author-name" > Soya, Naoto </span> <span class="author-type"> </span> ; <span class="author-name" > Lukács, Gergely L. </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013879"> <a href="/gui2/?type=authors&mode=browse&sel=10013879" target="_blank">Kellermayer, Miklós</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015687"> <a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs, Tamás ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32853643" mtid="32853643" target="_blank">Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1</a></div> <div class="pub-info"> <span class="journal-title">COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL</span> <span class="journal-volume">20</span> <span class="page"> pp. 2587-2599. , 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.csbj.2022.05.036" target="_blank" href="https://doi.org/10.1016/j.csbj.2022.05.036"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000812358200012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000812358200012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85131039699" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85131039699"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35685375" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35685375&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://linkinghub.elsevier.com/retrieve/pii/S2001037022001945" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S2001037022001945"> Other URL </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Locked</span> <span class="short-pub-mtid"> Publication:32853643 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Published </span></span> <span class="pub-core">Core Citing Suspect </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in Scopus: 1 | WoS/Scopus assigned: 1 | Number of citations with DOI: 1 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span>
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<span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span>
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<span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32853643" target="_blank">Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1</a></div> <div> <span class="journal-title">COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL</span>
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The number of unique transmembrane (TM) protein structures doubled in the last four years, which can be attributed to the revolution of cryo-electron microscopy. In addition, AlphaFold2 (AF2) also provided a large number of predicted structures with high quality. However, if a specific protein family is the subject of a study, collecting the structures of the family members is highly challenging in spite of existing general and protein domain-specific databases. Here, we demonstrate this and assess the applicability and usability of automatic collection and presentation of protein structures via the ABC protein superfamily. Our pipeline identifies and classifies transmembrane ABC protein structures using the PFAM search and also aims to determine their conformational states based on special geometric measures, conftors. Since the AlphaFold database contains structure predictions only for single polypeptide chains, we performed AF2-Multimer predictions for human ABC half transporters functioning as dimers. Our AF2 predictions warn of possibly ambiguous interpretation of some biochemical data regarding interaction partners and call for further experiments and experimental structure determination. We made our predicted ABC protein structures available through a web application, and we joined the 3D-Beacons Network to reach the broader scientific community through platforms such as PDBe-KB.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10010378"> <a href="/gui2/?type=authors&mode=browse&sel=10010378" target="_blank">Tordai, Hedvig</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10084842"> <a href="/gui2/?type=authors&mode=browse&sel=10084842" target="_blank">Suhajda, Erzsebet<sup>*</sup></a> </span> <span class="author-type"> </span> ; <span class="author-name" > Sillitoe, Ian </span> <span class="author-type"> </span> ; <span class="author-name" > Nair, Sreenath </span> <span class="author-type"> </span> ; <span class="author-name" > Varadi, Mihaly </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015687"> <a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedus, Tamas ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;33084278" mtid="33084278" target="_blank">Comprehensive Collection and Prediction of ABC Transmembrane Protein Structures in the AI Era of Structural Biology</a></div> <div class="pub-info"> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-volume">23</span> : <span class="journal-issue">16</span> <span class="page"> Paper: 8877 , 16 p. </span> <span class="year">(2022)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms23168877" target="_blank" href="https://doi.org/10.3390/ijms23168877"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000846710500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000846710500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137125327" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137125327"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36012140" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36012140&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:33084278 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Published </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 3 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus: 6 | WoS/Scopus assigned: 7 | Number of citations with DOI: 7 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10010378"><a href="/gui2/?type=authors&mode=browse&sel=10010378" target="_blank">Tordai Hedvig (<span class="authorship-author-name">Tordai Hedvig</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ; <span class="author-name" mtid="10084842"><a href="/gui2/?type=authors&mode=browse&sel=10084842" target="_blank">Suhajda Erzsebet<sup>*</sup> (<span class="authorship-author-name">Suhajda Erzébet</span> <span class="authorAux-mtmt"> Fizika</span>) </a> </span> <span class="author-affil"><span title="Wigner Research Centre for Physics">Wigner</span>/<span title="Institute for Solid State Physics and Optics">SZFI</span>/<span title="Komplex Folyadékok Osztály">KFO</span>/Részben rendezett rendszerek csoport</span> ; <span class="author-name" >Sillitoe Ian </span> ; <span class="author-name" >Nair Sreenath </span> ; <span class="author-name" >Varadi Mihaly </span> ; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedus Tamas ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/ELKH-SE Biophysical Virology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;33084278" target="_blank">Comprehensive Collection and Prediction of ABC Transmembrane Protein Structures in the AI Era of Structural Biology</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">16</span> <span class="page"> Paper 8877. 16 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms23168877" target="_blank" href="https://doi.org/10.3390/ijms23168877"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000846710500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000846710500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137125327" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137125327"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36012140" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36012140&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 3 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus: 6 | WoS/Scopus assigned: 7 | Number of citations with DOI: 7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33084278&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33084278</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (K127961) Funder: NRDIO, (K137610), (2020-2.1.1-ED-2021-00179), (HEGEDU20I0) </div> <div class="lastModified">Last Modified: 2024.02.07. 03:01 Andrea Kmety (MTA Wigner, admin) </div> </div></div>