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      <abstractText>BackgroundThe Ischemic Stroke System is a novel device designed to deliver stimulation to the sphenopalatine ganglion(SPG). The SPG sends parasympathetic innervations to the anterior cerebral circulation. In rat stroke models, SPG stimulation results in increased cerebral blood flow, reduced infarct volume, protects the blood brain barrier, and improved neurological outcome. We present here the results of a prospective, multinational, single-arm, feasibility study designed to assess the safety, tolerability, and potential benefit of SPG stimulation inpatients with acute ischemic stroke(AIS).MethodsPatients with anterior AIS, baseline NIHSS 7-20 and ability to initiate treatment within 24h from stroke onset, were implanted and treated with the SPG stimulation. Patients were followed up for 90 days. Effect was assessed by comparing the patient outcome to a matched population from the NINDS rt-PA trial placebo patients.ResultsNinety-eight patients were enrolled (mean age 57years, mean baseline NIHSS 12 and mean treatment time from stroke onset 19h). The observed mortality rate(12.2%), serious adverse events (SAE) incidence(23.5%) and nature of SAE were within the expected range for the population. The modified intention to treat cohort consisted of 84 patients who were compared to matched patients from the NINDS placebo arm. Patients treated with SPG stimulation had an average mRS lower by 0.76 than the historical controls(CMH test p = 0.001).ConclusionThe implantation procedure and the SPG stimulation, initiated within 24hr from stroke onset, are feasible, safe, and tolerable.</abstractText>
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(2019) PLOS ONE 1932-6203 14 7</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; &gt; Khurana, Dheeraj ✉ &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Kaul, Subhash &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Schneider, Dietmar &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10011385&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10011385&quot; target=&quot;_blank&quot;&gt;Csanyi, Attila&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Adam, Ilona &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Ichaporia, Nasli R. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Griewing, Bernd &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10000492&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000492&quot; target=&quot;_blank&quot;&gt;Csiba, Laszlo&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Valikovics, Attila &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Puri, Vinod &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; et al. &lt;/div &gt;&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;30879535&quot; mtid=&quot;30879535&quot; target=&quot;_blank&quot;&gt;Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). 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				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Neurology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt;
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2020.12.22. 13:38 Szuper Admin (admin)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: WoS:hiba:000321193900001 2019-03-07 22:31 cikkazonosító nem egyezik&lt;/pre&gt;
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            Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvárad tér 4, 1089 Budapest, Hungary            
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Third Department of Medicine, Kútvölgyi Clinical Center, Semmelweis University of Medicine, Kútvölgyi út 4, 1125 Budapest, Hungary            
            Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvárad tér 4, 1089 Budapest, Hungary            
            Department of Neurology, Aladár Petz Hospital, Vasvári Pál u. 2-4, 9023 Györ, Hungary            
            Department of Medicine, Affil. University of Rochester, School of Medicine and Dentistry, 1555 Long Pond Road, Rochester, NY 14626, United States            
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;1036590&quot; target=&quot;_blank&quot;&gt;Serum semicarbazide-sensitive amine oxidase (SSAO) activity is an independent marker of carotid atherosclerosis&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;CLINICA CHIMICA ACTA&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0009-8981&quot;&gt;0009-8981&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1873-3492&quot;&gt;1873-3492&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;323&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;1-2&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp 139-146
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2002)&lt;/span&gt;  
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				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Biochemistry (medical)&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q2&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Biochemistry&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q3&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Clinical Biochemistry&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q3&lt;/div&gt;
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2025.07.02. 00:31 Ladányi Gusztáv (MTMT API user, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Third Department of Medicine, Kútvölgyi Clinical Center, Semmelweis University of Medicine, Kútvölgyi út 4, 1125 Budapest, Hungary            
            Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvárad tér 4, 1089 Budapest, Hungary            
            Department of Neurology, Aladár Petz Hospital, Vasvári Pál u. 2-4, 9023 Györ, Hungary            
            D...&lt;/pre&gt;

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            Export Date: 7 September 2020            
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            Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvarad ter 4, H-1089 Budapest, Hungary
Cited By :6            
            Export Date: 26 July 2021            
            CODEN: NROBE            
            Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Nagyvarad ter 4, H-1089 Budapest, Hungary</comment>
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Cited By :6            
            Export Date: 7 September 2020            
            CODEN: NROBE            
            Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvarad ter 4, H-1089 Budapest, Hungary
Cited By :6            
            Export Date: 26 July 2021            
            CODEN: NROBE            
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&lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;MTA Támogatott Kutatócsoportok&quot;&gt;MTA TKI&lt;/span&gt;/MTA-SE Neurokémiai Kutatócsoport (2007-től társult tag)&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10000449&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000449&quot; target=&quot;_blank&quot;&gt;Karadi I (&lt;span class=&quot;authorship-author-name&quot;&gt;Karádi István&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Endokrinológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/III. 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Belgyógyászati Klinika&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10011385&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10011385&quot; target=&quot;_blank&quot;&gt;Csanyi A (&lt;span class=&quot;authorship-author-name&quot;&gt;Csányi Attila&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Neurológia, stroke, neurosonologia, elektrofizi...&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;Széchenyi István Egyetem&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; &gt;Szombathy T &lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10001049&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10001049&quot; target=&quot;_blank&quot;&gt;Romics L (&lt;span class=&quot;authorship-author-name&quot;&gt;Romics László&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Belgyógyászat&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/III. Sz. Belgyógyászati Klinika&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10000973&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000973&quot; target=&quot;_blank&quot;&gt;Magyar K (&lt;span class=&quot;authorship-author-name&quot;&gt;Magyar Kálmán&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Központi idegrendszer farmakobiokémiája&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;MTA Támogatott Kutatócsoportok&quot;&gt;MTA TKI&lt;/span&gt;/MTA-SE Neurokémiai Kutatócsoport (2007-től társult tag)&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;1036608&quot; target=&quot;_blank&quot;&gt;Determination of human serum semicarbazide-sensitive amine oxidase activity: a possible clinical marker of atherosclerosis&lt;/a&gt;&lt;/div&gt; &lt;div&gt; &lt;span class=&quot;journal-title&quot;&gt;EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS&lt;/span&gt; &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0378-7966&quot;&gt;0378-7966&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2107-0180&quot;&gt;2107-0180&lt;/a&gt;)&lt;/span&gt;: &lt;span class=&quot;journal-volume&quot;&gt;24&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; pp 299-302 &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(1999)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-footer&quot;&gt;  &lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv: Angol | &lt;/span&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;000087566800003&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/000087566800003&quot;&gt; WoS &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;0343183095&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-0343183095&quot;&gt; Scopus &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;10892891&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10892891&amp;dopt=Abstract&quot;&gt; PubMed &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt; &lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Pharmacology (medical)&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q2&lt;/div&gt; &lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Pharmacology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q3&lt;/div&gt; &lt;/div&gt;&lt;/OnlyViewableByAuthor&gt; &lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt; &lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 37&lt;/span&gt; | Független: 33 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 32 | Scopus jelölt:&amp;nbsp;34 | WoS/Scopus jelölt:&amp;nbsp;35 | DOI jelölt:&amp;nbsp;32 &lt;/div&gt;   &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 1036608&lt;/span&gt; | &lt;span class=&quot;status-data status-ADMIN_APPROVED&quot;&gt; Admin láttamozott &lt;/span&gt; &lt;span class=&quot;oldId&quot;&gt;Régi azonosító: 1036608&lt;/span&gt; | Forrás | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk ( Szakcikk ) &lt;/span&gt; | &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; | &lt;span class=&quot;publication-sourceOfData&quot;&gt;WOS&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;special-affiliations&quot;&gt; Speciális affiliáció: Akadémikus bibliográfia &lt;/div&gt; &lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2025.07.02. 01:30 Ladányi Gusztáv (MTMT API user, admin) &lt;/div&gt; &lt;/div&gt;&lt;/div&gt;</template2>
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