TY - JOUR AU - Khurana, Dheeraj AU - Kaul, Subhash AU - Schneider, Dietmar AU - Csányi, Attila AU - Adam, Ilona AU - Ichaporia, Nasli R. AU - Griewing, Bernd AU - Csiba, László AU - Valikovics, Attila AU - Puri, Vinod AU - Diener, Hans Christoph AU - Schwab, Stefan AU - Hetzel, Andreas AU - Bornstein, Natan ED - ImpACT-Study, Grp / Collaborative Organization TI - Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke JF - PLOS ONE J2 - PLOS ONE VL - 14 PY - 2019 IS - 7 PG - 14 SN - 1932-6203 DO - 10.1371/journal.pone.0217472 UR - https://m2.mtmt.hu/api/publication/30879535 ID - 30879535 AB - BackgroundThe Ischemic Stroke System is a novel device designed to deliver stimulation to the sphenopalatine ganglion(SPG). The SPG sends parasympathetic innervations to the anterior cerebral circulation. In rat stroke models, SPG stimulation results in increased cerebral blood flow, reduced infarct volume, protects the blood brain barrier, and improved neurological outcome. We present here the results of a prospective, multinational, single-arm, feasibility study designed to assess the safety, tolerability, and potential benefit of SPG stimulation inpatients with acute ischemic stroke(AIS).MethodsPatients with anterior AIS, baseline NIHSS 7-20 and ability to initiate treatment within 24h from stroke onset, were implanted and treated with the SPG stimulation. Patients were followed up for 90 days. Effect was assessed by comparing the patient outcome to a matched population from the NINDS rt-PA trial placebo patients.ResultsNinety-eight patients were enrolled (mean age 57years, mean baseline NIHSS 12 and mean treatment time from stroke onset 19h). The observed mortality rate(12.2%), serious adverse events (SAE) incidence(23.5%) and nature of SAE were within the expected range for the population. The modified intention to treat cohort consisted of 84 patients who were compared to matched patients from the NINDS placebo arm. Patients treated with SPG stimulation had an average mRS lower by 0.76 than the historical controls(CMH test p = 0.001).ConclusionThe implantation procedure and the SPG stimulation, initiated within 24hr from stroke onset, are feasible, safe, and tolerable. LA - English DB - MTMT ER - TY - JOUR AU - Németh, Dezső AU - Janacsek, Karolina AU - Király, K AU - Londe, Zs AU - Németh, Kornél AU - Fazekas, K AU - Ádám, I AU - Király, E E AU - Csányi, Attila TI - Probabilistic sequence learning in Mild Cognitive Impairment JF - FRONTIERS IN HUMAN NEUROSCIENCE J2 - FRONT HUM NEUROSCI VL - 7 PY - 2013 IS - JUN PG - 10 SN - 1662-5161 DO - 10.3389/fnhum.2013.00318 UR - https://m2.mtmt.hu/api/publication/2360549 ID - 2360549 N1 - WoS:hiba:000321193900001 2019-03-07 22:31 cikkazonosító nem egyezik AB - Mild Cognitive Impairment (MCI) causes slight but noticeable disruption in cognitive systems, primarily executive and memory functions. However, it is not clear if the development of sequence learning is affected by an impaired cognitive system and, if so, how. The goal of our study was to investigate the development of probabilistic sequence learning, from the initial acquisition to consolidation, in MCI and healthy elderly control groups. We used the Alternating Serial Reaction Time task (ASRT) to measure probabilistic sequence learning. Individuals with MCI showed weaker learning performance than the healthy elderly group. However, using the reaction times only from the second half of each learning block—after the reactivation phase—we found intact learning in MCI. Based on the assumption that the first part of each learning block is related to reactivation/recall processes, we suggest that these processes are affected in MCI. The 24-h offline period showed no effect on sequence-specific learning in either group but did on general skill learning: the healthy elderly group showed offline improvement in general reaction times while individuals with MCI did not. Our findings deepen our understanding regarding the underlying mechanisms and time course of sequence acquisition and consolidation. LA - English DB - MTMT ER - TY - JOUR AU - Diener, HC AU - Ringelstein, EB AU - von Kummer, RD AU - Landgraf, H AU - Koppenhagen, K AU - Harenberg, J AU - Rektor, I AU - Csányi, Attila AU - Schneider, D AU - Klingelhofer, J AU - Brom, J AU - Weidinger, G TI - Prophylaxis of thrombotic and embolic events in acute ischemic stroke with the low-molecular-weight heparin certoparin - Results of the PROTECT trial JF - STROKE J2 - STROKE VL - 37 PY - 2006 IS - 1 SP - 139 EP - 144 PG - 6 SN - 0039-2499 DO - 10.1161/01.STR.0000195182.67656.ee UR - https://m2.mtmt.hu/api/publication/30621566 ID - 30621566 AB - Background and Purpose - Patients with stroke are at substantial risk of thromboembolic complications and therefore require antithrombotic prophylaxis. To show the noninferiority of the low-molecular-weight heparin certoparin to unfractionated heparin (UFH) for the prevention of thromboembolic complications, we performed a randomized, double-blind, active-controlled multicenter trial in patients with acute ischemic stroke. LA - English DB - MTMT ER - TY - JOUR AU - Karádi, István AU - Mészáros, Zsuzsa AU - Csányi, Attila AU - Szombathy, T AU - Hosszúfalusi, Nóra AU - Romics, László AU - Magyar, Kálmán TI - Serum semicarbazide-sensitive amine oxidase (SSAO) activity is an independent marker of carotid atherosclerosis JF - CLINICA CHIMICA ACTA J2 - CLIN CHIM ACTA VL - 323 PY - 2002 IS - 1-2 SP - 139 EP - 146 PG - 8 SN - 0009-8981 DO - 10.1016/S0009-8981(02)00189-4 UR - https://m2.mtmt.hu/api/publication/1036590 ID - 1036590 N1 - Third Department of Medicine, Kútvölgyi Clinical Center, Semmelweis University of Medicine, Kútvölgyi út 4, 1125 Budapest, Hungary Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvárad tér 4, 1089 Budapest, Hungary Department of Neurology, Aladár Petz Hospital, Vasvári Pál u. 2-4, 9023 Györ, Hungary Department of Medicine, Affil. University of Rochester, School of Medicine and Dentistry, 1555 Long Pond Road, Rochester, NY 14626, United States Cited By :47 Export Date: 7 September 2020 CODEN: CCATA Correspondence Address: Szombathy, T.; Department of Medicine, University of Rochester, School of Medicine and Dentistry, 1555 Long Pond Road, Rochester, NY 14626, United States; email: szotam@hotmail.com Third Department of Medicine, Kútvölgyi Clinical Center, Semmelweis University of Medicine, Kútvölgyi út 4, 1125 Budapest, Hungary Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvárad tér 4, 1089 Budapest, Hungary Department of Neurology, Aladár Petz Hospital, Vasvári Pál u. 2-4, 9023 Györ, Hungary Department of Medicine, Affil. University of Rochester, School of Medicine and Dentistry, 1555 Long Pond Road, Rochester, NY 14626, United States Cited By :50 Export Date: 26 July 2021 CODEN: CCATA Correspondence Address: Szombathy, T.; Department of Medicine, 1555 Long Pond Road, Rochester, NY 14626, United States; email: szotam@hotmail.com LA - English DB - MTMT ER - TY - JOUR AU - Csányi, Attila AU - Egervari, A AU - Nagy, Zoltán TI - Influence of hypertension and smoking as the single vascular risk factors on the intima-media thickness JF - EUROPEAN JOURNAL OF EPIDEMIOLOGY J2 - EUR J EPIDEMIOL VL - 17 PY - 2001 IS - 9 SP - 855 EP - 861 PG - 7 SN - 0393-2990 DO - 10.1023/A:1015674024081 UR - https://m2.mtmt.hu/api/publication/1052649 ID - 1052649 LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, Zsuzsa AU - Csányi, Attila AU - Vallus, G AU - Szombathy, T AU - Karádi, István AU - Magyar, Kálmán TI - Inhibitor sensitivity of human serum and vascular semicarbazide-sensitive amine oxidases JF - NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES J2 - NEUROBIOLOGY VL - 8 PY - 2000 IS - 2 SP - 215 EP - 223 PG - 9 SN - 1216-8068 UR - https://m2.mtmt.hu/api/publication/1431249 ID - 1431249 N1 - Cited By :6 Export Date: 7 September 2020 CODEN: NROBE Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvarad ter 4, H-1089 Budapest, Hungary Cited By :6 Export Date: 26 July 2021 CODEN: NROBE Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Nagyvarad ter 4, H-1089 Budapest, Hungary AB - Recent data suggest that elevated serum semicarbazide-sensitive amine oxidase activity (SSAO) may cause endothelial injury. Formation of cytotoxic metabolites (especially formaldehyde) and increased oxidative stress might lead to initiation or progression of atherosclerosis. Effective and selective inhibitors of human SSAO might exert cytoprotective effect on endothelial cells. To compare the inhibitor sensitivity of human serum and vascular tissue SSAO enzyme, the inhibitory effect of semicarbazide and MDL 72974A was investigated. Serum and vascular SSAO activity has been determined using 14C-benzylamine as a substrate. The IC50 values of semicarbazide were estimated to be 5x10-3M and 5x10-4M for SSAO from human serum and saphenous vein, respectively. MDL 72974A amine oxidase inhibitor was more than thousand times more effective than semicarbazide. The IC50 values were 10-7M and 10-8M for SSAO from human serum and saphenous vein, respectively. This finding supports the hypothesis that soluble and membrane-bound vascular SSAO enzymes might have similar structure. LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, Zsuzsa AU - Karádi, István AU - Csányi, Attila AU - Szombathy, T AU - Romics, László AU - Magyar, Kálmán TI - Determination of human serum semicarbazide-sensitive amine oxidase activity: a possible clinical marker of atherosclerosis JF - EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS J2 - EUR J DRUG METAB PHARM VL - 24 PY - 1999 SP - 299 EP - 302 PG - 4 SN - 0378-7966 UR - https://m2.mtmt.hu/api/publication/1036608 ID - 1036608 LA - English DB - MTMT ER -