@article{MTMT:30879535, title = {Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke}, url = {https://m2.mtmt.hu/api/publication/30879535}, author = {Khurana, Dheeraj and Kaul, Subhash and Schneider, Dietmar and Csányi, Attila and Adam, Ilona and Ichaporia, Nasli R. and Griewing, Bernd and Csiba, László and Valikovics, Attila and Puri, Vinod and Diener, Hans Christoph and Schwab, Stefan and Hetzel, Andreas and Bornstein, Natan}, doi = {10.1371/journal.pone.0217472}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {14}, unique-id = {30879535}, abstract = {BackgroundThe Ischemic Stroke System is a novel device designed to deliver stimulation to the sphenopalatine ganglion(SPG). The SPG sends parasympathetic innervations to the anterior cerebral circulation. In rat stroke models, SPG stimulation results in increased cerebral blood flow, reduced infarct volume, protects the blood brain barrier, and improved neurological outcome. We present here the results of a prospective, multinational, single-arm, feasibility study designed to assess the safety, tolerability, and potential benefit of SPG stimulation inpatients with acute ischemic stroke(AIS).MethodsPatients with anterior AIS, baseline NIHSS 7-20 and ability to initiate treatment within 24h from stroke onset, were implanted and treated with the SPG stimulation. Patients were followed up for 90 days. Effect was assessed by comparing the patient outcome to a matched population from the NINDS rt-PA trial placebo patients.ResultsNinety-eight patients were enrolled (mean age 57years, mean baseline NIHSS 12 and mean treatment time from stroke onset 19h). The observed mortality rate(12.2%), serious adverse events (SAE) incidence(23.5%) and nature of SAE were within the expected range for the population. The modified intention to treat cohort consisted of 84 patients who were compared to matched patients from the NINDS placebo arm. Patients treated with SPG stimulation had an average mRS lower by 0.76 than the historical controls(CMH test p = 0.001).ConclusionThe implantation procedure and the SPG stimulation, initiated within 24hr from stroke onset, are feasible, safe, and tolerable.}, year = {2019}, eissn = {1932-6203} } @article{MTMT:2360549, title = {Probabilistic sequence learning in Mild Cognitive Impairment}, url = {https://m2.mtmt.hu/api/publication/2360549}, author = {Németh, Dezső and Janacsek, Karolina and Király, K and Londe, Zs and Németh, Kornél and Fazekas, K and Ádám, I and Király, E E and Csányi, Attila}, doi = {10.3389/fnhum.2013.00318}, journal-iso = {FRONT HUM NEUROSCI}, journal = {FRONTIERS IN HUMAN NEUROSCIENCE}, volume = {7}, unique-id = {2360549}, issn = {1662-5161}, abstract = {Mild Cognitive Impairment (MCI) causes slight but noticeable disruption in cognitive systems, primarily executive and memory functions. However, it is not clear if the development of sequence learning is affected by an impaired cognitive system and, if so, how. The goal of our study was to investigate the development of probabilistic sequence learning, from the initial acquisition to consolidation, in MCI and healthy elderly control groups. We used the Alternating Serial Reaction Time task (ASRT) to measure probabilistic sequence learning. Individuals with MCI showed weaker learning performance than the healthy elderly group. However, using the reaction times only from the second half of each learning block—after the reactivation phase—we found intact learning in MCI. Based on the assumption that the first part of each learning block is related to reactivation/recall processes, we suggest that these processes are affected in MCI. The 24-h offline period showed no effect on sequence-specific learning in either group but did on general skill learning: the healthy elderly group showed offline improvement in general reaction times while individuals with MCI did not. Our findings deepen our understanding regarding the underlying mechanisms and time course of sequence acquisition and consolidation.}, keywords = {Adult; Female; Male; ARTICLE; RECALL; human; controlled study; learning; clinical article; memory consolidation; CONSOLIDATION; MILD COGNITIVE IMPAIRMENT; mental performance; response time; Mental task; Skill learning; implicit learning; Offline learning; Statistical learning; Automaticity; Probabilistic sequence learning}, year = {2013}, eissn = {1662-5161}, orcid-numbers = {Németh, Dezső/0000-0002-9629-5856; Janacsek, Karolina/0000-0001-7829-8220} } @article{MTMT:30621566, title = {Prophylaxis of thrombotic and embolic events in acute ischemic stroke with the low-molecular-weight heparin certoparin - Results of the PROTECT trial}, url = {https://m2.mtmt.hu/api/publication/30621566}, author = {Diener, HC and Ringelstein, EB and von Kummer, RD and Landgraf, H and Koppenhagen, K and Harenberg, J and Rektor, I and Csányi, Attila and Schneider, D and Klingelhofer, J and Brom, J and Weidinger, G}, doi = {10.1161/01.STR.0000195182.67656.ee}, journal-iso = {STROKE}, journal = {STROKE}, volume = {37}, unique-id = {30621566}, issn = {0039-2499}, abstract = {Background and Purpose - Patients with stroke are at substantial risk of thromboembolic complications and therefore require antithrombotic prophylaxis. To show the noninferiority of the low-molecular-weight heparin certoparin to unfractionated heparin (UFH) for the prevention of thromboembolic complications, we performed a randomized, double-blind, active-controlled multicenter trial in patients with acute ischemic stroke.}, keywords = {VENOUS THROMBOSIS; cerebrovascular accident; HEPARIN}, year = {2006}, eissn = {1524-4628}, pages = {139-144}, orcid-numbers = {Harenberg, J/0000-0003-4590-4225} } @article{MTMT:1036590, title = {Serum semicarbazide-sensitive amine oxidase (SSAO) activity is an independent marker of carotid atherosclerosis}, url = {https://m2.mtmt.hu/api/publication/1036590}, author = {Karádi, István and Mészáros, Zsuzsa and Csányi, Attila and Szombathy, T and Hosszúfalusi, Nóra and Romics, László and Magyar, Kálmán}, doi = {10.1016/S0009-8981(02)00189-4}, journal-iso = {CLIN CHIM ACTA}, journal = {CLINICA CHIMICA ACTA}, volume = {323}, unique-id = {1036590}, issn = {0009-8981}, year = {2002}, eissn = {1873-3492}, pages = {139-146}, orcid-numbers = {Karádi, István/0000-0002-8253-2654; Hosszúfalusi, Nóra/0000-0002-9469-372X; Magyar, Kálmán/0000-0002-1852-3577} } @article{MTMT:1052649, title = {Influence of hypertension and smoking as the single vascular risk factors on the intima-media thickness}, url = {https://m2.mtmt.hu/api/publication/1052649}, author = {Csányi, Attila and Egervari, A and Nagy, Zoltán}, doi = {10.1023/A:1015674024081}, journal-iso = {EUR J EPIDEMIOL}, journal = {EUROPEAN JOURNAL OF EPIDEMIOLOGY}, volume = {17}, unique-id = {1052649}, issn = {0393-2990}, year = {2001}, eissn = {1573-7284}, pages = {855-861}, orcid-numbers = {Nagy, Zoltán/0000-0001-9756-5427} } @article{MTMT:1431249, title = {Inhibitor sensitivity of human serum and vascular semicarbazide-sensitive amine oxidases}, url = {https://m2.mtmt.hu/api/publication/1431249}, author = {Mészáros, Zsuzsa and Csányi, Attila and Vallus, G and Szombathy, T and Karádi, István and Magyar, Kálmán}, journal-iso = {NEUROBIOLOGY}, journal = {NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES}, volume = {8}, unique-id = {1431249}, issn = {1216-8068}, abstract = {Recent data suggest that elevated serum semicarbazide-sensitive amine oxidase activity (SSAO) may cause endothelial injury. Formation of cytotoxic metabolites (especially formaldehyde) and increased oxidative stress might lead to initiation or progression of atherosclerosis. Effective and selective inhibitors of human SSAO might exert cytoprotective effect on endothelial cells. To compare the inhibitor sensitivity of human serum and vascular tissue SSAO enzyme, the inhibitory effect of semicarbazide and MDL 72974A was investigated. Serum and vascular SSAO activity has been determined using 14C-benzylamine as a substrate. The IC50 values of semicarbazide were estimated to be 5x10-3M and 5x10-4M for SSAO from human serum and saphenous vein, respectively. MDL 72974A amine oxidase inhibitor was more than thousand times more effective than semicarbazide. The IC50 values were 10-7M and 10-8M for SSAO from human serum and saphenous vein, respectively. This finding supports the hypothesis that soluble and membrane-bound vascular SSAO enzymes might have similar structure.}, keywords = {ATHEROSCLEROSIS; SERUM; ARTICLE; human; controlled study; Support, Non-U.S. Gov't; clinical article; enzyme activity; enzyme inhibition; solubility; Diabetic Angiopathies; human tissue; Arteriosclerosis; benzylamine; Monoamine oxidase; cell protection; Muscle, Smooth, Vascular; varicosis; Monoamine Oxidase Inhibitors; Endothelium, Vascular; Diabetes Mellitus, Non-Insulin-Dependent; Butylamines; Allyl Compounds; saphenous vein; endothelium injury; mofegiline; Smooth muscle; Semicarbazide; Amine oxidase; Amine Oxidase (Copper-Containing); amine oxidase (copper containing); Oxidative stress}, year = {2000}, pages = {215-223}, orcid-numbers = {Karádi, István/0000-0002-8253-2654; Magyar, Kálmán/0000-0002-1852-3577} } @article{MTMT:1036608, title = {Determination of human serum semicarbazide-sensitive amine oxidase activity: a possible clinical marker of atherosclerosis}, url = {https://m2.mtmt.hu/api/publication/1036608}, author = {Mészáros, Zsuzsa and Karádi, István and Csányi, Attila and Szombathy, T and Romics, László and Magyar, Kálmán}, journal-iso = {EUR J DRUG METAB PHARM}, journal = {EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS}, volume = {24}, unique-id = {1036608}, issn = {0378-7966}, year = {1999}, eissn = {2107-0180}, pages = {299-302}, orcid-numbers = {Karádi, István/0000-0002-8253-2654; Magyar, Kálmán/0000-0002-1852-3577} }