The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta

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(2025) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490 122 16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Gudrun Meinhardt </span> ;    <span class="author-name" >Hanna Waldhäusl </span> ;    <span class="author-name" >Andreas I. Lackner </span> ;    <span class="author-name" >Jasmin Wächter </span> ;    <span class="author-name" >Theresa Maxian </span> ;    <span class="author-name" >Anna-Lena Höbler </span> ;    <span class="author-name" >Sigrid Vondra </span> ;    <span class="author-name" >Victoria Kunihs </span> ;    <span class="author-name" >Leila Saleh </span> ;    <span class="author-name" >Peter Haslinger </span> ;    <span class="author-name" >Peter Kiraly </span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Andras Szilagyi (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;    <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Nandor G. Than (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> ;    <span class="author-name" >Jürgen Pollheimer </span> ;    <span class="author-name" >Sandra Haider </span> ;    <span class="author-name" >Martin Knöfler ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36063062" target="_blank">The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta</a></div> <div> <span class="journal-title">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0027-8424">0027-8424</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1091-6490">1091-6490</a>)</span>: <span class="journal-volume">122</span> <span class="journal-issue">16</span> <span class="page"> Paper e2426385122. 11 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1073/pnas.2426385122" target="_blank" href="https://doi.org/10.1073/pnas.2426385122"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001477143300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001477143300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105003499505" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105003499505"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40228123" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40228123&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary   Rank: D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX   A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]   A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]   A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 4</span> | Independent citation: 3 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus: 3 | WoS/Scopus assigned: 4 | Number of citations with DOI: 4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36063062&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36063062</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing Suspect | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FIEK_16-1-2016-0005), (K128262), (K128262) </div> <div class="lastModified">Last Modified: 2025.05.18. 21:29 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> </div></div> JournalArticle 36313869 VALIDATED true Funding Agency and Grant Number: Hungarian Academy of Sciences (Momentum) [LP2014-7/2014, 2019-436]; Hungarian Research Network [HUN-REN SA-83/2021]; HUN-REN [TECH-2024-042]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [OTKA-K128262, 2024-2-1-1-EKP-2024-00004, FIEK-16-1-2016-0005, OTKA-K124862, 2020-1.1.2-PIACI-KFI-2021-00273, 2024-1.2.3-HU-RIZONT-2024-00062, 2019-2.1.7-ERANET-2020-00014, 2020-346] Funding text: The author(s) declare financial support was received for the research and/or publication of this article. This work was supported by grants from the Hungarian Academy of Sciences (Momentum LP2014-7/2014 to NGT, Premium postdoc 2019-436 to AB, Young Researcher to ET), the Hungarian Research Network (HUN-REN SA-83/2021 and HUN-REN TECH-2024-042 grant to NGT), and the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the OTKA-K128262 (to AS), 2024-2-1-1-EKOP-2024-00004 (to MP), FIEK-16-1-2016-0005, OTKA-K124862, 2020-1.1.2-PIACI-KFI-2021-00273, 2024-1.2.3-HU-RIZONT-2024-00062 and 2019-2.1.7-ERANET-2020-00014 (all to NGT) funding schemes, the latter under the frame of the European Union ERA PerMed (2020-346 grant). 0 false 2026-05-20T06:01:40.657+0000 2026-05-07T12:23:38.722+0000 2025-09-02T09:46:27.362+0000 true 10034624 Nagy Sándor /api/author/10034624 Author Sándor Nagy (szülészet-nőgyógyászat) true 10034624 2026-05-20T06:00:27.545+0000 2025-12-16T12:41:55.755+0000 true 10098493 Makkai Csilla /api/admin/10098493 Admin Csilla Makkai (SZE Szakreferens, admin) true 2025-12-23T00:43:00.601+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Tóth, Eszter Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface true true /api/journal/10023324 REVIEWED FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 16 1621168 1621168 18 2025 Funding 2057430 /api/funding/2057430 (LP2014-7/2014,) false true Funding 2057431 /api/funding/2057431 (HUN-REN SA-83/2021) Funder: HUN_REN false true Funding 2057432 /api/funding/2057432 (K128262) false true Funding 2057433 /api/funding/2057433 (2024-2-1-1-EKÖP-2024-00004) false true Funding 2057434 /api/funding/2057434 (FIEK-16-1-2016-0005) false true Funding 2057435 /api/funding/2057435 (K124862) false true Funding 2057436 /api/funding/2057436 Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2057437 /api/funding/2057437 (2024-1.2.3-HU-RIZONT-2024-00062) false true Funding 2057438 /api/funding/2057438 (2019-2.1.7-ERANET-2020-00014) false true Funding 2057439 /api/funding/2057439 ERA PerMed(2020-346 grant) Funder: EU false true true true 2025 true true true false true false GOLD 2026-05-20 false http://www.frontiersin.org/immunology 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 16 16 Q1 false false false false 2025-09-22T05:54:44.464+0000 Bioinformatika Tanszék (SE / AOK / I); Biológia Doktori Iskola (ELTE / TTK); Doktori Iskola (SE); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... 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Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface. (2025) FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025667"><a href="/gui2/?type=authors&mode=browse&sel=10025667" target="_blank">Tóth Eszter (<span class="authorship-author-name">Tóth Eszter</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté<sup>*</sup> (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;    <span class="author-name" mtid="10081331"><a href="/gui2/?type=authors&mode=browse&sel=10081331" target="_blank">Oravecz Orsolya (<span class="authorship-author-name">Oravecz Orsolya</span> <span class="authorAux-mtmt"> biológia, immunológia, molekuláris biológia, mi...</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology</span> ;    <span class="author-name" mtid="10100038"><a href="/gui2/?type=authors&mode=browse&sel=10100038" target="_blank">Farkas Emese (<span class="authorship-author-name">Farkas Emese</span> <span class="authorAux-mtmt"> reproduktív immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" mtid="10019319"><a href="/gui2/?type=authors&mode=browse&sel=10019319" target="_blank">Balogh Andrea (<span class="authorship-author-name">Balogh Andrea</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> ;    <span class="author-name" >Escher Claudia </span> ;    <span class="author-name" >Bober Magdalena </span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" >Hupuczi Petronella </span> ;    <span class="author-name" >Veress Lajos </span> ;    <span class="author-name" >Török Olga </span> ;    <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István University">Széchenyi István University</span>/<span title="Faculty of Health and Sport Sciences">FHSS</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" >Rinner Oliver </span> ;    <span class="author-name" >Erez Offer </span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> ;    <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;    <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department ; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36313869" target="_blank">Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">16</span> <span class="page"> Paper 1621168. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fimmu.2025.1621168" target="_blank" href="https://doi.org/10.3389/fimmu.2025.1621168"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001569279100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001569279100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105015399247" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105015399247"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40948775" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40948775&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105015399247&doi=10.3389%2ffimmu.2025.1621168&partnerID=40&md5=590f1db41dbcdf3ff44276a5ef667e8e" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105015399247&doi=10.3389%2ffimmu.2025.1621168&partnerID=40&md5=590f1db41dbcdf3ff44276a5ef667e8e"> Other URL </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105015399247?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105015399247?origin=resultslist"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Immunology   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy   Rank: Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus: 1 | WoS/Scopus assigned: 1 | Number of citations with DOI: 1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36313869&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36313869</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (LP2014-7/2014,), (HUN-REN SA-83/2021) Funder: HUN_REN, (K128262), (2024-2-1-1-EKÖP-2024-00004), (FIEK-16-1-2016-0005), (K124862), Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (2024-1.2.3-HU-RIZONT-2024-00062), (2019-2.1.7-ERANET-2020-00014), ERA PerMed(2020-346 grant) Funder: EU </div> <div class="lastModified">Last Modified: 2026.05.07. 14:23 Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian Academy of Sciences (Momentum) [LP2014-7/2014, 2019-436]; Hungarian Research Network [HUN-REN SA-83/2021]; HUN-REN [TECH-2024-042]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [OTKA-K128262, 2024-2-1-1-EKP-2024-00004, FIEK-16-1-2016-0005, OTKA-K124862, 2020-1.1.2-PIACI-KFI-2021-00273, 202...</pre> </div></div> JournalArticle 34477407 VALIDATED true Systems Biology of Reproduction Research Group, Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary Maternity Private Clinic of Obstetrics and Gynecology, Budapest, Hungary Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States Genesis Theranostix Group, Budapest, Hungary , NICHD/NIH/DHHS, Bethesda, MD, United States Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States Semmelweis University Doctoral School, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary Department of Surgery, School of Medicine, University of Pécs, Pécs, Hungary Department of Anesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary Faculty of Health and Sport Sciences, Széchenyi István University, Győr, Hungary Department of Obstetrics and Gynecology, School of Medicine, University of Debrecen, Debrecen, Hungary Department of Obstetrics and Gynecology, School of Medicine, Wayne State University School of Medicine, Detroit, MI, United States Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er Sheva, Israel Export Date: 09 January 2025; Cited By: 2; Correspondence Address: N.G. Than; Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 27 Baross Street, H-1088, Hungary; email: than.gabor@semmelweis.hu; CODEN: JRIMD 0 false 2026-05-07T11:29:16.818+0000 2025-06-04T07:35:07.245+0000 2024-01-04T11:50:08.153+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 2026-05-06T14:53:33.582+0000 2024-11-28T06:10:03.419+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2025-05-07T09:27:45.847+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Than, Nándor Gábor Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention true true /api/journal/2838 REVIEWED JOURNAL OF REPRODUCTIVE IMMUNOLOGY 0165-0378 1872-7603 true false 2838 false 2838 true 0165-0378 1872-7603 Journal FOREIGN 161 104172 104172 8 2024 The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings. Funding 2036049 /api/funding/2036049 (GINOP-2.1.7-15-2016-00415) false true Funding 2036050 /api/funding/2036050 (K128262) false true Funding 2036051 /api/funding/2036051 Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2036052 /api/funding/2036052 (2020-1.1.5-GYORSÍTÓSÁV-2021-00012) false true Funding 2036053 /api/funding/2036053 (2019-2.1.7-ERANET-2020-00014) false true true 2024 true true true false true false GOLD 2026-05-07 true https://doi.org/10.1016/j.jri.2023.104172 13 0 13 8 4 13 13 11 13 13 13 8 8 8 5 0 13 8 13 8 0 13 13 Q2 false 10012513,1373182 false false false 2024-01-03T12:48:56.801+0000 Aneszteziológiai és Intenzív Terápiás Klinika (SE / AOK / K); Doktori Iskola (SE); Egészség- és Sporttudományi Kar (SZE); Enzimológiai Intézet (TTK); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Sebészeti Klinika (PTE / ÁOK); Szülészeti és Nőgyógyászati Intézet (DE / ÁOK); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Szülészeti és Nőgyógyászati Tanszék (SZE / ESK) 10 61 11 14 0 true 10014568 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 113635671 /api/authorship/113635671 Than, Nándor Gábor ✉ [Than, Nándor Gábor (Rendszerbiológia), author] Institute of Enzymology (RCNS); Enzim_416 (IMLS); Department of Obsterics and Gynecology Baross S... (SU / FM / C / DOG) 1 0.071 true false true Author 10011696 /api/author/10011696 Nándor Gábor Than (Rendszerbiológia) Than Nándor Gábor true 10011696 true Than Nándor Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635672 /api/authorship/113635672 Romero, Roberto 2 0.071428575 false false false Romero Roberto true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635673 /api/authorship/113635673 Posta, Máté [Posta, Máté (Szülészet- és nőg...), author] Enzim_416 (IMLS); School of PhD Studies (SU) 3 0.071 false false false Author 10082656 /api/author/10082656 Máté Posta (Szülészet- és nőgyógyászat) Posta Máté true true Posta Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635674 /api/authorship/113635674 Györffy, Dániel [Györffy, Dániel (Bioinformatika), author] Institute of Enzymology (RCNS); Információs Technológiai és Bionikai Kar (PPCU) 4 0.071 false false false Author 10019484 /api/author/10019484 Dániel Györffy (Bioinformatika) Györffy Dániel true 10019484 true Györffy Dániel true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635675 /api/authorship/113635675 Szalai, Gábor [Szalai, Gábor (Radiológia), author] Surgery Clinic (UP / UPMS) 5 0.071428575 false false false Author 10025710 /api/author/10025710 Gábor Szalai (Radiológia) Szalai Gábor true 10025710 true Szalai Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635676 /api/authorship/113635676 Rossi, Simona W 6 0.071428575 false false false Rossi Simona W true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635677 /api/authorship/113635677 Szilágyi, András [Szilágyi, András (Bioinformatika), author] Institute of Enzymology (RCNS); Enzim_416 (IMLS) 7 0.071 false false false Author 10010376 /api/author/10010376 András Szilágyi (Bioinformatika) Szilágyi András true 10010376 true Szilágyi András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635678 /api/authorship/113635678 Hupuczi, Petronella [Hupuczi, Petronella (Aneszteziológia é...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C) 8 0.071428575 false false false Author 10012513 /api/author/10012513 Petronella Hupuczi (Aneszteziológia és intenzív terápia) Hupuczi Petronella true 10012513 true Hupuczi Petronella true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635679 /api/authorship/113635679 Nagy, Sándor [Nagy, Sándor (szülészet-nőgyógy...), author] Faculty of Health and Sport Sciences; Department of Obstetrics and Gynecology (FHSS) 9 0.071 false false false Author 10034624 /api/author/10034624 Sándor Nagy (szülészet-nőgyógyászat) Nagy Sándor true 10034624 true Nagy Sándor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635680 /api/authorship/113635680 Török, Olga [Török, Olga (szülészet-nőgyógy...), author] Department of Obstetrics and Gynecology (UD) 10 0.071428575 false false false Author 10039073 /api/author/10039073 Olga Török (szülészet-nőgyógyászat, klinikai genetika) Török Olga true 10039073 true Török Olga true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635681 /api/authorship/113635681 Tarca, Adi L 11 0.071428575 false false false Tarca Adi L true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635682 /api/authorship/113635682 Erez, Offer 12 0.071428575 false false false Erez Offer true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635683 /api/authorship/113635683 Ács, Nándor [Ács, Nándor (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG) 13 0.071 false false false Author 10013998 /api/author/10013998 Nándor Ács (Szülészet-nőgyógyászat) Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113635684 /api/authorship/113635684 Papp, Zoltán [Papp, Zoltán (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology Baross S... (SU / FM / C / DOG) 14 0.071 false true false Author 1373182 /api/author/1373182 Zoltán Papp (Szülészet-nőgyógyászat, klinikai genetika) Papp Zoltán true 1373182 true Papp Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25213299 /api/publicationidentifier/25213299 DOI: 10.1016/j.jri.2023.104172 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.jri.2023.104172 https://doi.org/10.1016/j.jri.2023.104172 false true PublicationIdentifier 31709499 /api/publicationidentifier/31709499 PPCE Publications: 3576 SwordSource 10035 /api/publicationsource/10035 PPCE Publications PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true PPKE Publikáció PPCE Publications https://publikacio.ppke.hu/id/eprint/@@@ true true true GOLD true 3576 https://publikacio.ppke.hu/id/eprint/3576 false true PublicationIdentifier 25445194 /api/publicationidentifier/25445194 WoS: 001147341400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001147341400001 https://www.webofscience.com/wos/woscc/full-record/001147341400001 false true PublicationIdentifier 25338207 /api/publicationidentifier/25338207 Scopus: 85182229542 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85182229542 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85182229542 false true PublicationIdentifier 25213298 /api/publicationidentifier/25213298 PubMed: 38141514 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38141514 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38141514&dopt=Abstract false true Keyword 1003856 /api/keyword/1003856 proteomics true 1003856 true Keyword 1003862 /api/keyword/1003862 personalized medicine true 1003862 true Keyword 1008071 /api/keyword/1008071 Screening true 1008071 true Keyword 1010236 /api/keyword/1010236 Prenatal Diagnosis true 1010236 true Keyword 1513174 /api/keyword/1513174 liquid biopsy true true Keyword 3278624 /api/keyword/3278624 Extracellular matrix-related pre-eclampsia true true Keyword 3278625 /api/keyword/3278625 Maternal anti-fetal rejection-type pre-eclampsia true true Keyword 3278626 /api/keyword/3278626 Metabolic pre-eclampsia true true Keyword 3278627 /api/keyword/3278627 Placental pre-eclampsia true true SjrRating 11472372 /api/sjrrating/11472372 sjr:Q2 (2024) Scopus - Immunology JOURNAL OF REPRODUCTIVE IMMUNOLOGY 0165-0378 1872-7603 120 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 Scopus - Immunology true 2403 true Q2 DIRECT true true /api/publication/34477407 Than Nándor Gábor et al. Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention. (2024) JOURNAL OF REPRODUCTIVE IMMUNOLOGY 0165-0378 1872-7603 161<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> ;    <span class="author-name" >Romero Roberto </span> ;    <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;    <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;    <span class="author-name" mtid="10025710"><a href="/gui2/?type=authors&mode=browse&sel=10025710" target="_blank">Szalai Gábor (<span class="authorship-author-name">Szalai Gábor</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Surgery Clinic</span> ;    <span class="author-name" >Rossi Simona W </span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" mtid="10012513"><a href="/gui2/?type=authors&mode=browse&sel=10012513" target="_blank">Hupuczi Petronella (<span class="authorship-author-name">Hupuczi Petronella</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy</span> ;    <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István University">Széchenyi István University</span>/Faculty of Health and Sport Sciences; <span title="Széchenyi István University">Széchenyi István University</span>/<span title="Faculty of Health and Sport Sciences">FHSS</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" mtid="10039073"><a href="/gui2/?type=authors&mode=browse&sel=10039073" target="_blank">Török Olga (<span class="authorship-author-name">Török Olga</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" >Tarca Adi L </span> ;    <span class="author-name" >Erez Offer </span> ;    <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34477407" target="_blank">Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention</a></div> <div> <span class="journal-title">JOURNAL OF REPRODUCTIVE IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0165-0378">0165-0378</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1872-7603">1872-7603</a>)</span>: <span class="journal-volume">161</span> <span class="page"> Paper 104172. 8 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.jri.2023.104172" target="_blank" href="https://doi.org/10.1016/j.jri.2023.104172"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="3576" target="_blank" href="https://publikacio.ppke.hu/id/eprint/3576"> PPCE Publications </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001147341400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001147341400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85182229542" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85182229542"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38141514" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38141514&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Immunology   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Obstetrics and Gynecology   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Reproductive Medicine   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 8 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus: 13 | WoS/Scopus assigned: 13 | Number of citations with DOI: 13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34477407&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34477407</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (GINOP-2.1.7-15-2016-00415), (K128262), Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (2020-1.1.5-GYORSÍTÓSÁV-2021-00012), (2019-2.1.7-ERANET-2020-00014) </div> <div class="lastModified">Last Modified: 2025.06.04. 09:35 Viktória Sifter (PPKE ITK admin 5) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Systems Biology of Reproduction Research Group, Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary Maternity Private Clinic of Obstetrics and Gynecology, Budapest, Hungary Department of...</pre> </div></div> JournalArticle 34563187 VALIDATED true Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, H-1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, H-1083, Hungary Doctoral School, Semmelweis University, Budapest, H-1085, Hungary Maternity Private Clinic of Obstetrics and Gynecology, Budapest, H-1126, Hungary Department of Surgery, Medical School, University of Pécs, Pécs, H-7624, Hungary Department of Obstetrics and Gynecology, Medical School, University of Debrecen, Debrecen, H-4032, Hungary Doctoral School of Biology, ELTE Eötvös Loránd University, Budapest, H-1117, Hungary Department of Pharmacology and Pharmacotherapy, Medical School, University of Debrecen, Debrecen, H-4032, Hungary Faculty of Health and Sport Sciences, Széchenyi István University, Győr, H-9026, Hungary Department of Pharmacology, Monash Biomedicine Discovery Institute, Clayton, 3168, Australia Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women’s Hospital, Parkville, 3052, Australia Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Be’er Sheva, 8410501, Israel Department of Obstetrics and Gynecology, Medical School, Wayne State University, Detroit, 48201, MI, United States Department of Obstetrics and Gynecology, Medical School, Semmelweis University, 27 Baross Street, Budapest, H-1088, Hungary Export Date: 09 January 2025; Cited By: 1; Correspondence Address: N.G. Than; Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Magyar Tudósok Körútja 2, H-1117, Hungary; email: than.gabor@semmelweis.hu 0 false 2026-05-05T15:21:10.588+0000 2024-11-28T06:10:30.246+0000 2024-02-07T08:40:55.120+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin Regina Szabó (ELTE TTK admin 5) true 2026-02-06T07:38:33.863+0000 2026-02-06T07:38:33.863+0000 2024-11-28T06:10:30.692+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2025-05-07T09:27:20.072+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Tóth, Eszter Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 3 1865 1865 23 2024 Miscarriages affect 50–70% of all conceptions and 15–20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1–5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pathophysiology of RPL is incomplete, and thus, reliable diagnostic/preventive tools are not yet available. Here, we aimed to define the diagnostic value of three placental proteins for RPL: human chorionic gonadotropin free beta-subunit (free-β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF). Blood samples were collected from women with RPL (n = 14) and controls undergoing elective termination of pregnancy (n = 30) at the time of surgery. Maternal serum protein concentrations were measured by BRAHMS KRYPTOR Analyzer. Daily multiple of median (dMoM) values were calculated for gestational age-specific normalization. To obtain classifiers, logistic regression analysis was performed, and ROC curves were calculated. There were differences in changes of maternal serum protein concentrations with advancing healthy gestation. Between 6 and 13 weeks, women with RPL had lower concentrations and dMoMs of free β-hCG, PAPP-A, and PlGF than controls. PAPP-A dMoM had the best discriminative properties (AUC = 0.880). Between 9 and 13 weeks, discriminative properties of all protein dMoMs were excellent (free β-hCG: AUC = 0.975; PAPP-A: AUC = 0.998; PlGF: AUC = 0.924). In conclusion, free-β-hCG and PAPP-A are valuable biomarkers for RPL, especially between 9 and 13 weeks. Their decreased concentrations indicate the deterioration of placental functions, while lower PlGF levels indicate problems with placental angiogenesis after 9 weeks. Funding 2036939 /api/funding/2036939 (LP2014-7/2014,) false true Funding 2036940 /api/funding/2036940 (Premium_2019-436) Funder: Premium Post-Doctoral Fellowship of the Hungarian Academy of Sciences false true Funding 2036941 /api/funding/2036941 (HUN-REN SA-83/2021) Funder: HUN_REN false true Funding 2036942 /api/funding/2036942 (FIEK-16-1-2016-0005) false true Funding 2036943 /api/funding/2036943 (K124862) false true Funding 2036944 /api/funding/2036944 (K128262) false true Funding 2036945 /api/funding/2036945 Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2036946 /api/funding/2036946 (2019-2.1.7-ERANET-2020-00014) false true Funding 2036947 /api/funding/2036947 ERA PerMed(2020-346 grant) Funder: EU false true true 2024 true true true false true false GOLD 2026-05-05 true https://doi.org/10.3390/ijms25031865 13 0 13 12 1 13 13 9 7 9 9 8 8 12 1 0 13 12 13 12 0 17 17 D1 false 10012513,10019319 false false false 2024-02-07T09:50:04.772+0000 Biológia Doktori Iskola (ELTE / TTK); Doktori Iskola (SE); Egészség- és Sporttudományi Kar (SZE); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... 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(SU / FM / C / DOG); Institute of Molecular Life Sciences 18 0.056 false true true Author 10011696 /api/author/10011696 Nándor Gábor Than (Rendszerbiológia) Than Nándor Gábor true 10011696 true Than Nándor Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25436504 /api/publicationidentifier/25436504 DOI: 10.3390/ijms25031865 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25031865 https://doi.org/10.3390/ijms25031865 false true PublicationIdentifier 31711333 /api/publicationidentifier/31711333 PPCE Publications: 3579 SwordSource 10035 /api/publicationsource/10035 PPCE Publications PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true PPKE Publikáció PPCE Publications https://publikacio.ppke.hu/id/eprint/@@@ true true true GREEN true 3579 https://publikacio.ppke.hu/id/eprint/3579 false true PublicationIdentifier 25718426 /api/publicationidentifier/25718426 WoS: 001160453700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001160453700001 https://www.webofscience.com/wos/woscc/full-record/001160453700001 false true PublicationIdentifier 25605710 /api/publicationidentifier/25605710 Scopus: 85184714647 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85184714647 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184714647 false true PublicationIdentifier 25463787 /api/publicationidentifier/25463787 PubMed: 38339143 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38339143 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38339143&dopt=Abstract false true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true /api/publication/34563187 Tóth Eszter et al. Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value. (2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 3<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025667"><a href="/gui2/?type=authors&mode=browse&sel=10025667" target="_blank">Tóth Eszter (<span class="authorship-author-name">Tóth Eszter</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;    <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;    <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;    <span class="author-name" mtid="10012513"><a href="/gui2/?type=authors&mode=browse&sel=10012513" target="_blank">Hupuczi Petronella (<span class="authorship-author-name">Hupuczi Petronella</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> ;    <span class="author-name" mtid="10019319"><a href="/gui2/?type=authors&mode=browse&sel=10019319" target="_blank">Balogh Andrea (<span class="authorship-author-name">Balogh Andrea</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;    <span class="author-name" mtid="10025710"><a href="/gui2/?type=authors&mode=browse&sel=10025710" target="_blank">Szalai Gábor (<span class="authorship-author-name">Szalai Gábor</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Surgery Clinic</span> ;    <span class="author-name" mtid="10059724"><a href="/gui2/?type=authors&mode=browse&sel=10059724" target="_blank">Orosz Gergő (<span class="authorship-author-name">Orosz Gergő Balázs</span> <span class="authorAux-mtmt"> Szülészet Nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" mtid="10032549"><a href="/gui2/?type=authors&mode=browse&sel=10032549" target="_blank">Orosz László (<span class="authorship-author-name">Orosz László</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" mtid="10081331"><a href="/gui2/?type=authors&mode=browse&sel=10081331" target="_blank">Oravecz Orsolya (<span class="authorship-author-name">Oravecz Orsolya</span> <span class="authorAux-mtmt"> biológia, immunológia, molekuláris biológia, mi...</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology</span> ;    <span class="author-name" >Veress Lajos </span> ;    <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István University">Széchenyi István University</span>/Faculty of Health and Sport Sciences; <span title="Széchenyi István University">Széchenyi István University</span>/<span title="Faculty of Health and Sport Sciences">FHSS</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" mtid="10039073"><a href="/gui2/?type=authors&mode=browse&sel=10039073" target="_blank">Török Olga (<span class="authorship-author-name">Török Olga</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" >Murthi Padma </span> ;    <span class="author-name" >Erez Offer </span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> ;    <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;    <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department ; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34563187" target="_blank">Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">3</span> <span class="page"> Paper 1865. 23 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25031865" target="_blank" href="https://doi.org/10.3390/ijms25031865"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="3579" target="_blank" href="https://publikacio.ppke.hu/id/eprint/3579"> PPCE Publications </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001160453700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001160453700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85184714647" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85184714647"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38339143" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38339143&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 12 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus: 7 | WoS/Scopus assigned: 9 | Number of citations with DOI: 13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34563187&sort=publishedYear,desc&sort=title"> Number of cited publications: 17 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34563187</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2014-7/2014,), (Premium_2019-436) Funder: Premium Post-Doctoral Fellowship of the Hungarian Academy of Sciences, (HUN-REN SA-83/2021) Funder: HUN_REN, (FIEK-16-1-2016-0005), (K124862), (K128262), Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (2019-2.1.7-ERANET-2020-00014), ERA PerMed(2020-346 grant) Funder: EU </div> <div class="lastModified">Last Modified: 2024.11.28. 07:10 Róbert Milánkovics (PTE ÁOK admin 4) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Systems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, H-1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, H-1083, Hungary Doctoral School, Semmelweis University, Budapest, H-1085,...</pre> </div></div> JournalArticle 34410484 VALIDATED true Export Date: 10 January 2024; Cited By: 0; Correspondence Address: A. Szilágyi; Systems Biology of Reproduction Research Group, Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary; email: szilagyi.andras@ttk.hu 0 false 2026-01-01T04:45:43.553+0000 2024-02-13T10:57:52.195+0000 2023-12-01T12:51:12.776+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin Regina Szabó (ELTE TTK admin 5) true 2024-04-03T10:45:31.748+0000 2024-04-03T10:45:31.748+0000 2024-02-13T10:57:52.386+0000 true 10058019 Serf András /api/admin/10058019 Admin András Serf (PPKE ITK admin 5) true 10058019 2024-02-16T21:58:42.254+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2024-04-04T10:42:31.810+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Györffy, Dániel A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms true true /api/journal/10018879 REVIEWED BIOMOLECULES 2218-273X 2218-273X true false 10018879 false 10018879 true 2218-273X 2218-273X Journal FOREIGN 13 12 1708 1708 2023 Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood. Kinetic transition networks of conformational states have provided insight into the folding mechanisms of monomeric proteins, but extending such a network to two protein chains is challenging as all the relative positions and orientations of the chains need to be included, greatly increasing the number of degrees of freedom. Here, we present a simplification of the problem by grouping all states of the two chains into two layers: a dissociated and an associated layer. We combined our two-layer approach with the Wako–Saito–Muñoz–Eaton method and used Transition Path Theory to investigate the dimer formation kinetics of eight homodimers. The analysis reveals a remarkable diversity of dimer formation mechanisms. Induced folding, conformational selection, and rigid docking are often simultaneously at work, and their contribution depends on the protein concentration. Pre-folded structural elements are always present at the moment of association, and asymmetric binding mechanisms are common. Our two-layer network approach can be combined with various methods that generate discrete states, yielding new insights into the kinetics and pathways of flexible binding processes. true 2023 true true true false false GOLD 2026-01-01 false http://www.mdpi.com/journal/biomolecules 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 2 2 Q1 false 10010376 false false false 2024-02-12T10:57:52.022+0000 Enzimológiai Intézet (TTK); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI) 3 20 3 3 0 true 10014568 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 112759491 /api/authorship/112759491 Györffy, Dániel [Györffy, Dániel (Bioinformatika), author] Institute of Enzymology (RCNS); Információs Technológiai és Bionikai Kar (PPCU) 1 0.333 true false false Author 10019484 /api/author/10019484 Dániel Györffy (Bioinformatika) Györffy Dániel true 10019484 true Györffy Dániel true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 112759492 /api/authorship/112759492 Závodszky, Péter [Závodszky, Péter (Molekuláris immun...), author] Institute of Enzymology (RCNS) 2 0.333 false false false Author 10000346 /api/author/10000346 Péter Závodszky (Molekuláris immunológia, biokémia) Závodszky Péter true 10000346 true Závodszky Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 112759493 /api/authorship/112759493 Szilágyi, András [Szilágyi, András (Bioinformatika), author] Institute of Enzymology (RCNS); Enzim_416 (IMLS) 3 0.333 false true false Author 10010376 /api/author/10010376 András Szilágyi (Bioinformatika) Szilágyi András true 10010376 true Szilágyi András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25051597 /api/publicationidentifier/25051597 DOI: 10.3390/biom13121708 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/biom13121708 https://doi.org/10.3390/biom13121708 false true PublicationIdentifier 25265355 /api/publicationidentifier/25265355 WoS: 001131139200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001131139200001 https://www.webofscience.com/wos/woscc/full-record/001131139200001 false true PublicationIdentifier 25265354 /api/publicationidentifier/25265354 Scopus: 85180480247 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85180480247 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85180480247 false true PublicationIdentifier 25333461 /api/publicationidentifier/25333461 PubMed: 38136580 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38136580 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38136580&dopt=Abstract false true PublicationIdentifier 25051598 /api/publicationidentifier/25051598 Other URL: https://www.mdpi.com/2218-273X/13/12/1708 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true https://www.mdpi.com/2218-273X/13/12/1708 https://www.mdpi.com/2218-273X/13/12/1708 false true SjrRating 11357702 /api/sjrrating/11357702 sjr:Q1 (2023) Scopus - Biochemistry BIOMOLECULES 2218-273X 2218-273X 88 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 Scopus - Biochemistry true 1303 true Q1 DIRECT true true /api/publication/34410484 Györffy Dániel et al. A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms. (2023) BIOMOLECULES 2218-273X 2218-273X 13 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;    <span class="author-name" mtid="10000346"><a href="/gui2/?type=authors&mode=browse&sel=10000346" target="_blank">Závodszky Péter (<span class="authorship-author-name">Závodszky Péter</span> <span class="authorAux-mtmt"> Molekuláris immunológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34410484" target="_blank">A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms</a></div> <div> <span class="journal-title">BIOMOLECULES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2218-273X">2218-273X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2218-273X">2218-273X</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">12</span> <span class="page"> Paper 1708. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/biom13121708" target="_blank" href="https://doi.org/10.3390/biom13121708"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001131139200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001131139200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85180480247" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85180480247"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38136580" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38136580&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/2218-273X/13/12/1708" target="_blank" href="https://www.mdpi.com/2218-273X/13/12/1708"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus: 1 | WoS/Scopus assigned: 1 | Number of citations with DOI: 1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34410484&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34410484</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2024.02.13. 11:57 András Serf (PPKE ITK admin 5) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:42 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 10 January 2024; Cited By: 0; Correspondence Address: A. Szilágyi; Systems Biology of Reproduction Research Group, Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary; email: szilagyi.andras@ttk.hu</pre> </div></div> JournalArticle 34083456 APPROVED true Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Export Date: 01 August 2023; Cited By: 0; Correspondence Address: I. Hajdú; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary; email: hajdu.istvan@ttk.hu; P. Závodszky; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary; email: zavodszky.peter@ttk.hu 0 false 2025-12-31T18:59:57.476+0000 2023-08-01T10:24:07.290+0000 2023-08-01T10:18:06.493+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) true 10035718 2024-04-03T10:56:31.835+0000 2024-04-03T10:56:31.835+0000 Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2024-04-04T10:41:44.202+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Hajdú, I. Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 13 10416 10416 2023 The amyloidogenic processing of APP depends on two events: its phosphorylation by ROCK2 (at Thr654) and the phosphorylation of the APP-cleaving enzyme BACE1 (at Ser498). However, the mechanisms and structural details of APP-ROCK2 and BACE1-ROCK2 binding are unknown. Using direct physical methods in combination with an in silico approach, we found that BACE1 binds into the substrate-binding groove of ROCK2 with a low affinity (Kd = 18 µM), while no binding of APP to ROCK2 alone could be detected. On the other hand, a strong association (Kd = 3.5 nM) of APP to the weak ROCK2-BACE1 complex was observed, although no stable ternary complex was detected, i.e., BACE1 was displaced by APP. We constructed a sequential functional model: (1) BACE1 weakly binds to ROCK2 and induces an allosteric conformational change in ROCK2; (2) APP strongly binds to the ROCK2-BACE1 complex, and BACE1 is released; and (3) ROCK2 phosphorylates APP at Thr654 (leading to a longer stay in the early endosome during APP processing). Direct fluorescence titration experiments showed that the APP646–664 or APP665–695 fragments did not bind separately to the ROCK2-BACE1 complex. Based on these observations, we conclude that two binding sites are involved in the ROCK2-APP interaction: (1) the substrate-binding groove, where the APP646–664 sequence containing Thr654 sits and (2) the allosteric binding site, where the APP665–695 sequence binds. These results open the way to attack the allosteric site to prevent APP phosphorylation at Thr654 by ROCK2 without inhibiting the activity of ROCK2 towards its other substrates. © 2023 by the authors. 2023 true true true false false GOLD 2025-12-31 false http://www.mdpi.com/journal/ijms 3 0 3 3 0 3 3 3 2 3 3 3 3 3 0 0 3 3 3 3 0 2 2 D1 false 10010376 false false false 2023-10-30T11:24:06.927+0000 Enzimológiai Intézet (TTK); Információs Technológiai és Bionikai Kar (PPKE) 4 22 2 4 0 true 10014568 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 109487547 /api/authorship/109487547 Hajdú, I. [Hajdú, István (Biofizika, Biokémia), author] Institute of Enzymology (RCNS) 1 0.25 true false false Author 10015238 /api/author/10015238 István Hajdú (Biofizika, Biokémia) Hajdú István true 10015238 true Hajdú I. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109487548 /api/authorship/109487548 Végh, B.M. [Végh, Barbara, author] Institute of Enzymology (RCNS) 2 0.25 false false false Author 10018761 /api/author/10018761 Barbara Végh Végh Barbara true 10018761 true Végh B.M. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109487549 /api/authorship/109487549 Szilágyi, A. [Szilágyi, András (Bioinformatika), author] Institute of Enzymology (RCNS) 3 0.25 false false false Author 10010376 /api/author/10010376 András Szilágyi (Bioinformatika) Szilágyi András true 10010376 true Szilágyi A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109487550 /api/authorship/109487550 Závodszky, P. [Závodszky, Péter (Molekuláris immun...), author] Institute of Enzymology (RCNS); Információs Technológiai és Bionikai Kar (PPCU) 4 0.25 false true false Author 10000346 /api/author/10000346 Péter Závodszky (Molekuláris immunológia, biokémia) Závodszky Péter true 10000346 true Závodszky P. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 24222561 /api/publicationidentifier/24222561 DOI: 10.3390/ijms241310416 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms241310416 https://doi.org/10.3390/ijms241310416 false true PublicationIdentifier 24422897 /api/publicationidentifier/24422897 WoS: 001032969000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001032969000001 https://www.webofscience.com/wos/woscc/full-record/001032969000001 false true PublicationIdentifier 24222560 /api/publicationidentifier/24222560 Scopus: 85164846724 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85164846724 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164846724 false true Keyword 65 /api/keyword/65 Humans true 65 true Keyword 81 /api/keyword/81 PHOSPHORYLATION true 81 true Keyword 81 /api/keyword/81 PHOSPHORYLATION true 81 true Keyword 81 /api/keyword/81 PHOSPHORYLATION true 81 true Keyword 334 /api/keyword/334 metabolism true 334 true Keyword 3122 /api/keyword/3122 human true 3122 true Keyword 12637 /api/keyword/12637 AMYLOID PRECURSOR PROTEIN true 12637 true Keyword 1009611 /api/keyword/1009611 Alzheimer disease true 1009611 true Keyword 1009611 /api/keyword/1009611 Alzheimer disease true 1009611 true Keyword 1033034 /api/keyword/1033034 Aspartic proteinase true 1033034 true Keyword 1033150 /api/keyword/1033150 rho-Associated Kinases true 1033150 true Keyword 1047376 /api/keyword/1047376 amyloid beta protein true 1047376 true Keyword 1065774 /api/keyword/1065774 Amyloid beta-Peptides true 1065774 true Keyword 1088580 /api/keyword/1088580 Rho kinase true 1088580 true Keyword 1115202 /api/keyword/1115202 Plaque, Amyloid true 1115202 true Keyword 1174880 /api/keyword/1174880 Amyloid beta-Protein Precursor true 1174880 true Keyword 1220426 /api/keyword/1220426 Amyloid Precursor Protein Secretases true 1220426 true Keyword 1266489 /api/keyword/1266489 SECRETASE true 1266489 true Keyword 1495684 /api/keyword/1495684 amyloid plaque true true Keyword 1514819 /api/keyword/1514819 Aspartic Acid Endopeptidases true true Keyword 1563194 /api/keyword/1563194 amyloid precursor protein (APP) true true Keyword 2154068 /api/keyword/2154068 beta-secretase (BACE1) true true Keyword 2537691 /api/keyword/2537691 Rho-kinase (ROCK) true true Keyword 2825057 /api/keyword/2825057 allosteric binding site true true Keyword 3138314 /api/keyword/3138314 ROCK2 protein, human true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true /api/publication/34083456 Hajdú I. et al. Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 13<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015238"><a href="/gui2/?type=authors&mode=browse&sel=10015238" target="_blank">Hajdú I. (<span class="authorship-author-name">Hajdú István</span> <span class="authorAux-mtmt"> Biofizika, Biokémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;    <span class="author-name" mtid="10018761"><a href="/gui2/?type=authors&mode=browse&sel=10018761" target="_blank">Végh B.M. (<span class="authorship-author-name">Végh Barbara</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi A. (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;    <span class="author-name" mtid="10000346"><a href="/gui2/?type=authors&mode=browse&sel=10000346" target="_blank">Závodszky P. (<span class="authorship-author-name">Závodszky Péter</span> <span class="authorAux-mtmt"> Molekuláris immunológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34083456" target="_blank">Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">13</span> <span class="page"> Paper 10416. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms241310416" target="_blank" href="https://doi.org/10.3390/ijms241310416"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001032969000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001032969000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85164846724" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164846724"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 3 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus: 2 | WoS/Scopus assigned: 3 | Number of citations with DOI: 3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34083456&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34083456</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2023.08.01. 12:24 Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:41 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Export Date: 01 August 2023; Cited By: 0; Correspondence Address: I. Hajdú; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, H...</pre> </div></div> JournalArticle 33186504 APPROVED true Systems Biology of Reproduction Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary Maternity Private Clinic of Obstetrics and Gynecology, Budapest, Hungary Genesis Theranostix Group, Budapest, Hungary First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States Detroit Medical Center, Detroit, MI, United States Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, Budapest, Hungary Department of Obstetrics and Gynecology, Wayne State University, School of Medicine, Detroit, MI, United States Department of Obstetrics and Gynecology, Universidad Del Valle, Cali, Colombia Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, United States Department of Pathology, Haeundae Paik Hospital, Inje University, College of Medicine, Busan, South Korea Department of Obstetrics and Gynecology, HaEmek Medical Center, Afula, Israel Department of Computer Science, Wayne State University, College of Engineering, Detroit, MI, United States Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI, United States Cited By :4 Export Date: 25 October 2023 CODEN: JPEMA Correspondence Address: Than, N.G.; Perinatology Research Branch, United States; email: than.gabor@ttk.hu Correspondence Address: Papp, Z.; Maternity Private Clinic of Obstetrics and GynecologyHungary; email: pzorvosihetilap@maternity.hu 0 false 2026-02-25T10:19:01.118+0000 2025-02-26T14:13:41.235+0000 2022-10-23T19:49:20.631+0000 true 10052223 Orbán Zsófia /api/admin/10052223 Admin Zsófia Orbán (SE_ETK_Admin5_OZs, admin) true 10052223 2025-09-02T11:38:56.876+0000 Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2024-04-04T10:40:40.736+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Than, Nándor Gábor Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention true true /api/journal/2757 REVIEWED JOURNAL OF PERINATAL MEDICINE 0300-5577 1619-3997 true false 2757 false 2757 true 0300-5577 1619-3997 Journal FOREIGN 51 1 51 68 51 18 2023 The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, and a molecular taxonomy of disease is needed. We have previously identified four subclasses of preeclampsia based on first-trimester plasma proteomic profiles. Herein, we expanded this approach by using a more comprehensive panel of proteins profiled in longitudinal samples. Funding 2019984 /api/funding/2019984 (LP2014-7/2014,) false true Funding 2022722 /api/funding/2022722 (FIEK_16-1-2016-0005) false true Funding 2022723 /api/funding/2022723 (K124862) false true Funding 2022724 /api/funding/2022724 (K128262) false true Funding 2022725 /api/funding/2022725 Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2022726 /api/funding/2022726 Gyorsítósáv (2020-1.1.5-GYORSÍTÓSÁV)” pályázat(2020- 1.1.5-GYORSÍTÓSÁV-2021-00012) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true true false 2022 true true true false true false NONE 2026-02-25 false 27 0 27 20 5 27 26 27 25 27 27 20 20 20 7 0 27 20 27 20 0 13 13 Q2 false 1373182 false false false 2022-11-21T10:05:51.578+0000 Doktori Iskola (SE); Enzimológiai Intézet (TTK); I. Sz. Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 5 31 6 20 0 true 10014568 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 104001612 /api/authorship/104001612 Than, Nándor Gábor ✉ [Than, Nándor Gábor (Rendszerbiológia), author] Institute of Enzymology (RCNS); I. Department of Pathology and experimental Can... (SU / FM / I); Enzim_416 (IMLS) 1 0.05 true false true Author 10011696 /api/author/10011696 Nándor Gábor Than (Rendszerbiológia) Than Nándor Gábor true 10011696 true Than Nándor Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001613 /api/authorship/104001613 Romero, Roberto 2 0.05 false false false Romero Roberto true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001614 /api/authorship/104001614 Györffy, Dániel [Györffy, Dániel (Bioinformatika), author] Institute of Enzymology (RCNS); Információs Technológiai és Bionikai Kar (PPCU) 3 0.05 false false false Author 10019484 /api/author/10019484 Dániel Györffy (Bioinformatika) Györffy Dániel true 10019484 true Györffy Dániel true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001615 /api/authorship/104001615 Posta, Máté [Posta, Máté (Szülészet- és nőg...), author] Enzim_416 (IMLS); School of PhD Studies (SU) 4 0.05 false false false Author 10082656 /api/author/10082656 Máté Posta (Szülészet- és nőgyógyászat) Posta Máté true true Posta Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001616 /api/authorship/104001616 Bhatti, Gaurav 5 0.05 false false false Bhatti Gaurav true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001617 /api/authorship/104001617 Done, Bogdan 6 0.05 false false false Done Bogdan true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001618 /api/authorship/104001618 Chaemsaithong, Piya 7 0.05 false false false Chaemsaithong Piya true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001619 /api/authorship/104001619 Jung, Eunjung 8 0.05 false false false Jung Eunjung true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001620 /api/authorship/104001620 Suksai, Manaphat 9 0.05 false false false Suksai Manaphat true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001621 /api/authorship/104001621 Gotsch, Francesca 10 0.05 false false false Gotsch Francesca true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001622 /api/authorship/104001622 Gallo, Dahiana M. 11 0.05 false false false Gallo Dahiana M. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001623 /api/authorship/104001623 Bosco, Mariachiara 12 0.05 false false false Bosco Mariachiara true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001624 /api/authorship/104001624 Kim, Bomi 13 0.05 false false false Kim Bomi true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001625 /api/authorship/104001625 Kim, Yeon Mee 14 0.05 false false false Kim Yeon Mee true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001626 /api/authorship/104001626 Chaiworapongsa, Tinnakorn 15 0.05 false false false Chaiworapongsa Tinnakorn true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001627 /api/authorship/104001627 Rossi, Simona W. 16 0.05 false false false Rossi Simona W. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001628 /api/authorship/104001628 Szilágyi, András [Szilágyi, András (Bioinformatika), author] Enzim_416 (IMLS) 17 0.05 false false false Author 10010376 /api/author/10010376 András Szilágyi (Bioinformatika) Szilágyi András true 10010376 true Szilágyi András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001629 /api/authorship/104001629 Erez, Offer 18 0.05 false false false Erez Offer true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001630 /api/authorship/104001630 Tarca, Adi L. 19 0.05 false false false Tarca Adi L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104001631 /api/authorship/104001631 Papp, Zoltán ✉ [Papp, Zoltán (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology Baross S... 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Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention. (2023) JOURNAL OF PERINATAL MEDICINE 0300-5577 1619-3997 51 1 51-68<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/I. Department of Pathology and experimental Cancer Research; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" >Romero Roberto </span> ;    <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;    <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;    <span class="author-name" >Bhatti Gaurav </span> ;    <span class="author-name" >Done Bogdan </span> ;    <span class="author-name" >Chaemsaithong Piya </span> ;    <span class="author-name" >Jung Eunjung </span> ;    <span class="author-name" >Suksai Manaphat </span> ;    <span class="author-name" >Gotsch Francesca </span> ;    <span class="author-name" >Gallo Dahiana M. </span> ;    <span class="author-name" >Bosco Mariachiara </span> ;    <span class="author-name" >Kim Bomi </span> ;    <span class="author-name" >Kim Yeon Mee </span> ;    <span class="author-name" >Chaiworapongsa Tinnakorn </span> ;    <span class="author-name" >Rossi Simona W. </span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;    <span class="author-name" >Erez Offer </span> ;    <span class="author-name" >Tarca Adi L. </span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán ✉ (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33186504" target="_blank">Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention</a></div> <div> <span class="journal-title">JOURNAL OF PERINATAL MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0300-5577">0300-5577</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1619-3997">1619-3997</a>)</span>: <span class="journal-volume">51</span> <span class="journal-issue">1</span> <span class="page"> pp 51-68 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1515/jpm-2022-0433" target="_blank" href="https://doi.org/10.1515/jpm-2022-0433"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000869316500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000869316500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85141181054" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85141181054"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36253935" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36253935&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Obstetrics and Gynecology   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Pediatrics, Perinatology and Child Health   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 27</span> | Independent citation: 20 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 27 | Number of citations in Scopus: 25 | WoS/Scopus assigned: 27 | Number of citations with DOI: 26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33186504&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33186504</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2014-7/2014,), (FIEK_16-1-2016-0005), (K124862), (K128262), Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, Gyorsítósáv (2020-1.1.5-GYORSÍTÓSÁV)” pályázat(2020- 1.1.5-GYORSÍTÓSÁV-2021-00012) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal </div> <div class="lastModified">Last Modified: 2025.02.26. 15:13 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:40 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Systems Biology of Reproduction Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary Maternity Private Clinic of Obstetrics and Gynecology, Budapest, Hungary Genesis Theranostix Group, Budapest, Hungary First Department of Pathology and Experimental Cancer Research, Semmelweis Uni...</pre> </div></div> JournalArticle 32725682 VALIDATED true A dolgozat angol nyelven a Placenta (Trophoblast Research) folyóiratban 2022-ben jelenik meg, jelenleg elfogadás alatt áll. 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A praeeclampsia korai betegségútvonalai, biomarkerei és négy különböző molekuláris alosztálya. (2022) NŐGYÓGYÁSZATI ÉS SZÜLÉSZETI TOVÁBBKÉPZŐ SZEMLE 1585-8731 24 1 6-16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;    <span class="author-name" >Orosz László </span> ;    <span class="author-name" >Orosz Gergő </span> ;    <span class="author-name" >Rossi Simona Wilma </span> ;    <span class="author-name" >Ambrus-Aikelin Géza </span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil">Széchenyi István University; <span title="Széchenyi István University">Széchenyi István University</span>/<span title="Faculty of Health and Sport Sciences">FHSS</span>/Egészségtudományi Tanszék</span> ;    <span class="author-name" mtid="10012513"><a href="/gui2/?type=authors&mode=browse&sel=10012513" target="_blank">Hupuczi Petronella (<span class="authorship-author-name">Hupuczi Petronella</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> ;    <span class="author-name" mtid="10039073"><a href="/gui2/?type=authors&mode=browse&sel=10039073" target="_blank">Török Olga (<span class="authorship-author-name">Török Olga</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" >Tarca Adi Laurentiu </span> ;    <span class="author-name" >Erez Offer </span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> ;    <span class="author-name" >Romero Roberto </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32725682" target="_blank">A praeeclampsia korai betegségútvonalai, biomarkerei és négy különböző molekuláris alosztálya</a></div> <div> <span class="journal-title">NŐGYÓGYÁSZATI ÉS SZÜLÉSZETI TOVÁBBKÉPZŐ SZEMLE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1585-8731">1585-8731</a> )</span>: <span class="journal-volume">24</span> <span class="journal-issue">1</span> <span class="page"> pp 6-16 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: Hungarian | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="3133402" target="_blank" href="https://matarka.hu/egy-kozlemeny-oldala.php?MatarkaID=3133402"> Matarka </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="152446" target="_blank" href="https://mob.aeek.hu/detailsperm.jsp?PERMID=152446"> MOB </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32725682&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32725682</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Republication ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (GINOP-2.1.7-15-2016-00415), (LP2014-7/2014,), (FIEK_16-1-2016-0005), (K128262) Funder: NRDIO, (K124862) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2025.05.16. 10:15 Éva Miskolczi (SE_KK_Admin5_DME, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: A dolgozat angol nyelven a Placenta (Trophoblast Research) folyóiratban 2022-ben jelenik meg, jelenleg elfogadás alatt áll. A magyar változat közlése az Elsevier kiadó hozzájárulásával történik.</pre> </div></div> JournalArticle 32760816 VALIDATED true 0 false 2026-05-07T08:28:32.157+0000 2025-05-16T08:24:34.340+0000 2022-03-28T13:46:43.264+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin Regina Szabó (ELTE TTK admin 5) true 2025-09-02T11:39:09.942+0000 2024-12-06T18:00:52.797+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Than, Nándor Gábor Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies true true /api/journal/3698 REVIEWED PLACENTA 0143-4004 1532-3102 true false 3698 false 3698 true 0143-4004 1532-3102 Journal FOREIGN 125 10 19 10 10 2022 Funding 2052965 /api/funding/2052965 (GINOP-2.1.7-15-2016-00415) false true Funding 2052966 /api/funding/2052966 (LP2014-7/2014,) false true Funding 2052967 /api/funding/2052967 (FIEK_16-1-2016-0005) false true Funding 2052968 /api/funding/2052968 (K124862) Funder: NRDIO false true Funding 2052969 /api/funding/2052969 (K128262) Funder: NRDIO false true Funding 2052970 /api/funding/2052970 Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true true true 2022 true true true false true false NONE 2026-05-07 false 59 0 59 49 9 59 59 45 40 48 48 38 38 49 10 0 59 49 59 49 0 10 10 Q1 false false false false 2022-04-26T12:49:07.577+0000 Egészség- és Sporttudományi Kar (SZE); Enzimológiai Intézet (TTK); Információs Technológiai és Bionikai Kar (PPKE); Lendület Reprodukció Rendszerbiológiája Kutatóc... 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Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies. (2022) PLACENTA 0143-4004 1532-3102 125 10-19<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nándor Gábor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta Máté (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10019484"><a href="/gui2/?type=authors&mode=browse&sel=10019484" target="_blank">Györffy Dániel (<span class="authorship-author-name">Györffy Dániel</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;    <span class="author-name" mtid="10032549"><a href="/gui2/?type=authors&mode=browse&sel=10032549" target="_blank">Orosz László (<span class="authorship-author-name">Orosz László</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" mtid="10059724"><a href="/gui2/?type=authors&mode=browse&sel=10059724" target="_blank">Orosz Gergő (<span class="authorship-author-name">Orosz Gergő Balázs</span> <span class="authorAux-mtmt"> Szülészet Nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" >Rossi Simona W. </span> ;    <span class="author-name" >Ambrus-Aikelin Géza </span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilágyi András (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10034624"><a href="/gui2/?type=authors&mode=browse&sel=10034624" target="_blank">Nagy Sándor (<span class="authorship-author-name">Nagy Sándor</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István University">Széchenyi István University</span>/Faculty of Health and Sport Sciences</span> ;    <span class="author-name" >Hupuczi Petronella </span> ;    <span class="author-name" mtid="10039073"><a href="/gui2/?type=authors&mode=browse&sel=10039073" target="_blank">Török Olga (<span class="authorship-author-name">Török Olga</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Obstetrics and Gynecology</span> ;    <span class="author-name" >Tarca Adi L. </span> ;    <span class="author-name" >Erez Offer </span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> ;    <span class="author-name" >Romero Roberto </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32760816" target="_blank">Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies</a></div> <div> <span class="journal-title">PLACENTA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0143-4004">0143-4004</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-3102">1532-3102</a>)</span>: <span class="journal-volume">125</span> <span class="page"> pp 10-19 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.placenta.2022.03.009" target="_blank" href="https://doi.org/10.1016/j.placenta.2022.03.009"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000819432200004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000819432200004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85128172987" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85128172987"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35428514" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35428514&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Obstetrics and Gynecology   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Reproductive Medicine   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Developmental Biology   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 59</span> | Independent citation: 49 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 45 | Number of citations in Scopus: 40 | WoS/Scopus assigned: 48 | Number of citations with DOI: 59 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32760816&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32760816</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (GINOP-2.1.7-15-2016-00415), (LP2014-7/2014,), (FIEK_16-1-2016-0005), (K124862) Funder: NRDIO, (K128262) Funder: NRDIO, Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal </div> <div class="lastModified">Last Modified: 2025.05.16. 10:24 Éva Miskolczi (SE_KK_Admin5_DME, admin) </div> </div></div> JournalArticle 32546517 ADMIN_APPROVED true Funding Agency and Grant Number: Hungarian Academy of Sciences, Momentum Grant [LP2014-7/2014]; Hungarian Academy of Sciences, Premium Postdoc Grant [2019-436]; Hungarian Academy of Sciences, Young Researcher Fellowships; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [OTKA K128262, OTKA K124862, FIEK_16-1-2016-0005]; Hungarian Ministry For National Economy [VEKOP-2.3.3-15-2017-0014]; MedInProt, Protein Science Research Synergy IV Program Grant; Adhoc Program Grant; USC Gynecology Oncology Research Fund Funding text: This research was funded by the Hungarian Academy of Sciences, Momentum Grant No LP2014-7/2014, Premium Postdoc_2019-436 Grant and Young Researcher Fellowships; the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the OTKA K128262, OTKA K124862 and FIEK_16-1-2016-0005 funding schemes; Hungarian Ministry For National Economy, Grant No VEKOP-2.3.3-15-2017-0014; MedInProt, Protein Science Research Synergy IV and Adhoc Program Grants; and the USC Gynecology Oncology Research Fund. 0 false 2026-03-04T07:38:58.452+0000 2026-01-13T09:29:00.162+0000 2021-12-21T09:47:21.355+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) true 10035718 2026-02-06T07:38:31.257+0000 2026-02-06T07:38:31.257+0000 2026-01-13T09:29:00.711+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Edit Csajbók (SE_KK_Admin5_CSE, admin) true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Szabolcsi, Zoltan Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease true true /api/journal/10056704 REVIEWED BIOMEDICINES 2227-9059 true false 10056704 false 10056704 true 2227-9059 Journal FOREIGN 9 12 1935 1935 21 2021 Gestational trophoblastic diseases (GTDs) have not been investigated for their epigenetic marks and consequent transcriptomic changes. Here, we analyzed genome-wide DNA methylation and transcriptome data to reveal the epigenetic basis of disease pathways that may lead to benign or malignant GTDs. RNA-Seq, mRNA microarray, and Human Methylation 450 BeadChip data from complete moles and choriocarcinoma cells were bioinformatically analyzed. Paraffin-embedded tissues from complete moles and control placentas were used for tissue microarray construction, DNMT3B immunostaining and immunoscoring. We found that DNA methylation increases with disease severity in GTDs. Differentially expressed genes are mainly upregulated in moles while predominantly downregulated in choriocarcinoma. DNA methylation principally influences the gene expression of villous trophoblast differentiation-related or predominantly placenta-expressed genes in moles and choriocarcinoma cells. Affected genes in these subsets shared focal adhesion and actin cytoskeleton pathways in moles and choriocarcinoma. In moles, cell cycle and differentiation regulatory pathways, essential for trophoblast/placental development, were enriched. In choriocarcinoma cells, hormone biosynthetic, extracellular matrix-related, hypoxic gene regulatory, and differentiation-related signaling pathways were enriched. In moles, we found slight upregulation of DNMT3B protein, a developmentally important de novo DNA methylase, which is strongly overexpressed in choriocarcinoma cells that may partly be responsible for the large DNA methylation differences. Our findings provide new insights into the shared and disparate molecular pathways of disease in GTDs and may help in designing new diagnostic and therapeutic tools. Funding 2007165 /api/funding/2007165 (LP2014-7/2014,) false true Funding 2007166 /api/funding/2007166 (K128262) false true Funding 2007167 /api/funding/2007167 (K124862) false true Funding 2007168 /api/funding/2007168 (FIEK_16-1-2016-0005) false true Funding 2007169 /api/funding/2007169 (VEKOP-2.3.3-15-2017-0014) false true true 2021 true true true false true false GOLD 2026-03-04 true https://doi.org/10.3390/biomedicines9121935 13 0 13 13 1 13 13 11 12 13 13 13 13 13 0 0 13 13 13 13 0 13 13 Q1 false 10012513,1373182 false false false 2021-12-27T11:26:48.518+0000 Aneszteziológiai és Intenzív Terápiás Klinika (SE / AOK / K); Enzimológiai Intézet (TTK); I. Sz. Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI); Szülészeti és Nőgyógyászati Klinika (SE / AOK / K) 9 39 5 17 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 99715714 /api/authorship/99715714 Szabolcsi, Zoltan 1 0.059 true false false Szabolcsi Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715715 /api/authorship/99715715 Demeter, Amanda* [Demeter, Amanda (Biológia), author] Enzim_416 (IMLS) 2 0.059 true false false Author 10055081 /api/author/10055081 Amanda Demeter (Biológia) Demeter Amanda true 10055081 true Demeter Amanda true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715716 /api/authorship/99715716 Kiraly, Peter* [Király, Péter (Fizikai-kémia), author] 3 0.059 true false false Author 10084062 /api/author/10084062 Péter Király (Fizikai-kémia) Király Péter true true Kiraly Peter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715717 /api/authorship/99715717 Balogh, Andrea [Balogh, Andrea (Immunológia), author] 4 0.05882353 false false false Author 10019319 /api/author/10019319 Andrea Balogh (Immunológia) Balogh Andrea true 10019319 true Balogh Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715718 /api/authorship/99715718 Wilson, Melissa L. 5 0.05882353 false false false Wilson Melissa L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715719 /api/authorship/99715719 King, Jennifer R. 6 0.05882353 false false false King Jennifer R. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715720 /api/authorship/99715720 Hetey, Szabolcs 7 0.05882353 false false false Hetey Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715721 /api/authorship/99715721 Gelencser, Zsolt [Gelencsér, Zsolt (bioinformatika), author] Enzim_416 (IMLS) 8 0.059 false false false Author 10029869 /api/author/10029869 Zsolt Gelencsér (bioinformatika) Gelencsér Zsolt true 10029869 true Gelencser Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715722 /api/authorship/99715722 Matsuo, Koji 9 0.05882353 false false false Matsuo Koji true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715723 /api/authorship/99715723 Hargitai, Beata [Hargitai, Beáta (Patológia), author] 10 0.05882353 false false false Author 10032563 /api/author/10032563 Beáta Hargitai (Patológia) Hargitai Beáta true 10032563 true Hargitai Beata true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715724 /api/authorship/99715724 Mhawech-Fauceglia, Paulette 11 0.05882353 false false false Mhawech-Fauceglia Paulette true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715725 /api/authorship/99715725 Hupuczi, Petronella [Hupuczi, Petronella (Aneszteziológia é...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C) 12 0.05882353 false false false Author 10012513 /api/author/10012513 Petronella Hupuczi (Aneszteziológia és intenzív terápia) Hupuczi Petronella true 10012513 true Hupuczi Petronella true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715726 /api/authorship/99715726 Szilagyi, Andras [Szilágyi, András (Bioinformatika), author] Institute of Enzymology (RCNS); Enzim_416 (IMLS) 13 0.059 false false false Author 10010376 /api/author/10010376 András Szilágyi (Bioinformatika) Szilágyi András true 10010376 true Szilagyi Andras true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715727 /api/authorship/99715727 Papp, Zoltan [Papp, Zoltán (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology (SU / FM / C) 14 0.059 false false false Author 1373182 /api/author/1373182 Zoltán Papp (Szülészet-nőgyógyászat, klinikai genetika) Papp Zoltán true 1373182 true Papp Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715728 /api/authorship/99715728 Roman, Lynda D. 15 0.05882353 false false false Roman Lynda D. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715729 /api/authorship/99715729 Cortessis, Victoria K. 16 0.05882353 false false false Cortessis Victoria K. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99715730 /api/authorship/99715730 Than, Nandor Gabor ✉ [Than, Nándor Gábor (Rendszerbiológia), author] Institute of Enzymology (RCNS); I. Department of Pathology and experimental Can... (SU / FM / I); Enzim_416 (IMLS) 17 0.059 false true true Author 10011696 /api/author/10011696 Nándor Gábor Than (Rendszerbiológia) Than Nándor Gábor true 10011696 true Than Nandor Gabor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 20312358 /api/publicationidentifier/20312358 DOI: 10.3390/biomedicines9121935 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/biomedicines9121935 https://doi.org/10.3390/biomedicines9121935 false true PublicationIdentifier 20392783 /api/publicationidentifier/20392783 WoS: 000736261600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000736261600001 https://www.webofscience.com/wos/woscc/full-record/000736261600001 false true PublicationIdentifier 20321548 /api/publicationidentifier/20321548 Scopus: 85121436375 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85121436375 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85121436375 true true PublicationIdentifier 20424481 /api/publicationidentifier/20424481 PubMed: 34944751 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34944751 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34944751&dopt=Abstract true true SjrRating 11225445 /api/sjrrating/11225445 sjr:Q1 (2021) Scopus - Medicine (miscellaneous) BIOMEDICINES 2227-9059 587 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q1 DIRECT true true /api/publication/32546517 Szabolcsi Zoltan et al. Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease. (2021) BIOMEDICINES 2227-9059 9 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Szabolcsi Zoltan </span> ;    <span class="author-name" mtid="10055081"><a href="/gui2/?type=authors&mode=browse&sel=10055081" target="_blank">Demeter Amanda<sup>*</sup> (<span class="authorship-author-name">Demeter Amanda</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="10084062"><a href="/gui2/?type=authors&mode=browse&sel=10084062" target="_blank">Kiraly Peter<sup>*</sup> (<span class="authorship-author-name">Király Péter</span> <span class="authorAux-mtmt"> Fizikai-kémia</span>) </a> </span> ;    <span class="author-name" mtid="10019319"><a href="/gui2/?type=authors&mode=browse&sel=10019319" target="_blank">Balogh Andrea (<span class="authorship-author-name">Balogh Andrea</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> ;    <span class="author-name" >Wilson Melissa L. </span> ;    <span class="author-name" >King Jennifer R. </span> ;    <span class="author-name" >Hetey Szabolcs </span> ;    <span class="author-name" mtid="10029869"><a href="/gui2/?type=authors&mode=browse&sel=10029869" target="_blank">Gelencser Zsolt (<span class="authorship-author-name">Gelencsér Zsolt</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" >Matsuo Koji </span> ;    <span class="author-name" mtid="10032563"><a href="/gui2/?type=authors&mode=browse&sel=10032563" target="_blank">Hargitai Beata (<span class="authorship-author-name">Hargitai Beáta</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> ;    <span class="author-name" >Mhawech-Fauceglia Paulette </span> ;    <span class="author-name" mtid="10012513"><a href="/gui2/?type=authors&mode=browse&sel=10012513" target="_blank">Hupuczi Petronella (<span class="authorship-author-name">Hupuczi Petronella</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy</span> ;    <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilagyi Andras (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> ;    <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltan (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology</span> ;    <span class="author-name" >Roman Lynda D. </span> ;    <span class="author-name" >Cortessis Victoria K. </span> ;    <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nandor Gabor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/I. Department of Pathology and experimental Cancer Research; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_416</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32546517" target="_blank">Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease</a></div> <div> <span class="journal-title">BIOMEDICINES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2227-9059">2227-9059</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">12</span> <span class="page"> Paper 1935. 21 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/biomedicines9121935" target="_blank" href="https://doi.org/10.3390/biomedicines9121935"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000736261600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000736261600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85121436375" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85121436375"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34944751" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34944751&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 13 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus: 12 | WoS/Scopus assigned: 13 | Number of citations with DOI: 13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32546517&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32546517</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2014-7/2014,), (K128262), (K124862), (FIEK_16-1-2016-0005), (VEKOP-2.3.3-15-2017-0014) </div> <div class="lastModified">Last Modified: 2026.01.13. 10:29 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian Academy of Sciences, Momentum Grant [LP2014-7/2014]; Hungarian Academy of Sciences, Premium Postdoc Grant [2019-436]; Hungarian Academy of Sciences, Young Researcher Fellowships; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [OTKA K128262, OTKA K124862, FIEK_16-1-2016-0005]; Hungarian Minis...</pre> </div></div>