@article{MTMT:34556248,
	title = {Diverse diterpenoids and a triterpenoid from Euphorbia spinidens Bornm. ex Prokh},
	url = {https://m2.mtmt.hu/api/publication/34556248},
	author = {Shakeri, Abolfazl and Mirahmadi, Mohammad Reza and Kunert, Olaf and Tsai, Yu-Chi and Barta, Anita and Hohmann, Judit and Asili, Javad},
	doi = {10.1016/j.fitote.2024.105838},
	journal-iso = {FITOTERAPIA},
	journal = {FITOTERAPIA},
	volume = {173},
	unique-id = {34556248},
	issn = {0367-326X},
	year = {2024},
	eissn = {1873-6971},
	orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:33049439,
	title = {Antiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines.},
	url = {https://m2.mtmt.hu/api/publication/33049439},
	author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Yu-Chi and Rácz, Bálint and Spengler, Gabriella and Csupor, Dezső},
	doi = {10.1080/13880209.2022.2103574},
	journal-iso = {PHARM BIOL},
	journal = {PHARMACEUTICAL BIOLOGY},
	volume = {60},
	unique-id = {33049439},
	issn = {1388-0209},
	abstract = {Ambrosia artemisiifolia L. (Asteraceae) contains sesquiterpene lactones as characteristic secondary metabolites. Many of these compounds exert antiproliferative and cytotoxic effects.To isolate the sesquiterpene lactones from the aerial part of A. artemisiifolia and to elucidate their cytotoxic, antiproliferative and antibacterial effects.The compounds were identified by one-dimensional (1D) and 2D NMR, HR-MS spectroscopy from the methanol extract. Isolated compounds were investigated for their cytotoxic and antiproliferative effects on human colonic adenocarcinoma cell lines and human embryonal lung fibroblast cell line using MTT assay. The selectivity of the sesquiterpenes was calculated towards the normal cell line. To check the effect of drug interactions between compounds and doxorubicin, multidrug-resistant Colo 320 cells were used.A new seco-psilostachyinolide derivative, 1,10-dihydro-1'-noraltamisin, and seven known compounds were isolated from the methanol extract. Acetoxydihydrodamsin had the most potent cytotoxic effect on sensitive (Colo205) cell line (IC50 = 7.64 µM), also the strongest antiproliferative effect on Colo205 (IC50 = 5.14 µM) and Colo320 (IC50 = 3.67 µM) cell lines. 1'-Noraltamisin (IC50 = 8.78 µM) and psilostachyin (IC50 = 5.29 µM) showed significant antiproliferative effects on the multidrug-resistant Colo320 cell line and had moderate selectivity against human embryonal lung fibroblast cell line. Psilostachyin C exhibited cytotoxic effects on Colo205 cells (IC50 = 26.60 µM). None of the isolated compounds inhibited ABCB1 efflux pump (EP; P-glycoprotein) or the bacterial EPs.Acetoxydihydrodamsin, 1'-noraltamisin, and psilostachyin showed the most remarkable cytotoxic and antiproliferative activity on tumour cell lines and exerted selectivity towards MRC-5 cell line.},
	keywords = {ASTERACEAE; RAGWEED; 1,10-dihydro-1′-noraltamisin; human colonic},
	year = {2022},
	eissn = {1744-5116},
	pages = {1511-1519},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:32765771,
	title = {Triterpenes and Phenolic Compounds from Euphorbia deightonii with Antiviral Activity against Herpes Simplex Virus Type-2},
	url = {https://m2.mtmt.hu/api/publication/32765771},
	author = {Saidu, Muhammad Bello and Kúsz, Norbert and Tsai, Yu-Chi and Vágvölgyi, Máté and Berkecz, Róbert and Kókai, Dávid and Burián, Katalin and Hohmann, Judit and Rédei, Dóra},
	doi = {10.3390/plants11060764},
	journal-iso = {PLANTS-BASEL},
	journal = {PLANTS-BASEL},
	volume = {11},
	unique-id = {32765771},
	abstract = {Two undescribed compounds, 3 beta,7 beta-dihydroxy-24-methylenelanosta-8-ene-11-one (1) and neolignane deightonin (4) were isolated from the aerial parts of Euphorbia deightonii Croizat together with six known compounds, namely, kansenone (2), euphorbol-7-one (3), dehydrodiconiferyl diacetate (5), marylaurencinol D (6), scoparon (7), and 3,4,3'-tri-O-methylellagic acid (8). The structures of the isolated compounds were determined by HRESIMS, 1D (H-1, C-13 JMOD) and 2D NMR (HSQC, HMBC, H-1-H-1 COSY, NOESY) spectroscopic analysis, and by comparison of the assignments with literature data. The anti-herpes simplex virus type-2 activity of the isolated compounds were investigated by qRT-PCR assay on Vero cells after determining cytotoxic concentration 50% (CC50). Compounds 1, 3, 4, and 7 exhibited inhibitory effects with respective IC50 values of 7.05, 2.42, 11.73, and 0.032 mu M. Scoparon (7) showed the strongest anti-HSV activity with a selectivity index of 10.93.},
	year = {2022},
	eissn = {2223-7747},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Vágvölgyi, Máté/0000-0002-2233-9422; Berkecz, Róbert/0000-0002-9076-2177; Burián, Katalin/0000-0003-1300-2374; Hohmann, Judit/0000-0002-2887-6392; Rédei, Dóra/0000-0002-5013-247X}
}

@article{MTMT:31388948,
	title = {Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus},
	url = {https://m2.mtmt.hu/api/publication/31388948},
	author = {Mottaghipisheh, Javad and Kúsz, Norbert and Hohmann, Judit and Tsai, Yu-Chi and Csupor, Dezső},
	doi = {10.1515/znc-2020-0059},
	journal-iso = {Z NATURFORSCH C},
	journal = {ZEITSCHRIFT FÜR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES},
	volume = {76},
	unique-id = {31388948},
	issn = {0939-5075},
	year = {2021},
	eissn = {1865-7125},
	pages = {43-47},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:32100393,
	title = {Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity},
	url = {https://m2.mtmt.hu/api/publication/32100393},
	author = {Tsai, Yu-Chi and Nell, Racheal A. and Buckendorf, Jonathan E. and Kúsz, Norbert and Mwangi, Peter Waweru and Berkecz, Róbert and Rédei, Dóra and Vasas, Andrea and Spivak, Adam M. and Hohmann, Judit},
	doi = {10.3390/ph14070653},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {14},
	unique-id = {32100393},
	year = {2021},
	eissn = {1424-8247},
	orcid-numbers = {Nell, Racheal A./0000-0002-0324-7522; Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Rédei, Dóra/0000-0002-5013-247X; Vasas, Andrea/0000-0002-1818-7702; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:31629692,
	title = {12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells via Activation of PKC-δ/PKD/ERK Signaling Pathway},
	url = {https://m2.mtmt.hu/api/publication/31629692},
	author = {Tsai, Yu-Chi and Rédei, Dóra and Hohmann, Judit and Wu, Chin-Chung},
	doi = {10.3390/ijms21207579},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31629692},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Rédei, Dóra/0000-0002-5013-247X; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:31192304,
	title = {Bioactive constituents of Lindernia crustacea and its anti-EBV effect via Rta expression inhibition in the viral lytic cycle},
	url = {https://m2.mtmt.hu/api/publication/31192304},
	author = {Tsai, Yu-Chi and Hohmann, Judit and El-Shazly, Mohamed and Chang, Li-Kwan and Dankó, Balázs Ödön and Kúsz, Norbert and Hsieh, Chi-Ting and Hunyadi, Attila and Chang, Fang-Rong},
	doi = {10.1016/j.jep.2019.112493},
	journal-iso = {J ETHNOPHARMACOL},
	journal = {JOURNAL OF ETHNOPHARMACOLOGY},
	volume = {250},
	unique-id = {31192304},
	issn = {0378-8741},
	abstract = {Ethnopharmacological relevance
		Lindernia crustacea (L.) F.Muell. (Scrophulariaceae) was selected for phytochemical investigation owing to its traditional use against human herpes virus infection and its anti-Epstein–Barr virus (EBV) effect.
		
		Aims of the study
		The present study focused on the phytochemical investigation of L. crustacea including the isolation and structure determination of its biologically active compounds. Compounds with anti-EBV effects were also investigated.
		
		Materials and methods
		The EtOH extract of L. crustacea was subsequently partitioned using different solvents. The EtOAc fraction was subjected to several chromatographic methods to obtain pure compounds. The structures of all isolates were established by spectroscopic analysis and compared with previously reported physical data. The anti-EBV effect was evaluated in an EBV-containing Burkitt's lymphoma cell line (P3HR1) to study the expression of EBV lytic proteins.
		
		Results
		Thirty-three compounds, including one diterpene (1), four anthraquinones (2–5), two ionones (6 and 7), fourteen phenylpropanoid glycosides (8–21), five flavonoids (22–26), one lignan glycoside (27), one phenethyl alcohol glycoside (28), one phenylpropene glycoside (29), one glucosyl glycerol derivative (30), one furanone (31), and two cinnamic acid derivatives (32 and 33), were isolated from the ethanolic extract of the plant. All isolated compounds were obtained for the first time from Lindernia sp. The evaluation of the anti-EBV activity of L. crustacea crude extract, partitioned fractions, and constituents was performed for the first time. Phytol (1), aloe-emodin (2), byzantionoside B (7), a mixture of trans-martynoside (8) and cis-martynoside (9), a mixture of trans-isomartynoside (10) and cis-isomartynoside (11), luteolin-7-O-β-D-glucopyranoside (24), and apigenin-7-O-[β-D-apiofuranosyl (1→6)-β-D-glucopyranoside] (25) exhibited significant inhibitory effects on the EBV lytic cycle at 20 μg/mL in the immunoblot analysis. On the other hand, (6R,7E,9R)-3-oxo-α-ionol-β-D-glucopyranoside (6) and a mixture of trans-dolichandroside A (12) and cis-dolichandroside A (13) showed moderate anti-EBV activity at 20 μg/mL.
		
		Conclusions
		L. crustacea and its active isolates could be developed as potential candidates against EBV. Our findings provide scientific evidence for the traditional use of L. crustacea for its antiviral effects.},
	year = {2020},
	eissn = {1872-7573},
	orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392; Kúsz, Norbert/0000-0002-9973-6442; Hunyadi, Attila/0000-0003-0074-3472}
}

@{MTMT:30718576,
	title = {Isolation of sesquiterpene lactones from common ragweed (Ambrosia artemisiifolia L.)},
	url = {https://m2.mtmt.hu/api/publication/30718576},
	author = {Kovács, Balázs and Kiss, Tivadar and Csupor-Löffler, Boglárka and Ferencz, Elek and Kúsz, Norbert and Tsai, Yu-Chi and Hohmann, Judit and Csupor, Dezső},
	booktitle = {Trends in Natural Product Research - PSE Young Scientists’ Meeting on Biochemistry, Molecular Aspects and Pharmacology of Bioactive Natural Products},
	doi = {10.14232/tnpr.2019.po21},
	unique-id = {30718576},
	abstract = {Common ragweed (Ambrosia artemisiifolia L., Asteraceae) is an invasive species in Europe with allergic pollens. Ragweed originates from North America, but it also occurs and is spreading in Europe, due to the plant’s successful reproductive potential and a strong allelopathic effects against the native flora. Some of the plant’s secondary metabolites, called sesquiterpene lactones possess allergic, allopathic, anti-inflammatory, antitumor, antimicrobial activity. In a phytochemical view the plant secondary metabolites have not explored completely. The aim of our study was to isolate the major phytochemicals from the aerial parts of Ambrosia artemisiifolia, especially focusing on the sesquiterpene lactone compounds, and elucidate their chemical structure. The methanolic extract of the plant was separated by several chromatographic techniques, including preparative TLC and HPLC analysis. One new and six known sesquiterpene lactones were isolated from the aerial parts of ragweed. Their structure was identified by 1H NMR, 13C NMR and mass spectroscopy. 1’-Noraltamisin, a seco-pseudoguaianolide was reported for the first time from this plant. Further investigation needed to identify the biological activities and molecular mechanisms of the isolated compounds, particularly the new seco-pseudoguaianolide.},
	year = {2019},
	pages = {103-103},
	orcid-numbers = {Kiss, Tivadar/0000-0003-3538-377X; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333}
}

@{MTMT:30718583,
	title = {Isolation and structural elucidation of secondary metabolites from Eremurus persicus},
	url = {https://m2.mtmt.hu/api/publication/30718583},
	author = {Mottaghipisheh, Javad and Kúsz, Norbert and Hohmann, Judit and Tsai, Yu-Chi and Csupor, Dezső},
	booktitle = {Trends in Natural Product Research - PSE Young Scientists’ Meeting on Biochemistry, Molecular Aspects and Pharmacology of Bioactive Natural Products},
	doi = {10.14232/tnpr.2019.po22},
	unique-id = {30718583},
	year = {2019},
	pages = {104-104},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:30436568,
	title = {Isolation and absolute configuration determination of alkaloids from Pandanus amaryllifolius},
	url = {https://m2.mtmt.hu/api/publication/30436568},
	author = {Cheng, Y.-B. and Hu, H.-C. and Tsai, Yu-Chi and Chen, S.-L. and El-Shazly, M. and Nonato, M.G. and Wu, Y.-C. and Chang, F.-R.},
	doi = {10.1016/j.tet.2017.05.002},
	journal-iso = {TETRAHEDRON},
	journal = {TETRAHEDRON},
	volume = {73},
	unique-id = {30436568},
	issn = {0040-4020},
	abstract = {Seven new alkaloids belonging to three typical classes, isolated from an ethanolic extract of Pandanus amaryllifolius, were applied to establish the models in structural elucidation. The first type [pandanusines A and B (1 and 2)] was applied to alkaloids with a diazaspirocyclic ring system. The absolute stereochemistry of aminal carbon is determined by analysis of J-based configuration analysis and circular dichroism spectroscopy, which has never been revealed before. The second type [pandalizines C–E (3–5)], the stereochemistry of unusual indolizinone with chiral hydroxyl substitutions were determined by circular dichroism spectroscopy and vibrational circular dichroism experiments. The last type [norpandamarilactonines C and D (6 and 7)], a comparing model in determination of diastereomers of pyrrolidinyl α,β-unsaturated γ-lactone alkaloids was established. Our study provides solutions for a challenging subject in stereochemistry determination for three different types of Pandanus alkaloids. © 2017 Elsevier Ltd},
	keywords = {ARTICLE; STEREOCHEMISTRY; ALKALOIDS; priority journal; controlled study; unclassified drug; Circular Dichroism; density functional theory; diastereoisomer; alkaloid derivative; Absolute configuration; norpandamarilactonine C; norpandamarilactonine d; pandalizine c; pandalizine d; pandalizine e; pandanusine a; pandanusine b; Pandanus amaryllifolius; Pandanus amaryllifolius},
	year = {2017},
	eissn = {1464-5416},
	pages = {3423-3429}
}