{ "labelLang" : "hun", "responseDate" : "2024-03-29 00:31", "paging" : { "last" : false, "first" : true, "totalPages" : 2, "totalElements" : 11, "totalUncutElements" : 11, "totalEstimatedElements" : 20, "size" : 10, "number" : 1, "numberOfElements" : 10, "sort" : [ { "direction" : "DESC", "property" : "publishedYear", "ascending" : false }, { "direction" : "ASC", "property" : "firstAuthor", "ascending" : true } ] }, "content" : [ { "otype" : "JournalArticle", "mtid" : 33709440, "status" : "VALIDATED", "published" : true, "comment" : "Institute of Pharmacognosy, University of Szeged, Szeged, H-6720, Hungary \n Institute of Pharmaceutical Analysis, University of Szeged, Szeged, H-6720, Hungary \n Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan \n Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, H-6720, Hungary \n Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Budapest, H-1111, Hungary \n Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, H-6720, Hungary \n Export Date: 11 April 2023 \n Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Hungary; email: hunyadi.attila@szte.hu", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2024-02-28T11:38:05.711+0000", "lastModified" : "2023-03-31T08:01:56.119+0000", "created" : "2023-03-21T15:00:33.672+0000", "creator" : { "otype" : "Admin", "mtid" : 10028925, "link" : "/api/admin/10028925", "label" : "Kiss Tivadar (SZTE GYTK admin5 Farmakognózia)", "familyName" : "Kiss", "givenName" : "Tivadar", "published" : true, "oldId" : 10028925, "snippet" : true }, "lastDuplumOK" : "2023-08-28T16:13:42.264+0000", "lastDuplumSearch" : "2023-08-28T16:13:42.264+0000", "validated" : "2023-03-22T07:18:21.030+0000", "validator" : { "otype" : "Admin", "mtid" : 10073049, "link" : "/api/admin/10073049", "label" : "Sóki Edina (SZTE admin5)", "familyName" : "Sóki", "givenName" : "Edina", "published" : true, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Ahmed, Sara H. H.", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 107084770, "link" : "/api/authorship/107084770", "label" : "Ahmed, Sara H. H. [AHMED, Sara Hassan Hassan (farmakognózia), szerző] Farmakognóziai Intézet (SZTE / GYTK)", "listPosition" : 1, "share" : 0.1, "first" : true, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10078345, "link" : "/api/author/10078345", "label" : "AHMED Sara Hassan Hassan (farmakognózia)", "familyName" : "AHMED", "givenName" : "Sara Hassan Hassan", "published" : true, "snippet" : true }, "familyName" : "Ahmed", "givenName" : "Sara H. H.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084771, "link" : "/api/authorship/107084771", "label" : "Gonda, Tímea* [Gonda, Tímea (farmakognózia), szerző] Farmakognóziai Intézet (SZTE / GYTK)", "listPosition" : 2, "share" : 0.1, "first" : true, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10057647, "link" : "/api/author/10057647", "label" : "Gonda Tímea (farmakognózia)", "familyName" : "Gonda", "givenName" : "Tímea", "published" : true, "oldId" : 10057647, "snippet" : true }, "familyName" : "Gonda", "givenName" : "Tímea", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084772, "link" : "/api/authorship/107084772", "label" : "Agbadua, Orinamhe G. [Agbadua, Orinamhe Godwin (pharmacognosy), szerző] Farmakognóziai Intézet (SZTE / GYTK)", "listPosition" : 3, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10065540, "link" : "/api/author/10065540", "label" : "Agbadua Orinamhe Godwin (pharmacognosy)", "familyName" : "Agbadua", "givenName" : "Orinamhe Godwin", "published" : true, "snippet" : true }, "familyName" : "Agbadua", "givenName" : "Orinamhe G.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084773, "link" : "/api/authorship/107084773", "label" : "Girst, Gábor [Girst, Gábor (farmakognózia), szerző] Farmakognóziai Intézet (SZTE / GYTK)", "listPosition" : 4, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10063365, "link" : "/api/author/10063365", "label" : "Girst Gábor (farmakognózia)", "familyName" : "Girst", "givenName" : "Gábor", "published" : true, "oldId" : 10063365, "snippet" : true }, "familyName" : "Girst", "givenName" : "Gábor", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084774, "link" : "/api/authorship/107084774", "label" : "Berkecz, Róbert [Berkecz, Róbert (analitikai kémia), szerző] Gyógyszeranalitikai Intézet (SZTE / GYTK)", "listPosition" : 5, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10027474, "link" : "/api/author/10027474", "label" : "Berkecz Róbert (analitikai kémia)", "familyName" : "Berkecz", "givenName" : "Róbert", "published" : true, "oldId" : 10027474, "snippet" : true }, "familyName" : "Berkecz", "givenName" : "Róbert", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084775, "link" : "/api/authorship/107084775", "label" : "Kúsz, Norbert [Kúsz, Norbert (Farmakognózia), szerző] Farmakognóziai Intézet (SZTE / GYTK)", "listPosition" : 6, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10039523, "link" : "/api/author/10039523", "label" : "Kúsz Norbert (Farmakognózia)", "familyName" : "Kúsz", "givenName" : "Norbert", "published" : true, "oldId" : 10039523, "snippet" : true }, "familyName" : "Kúsz", "givenName" : "Norbert", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084776, "link" : "/api/authorship/107084776", "label" : "Tsai, Meng-Chun", "listPosition" : 7, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Tsai", "givenName" : "Meng-Chun", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084777, "link" : "/api/authorship/107084777", "label" : "Wu, Chin-Chung", "listPosition" : 8, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Wu", "givenName" : "Chin-Chung", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084778, "link" : "/api/authorship/107084778", "label" : "Balogh, György T. [Balogh, György Tibor (Gyógyszerkémia), szerző] Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK); Gyógyszerhatástani és Biofarmáciai Intézet (SZTE / GYTK)", "listPosition" : 9, "share" : 0.1, "first" : false, "last" : false, "corresponding" : false, "author" : { "otype" : "Author", "mtid" : 10011949, "link" : "/api/author/10011949", "label" : "Balogh György Tibor (Gyógyszerkémia)", "familyName" : "Balogh", "givenName" : "György Tibor", "published" : true, "oldId" : 10011949, "snippet" : true }, "familyName" : "Balogh", "givenName" : "György T.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 107084779, "link" : "/api/authorship/107084779", "label" : "Hunyadi, Attila ✉ [Hunyadi, Attila (Farmakognózia), szerző] Farmakognóziai Intézet (SZTE / GYTK); Természetes Vegyületek Interdiszciplináris Központ (SZTE / KE)", "listPosition" : 10, "share" : 0.1, "first" : false, "last" : true, "corresponding" : true, "author" : { "otype" : "Author", "mtid" : 10020644, "link" : "/api/author/10020644", "label" : "Hunyadi Attila (Farmakognózia)", "familyName" : "Hunyadi", "givenName" : "Attila", "published" : true, "oldId" : 10020644, "snippet" : true }, "familyName" : "Hunyadi", "givenName" : "Attila", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Preparation and Evaluation of 6-Gingerol Derivatives as Novel Antioxidants and Antiplatelet Agents", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 23261845, "link" : "/api/publicationidentifier/23261845", "label" : "DOI: 10.3390/antiox12030744", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaType" : "GOLD", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "10.3390/antiox12030744", "realUrl" : "https://doi.org/10.3390/antiox12030744", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 23333705, "link" : "/api/publicationidentifier/23333705", "label" : "WoS: 000952792800001", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000952792800001", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000952792800001", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 23351399, "link" : "/api/publicationidentifier/23351399", "label" : "Scopus: 85151374065", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85151374065", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151374065", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 23305852, "link" : "/api/publicationidentifier/23305852", "label" : "PubMed: 36978992", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "36978992", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36978992&dopt=Abstract", "published" : true, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 23261846, "link" : "/api/publicationidentifier/23261846", "label" : "Egyéb URL: https://www.mdpi.com/2076-3921/12/3/744", "source" : { "otype" : "PlainSource", "mtid" : 40, "link" : "/api/publicationsource/40", "label" : "Egyéb URL", "type" : { "otype" : "PublicationSourceType", "mtid" : 10006, "link" : "/api/publicationsourcetype/10006", "label" : "Link", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "Egyéb URL", "nameEng" : "Other URL", "linkPattern" : "@@@", "publiclyVisible" : true, "published" : true, "oldId" : 40, "snippet" : true }, "idValue" : "https://www.mdpi.com/2076-3921/12/3/744", "realUrl" : "https://www.mdpi.com/2076-3921/12/3/744", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 23261849, "link" : "/api/publicationidentifier/23261849", "label" : "SZTE Publicatio: 26790", "source" : { "otype" : "SwordSource", "mtid" : 90, "link" : "/api/publicationsource/90", "label" : "SZTE Publicatio", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "SZTE Publicatio", "nameEng" : "SZTE Publicatio", "linkPattern" : "http://publicatio.bibl.u-szeged.hu/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 90, "snippet" : true }, "oaType" : "GREEN", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "26790", "realUrl" : "http://publicatio.bibl.u-szeged.hu/26790", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10052535, "link" : "/api/journal/10052535", "label" : "ANTIOXIDANTS 2076-3921", "eIssn" : "2076-3921", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10052535, "snippet" : true }, "volume" : "12", "issue" : "3", "internalId" : "744", "firstPageOrInternalIdForSort" : "744", "pageLength" : 18, "publishedYear" : 2023, "abstractText" : "Ginger (Zingiber officinale) is widely used as a spice and a traditional medicine. Many bioactivities have been reported for its extracts and the isolated compounds, including cardiovascular protective effects. Different pathways were suggested to contribute to these effects, like the inhibition of platelet aggregation. In this study, we synthesised fourteen 6-gingerol derivatives, including eight new compounds, and studied their antiplatelet, COX-1 inhibitor, and antioxidant activities. In silico docking of selected compounds to h-COX-1 enzyme revealed favourable interactions. The investigated 6-gingerol derivatives were also characterised by in silico and experimental physicochemical and blood–brain barrier-related parameters for lead and preclinical candidate selection. 6-Shogaol (2) was identified as the best overall antiplatelet lead, along with compounds 3 and 11 and the new compound 17, which require formulation to optimize their water solubility. Compound 5 was identified as the most potent antioxidant that is also promising for use in the central nervous system (CNS).", "subjects" : [ { "otype" : "Classification", "mtid" : 12184, "link" : "/api/classification/12184", "label" : "Farmakológia és gyógyszerészet", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12187, "link" : "/api/classification/12187", "label" : "Gyógyszerismeret", "published" : true, "snippet" : true } ], "fundings" : [ { "otype" : "Funding", "mtid" : 2024809, "link" : "/api/funding/2024809", "label" : "(K-134704) Támogató: NKFIH", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 2024810, "link" : "/api/funding/2024810", "label" : "(TKP2021-EGA-32) Támogató: NKFIH", "published" : false, "snippet" : true } ], "digital" : true, "printed" : null, "sourceYear" : 2023, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-28", "oaFree" : true, "oaLink" : "https://doi.org/10.3390/antiox12030744", "citationCount" : 1, "citationCountUnpublished" : 0, "citationCountWoOther" : 1, "independentCitCountWoOther" : 1, "nationalOriginCitationCount" : 0, "foreignEditionCitationCount" : 1, "doiCitationCount" : 1, "wosCitationCount" : 1, "scopusCitationCount" : 1, "wosScopusCitationCount" : 1, "wosScopusCitationCountWoOther" : 1, "wosScopusIndependentCitationCount" : 1, "wosScopusIndependentCitationCountWoOther" : 1, "independentCitationCount" : 1, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 1, "independentCitingPubCount" : 1, "citingPubCountWoOther" : 1, "independentCitingPubCountWoOther" : 1, "unhandledCitingPubCount" : 0, "citedPubCount" : 4, "citedCount" : 4, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11379439, "link" : "/api/sjrrating/11379439", "label" : "sjr:D1 (2023) Scopus - Food Science ANTIOXIDANTS 2076-3921", "listPos" : 29, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1106, "link" : "/api/classificationexternal/1106", "label" : "Scopus - Food Science", "published" : true, "oldId" : 1106, "snippet" : true }, "ranking" : "D1", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "userChangeableUntil" : "2023-03-20T15:00:39.791+0000", "directInstitutesForSort" : "Farmakognóziai Intézet (SZTE / GYTK); Gyógyszeranalitikai Intézet (SZTE / GYTK); Gyógyszerhatástani és Biofarmáciai Intézet (SZTE / GYTK); Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK); Természetes Vegyületek Interdiszciplináris Központ (SZTE / KE)", "ownerAuthorCount" : 8, "ownerInstituteCount" : 32, "directInstituteCount" : 5, "authorCount" : 10, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/33709440", "label" : "Ahmed Sara H. et al. Preparation and Evaluation of 6-Gingerol Derivatives as Novel Antioxidants and Antiplatelet Agents. (2023) ANTIOXIDANTS 2076-3921 12 3", "template" : "