TY - JOUR AU - Sargazifar, Zahra AU - Esmaeilzadeh Kashi, Marziyeh AU - Tazik, Zahra AU - Mottaghipisheh, Javad AU - Hosseini, Seyed Hamzeh AU - Stuppner, Hermann AU - Shakeri, Abolfazl AU - Asili, Javad TI - A new diterpenoid from Salvia santolinifolia boiss JF - NATURAL PRODUCT RESEARCH J2 - NAT PROD RES VL - 38 PY - 2024 IS - 9 SP - 1570 EP - 1576 PG - 7 SN - 1478-6419 DO - 10.1080/14786419.2022.2161538 UR - https://m2.mtmt.hu/api/publication/33924008 ID - 33924008 AB - Phytochemical study of the Salvia santolinifolia root extract resulted in the isolation of one new quinone diterpenoid, aegyptinone E (1) as well as two known ones, aegyptinone A (2) and aegyptinone D (3). All the isolated compounds were reported for the first time from S. santolinifolia. Spectroscopic analyses including 1 D and 2 D NMR and HRESIMS were used to determine the chemical structures. Aegyptinone A (2) showed moderate antibacterial activity against Staphylococcus aureus, Staphylococcus epidermis, and Bacillus subtilis with MIC of 25 mu g/mL. LA - English DB - MTMT ER - TY - JOUR AU - Khosravi, Saeed AU - Haghighi, Maryam AU - Mottaghipisheh, Javad TI - Effects of melatonin foliar application on hot pepper growth and stress tolerance JF - PLANT STRESS J2 - PLANT STRESS VL - 9 PY - 2023 PG - 12 SN - 2667-064X DO - 10.1016/j.stress.2023.100192 UR - https://m2.mtmt.hu/api/publication/34318164 ID - 34318164 AB - Purpose: Drought and waterlogging are one of the most severe abiotic stresses towards plant growth and development. The experiment was implemented in the Isfahan University of Technology's research greenhouse to examine the effect of melatonin foliar spraying in hot pepper plants under waterlogging and drought stresses. Methods: This factorial experiment was performed as a complete randomized design (CRD) in triplicate. The treatments included controls, waterlogging, drought stress, and melatonin foliar spraying at 0 and 500 & mu;M concentrations. Results: The results demonstrated that the foliar melatonin spraying was more advantageous under drought and waterlogging stress conditions via increasing ammonium content, NR (nitrate reductase activity), chlorophyll content, proline, protein, transpiration, shoot length, root water content, amino acid alterations, and PIP gene expression. Conclusions: Melatonin influenced the hot pepper's growth by affecting enzyme activity NR hormonal changes (ABA), amino acid changes, and PIP gene expression. LA - English DB - MTMT ER - TY - JOUR AU - Rahimpour, Yahya AU - Doorandishan, Mina AU - Dehsheikh, Anahita Boveiri AU - Mahmoodi Sourestani, Mohammad AU - Mottaghipisheh, Javad TI - A review on Torilis japonica: ethnomedicinal, phytochemical, and biological features JF - CHEMISTRY & BIODIVERSITY J2 - CHEM BIODIVERS VL - 20 PY - 2023 IS - 5 SN - 1612-1872 DO - 10.1002/cbdv.202201071 UR - https://m2.mtmt.hu/api/publication/33778473 ID - 33778473 LA - English DB - MTMT ER - TY - JOUR AU - Rodríguez-Mejías, Francisco J. AU - Mottaghipisheh, Javad AU - Schwaiger, Stefan AU - Kiss, Tivadar AU - Csupor, Dezső AU - Varela, Rosa M. AU - Macías, Francisco A. TI - Allelopathic studies with furanocoumarins isolated from Ducrosia anethifolia. In vitro and in silico investigations to protect legumes, rice and grain crops JF - PHYTOCHEMISTRY J2 - PHYTOCHEMISTRY VL - 215 PY - 2023 PG - 11 SN - 0031-9422 DO - 10.1016/j.phytochem.2023.113838 UR - https://m2.mtmt.hu/api/publication/34117692 ID - 34117692 N1 - Export Date: 28 November 2023; CODEN: PYTCA LA - English DB - MTMT ER - TY - JOUR AU - Salehi, Vahid AU - Malekiasl, Haniyeh AU - Azizi, Mahdokht AU - Nouripour-Sisakht, Sadegh AU - Gharaghani, Maral AU - Saberinejad, Ali Akbar AU - Moslemi, Zahra AU - Eftekhari, Mahdieh AU - Mottaghipisheh, Javad AU - Ghaderi, Sajad AU - Doustimotlagh, Amir Hossein AU - Karimifard, Farzaneh TI - Oliveria decumbens Extract Exhibits Hepatoprotective Effects Against Bile Duct Ligation-Induced Liver Injury in Rats by Reducing Oxidative Stress JF - HEPATITIS MONTHLY J2 - HEPAT MON VL - 23 PY - 2023 IS - 1 PG - 13 SN - 1735-143X DO - 10.5812/hepatmon-131160 UR - https://m2.mtmt.hu/api/publication/34361114 ID - 34361114 AB - Background: Cholestasis is described as a disease in which bile flow from the liver is reduced or stopped, and due to its oxidative effects, irreversible consequences may occur.Objectives: Due to the remarkable antioxidant properties of Oliveria decumbens (OD) and the contribution of oxidants to the pro-gression of bile duct ligation (BDL)-induced cholestasis, this research aimed to examine how the OD ethanolic extract affected liver damage and oxidant-antioxidant balance markers in BDL-induced cholestasis. Methods: Forty male Wistar rats weighing 200 -250 g were used. Cholestasis was induced using the BDL approach. The rats were categorized into four groups: Group 1, sham-control (SC); group 2, cholestatic; group 3, SC + OD; and group 4, cholestatic + OD. A dose of OD ethanolic extract was administered orally (500 mg/kg/day) to rats for seven days. Seven days following surgery, the rats' blood samples were collected; after sacrifice, a part of the liver tissue was isolated. A histopathological examination was performed, while the rest was stored at-70 & DEG;C in liquid nitrogen. Heparin-containing tubes were used to gather blood samples. In plasma and hepatic tissue, biochemical tests, histopathological evaluations, and oxidative stress markers staining levels were performed. Results: Our findings showed that OD could effectively reduce liver injury by reducing the activity of liver function enzymes (AST and ALP). At the same time, it did not affect total bilirubin and protein. Bile duct ligation-induced hepatic markers of protein oxi-dation (PCO) and reactive nitrogen species (NO) were significantly decreased by OD, and it also promoted liver antioxidant capacity by enhancing superoxide dismutase (SOD) activities. Moreover, OD treatment prevented liver bile duct proliferative changes in histopathologic analysis.Conclusions: Our study confirmed that OD exerts substantial hepatoprotective activities against BDL-induced cholestasis by im-proving liver damage markers and regulating oxidative stress. It may be a beneficial therapeutic agent for managing cholestasis. Bioassay-guided isolation and identification of bioactive OD secondary metabolites can further direct the discovery of potential natural-based drug candidates. LA - English DB - MTMT ER - TY - JOUR AU - Khanam, Mehrun Nisha AU - Anis, Mohammad AU - Bin, Javed Saad AU - Mottaghipisheh, Javad AU - Csupor, Dezső TI - Adventitious Root Culture-An Alternative Strategy for Secondary Metabolite Production: A Review JF - AGRONOMY (BASEL) J2 - AGRONOMY-BASEL VL - 12 PY - 2022 IS - 5 PG - 18 SN - 2073-4395 DO - 10.3390/agronomy12051178 UR - https://m2.mtmt.hu/api/publication/32870684 ID - 32870684 AB - Medicinal plants are valuable sources of botanical drugs, extracts and pure compounds. Although several species can be propagated or collected, the access to herbal material is limited in certain cases. The protection of natural habitats and biodiversity demands new sources to provide plant secondary metabolites of medical importance. Adventitious root culture is used to harvest the secondary metabolites from the medicinally important plants, thereby offering an alternative to collection and propagation of medicinal plants. In this review, we comprehensively summarize the previously published data on the use of adventitious root cultures for numerous therapeutic plants. Adventitious roots showed elevated growth rates and production of pharmaceutically important metabolites under sterilized condition with optimized plant-growth regulators in culture media. In the present study, major influencing factors, such as the stages involved in the process of adventitious root formation, medium composition and type of growth regulators, specifically the effect of different auxins on the initiation and formation of roots, are discussed. Elicitation strategies using biotic (yeast extracts, chitosan and pectin) and abiotic factors (MJ, SA, CuSO4, AgNO3, NaCl) that affect the in vitro growth of adventitious roots and the role of bioreactors, which are new advancements in the scale-up process, are also highlighted. The development of adventitious root cultures for the production of secondary metabolites of medicinal importance is a perspective that is advantageous from ecological and economical aspects as well. LA - English DB - MTMT ER - TY - JOUR AU - Mottaghipisheh, Javad AU - Doustimotlagh, Amir Hossein AU - Irajie, Cambyz AU - Tanideh, Nader AU - Barzegar, Alireza AU - Iraji, Aida TI - The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer JF - CELLS J2 - CELLS-BASEL VL - 11 PY - 2022 IS - 7 PG - 27 SN - 2073-4409 DO - 10.3390/cells11071070 UR - https://m2.mtmt.hu/api/publication/33395980 ID - 33395980 AB - As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity properties of these advantageous phytochemicals have been reported; among them, their significant abilities in the suppression of tumor cells are of the promising therapeutic features, which have recently attracted great attention. The prostate malignancy, is considered the 2nd fatal and the most distributed cancer type in men worldwide. The present study was designated to gather the preclinical and clinical studies evaluating potencies of anthocyanidins/anthocyanins for the treatment and prevention of this cancer type for the first time. In general, findings confirm that the anthocyanins (especifically cyanidin-3-O-glucoside) indicated higher activity against prostatic neoplasms compared to their correlated anthocyanidins (e.g., delphinidin); in which potent anti-inflammatory, apoptosis, and anti-proliferative activities were analyzed. Complementary anti-prostate cancer assessment of diverse naturally occurred anthocyanidins/anthocyanins and their synthetically optimized derivatives through preclinical experiments and eventually confirmed by clinical trials can promisingly lead to discover natural-based chemotherapeutic drug options. LA - English DB - MTMT ER - TY - JOUR AU - Shakeri, Abolfazl AU - Hafezian, Toktam AU - Kúsz, Norbert AU - Hohmann, Judit AU - Boozari, Motahare AU - Mottaghipisheh, Javad AU - Emami, Seyed Ahmad AU - Tayarani-Najaran, Zahra AU - Asili, Javad TI - Cytotoxicity, apoptosis inducing activity and Western blot analysis of tanshinone derivatives from Stachys parviflora on prostate and breast cancer cells JF - MOLECULAR BIOLOGY REPORTS J2 - MOL BIOL REP VL - 49 PY - 2022 IS - 9 SP - 8251 EP - 8258 PG - 8 SN - 0301-4851 DO - 10.1007/s11033-022-07541-8 UR - https://m2.mtmt.hu/api/publication/33369323 ID - 33369323 AB - Cytotoxic activities of methanolic crude extract of Stachys parviflora (Lamiaceae family) and its sub-fractions were primarily evaluated against human breast adenocarcinoma (MCF-7 and MDA-MB-231) and prostate (PC3) cell lines. The methanolic extract exhibited the highest activity, and was chosen for the isolation procedure. Four diterpenoid qui- nones, namely miltirone [1], tanshinone IIA [2], 1-hydroxy-tanshinone IIA [3], and cryptotanshinone [4] were isolated. Notably, this is the first report on the isolation and/or characterization of the mentioned diterpenoids from the Stachys genus. In this study, 1-hydroxy-tanshinone IIA [3] displayed the highest cytotoxicity among the isolated compounds. The mechanism of the cytotoxicity of methanolic extract and isolated compounds was further investigated by the utilization of propidium iodide staining (PI) assay. The results showed that the methanolic extract and 1-hydroxy-tanshinone IIA [3] enhanced DNA fragmentation in PC3 and MCF-7 cells. Moreover, the western blotting analysis demonstrated increasing and decreasing protein levels of Bax and Bcl2, respectively, and cleaved poly ADP-ribose polymerase (PARP). Further bioassay-guided phytochemical assessments of S. parviflora can be suggested as a promising approach for discovering potent bioactive secondary metabolites. LA - English DB - MTMT ER - TY - JOUR AU - Amiri, Azam AU - Mortazavi, Seyed Mohammad Hassan AU - Ramezanian, Asghar AU - Sourestani, Mohammad Mahmoodi AU - Mottaghipisheh, Javad AU - Iriti, Marcello AU - Vitalini, Sara TI - Prevention of decay and maintenance of bioactive compounds in strawberry by application of UV-C and essential oils JF - JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION J2 - J FOOD MEAS CHARACT VL - 15 PY - 2021 IS - 6 SP - 5310 EP - 5317 PG - 8 SN - 2193-4126 DO - 10.1007/s11694-021-01095-2 UR - https://m2.mtmt.hu/api/publication/32385430 ID - 32385430 AB - The present study investigated the impact of exposing strawberry fruits against UV-C intensity, besides basil and eucalyptus essential oils (EOs) with 40 mu L on phytochemical content of the strawberry fruit. After treatment, fruits were transferred to 4 degrees C and the quality parameters comprising weight loss, firmness, antioxidant capacity, total phenolics, ascorbic acid, anthocyanins, titratable acidity, total soluble solids, and decay index were assessed after 1, 4, 8 and 12 days of cold storage. Results showed that all the factors were affected by the applied treatments, as well as the storage duration. The highest levels of firmness were found in BEO (2.47 N) and UV-C (2.44 N) treated fruits without significant difference. At the end of storage, the highest total phenol content (198.21 mg GAE L- 1) and antioxidant activity (3.51 mmol Fe II g(- 1) FW) were found in fruits treated with UV-C radiation, as well as l-ascorbic acid content (33.0 mg ascorbic acid/100 g FW) compared to the control group. The highest and lowest decays were recorded in control fruits (80%) and those treated with basil essential oils (43.3%), respectively. Applying UV-C radiation and volatile oils in vapor phase could improve the quality properties of treated strawberry fruits by increasing antioxidant activity due to the preservation of phenolic compounds. Further investigations are required to introduce the most convenient, optimized, and effective methods for increasing the strawberry fruits storage time. LA - English DB - MTMT ER - TY - JOUR AU - Mottaghipisheh, Javad AU - Taghrir, Hadi AU - Dehsheikh, Anahita Boveiri AU - Zomorodian, Kamiar AU - Irajie, Cambyz AU - Sourestani, Mohammad Mahmoodi AU - Iraji, Aida TI - Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 11 SN - 1424-8247 DO - 10.3390/ph14111104 UR - https://m2.mtmt.hu/api/publication/32670870 ID - 32670870 N1 - Export Date: 14 February 2022 Correspondence Address: Mottaghipisheh, J.; Center for Molecular Biosciences (CMBI), Innrain 80-82, Austria; email: javad.mottaghipisheh@uibk.ac.at Correspondence Address: Iraji, A.; Central Research laboratory, Iran; email: iraji@sums.ac.ir LA - English DB - MTMT ER -