@article{MTMT:33924008,
	title = {A new diterpenoid from Salvia santolinifolia boiss},
	url = {https://m2.mtmt.hu/api/publication/33924008},
	author = {Sargazifar, Zahra and Esmaeilzadeh Kashi, Marziyeh and Tazik, Zahra and Mottaghipisheh, Javad and Hosseini, Seyed Hamzeh and Stuppner, Hermann and Shakeri, Abolfazl and Asili, Javad},
	doi = {10.1080/14786419.2022.2161538},
	journal-iso = {NAT PROD RES},
	journal = {NATURAL PRODUCT RESEARCH},
	volume = {38},
	unique-id = {33924008},
	issn = {1478-6419},
	abstract = {Phytochemical study of the Salvia santolinifolia root extract resulted in the isolation of one new quinone diterpenoid, aegyptinone E (1) as well as two known ones, aegyptinone A (2) and aegyptinone D (3). All the isolated compounds were reported for the first time from S. santolinifolia. Spectroscopic analyses including 1 D and 2 D NMR and HRESIMS were used to determine the chemical structures. Aegyptinone A (2) showed moderate antibacterial activity against Staphylococcus aureus, Staphylococcus epidermis, and Bacillus subtilis with MIC of 25 mu g/mL.},
	keywords = {antibacterial activity; Lamiaceae; Salvia; Quinone diterpenoids},
	year = {2024},
	eissn = {1478-6427},
	pages = {1570-1576},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189}
}

@article{MTMT:34318164,
	title = {Effects of melatonin foliar application on hot pepper growth and stress tolerance},
	url = {https://m2.mtmt.hu/api/publication/34318164},
	author = {Khosravi, Saeed and Haghighi, Maryam and Mottaghipisheh, Javad},
	doi = {10.1016/j.stress.2023.100192},
	journal-iso = {PLANT STRESS},
	journal = {PLANT STRESS},
	volume = {9},
	unique-id = {34318164},
	issn = {2667-064X},
	abstract = {Purpose: Drought and waterlogging are one of the most severe abiotic stresses towards plant growth and development. The experiment was implemented in the Isfahan University of Technology's research greenhouse to examine the effect of melatonin foliar spraying in hot pepper plants under waterlogging and drought stresses. Methods: This factorial experiment was performed as a complete randomized design (CRD) in triplicate. The treatments included controls, waterlogging, drought stress, and melatonin foliar spraying at 0 and 500 & mu;M concentrations. Results: The results demonstrated that the foliar melatonin spraying was more advantageous under drought and waterlogging stress conditions via increasing ammonium content, NR (nitrate reductase activity), chlorophyll content, proline, protein, transpiration, shoot length, root water content, amino acid alterations, and PIP gene expression. Conclusions: Melatonin influenced the hot pepper's growth by affecting enzyme activity NR hormonal changes (ABA), amino acid changes, and PIP gene expression.},
	keywords = {PROTEIN; phytohormone; NITRATE REDUCTASE; Abiotic stresses},
	year = {2023},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189}
}

@article{MTMT:33778473,
	title = {A review on Torilis japonica: ethnomedicinal, phytochemical, and biological features},
	url = {https://m2.mtmt.hu/api/publication/33778473},
	author = {Rahimpour, Yahya and Doorandishan, Mina and Dehsheikh, Anahita Boveiri and Mahmoodi Sourestani, Mohammad and Mottaghipisheh, Javad},
	doi = {10.1002/cbdv.202201071},
	journal-iso = {CHEM BIODIVERS},
	journal = {CHEMISTRY & BIODIVERSITY},
	volume = {20},
	unique-id = {33778473},
	issn = {1612-1872},
	year = {2023},
	eissn = {1612-1880},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189}
}

@article{MTMT:34117692,
	title = {Allelopathic studies with furanocoumarins isolated from Ducrosia anethifolia. In vitro and in silico investigations to protect legumes, rice and grain crops},
	url = {https://m2.mtmt.hu/api/publication/34117692},
	author = {Rodríguez-Mejías, Francisco J. and Mottaghipisheh, Javad and Schwaiger, Stefan and Kiss, Tivadar and Csupor, Dezső and Varela, Rosa M. and Macías, Francisco A.},
	doi = {10.1016/j.phytochem.2023.113838},
	journal-iso = {PHYTOCHEMISTRY},
	journal = {PHYTOCHEMISTRY},
	volume = {215},
	unique-id = {34117692},
	issn = {0031-9422},
	year = {2023},
	eissn = {1873-3700},
	orcid-numbers = {Rodríguez-Mejías, Francisco J./0000-0001-6952-2964; Mottaghipisheh, Javad/0000-0002-4725-9189; Schwaiger, Stefan/0000-0002-3731-7349; Kiss, Tivadar/0000-0003-3538-377X; Csupor, Dezső/0000-0002-4088-3333; Macías, Francisco A./0000-0001-8862-2864}
}

@article{MTMT:34361114,
	title = {Oliveria decumbens Extract Exhibits Hepatoprotective Effects Against Bile Duct Ligation-Induced Liver Injury in Rats by Reducing Oxidative Stress},
	url = {https://m2.mtmt.hu/api/publication/34361114},
	author = {Salehi, Vahid and Malekiasl, Haniyeh and Azizi, Mahdokht and Nouripour-Sisakht, Sadegh and Gharaghani, Maral and Saberinejad, Ali Akbar and Moslemi, Zahra and Eftekhari, Mahdieh and Mottaghipisheh, Javad and Ghaderi, Sajad and Doustimotlagh, Amir Hossein and Karimifard, Farzaneh},
	doi = {10.5812/hepatmon-131160},
	journal-iso = {HEPAT MON},
	journal = {HEPATITIS MONTHLY},
	volume = {23},
	unique-id = {34361114},
	issn = {1735-143X},
	abstract = {Background: Cholestasis is described as a disease in which bile flow from the liver is reduced or stopped, and due to its oxidative effects, irreversible consequences may occur.Objectives: Due to the remarkable antioxidant properties of Oliveria decumbens (OD) and the contribution of oxidants to the pro-gression of bile duct ligation (BDL)-induced cholestasis, this research aimed to examine how the OD ethanolic extract affected liver damage and oxidant-antioxidant balance markers in BDL-induced cholestasis. Methods: Forty male Wistar rats weighing 200 -250 g were used. Cholestasis was induced using the BDL approach. The rats were categorized into four groups: Group 1, sham-control (SC); group 2, cholestatic; group 3, SC + OD; and group 4, cholestatic + OD. A dose of OD ethanolic extract was administered orally (500 mg/kg/day) to rats for seven days. Seven days following surgery, the rats' blood samples were collected; after sacrifice, a part of the liver tissue was isolated. A histopathological examination was performed, while the rest was stored at-70 & DEG;C in liquid nitrogen. Heparin-containing tubes were used to gather blood samples. In plasma and hepatic tissue, biochemical tests, histopathological evaluations, and oxidative stress markers staining levels were performed. Results: Our findings showed that OD could effectively reduce liver injury by reducing the activity of liver function enzymes (AST and ALP). At the same time, it did not affect total bilirubin and protein. Bile duct ligation-induced hepatic markers of protein oxi-dation (PCO) and reactive nitrogen species (NO) were significantly decreased by OD, and it also promoted liver antioxidant capacity by enhancing superoxide dismutase (SOD) activities. Moreover, OD treatment prevented liver bile duct proliferative changes in histopathologic analysis.Conclusions: Our study confirmed that OD exerts substantial hepatoprotective activities against BDL-induced cholestasis by im-proving liver damage markers and regulating oxidative stress. It may be a beneficial therapeutic agent for managing cholestasis. Bioassay-guided isolation and identification of bioactive OD secondary metabolites can further direct the discovery of potential natural-based drug candidates.},
	keywords = {STRESS; oxidative; Cholestasis; bile duct obstruction; Oliveria decumbens},
	year = {2023},
	eissn = {1735-3408},
	orcid-numbers = {Gharaghani, Maral/0000-0002-0144-3407; Mottaghipisheh, Javad/0000-0002-4725-9189}
}

@article{MTMT:32870684,
	title = {Adventitious Root Culture-An Alternative Strategy for Secondary Metabolite Production: A Review},
	url = {https://m2.mtmt.hu/api/publication/32870684},
	author = {Khanam, Mehrun Nisha and Anis, Mohammad and Bin, Javed Saad and Mottaghipisheh, Javad and Csupor, Dezső},
	doi = {10.3390/agronomy12051178},
	journal-iso = {AGRONOMY-BASEL},
	journal = {AGRONOMY (BASEL)},
	volume = {12},
	unique-id = {32870684},
	abstract = {Medicinal plants are valuable sources of botanical drugs, extracts and pure compounds. Although several species can be propagated or collected, the access to herbal material is limited in certain cases. The protection of natural habitats and biodiversity demands new sources to provide plant secondary metabolites of medical importance. Adventitious root culture is used to harvest the secondary metabolites from the medicinally important plants, thereby offering an alternative to collection and propagation of medicinal plants. In this review, we comprehensively summarize the previously published data on the use of adventitious root cultures for numerous therapeutic plants. Adventitious roots showed elevated growth rates and production of pharmaceutically important metabolites under sterilized condition with optimized plant-growth regulators in culture media. In the present study, major influencing factors, such as the stages involved in the process of adventitious root formation, medium composition and type of growth regulators, specifically the effect of different auxins on the initiation and formation of roots, are discussed. Elicitation strategies using biotic (yeast extracts, chitosan and pectin) and abiotic factors (MJ, SA, CuSO4, AgNO3, NaCl) that affect the in vitro growth of adventitious roots and the role of bioreactors, which are new advancements in the scale-up process, are also highlighted. The development of adventitious root cultures for the production of secondary metabolites of medicinal importance is a perspective that is advantageous from ecological and economical aspects as well.},
	keywords = {antioxidant activity; SUSPENSION-CULTURES; PHENOLIC-COMPOUNDS; Bioreactors; agronomy; micropropagation; Elicitors; PANAX-GINSENG; indole-3-butyric acid; Methyl jasmonate; Auxins; IN-VITRO PRODUCTION; ENHANCED PLUMBAGIN PRODUCTION; BASIPETAL TRANSPORT},
	year = {2022},
	eissn = {2073-4395},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:33395980,
	title = {The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer},
	url = {https://m2.mtmt.hu/api/publication/33395980},
	author = {Mottaghipisheh, Javad and Doustimotlagh, Amir Hossein and Irajie, Cambyz and Tanideh, Nader and Barzegar, Alireza and Iraji, Aida},
	doi = {10.3390/cells11071070},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {11},
	unique-id = {33395980},
	abstract = {As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity properties of these advantageous phytochemicals have been reported; among them, their significant abilities in the suppression of tumor cells are of the promising therapeutic features, which have recently attracted great attention. The prostate malignancy, is considered the 2nd fatal and the most distributed cancer type in men worldwide. The present study was designated to gather the preclinical and clinical studies evaluating potencies of anthocyanidins/anthocyanins for the treatment and prevention of this cancer type for the first time. In general, findings confirm that the anthocyanins (especifically cyanidin-3-O-glucoside) indicated higher activity against prostatic neoplasms compared to their correlated anthocyanidins (e.g., delphinidin); in which potent anti-inflammatory, apoptosis, and anti-proliferative activities were analyzed. Complementary anti-prostate cancer assessment of diverse naturally occurred anthocyanidins/anthocyanins and their synthetically optimized derivatives through preclinical experiments and eventually confirmed by clinical trials can promisingly lead to discover natural-based chemotherapeutic drug options.},
	keywords = {APOPTOSIS; CYTOTOXICITY; Cell Cycle; ANTHOCYANINS; Prostate cancer; Anthocyanidins},
	year = {2022},
	eissn = {2073-4409},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Doustimotlagh, Amir Hossein/0000-0002-9166-419X}
}

@article{MTMT:33369323,
	title = {Cytotoxicity, apoptosis inducing activity and Western blot analysis of tanshinone derivatives from Stachys parviflora on prostate and breast cancer cells},
	url = {https://m2.mtmt.hu/api/publication/33369323},
	author = {Shakeri, Abolfazl and Hafezian, Toktam and Kúsz, Norbert and Hohmann, Judit and Boozari, Motahare and Mottaghipisheh, Javad and Emami, Seyed Ahmad and Tayarani-Najaran, Zahra and Asili, Javad},
	doi = {10.1007/s11033-022-07541-8},
	journal-iso = {MOL BIOL REP},
	journal = {MOLECULAR BIOLOGY REPORTS},
	volume = {49},
	unique-id = {33369323},
	issn = {0301-4851},
	abstract = {Cytotoxic activities of methanolic crude extract of Stachys parviflora (Lamiaceae family) and its sub-fractions were primarily evaluated against human breast adenocarcinoma (MCF-7 and MDA-MB-231) and prostate (PC3) cell lines. The methanolic extract exhibited the highest activity, and was chosen for the isolation procedure. Four diterpenoid qui- nones, namely miltirone [1], tanshinone IIA [2], 1-hydroxy-tanshinone IIA [3], and cryptotanshinone [4] were isolated. Notably, this is the first report on the isolation and/or characterization of the mentioned diterpenoids from the Stachys genus. In this study, 1-hydroxy-tanshinone IIA [3] displayed the highest cytotoxicity among the isolated compounds. The mechanism of the cytotoxicity of methanolic extract and isolated compounds was further investigated by the utilization of propidium iodide staining (PI) assay. The results showed that the methanolic extract and 1-hydroxy-tanshinone IIA [3] enhanced DNA fragmentation in PC3 and MCF-7 cells. Moreover, the western blotting analysis demonstrated increasing and decreasing protein levels of Bax and Bcl2, respectively, and cleaved poly ADP-ribose polymerase (PARP). Further bioassay-guided phytochemical assessments of S. parviflora can be suggested as a promising approach for discovering potent bioactive secondary metabolites.},
	keywords = {APOPTOSIS; CYTOTOXICITY; Diterpenes; Western blot; tanshinones; Stachys parviflora},
	year = {2022},
	eissn = {1573-4978},
	pages = {8251-8258},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Mottaghipisheh, Javad/0000-0002-4725-9189}
}

@article{MTMT:32385430,
	title = {Prevention of decay and maintenance of bioactive compounds in strawberry by application of UV-C and essential oils},
	url = {https://m2.mtmt.hu/api/publication/32385430},
	author = {Amiri, Azam and Mortazavi, Seyed Mohammad Hassan and Ramezanian, Asghar and Sourestani, Mohammad Mahmoodi and Mottaghipisheh, Javad and Iriti, Marcello and Vitalini, Sara},
	doi = {10.1007/s11694-021-01095-2},
	journal-iso = {J FOOD MEAS CHARACT},
	journal = {JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION},
	volume = {15},
	unique-id = {32385430},
	issn = {2193-4126},
	abstract = {The present study investigated the impact of exposing strawberry fruits against UV-C intensity, besides basil and eucalyptus essential oils (EOs) with 40 mu L on phytochemical content of the strawberry fruit. After treatment, fruits were transferred to 4 degrees C and the quality parameters comprising weight loss, firmness, antioxidant capacity, total phenolics, ascorbic acid, anthocyanins, titratable acidity, total soluble solids, and decay index were assessed after 1, 4, 8 and 12 days of cold storage. Results showed that all the factors were affected by the applied treatments, as well as the storage duration. The highest levels of firmness were found in BEO (2.47 N) and UV-C (2.44 N) treated fruits without significant difference. At the end of storage, the highest total phenol content (198.21 mg GAE L- 1) and antioxidant activity (3.51 mmol Fe II g(- 1) FW) were found in fruits treated with UV-C radiation, as well as l-ascorbic acid content (33.0 mg ascorbic acid/100 g FW) compared to the control group. The highest and lowest decays were recorded in control fruits (80%) and those treated with basil essential oils (43.3%), respectively. Applying UV-C radiation and volatile oils in vapor phase could improve the quality properties of treated strawberry fruits by increasing antioxidant activity due to the preservation of phenolic compounds. Further investigations are required to introduce the most convenient, optimized, and effective methods for increasing the strawberry fruits storage time.},
	keywords = {antioxidant activity; polyphenols; SHELF-LIFE; post-harvest; fruit decay; Spoilage prevention},
	year = {2021},
	eissn = {2193-4134},
	pages = {5310-5317},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189}
}

@article{MTMT:32670870,
	title = {Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review},
	url = {https://m2.mtmt.hu/api/publication/32670870},
	author = {Mottaghipisheh, Javad and Taghrir, Hadi and Dehsheikh, Anahita Boveiri and Zomorodian, Kamiar and Irajie, Cambyz and Sourestani, Mohammad Mahmoodi and Iraji, Aida},
	doi = {10.3390/ph14111104},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {14},
	unique-id = {32670870},
	year = {2021},
	eissn = {1424-8247},
	orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189}
}