TY - CONF AU - Barta, Anita AU - Petz, Petra AU - Stefkó, Dóra AU - Purger, Dragica AU - Bakacsy, László AU - Hohmann, Judit AU - Vasas, Andrea ED - Hohmann, Judit TI - Isolation and structure determination of compounds from Juncus species T2 - 4th Symposium of Young Researchers on Pharmacognosy PB - Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged C1 - Szeged PY - 2023 SP - 9 EP - 9 PG - 1 DO - 10.14232/syrmpnpr.2023.3 UR - https://m2.mtmt.hu/api/publication/33963376 ID - 33963376 LA - English DB - MTMT ER - TY - THES AU - Stefkó, Dóra TI - Isolation and structure elucidation of phenanthrenes from Juncus species [Juncus fajok fenantrénjeinek izolálása és szerkezetmeghatározása] PB - Szegedi Tudományegyetem PY - 2023 SP - 56 DO - 10.14232/phd.11604 UR - https://m2.mtmt.hu/api/publication/34116252 ID - 34116252 LA - English DB - MTMT ER - TY - JOUR AU - Bakacsy, László AU - Sípos, Lilla AU - Barta, Anita AU - Stefkó, Dóra AU - Vasas, Andrea AU - Szepesi, Ágnes TI - Concentration-dependent effects of effusol and juncusol from Juncus compressus on seedling development of Arabidopsis thaliana JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-022-18063-5 UR - https://m2.mtmt.hu/api/publication/33053853 ID - 33053853 N1 - Department of Plant Biology, Institute of Biology, Faculty of Science and Informatics, University of Szeged, Közép Fasor 52., Szeged, 6726, Hungary Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Cited By :2 Export Date: 14 November 2023 Correspondence Address: Szepesi, Á.; Department of Plant Biology, Közép Fasor 52., Hungary; email: szepesia@bio.u-szeged.hu Chemicals/CAS: effusol; juncusol; Phenanthrenes; Polyamines Funding details: FK129061, NTP-NFTÖ-19-B-0208 Funding details: 5395 Funding details: Emberi Eroforrások Minisztériuma, EMMI, OTKA K 128963 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding text 1: The authors thank Réka Szőllősi for help with the statistical analysis. This work was conducted with the financial support of NKFIH OTKA Grant FK129061, Grant NTP-NFTÖ-19-B-0208 from the Ministry of Human Capacities, and partly from Grant OTKA K 128963 from NKFIH. The publication was financed by the University of Szeged Open Access Fund, Grant No. 5395. AB - Juncus species are valuable sources of phenanthrene compounds that have been used in traditional Chinese medicine for thousands of years. Effusol and juncusol are the most investigated compounds reported to have antimicrobial and anticancer effects; however, to date, their effects on higher plants have not been investigated. In this study, we examined the effects of effusol and juncusol on the growth and other biochemical parameters of the dicot model plant Arabidopsis thaliana in a concentration-dependent manner with a focus on polyamine metabolism. Phenanthrene induced toxic effects on plant growth and development, while effusol and juncusol induced higher biomass and maintained antioxidant defence mechanisms associated with reduced polyamine degradation. Taken together, our results suggest that these compounds could be good candidates for new biopesticide or biostimulant plant growth regulators in the future. LA - English DB - MTMT ER - TY - JOUR AU - Barta, Anita AU - Körmöczi, Tímea AU - Bús, Csaba AU - Stefkó, Dóra AU - Hohmann, Judit AU - Vasas, Andrea AU - Berkecz, Róbert TI - Targeted liquid chromatography-quadrupole Orbitrap mass spectrometry method for the quantification of phenanthrenes in Juncus compressus Jacq JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 88 PY - 2022 IS - 15 SP - 1525 SN - 0032-0943 DO - 10.1055/s-0042-1759219 UR - https://m2.mtmt.hu/api/publication/33575918 ID - 33575918 LA - English DB - MTMT ER - TY - JOUR AU - Dávid, Csilla Zsuzsanna AU - Kúsz, Norbert AU - Stefkó, Dóra AU - Papp, L AU - Hohmann, Judit AU - Vasas, Andrea TI - Screening of the antioxidant capacity of Cyperaceae species and isolation of stilbenoids and other phenolic compounds from Carex praecox JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 88 PY - 2022 IS - 15 SP - 1542 SN - 0032-0943 DO - 10.1055/s-0042-1759267 UR - https://m2.mtmt.hu/api/publication/33686911 ID - 33686911 LA - English DB - MTMT ER - TY - JOUR AU - Stefkó, Dóra AU - Kúsz, Norbert AU - Szemerédi, Nikoletta AU - Barta, Anita AU - Spengler, Gabriella AU - Berkecz, Róbert AU - Hohmann, Judit AU - Vasas, Andrea TI - Unique Phenanthrenes from Juncus ensifolius and Their Antiproliferative and Synergistic Effects with the Conventional Anticancer Agent Doxorubicin against Human Cancer Cell Lines JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 3 PG - 17 SN - 1999-4923 DO - 10.3390/pharmaceutics14030608 UR - https://m2.mtmt.hu/api/publication/32793306 ID - 32793306 N1 - Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, 6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, 6725, Hungary Institute of Pharmaceutical Analysis, University of Szeged, Szeged, 6720, Hungary Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, 6720, Hungary Cited By :1 Export Date: 19 June 2023 Correspondence Address: Vasas, A.; Department of Pharmacognosy, Hungary; email: vasas.andrea@szte.hu Chemicals/CAS: 4 hydroxybenzaldehyde, 123-08-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; dimethyl sulfoxide, 67-68-5; doxorubicin, 23214-92-8, 25316-40-9; luteolin, 491-70-3; phenanthrene, 85-01-8 Tradenames: Avance DRX 500, Bruker; Multiscan EX, Thermo Labsystems, United States; Q Exactive, Thermo Manufacturers: Bruker; Jasco, Japan; Thermo; Thermo Labsystems, United States Funding details: GINOP-2.3.2-15-2016-00012 Funding details: Emberi Eroforrások Minisztériuma, EMMI, EFOP-3.6.3-VEKOP-16-2017-00009 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K128963 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: This research was funded by the Economic Development and Innovation Operative Program GINOP-2.3.2-15-2016-00012, the UNKP-20-3-II New National Excellence Program of the Ministry of Human Capacities, EFOP-3.6.3-VEKOP-16-2017-00009, and the National Research, Development and Innovation Office, Hungary (NKFIH; K128963). LA - English DB - MTMT ER - TY - CONF AU - Szepesi, Ágnes AU - Sípos, Lilla AU - Barta, Anita AU - Stefkó, Dóra AU - Vasas, Andrea AU - Bakacsy, László TI - Bioactivity of rush-specific (Juncus sp.) compounds on antioxidant defence mechanisms of Arabidopsis thaliana T2 - Abstract Book Redox Biology Congress Ghent 2022 PY - 2022 SP - 113 EP - 113 PG - 1 UR - https://m2.mtmt.hu/api/publication/33093357 ID - 33093357 LA - English DB - MTMT ER - TY - CONF AU - Stefkó, Dóra ED - Kiss, Tivadar ED - Hohmann, Judit TI - Ensifolins A-M, new phenanthrenes from Juncus ensifolius T2 - 2nd Symposium of Young Researchers on Pharmacognosy PB - Szegedi Tudományegyetem, Gyógyszerésztudományi Kar, Farmakognóziai Intézet C1 - Szeged PY - 2021 PG - 1 DO - 10.14232/syrpharmacognosy.2021.a16 UR - https://m2.mtmt.hu/api/publication/32013412 ID - 32013412 LA - English DB - MTMT ER - TY - JOUR AU - Kúsz, Norbert AU - Stefkó, Dóra AU - Barta, Anita AU - Kincses, Annamária AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Vasas, Andrea TI - Juncaceae Species as Promising Sources of Phenanthrenes: Antiproliferative Compounds from Juncus maritimus Lam JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 4 PG - 11 SN - 1420-3049 DO - 10.3390/molecules26040999 UR - https://m2.mtmt.hu/api/publication/31921807 ID - 31921807 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology from the National Research, Development and Innovation Funds [UNKP-20-4, UNKP-18-3-I, NTP-NFTO-19-B-0208, EFOP 3.6.3-VEKOP16-2017-00009]; Economic Development and Innovation Operative Programme of the Ministry of Human Capacities [GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00020, 20391-3/2018/FEKUSTRAT]; National Research, Development and Innovation Office, Hungary (NKFIH) [K128963] Funding text: This research was funded by the UNKP-20-4 (first author N.K.) and UNKP-18-3-I (first author D.S.)-New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Funds, grant NTP-NFTO-19-B-0208, EFOP 3.6.3-VEKOP16-2017-00009, Economic Development and Innovation Operative Programme GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00020, and grant 20391-3/2018/FEKUSTRAT of the Ministry of Human Capacities, and the National Research, Development and Innovation Office, Hungary (NKFIH; K128963). AB - Juncaceae family represents an abundant source of phenanthrenes. In continuation of our work aiming at the isolation of biologically active compounds from Juncaceae species, Juncus maritimus Lam. was subjected to phytochemical and pharmacological investigations. The isolation process was carried out by using combined extraction and chromatographic methods. The structures of the obtained chemical compounds were elucidated by spectroscopic analysis, including HRESIMS, 1D (H-1, C-13-JMOD), and 2D (H-1-H-1-COSY, HSQC, HMBC, NOESY) NMR spectra. Four new [maritins A-D (1-4)] and seven known phenanthrenes (5-11) were isolated from the plant, of which two (4 and 11) are phenanthrene dimers composed of effusol monomers. Maritin C (3) has an unusual 4,5-ethanophenanthrene skeleton most likely produced by biosynthetic incorporation of a vinyl group into a cyclohexadiene ring. Compounds 1-11 were tested for their antiproliferative activity on seven human tumor cell lines (HeLa, HTM-26, T-47D, A2780, A2780cis, MCF-7, KCR) and one normal cell line (MRC-5) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The dimeric phenanthrenes showed strong antiproliferative activity against T-47D cells with IC50 values of 9.1 and 6.2 mu M, respectively. LA - English DB - MTMT ER - TY - JOUR AU - Stefkó, Dóra AU - Kúsz, Norbert AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Vasas, Andrea TI - Biologically active phenanthrenes from four Juncus species native to Hungary JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 87 PY - 2021 IS - 15 SP - 1251 EP - 1251 PG - 1 SN - 0032-0943 DO - 10.1055/s-0041-1736786 UR - https://m2.mtmt.hu/api/publication/33041581 ID - 33041581 LA - English DB - MTMT ER -