@CONFERENCE{MTMT:33963376, title = {Isolation and structure determination of compounds from Juncus species}, url = {https://m2.mtmt.hu/api/publication/33963376}, author = {Barta, Anita and Petz, Petra and Stefkó, Dóra and Purger, Dragica and Bakacsy, László and Hohmann, Judit and Vasas, Andrea}, booktitle = {4th Symposium of Young Researchers on Pharmacognosy}, doi = {10.14232/syrmpnpr.2023.3}, unique-id = {33963376}, year = {2023}, pages = {9-9}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Purger, Dragica/0000-0003-2480-0777; Bakacsy, László/0000-0003-2593-1795; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @mastersthesis{MTMT:34116252, title = {Isolation and structure elucidation of phenanthrenes from Juncus species [Juncus fajok fenantrénjeinek izolálása és szerkezetmeghatározása]}, url = {https://m2.mtmt.hu/api/publication/34116252}, author = {Stefkó, Dóra}, doi = {10.14232/phd.11604}, publisher = {Universití of Szeged}, unique-id = {34116252}, year = {2023}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X} } @article{MTMT:33053853, title = {Concentration-dependent effects of effusol and juncusol from Juncus compressus on seedling development of Arabidopsis thaliana}, url = {https://m2.mtmt.hu/api/publication/33053853}, author = {Bakacsy, László and Sípos, Lilla and Barta, Anita and Stefkó, Dóra and Vasas, Andrea and Szepesi, Ágnes}, doi = {10.1038/s41598-022-18063-5}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {33053853}, issn = {2045-2322}, abstract = {Juncus species are valuable sources of phenanthrene compounds that have been used in traditional Chinese medicine for thousands of years. Effusol and juncusol are the most investigated compounds reported to have antimicrobial and anticancer effects; however, to date, their effects on higher plants have not been investigated. In this study, we examined the effects of effusol and juncusol on the growth and other biochemical parameters of the dicot model plant Arabidopsis thaliana in a concentration-dependent manner with a focus on polyamine metabolism. Phenanthrene induced toxic effects on plant growth and development, while effusol and juncusol induced higher biomass and maintained antioxidant defence mechanisms associated with reduced polyamine degradation. Taken together, our results suggest that these compounds could be good candidates for new biopesticide or biostimulant plant growth regulators in the future.}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Bakacsy, László/0000-0003-2593-1795; Stefkó, Dóra/0000-0002-5435-546X; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:33575918, title = {Targeted liquid chromatography-quadrupole Orbitrap mass spectrometry method for the quantification of phenanthrenes in Juncus compressus Jacq}, url = {https://m2.mtmt.hu/api/publication/33575918}, author = {Barta, Anita and Körmöczi, Tímea and Bús, Csaba and Stefkó, Dóra and Hohmann, Judit and Vasas, Andrea and Berkecz, Róbert}, doi = {10.1055/s-0042-1759219}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {88}, unique-id = {33575918}, issn = {0032-0943}, year = {2022}, eissn = {1439-0221}, pages = {1525}, orcid-numbers = {Körmöczi, Tímea/0000-0002-0973-2473; Bús, Csaba/0000-0002-4515-8317; Stefkó, Dóra/0000-0002-5435-546X; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702; Berkecz, Róbert/0000-0002-9076-2177} } @article{MTMT:33686911, title = {Screening of the antioxidant capacity of Cyperaceae species and isolation of stilbenoids and other phenolic compounds from Carex praecox}, url = {https://m2.mtmt.hu/api/publication/33686911}, author = {Dávid, Csilla Zsuzsanna and Kúsz, Norbert and Stefkó, Dóra and Papp, L and Hohmann, Judit and Vasas, Andrea}, doi = {10.1055/s-0042-1759267}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {88}, unique-id = {33686911}, issn = {0032-0943}, year = {2022}, eissn = {1439-0221}, pages = {1542}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Stefkó, Dóra/0000-0002-5435-546X; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:32793306, title = {Unique Phenanthrenes from Juncus ensifolius and Their Antiproliferative and Synergistic Effects with the Conventional Anticancer Agent Doxorubicin against Human Cancer Cell Lines}, url = {https://m2.mtmt.hu/api/publication/32793306}, author = {Stefkó, Dóra and Kúsz, Norbert and Szemerédi, Nikoletta and Barta, Anita and Spengler, Gabriella and Berkecz, Róbert and Hohmann, Judit and Vasas, Andrea}, doi = {10.3390/pharmaceutics14030608}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32793306}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Berkecz, Róbert/0000-0002-9076-2177; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @CONFERENCE{MTMT:33093357, title = {Bioactivity of rush-specific (Juncus sp.) compounds on antioxidant defence mechanisms of Arabidopsis thaliana}, url = {https://m2.mtmt.hu/api/publication/33093357}, author = {Szepesi, Ágnes and Sípos, Lilla and Barta, Anita and Stefkó, Dóra and Vasas, Andrea and Bakacsy, László}, booktitle = {Abstract Book Redox Biology Congress Ghent 2022}, unique-id = {33093357}, year = {2022}, pages = {113-113}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Vasas, Andrea/0000-0002-1818-7702; Bakacsy, László/0000-0003-2593-1795} } @CONFERENCE{MTMT:32013412, title = {Ensifolins A-M, new phenanthrenes from Juncus ensifolius}, url = {https://m2.mtmt.hu/api/publication/32013412}, author = {Stefkó, Dóra}, booktitle = {2nd Symposium of Young Researchers on Pharmacognosy}, doi = {10.14232/syrpharmacognosy.2021.a16}, unique-id = {32013412}, year = {2021}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X} } @article{MTMT:31921807, title = {Juncaceae Species as Promising Sources of Phenanthrenes: Antiproliferative Compounds from Juncus maritimus Lam}, url = {https://m2.mtmt.hu/api/publication/31921807}, author = {Kúsz, Norbert and Stefkó, Dóra and Barta, Anita and Kincses, Annamária and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Vasas, Andrea}, doi = {10.3390/molecules26040999}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {26}, unique-id = {31921807}, issn = {1420-3049}, abstract = {Juncaceae family represents an abundant source of phenanthrenes. In continuation of our work aiming at the isolation of biologically active compounds from Juncaceae species, Juncus maritimus Lam. was subjected to phytochemical and pharmacological investigations. The isolation process was carried out by using combined extraction and chromatographic methods. The structures of the obtained chemical compounds were elucidated by spectroscopic analysis, including HRESIMS, 1D (H-1, C-13-JMOD), and 2D (H-1-H-1-COSY, HSQC, HMBC, NOESY) NMR spectra. Four new [maritins A-D (1-4)] and seven known phenanthrenes (5-11) were isolated from the plant, of which two (4 and 11) are phenanthrene dimers composed of effusol monomers. Maritin C (3) has an unusual 4,5-ethanophenanthrene skeleton most likely produced by biosynthetic incorporation of a vinyl group into a cyclohexadiene ring. Compounds 1-11 were tested for their antiproliferative activity on seven human tumor cell lines (HeLa, HTM-26, T-47D, A2780, A2780cis, MCF-7, KCR) and one normal cell line (MRC-5) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The dimeric phenanthrenes showed strong antiproliferative activity against T-47D cells with IC50 values of 9.1 and 6.2 mu M, respectively.}, keywords = {d; Biochemistry & Molecular Biology; Juncus maritimus; maritins A–; phenanthrene dimers}, year = {2021}, eissn = {1420-3049}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Stefkó, Dóra/0000-0002-5435-546X; Kincses, Annamária/0000-0002-1591-1419; Szemerédi, Nikoletta/0000-0002-8638-5815; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:33041581, title = {Biologically active phenanthrenes from four Juncus species native to Hungary}, url = {https://m2.mtmt.hu/api/publication/33041581}, author = {Stefkó, Dóra and Kúsz, Norbert and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Vasas, Andrea}, doi = {10.1055/s-0041-1736786}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {87}, unique-id = {33041581}, issn = {0032-0943}, year = {2021}, eissn = {1439-0221}, pages = {1251-1251}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} }