TY  - JOUR
AU  - Heger, Vladimir
AU  - Benesova, Barbora
AU  - Viskupicova, Jana
AU  - Majekova, Magdalena
AU  - Zoofishan, Zoofishan
AU  - Hunyadi, Attila
AU  - Horakova, Lubica
TI  - Phenolic Compounds from Morus nigra Regulate Viability and Apoptosis of Pancreatic β-Cells Possibly via SERCA Activity
JF  - ACS MEDICINAL CHEMISTRY LETTERS
J2  - ACS MED CHEM LETT
VL  - 11
PY  - 2020
IS  - 5
SP  - 1006
EP  - 1013
PG  - 8
SN  - 1948-5875
DO  - 10.1021/acsmedchemlett.0c00047
UR  - https://m2.mtmt.hu/api/publication/31264880
ID  - 31264880
LA  - English
DB  - MTMT
ER  - 

TY  - THES
AU  - Zoofishan, Zoofishan
TI  - Isolation of bioactive phenolic compounds from the root bark of Morus nigra
PB  - Szegedi Tudományegyetem (SZTE)
PY  - 2020
SP  - 60
DO  - 10.14232/phd.10604
UR  - https://m2.mtmt.hu/api/publication/31404653
ID  - 31404653
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Fási, Laura
AU  - Vágvölgyi, Máté
AU  - Latif, Ahmed Dhahir
AU  - Issaadi, Halima Meriem
AU  - Zoofishan, Zoofishan
AU  - Zupkó, István
AU  - Spengler, Gabriella
AU  - Martins, Ana
AU  - Hunyadi, Attila
TI  - Natural product inspired chemical approaches against MDR cancer
T2  - New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours
PY  - 2019
SP  - 12
EP  - 13
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/31192702
ID  - 31192702
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zoofishan, Zoofishan
AU  - Kúsz, Norbert
AU  - Tóth, G
AU  - Hajagos-Tóth, Judit
AU  - Kothencz, Anna
AU  - Gáspár, Róbert
AU  - Hunyadi, Attila
TI  - Antispasmodic phenolic compounds isolated from Morus nigra root bark
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 18
PY  - 2019
IS  - 85
SP  - 1515
EP  - 1515
PG  - 1
SN  - 0032-0943
DO  - 10.1055/s-0039-3399964
UR  - https://m2.mtmt.hu/api/publication/31192717
ID  - 31192717
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zoofishan, Zoofishan
AU  - Kúsz, Norbert
AU  - Csorba, Attila
AU  - Tóth, Gábor
AU  - Hajagos-Tóth, Judit
AU  - Kothencz, Anna
AU  - Gáspár, Róbert
AU  - Hunyadi, Attila
TI  - Antispasmodic Activity of Prenylated Phenolic Compounds from the Root Bark of Morus nigra
JF  - MOLECULES
J2  - MOLECULES
VL  - 24
PY  - 2019
IS  - 13
PG  - 12
SN  - 1420-3049
DO  - 10.3390/molecules24132497
UR  - https://m2.mtmt.hu/api/publication/30734475
ID  - 30734475
N1  - Institute of Pharmacognosy, Interdisciplinary Excellence Center, University of Szeged, Szeged, H-6720, Hungary            
            NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért Sq. 4, Budapest, H-1111, Hungary            
            Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, H-6720, Hungary            
            Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, H-670, Hungary            
            Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, H-6720, Hungary            
            Institute of Plant Biology, Biological Research Centre, Szeged, H-6720, Hungary            
            Cited By :1            
            Export Date: 21 October 2020            
            CODEN: MOLEF            
            Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Interdisciplinary Excellence Center, University of SzegedHungary; email: hunyadi.a@pharm.u-szeged.hu
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Vladimir, Heger
AU  - Minna, Rahnasto-Rilla
AU  - Jana, Viskupicova
AU  - Zoofishan, Zoofishan
AU  - Hunyadi, Attila
AU  - Lubica, Horakova
AU  - Maria, Mastihubova
AU  - Maija, Lahtela-Kakkonen
TI  - Modulation of SIRT6 deacetylation activity by flavonoid derivatives
T2  - Challenging organic syntheses inspired by nature - From natural products chemistry to drug discovery
PY  - 2018
UR  - https://m2.mtmt.hu/api/publication/3367121
ID  - 3367121
N1  - [poszter]
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zoofishan, Zoofishan
AU  - Hohmann, Judit
AU  - Hunyadi, Attila
TI  - Phenolic antioxidants of Morus nigra roots, and antitumor potential of morusin
JF  - PHYTOCHEMISTRY REVIEWS
J2  - PHYTOCHEM REV
VL  - 17
PY  - 2018
IS  - 5
SP  - 1031
EP  - 1045
PG  - 15
SN  - 1568-7767
DO  - 10.1007/s11101-018-9565-1
UR  - https://m2.mtmt.hu/api/publication/3352785
ID  - 3352785
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vladimir, Heger
AU  - Jana, Viskupicova
AU  - Zoofishan, Zoofishan
AU  - Hunyadi, Attila
AU  - Lubica, Horakova
TI  - Sarco/endoplasmic Ca2+ -ATPase (SERCA) and pancreatic beta cells modified by prenylated phenolic compounds from Morus nigra
JF  - JORNAL DE INVESTIGACAO BIOMEDICA E BIOFARMACEUTICA / JOURNAL BIOMEDICAL AND BIOPHARMACEUTICAL RESEARCH
J2  - J BIOMED BIOPHARM RES
VL  - 14
PY  - 2017
IS  - 2
SP  - 282
EP  - 282
PG  - 1
SN  - 2182-2360
UR  - https://m2.mtmt.hu/api/publication/3287585
ID  - 3287585
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zoofishan, Zoofishan
AU  - Kúsz, Norbert
AU  - Zomborszki, Zoltán Péter
AU  - Csorba, Attila
AU  - Hunyadi, Attila
TI  - In vitro angiotensin-converting enzyme inhibition by phenolic compounds isolated from the root bark of Morus nigra
JF  - PLANTA MEDICA INTERNATIONAL OPEN
J2  - PLANTA MEDICA INT OPEN
VL  - 4
PY  - 2017
IS  - S 01
SN  - 2509-6656
DO  - 10.1055/s-0037-1608143
UR  - https://m2.mtmt.hu/api/publication/3287861
ID  - 3287861
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Zoofishan, Zoofishan
AU  - Kúsz, Norbert
AU  - Zomborszki, Zoltán Péter
AU  - Csorba, Attila
AU  - Hunyadi, Attila
ED  - Céline, Rivière
TI  - Angiotensin-Converting Enzyme inhibition by phenolic compounds isolated from the root bark of Morus nigra
T2  - Trends in Natural Product Research - PSE Young Scientists’ Meeting Lille 2017. Natural Products in Health, Agro-food and Cosmetics: Abstracts of the Phytochemical Society of Europe
PB  - Phytochemical Society of Europe
CY  - Leicester
SN  - 9780956547262
PY  - 2017
SP  - 190
EP  - 190
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/3245172
ID  - 3245172
AB  - Previous studies have demonstrated that certain flavonoids 
can have an inhibitory effect on the activity of angiotensin-
converting enzyme (ACE), involved in several pathological 
cardiovascular conditions including hypertension1. The black 
mulberry tree, Morus nigra L.(Moraceae), is known for its 
very high total phenolic and flavonoid content, making it the 
richest source of such compounds when compared to other Morus 
species. The root bark of M. nigra has been reported to 
possess a broad range of bioactivities including 
antihypertensive effect, supporting its related traditional 
use2. Nevertheless, only limited information is available on 
the ACE inhibitory activity of this drug or its constituents.
In the present study, a methanolic extract of M. nigra root 
bark was subjected to a phytochemical study through the 
consecutive use of various preparative chromatographic 
techniques, leading to the isolation and characterization of 
seven phenolic compounds. Their chemical structures were 
elucidated by one- and two-dimensional NMR spectroscopy and 
HRMS, identifying them as prenylated arylbenzofurans such as 
Moracin P (1) and Moracin R (2), and prenylated flavonoids 
such as Kuwanon U (3), Morusin (4), Kuwanon E (5), Albanol A 
(6) and Albanol B (7). Compounds 1-7 were evaluated for their 
potential to inhibit ACE in vitro. Our preliminary results 
revealed the highest ACE inhibition activity for compounds 5-
7, each showing a complete inhibition of the enzyme at a 
concentration of 36.4 μg/mL, whereas compound (3) exhibited 
nearly 50% inhibition at the same concentration.
Our results suggest that M. nigra is an excellent source of 
potentially anti-hypertensive compounds, and that ACE 
inhibition by its prenylated phenolic compounds might provide 
a rationale for its related traditional use.
LA  - English
DB  - MTMT
ER  -