@article{MTMT:31264880, title = {Phenolic Compounds from Morus nigra Regulate Viability and Apoptosis of Pancreatic β-Cells Possibly via SERCA Activity}, url = {https://m2.mtmt.hu/api/publication/31264880}, author = {Heger, Vladimir and Benesova, Barbora and Viskupicova, Jana and Majekova, Magdalena and Zoofishan, Zoofishan and Hunyadi, Attila and Horakova, Lubica}, doi = {10.1021/acsmedchemlett.0c00047}, journal-iso = {ACS MED CHEM LETT}, journal = {ACS MEDICINAL CHEMISTRY LETTERS}, volume = {11}, unique-id = {31264880}, issn = {1948-5875}, year = {2020}, pages = {1006-1013}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @mastersthesis{MTMT:31404653, title = {Isolation of bioactive phenolic compounds from the root bark of Morus nigra}, url = {https://m2.mtmt.hu/api/publication/31404653}, author = {Zoofishan, Zoofishan}, doi = {10.14232/phd.10604}, publisher = {SZTE}, unique-id = {31404653}, year = {2020} } @CONFERENCE{MTMT:31192702, title = {Natural product inspired chemical approaches against MDR cancer}, url = {https://m2.mtmt.hu/api/publication/31192702}, author = {Fási, Laura and Vágvölgyi, Máté and Latif, Ahmed Dhahir and Issaadi, Halima Meriem and Zoofishan, Zoofishan and Zupkó, István and Spengler, Gabriella and Martins, Ana and Hunyadi, Attila}, booktitle = {New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours}, unique-id = {31192702}, year = {2019}, pages = {12-13}, orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Zupkó, István/0000-0003-3243-5300; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:31192717, title = {Antispasmodic phenolic compounds isolated from Morus nigra root bark}, url = {https://m2.mtmt.hu/api/publication/31192717}, author = {Zoofishan, Zoofishan and Kúsz, Norbert and Tóth, G and Hajagos-Tóth, Judit and Kothencz, Anna and Gáspár, Róbert and Hunyadi, Attila}, doi = {10.1055/s-0039-3399964}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {18}, unique-id = {31192717}, issn = {0032-0943}, year = {2019}, eissn = {1439-0221}, pages = {1515-1515}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kothencz, Anna/0000-0003-4359-7049; Gáspár, Róbert/0000-0002-1571-7579; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:30734475, title = {Antispasmodic Activity of Prenylated Phenolic Compounds from the Root Bark of Morus nigra}, url = {https://m2.mtmt.hu/api/publication/30734475}, author = {Zoofishan, Zoofishan and Kúsz, Norbert and Csorba, Attila and Tóth, Gábor and Hajagos-Tóth, Judit and Kothencz, Anna and Gáspár, Róbert and Hunyadi, Attila}, doi = {10.3390/molecules24132497}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {24}, unique-id = {30734475}, issn = {1420-3049}, year = {2019}, eissn = {1420-3049}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Csorba, Attila/0000-0002-4032-1605; Kothencz, Anna/0000-0003-4359-7049; Gáspár, Róbert/0000-0002-1571-7579; Hunyadi, Attila/0000-0003-0074-3472} } @CONFERENCE{MTMT:3367121, title = {Modulation of SIRT6 deacetylation activity by flavonoid derivatives}, url = {https://m2.mtmt.hu/api/publication/3367121}, author = {Vladimir, Heger and Minna, Rahnasto-Rilla and Jana, Viskupicova and Zoofishan, Zoofishan and Hunyadi, Attila and Lubica, Horakova and Maria, Mastihubova and Maija, Lahtela-Kakkonen}, booktitle = {Challenging organic syntheses inspired by nature - From natural products chemistry to drug discovery}, unique-id = {3367121}, year = {2018}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:3352785, title = {Phenolic antioxidants of Morus nigra roots, and antitumor potential of morusin}, url = {https://m2.mtmt.hu/api/publication/3352785}, author = {Zoofishan, Zoofishan and Hohmann, Judit and Hunyadi, Attila}, doi = {10.1007/s11101-018-9565-1}, journal-iso = {PHYTOCHEM REV}, journal = {PHYTOCHEMISTRY REVIEWS}, volume = {17}, unique-id = {3352785}, issn = {1568-7767}, year = {2018}, eissn = {1572-980X}, pages = {1031-1045}, orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:3287585, title = {Sarco/endoplasmic Ca2+ -ATPase (SERCA) and pancreatic beta cells modified by prenylated phenolic compounds from Morus nigra}, url = {https://m2.mtmt.hu/api/publication/3287585}, author = {Vladimir, Heger and Jana, Viskupicova and Zoofishan, Zoofishan and Hunyadi, Attila and Lubica, Horakova}, journal-iso = {J BIOMED BIOPHARM RES}, journal = {JORNAL DE INVESTIGACAO BIOMEDICA E BIOFARMACEUTICA / JOURNAL BIOMEDICAL AND BIOPHARMACEUTICAL RESEARCH}, volume = {14}, unique-id = {3287585}, issn = {2182-2360}, year = {2017}, eissn = {2182-2379}, pages = {282-282}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:3287861, title = {In vitro angiotensin-converting enzyme inhibition by phenolic compounds isolated from the root bark of Morus nigra}, url = {https://m2.mtmt.hu/api/publication/3287861}, author = {Zoofishan, Zoofishan and Kúsz, Norbert and Zomborszki, Zoltán Péter and Csorba, Attila and Hunyadi, Attila}, doi = {10.1055/s-0037-1608143}, journal-iso = {PLANTA MEDICA INT OPEN}, journal = {PLANTA MEDICA INTERNATIONAL OPEN}, volume = {4}, unique-id = {3287861}, year = {2017}, eissn = {2509-6656}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Zomborszki, Zoltán Péter/0000-0002-7412-9793; Csorba, Attila/0000-0002-4032-1605; Hunyadi, Attila/0000-0003-0074-3472} } @{MTMT:3245172, title = {Angiotensin-Converting Enzyme inhibition by phenolic compounds isolated from the root bark of Morus nigra}, url = {https://m2.mtmt.hu/api/publication/3245172}, author = {Zoofishan, Zoofishan and Kúsz, Norbert and Zomborszki, Zoltán Péter and Csorba, Attila and Hunyadi, Attila}, booktitle = {Trends in Natural Product Research - PSE Young Scientists’ Meeting Lille 2017. Natural Products in Health, Agro-food and Cosmetics: Abstracts of the Phytochemical Society of Europe}, unique-id = {3245172}, abstract = {Previous studies have demonstrated that certain flavonoids can have an inhibitory effect on the activity of angiotensin- converting enzyme (ACE), involved in several pathological cardiovascular conditions including hypertension1. The black mulberry tree, Morus nigra L.(Moraceae), is known for its very high total phenolic and flavonoid content, making it the richest source of such compounds when compared to other Morus species. The root bark of M. nigra has been reported to possess a broad range of bioactivities including antihypertensive effect, supporting its related traditional use2. Nevertheless, only limited information is available on the ACE inhibitory activity of this drug or its constituents. In the present study, a methanolic extract of M. nigra root bark was subjected to a phytochemical study through the consecutive use of various preparative chromatographic techniques, leading to the isolation and characterization of seven phenolic compounds. Their chemical structures were elucidated by one- and two-dimensional NMR spectroscopy and HRMS, identifying them as prenylated arylbenzofurans such as Moracin P (1) and Moracin R (2), and prenylated flavonoids such as Kuwanon U (3), Morusin (4), Kuwanon E (5), Albanol A (6) and Albanol B (7). Compounds 1-7 were evaluated for their potential to inhibit ACE in vitro. Our preliminary results revealed the highest ACE inhibition activity for compounds 5- 7, each showing a complete inhibition of the enzyme at a concentration of 36.4 μg/mL, whereas compound (3) exhibited nearly 50% inhibition at the same concentration. Our results suggest that M. nigra is an excellent source of potentially anti-hypertensive compounds, and that ACE inhibition by its prenylated phenolic compounds might provide a rationale for its related traditional use.}, year = {2017}, pages = {190-190}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Zomborszki, Zoltán Péter/0000-0002-7412-9793; Csorba, Attila/0000-0002-4032-1605; Hunyadi, Attila/0000-0003-0074-3472} }